Central granular cell odontogenic tumor: immunohistochemistry and ultrastructure.

Abstract:

:Central granular cell odontogenic tumors are rare, with only 30 cases having been reported. The tumors usually occur in the mandibular molar area and are seen as localized painless swellings in patients older than 40 years. We report an additional case that occurred in the posterior mandible of an elderly black woman. All reported cases of this tumor are benign, and cure is effected by localized surgical excision. Ultrastructurally, the cells contain numerous lysosomes and phagocytic vacuoles. Immunohistochemically, the granular cells were positive for vimentin, CD68, muramidase, carcinogenic embryonic antigen, and bcl-2. These features support a mesenchymal origin with a possible histiocytic lineage for the granular cells. Awareness of the occurrence of this neoplasm is important to promote detection and differentiation from other intraoral granular cell lesions.

journal_name

Am J Otolaryngol

authors

Meer S,Altini M,Coleman H,Daya N

doi

10.1016/j.amjoto.2003.09.002

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

73-8

issue

1

eissn

0196-0709

issn

1532-818X

pii

S0196070903001170

journal_volume

25

pub_type

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