Abstract:
:The purpose of this study was to compare the beneficial effects of radioactive stents and radioactive stents plus additional chemotherapy in the palliative treatment of cholangiocellular carcinomas. Cholangiocellular carcinoma cells (TFK-1 cells) were treated either with 8 Gy (RTB group) or 16 Gy (RTA group) (188)Re or with (188)Re irradiation (8 Gy) combined with either gemcitabine (8 Gy/Gem) or 5-fluorouracil (8 Gy/5-FU) at a dosage of 20 microg/ml medium for 4 days and subsequently compared with an untreated control group. Proliferation kinetics were assessed on days 4, 7, 11, 18, 25, and 32. Colony formation assays were performed on days 7, 18, and 32 and cell cycle distribution was examined on days 4, 7, 11, 15, 25, and 39. Cell proliferation kinetics showed the lowest cell numbers in the 8 Gy/5-FU group (control, 15,390,000; RTA group, 8,394,000; RTB group, 5,609,000; 8 Gy/Gem group, 423,000; and 8 Gy/5-FU group, 297,667). In contrast, clonogenic activity on day 32 was lower in the 8 Gy/Gem group (control, 29.3 colonies; RTB group, 23.1 colonies; 8 Gy/5-FU group, 21.5 colonies; 8 Gy/Gem, 3.3 colonies; and even augmented in the RTA group, with 37.7 colonies). Cell cycle distribution showed similar curves for all groups on slightly different levels except for the 8 Gy/5-FU group, which showed a relatively augmented percentage of cells on day 7 in the G2 M cycle phase and on day 4 in the S phase. In conclusion, irradiation (8 Gy) with (188)Re administered, e.g., via coated stents, combined with Gem could be a valid option for the treatment of CCCs.
journal_name
Cardiovasc Intervent Radioljournal_title
Cardiovascular and interventional radiologyauthors
Wiesinger B,Farkas E,Kehlbach R,Bantleon R,Werner M,Wiskirchen Jdoi
10.1007/s00270-009-9563-1subject
Has Abstractpub_date
2009-07-01 00:00:00pages
737-44issue
4eissn
0174-1551issn
1432-086Xjournal_volume
32pub_type
杂志文章abstract:PURPOSE:To assess the role of transcatheter arterial chemoembolization (TACE) and percutaneous ethanol injection (PEI) in patients with hepatocellular carcinoma (HCC) and transjugular intrahepatic portosystemic shunts (TIPS). METHODS:Between January 1999 and September 2004, 6 patients with HCC and TIPS were treated wi...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-005-0063-7
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to establish an animal model of implanted inferior vena cava tumor thrombus (IVCTT) and to evaluate the effect of linear iodine-125 seeds strand in treating implanted IVCTT. METHODS:Tumor cell line VX2 was inoculated subcutaneously into New Zealand rabbit to develop the parent t...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-013-0628-9
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:This study was designed to evaluate the accuracy and safety of electromagnetic needle tracking for sonographically guided percutaneous liver biopsies. METHODS:We performed 23 consecutive ultrasound-guided liver biopsies for liver nodules with an electromagnetic tracking of the needle. A sensor placed at the ti...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-011-0278-8
更新日期:2012-08-01 00:00:00
abstract::The results of the first 100 patients to receive Gianturco-Rösch "Z" stents is presented along with recommendations for their use. The patient population was comprised of 57 men and 43 women, age range 17-85 years (mean 65 years). Fifty-four of the patients had benign obstruction and 46 had malignant obstruction. Of t...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02734120
更新日期:1992-11-01 00:00:00
abstract::A 32-year-old woman presented with a pulsatile, painful mass in her left upper arm, originating several days after removal of an Ilizarov external fixation. The diagnosis of a pseudoaneurysm was made by medical history and by physical and ultrasonographic examination of the mass. Angiography confirmed the presence of ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s002709910028
更新日期:2000-03-01 00:00:00
abstract::The purpose of the study was to evaluate the efficacy of percutaneous drainage of intraperitoneal abscesses with attention to recurrence and failure rates. A retrospective analysis of percutaneous treatment of 300 intraperitoneal abscesses in 255 patients (147 male, 108 female; average age: 38 years; range: 40 days to...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-004-0281-4
更新日期:2005-11-01 00:00:00
abstract::Purpose To evaluate the technical feasibility and safety of percutaneous cryoablation (CA) for the treatment of single/oligometastatic lymph-node (LN) relapse in different anatomic regions. MATERIALS AND METHODS:This is a retrospective study of all patients who underwent percutaneous CA of LN metastases (May 2014-Apr...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-019-02341-3
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:Airway stent placement is an effective treatment for the immediate palliation of malignant airway obstruction. However, restenosis caused by tumor ingrowth and/or overgrowth after stenting is common. The purpose of this study was to investigate the feasibility and safety of a novel self-expandable stent loaded ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-017-1639-8
更新日期:2017-07-01 00:00:00
abstract::We present the acute management and outcome of a patient after an accidental mesenteric distribution of Y90 microspheres during radioembolization (RE). This report describes and highlights: (1) the incidence of a significant reflux during a RE session while injecting into a replaced right hepatic artery from the super...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-011-0286-8
更新日期:2012-08-01 00:00:00
abstract::The purpose of this study was to assess a new open system with a field-strength of 1.0 T for the feasibility of liver biopsy using the freehand technique with fast continuous imaging. Fifty patients with focal liver lesions measuring 5 to 30 mm in diameter were included in the study. Guidance and monitoring was perfor...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-010-9836-8
更新日期:2011-02-01 00:00:00
abstract::The sacroiliac joint is the culprit in 15-30% of patients with chronic lumbar back pain. Ablation of the posterior sensory nerves supplying the joint is an established treatment option before arthrodesis. We report the successful application of MR-HIFU in a patient with therapy-refractory pain using the Sonalleve MR-H...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-019-02263-0
更新日期:2019-09-01 00:00:00
abstract::We report the percutaneous injection of tissue adhesive (Tisseal, Immuno, Vienna, Austria) to ablate a 12-cm internal iliac aneurysm. The complex history of this lesion included previous surgery for a ruptured aortic aneurysm, attempted repair of the internal iliac aneurysm, and several embolization procedures. These ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s002700010088
更新日期:2000-09-01 00:00:00
abstract::We would like to correct one of the references that was listed incorrectly in our article. ...
journal_title:Cardiovascular and interventional radiology
pub_type: 已发布勘误
doi:10.1007/s00270-020-02668-2
更新日期:2020-12-01 00:00:00
abstract::The aim of the present study was to determine whether there is a linear relation between the doses measured above and those measured under the lead apron of the radiologists performing interventional procedures. To monitor radiation exposure the International Commission of Radiological Protection (ICRP) recommends the...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-008-9307-7
更新日期:2008-05-01 00:00:00
abstract::A 34-year-old man with digital ischemia is reported. Angiography revealed thromboembolic occlusions of the proper digital arteries of the index, middle, and ring fingers and a tortuous ulnar artery in Guyon's canal. Though hypothenar hammer syndrome was suspected, there was no relevant occupational history. Magnetic r...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02570191
更新日期:1996-09-01 00:00:00
abstract:PURPOSE:We compared the safety and efficacy of three closure devices (Angioseal, Vasoseal and Duett) used to close arterial puncture sites in patients who underwent coronary percutaneous procedures. METHODS:A prospective randomized, single-center trial was carried out of consecutive patients who underwent coronary ang...
journal_title:Cardiovascular and interventional radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00270-002-1942-9
更新日期:2002-09-01 00:00:00
abstract::The purpose of this paper is to describe a unique "eighth note" deformity of the autogenous radiocephalic fistula for hemodialysis and to retrospectively evaluate the efficacy and safety of its endovascular treatment. Over 3 years, a total of 808 patients and 558 autogenous radiocephalic fistulas were treated for vasc...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-009-9639-y
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:Epistaxis is a common clinical problem, and the majority of bleedings can be managed conservatively. However, due to extensive and sometimes life-threatening bleeding, further treatment, such as superselective embolization, may be required. We report our experience with endovascular treatment of life-threaten...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-011-0155-5
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:This study was designed to evaluate preliminarily the feasibility and safety of magnetic resonance-guided focused ultrasound (MRgFUS) for treatment of solid tumors in the upper abdomen. METHODS:We enrolled one patient with hepatocellular carcinoma and two patients with pancreatic adenocarcinoma for MRgFUS abla...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-014-0861-x
更新日期:2014-12-01 00:00:00
abstract::Radiology is a key specialty within a liver transplant program. Interventional techniques not only contribute to graft and recipient survival but also allow appropriate patient selection and ensure that recipients with severe liver decompensation, hepatocellular carcinoma or portal hypertension are transplanted with t...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章,评审
doi:10.1007/s00270-004-0074-9
更新日期:2005-05-01 00:00:00
abstract::Rupture of the central veins with venous pseudoaneurysm formation is an unusual complication of central venous catheterization. Only seven cases of brachiocephalic venous pseudoaneurysm have been reported in the literature (among these only one was secondary to central venous catheterization). Plain radiographic exami...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-013-0729-5
更新日期:2014-08-01 00:00:00
abstract::The purpose of this study was to demonstrate feasibility of percutaneous transluminal aortic stenting and cava filter placement under magnetic resonance imaging (MRI) guidance exclusively using a polyetheretherketone (PEEK)-based MRI-compatible guidewire. Percutaneous transluminal aortic stenting and cava filter place...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-008-9483-5
更新日期:2009-05-01 00:00:00
abstract:PURPOSE:To describe our experiences with treatment of visceral artery pseudoaneurysms (VAPA) by transcatheter coil embolization using an isolation technique and to propose indications for treating VAPA with this method. MATERIALS AND METHODS:We treated 37 patients with VAPA endovascularly: There were 15 pancreaticoduo...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-010-9973-0
更新日期:2010-12-01 00:00:00
abstract::Splenic artery aneurysms and pseudoaneurysms are being diagnosed with increasing frequency by modern imaging. The question of appropriate treatment--surgical or endovascular--arises more often. We review our experience and that of others as documented in the literature. The information available suggests that endovasc...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章,评审
doi:10.1007/BF00571531
更新日期:1994-07-01 00:00:00
abstract:PURPOSE:Two stent types (a new Wallstent and a Z-stent) were investigated in 30 patients with recurrent malignant superior vena caval syndrome (SVCS). METHODS:Eligibility requirements were that the patient had recurrent symptoms after appropriate radiation therapy, chemotherapy, or both; >/= 75% of the vessel was occl...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02577610
更新日期:1996-05-01 00:00:00
abstract:PURPOSE:Morton's neuroma (MN) is a leading cause of disability. The purpose of this study was to investigate the effectiveness of radiofrequency (RF) in patients with chronic pain refractory to conservative therapies. METHODS:Between September 2012 and December 2016, RF was performed on 52 patients. A sterile RF needl...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-017-1786-y
更新日期:2018-01-01 00:00:00
abstract::In this article we present an unusual case of hepatic artery aneurysm bleeding due to a hepatic artery thrombosis after liver transplantation. The patient developed a recurrent hepatic artery thrombosis leading to severe graft failure in four consecutive liver transplantations. While being evaluated for a fifth transp...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-004-0170-x
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Transarterial (chemo-)embolization/lipiodolization (TAE/TAL) might be an attractive minimally invasive alternative to surgery in the treatment of symptomatic hepatic haemangioma. This review assesses the efficacy and safety of TAE/TAL as primary treatment for symptomatic hepatic haemangioma. METHODS:A syste...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章,评审
doi:10.1007/s00270-019-02169-x
更新日期:2019-06-01 00:00:00
abstract::Intra-arterial radiotherapy with yttrium-90 microspheres (radioembolization) is a therapeutic procedure exclusively applied to the liver that allows the direct delivery of high-dose radiation to liver tumors, by means of endovascular catheters, selectively placed within the tumor vasculature. The aim of the study was ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-009-9592-9
更新日期:2009-07-01 00:00:00
abstract::Complete inferior vena cava thrombosis (IVC) in neonates is uncommon, but may cause significant morbidity. A 13-day-old neonate suffered IVC thrombosis secondary to antithrombin III deficiency, possibly contributed to by a mutation in the methyl tetrahydrofolate reductase gene. Catheter-directed thrombolysis (CDT) wit...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章,评审
doi:10.1007/s00270-007-9229-9
更新日期:2008-07-01 00:00:00