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A Novel Self-Expandable, Radioactive Airway Stent Loaded with 125I Seeds: A Feasibility and Safety Study in Healthy Beagle Dog.

Abstract：

PURPOSE:Airway stent placement is an effective treatment for the immediate palliation of malignant airway obstruction. However, restenosis caused by tumor ingrowth and/or overgrowth after stenting is common. The purpose of this study was to investigate the feasibility and safety of a novel self-expandable stent loaded with 125I seeds in healthy beagle dog. MATERIALS AND METHODS:Under fluoroscopic guidance, forty-eight self-expandable airway stents loaded with 125I seeds were perorally placed in the main trachea of 48 healthy beagle dogs, who were randomly divided into four groups (Group A: 0.3 mCi; Group B: 0.6 mCi; Group C: 0.9 mCi; Control group: 0 mCi). The estimated radiation dose was calculated using the isotropic point source approximation. Radiological follow-up examinations and histopathological examinations of stented tracheal segments and their adjacent organs and tissues were performed at 2, 4, 8, and 16 weeks following the stenting. RESULTS:All stents were successfully deployed in the targeted tracheal segment in the beagle dogs without procedure-related complications. Tracheal stenosis became severe gradually in all the four groups, which was not associated with the radioactivity of 125I seeds (p > 0.05). The tracheal injury scores increased along with the higher dose of radioactive seeds which reached peak at 8 weeks and then turned back slightly at 16 weeks. The adjacent tissue did not show pathohistological changes under microscope, while mild and reversible ultrastructure changes were showed under electronic microscope. CONCLUSIONS:This study demonstrates that it is feasible and safe to insert this novel self-expandable airway stent loaded with 125I seeds in healthy beagle dog.

journal_name

Cardiovasc Intervent Radiol

journal_title

Cardiovascular and interventional radiology

authors

Wang Y,Guo JH,Zhu GY,Zhu HD,Chen L,Lu J,Wang C,Teng GJ

doi

10.1007/s00270-017-1639-8

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

1086-1093

issue

eissn

0174-1551

issn

1432-086X

pii

10.1007/s00270-017-1639-8

journal_volume

pub_type

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A Novel Self-Expandable, Radioactive Airway Stent Loaded with 125I Seeds: A Feasibility and Safety Study in Healthy Beagle Dog.