Abstract：
:We evaluated the effectiveness of the Jeryl Lynn strain vaccine in a large outbreak of mumps in Navarre, Spain, 2006-2008. Each of the 241 cases of mumps occurring in children over 15 months of age born between 1998 and 2005 was compared with 5 controls individually matched by sex, birth date, district of residence and paediatrician. Vaccination history was obtained blindly from clinical records. Conditional logistic regression was used to obtain the matched odds ratios (ORs), and effectiveness was calculated as 1-OR. Some 70% of cases had received one dose of measles-mumps-rubella vaccine, and 24% had received two doses. Overall vaccine effectiveness was 72% (95% CI, 39-87%). Two doses were more effective (83%; 54-94%) than a single dose (66%; 25-85%). Among vaccinated children, risk was higher in those who had received the first dose after 36 months of age (OR=3.1; 1.2-8.4) and those who had received the second dose 3 or more years before study enrolment (OR=10.2; 1.5-70.7). Early waning of immunity in children after the second dose may contribute to reduced vaccine effectiveness for mumps prevention.
journal_name
Vaccinejournal_title
Vaccineauthors
Castilla J,García Cenoz M,Arriazu M,Fernández-Alonso M,Martínez-Artola V,Etxeberria J,Irisarri F,Barricarte Adoi
10.1016/j.vaccine.2009.02.001subject
Has Abstractpub_date
2009-03-26 00:00:00pages
2089-93issue
15eissn
0264-410Xissn
1873-2518pii
S0264-410X(09)00216-3journal_volume
27pub_type
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