Effectiveness of Jeryl Lynn-containing vaccine in Spanish children.


:We evaluated the effectiveness of the Jeryl Lynn strain vaccine in a large outbreak of mumps in Navarre, Spain, 2006-2008. Each of the 241 cases of mumps occurring in children over 15 months of age born between 1998 and 2005 was compared with 5 controls individually matched by sex, birth date, district of residence and paediatrician. Vaccination history was obtained blindly from clinical records. Conditional logistic regression was used to obtain the matched odds ratios (ORs), and effectiveness was calculated as 1-OR. Some 70% of cases had received one dose of measles-mumps-rubella vaccine, and 24% had received two doses. Overall vaccine effectiveness was 72% (95% CI, 39-87%). Two doses were more effective (83%; 54-94%) than a single dose (66%; 25-85%). Among vaccinated children, risk was higher in those who had received the first dose after 36 months of age (OR=3.1; 1.2-8.4) and those who had received the second dose 3 or more years before study enrolment (OR=10.2; 1.5-70.7). Early waning of immunity in children after the second dose may contribute to reduced vaccine effectiveness for mumps prevention.






Castilla J,García Cenoz M,Arriazu M,Fernández-Alonso M,Martínez-Artola V,Etxeberria J,Irisarri F,Barricarte A




Has Abstract


2009-03-26 00:00:00
















  • Estimating the effect of measles vaccination on child growth using 191 DHS from 65 low- and middle-income countries.

    abstract:BACKGROUND:Childhood vaccinations reduce morbidity and mortality and are highly cost-effective. They may also protect children from malnutrition and lead to improved child growth. Stunting, wasting and underweight are targets used to monitor progress towards the achievement of the sustainable development goals (SDGs). ...


    pub_type: 杂志文章


    authors: Bogler L,Jantos N,Bärnighausen T,Vollmer S

    更新日期:2019-08-14 00:00:00

  • Impact of postpartum information about pertussis booster to parents in a university maternity hospital.

    abstract::Parent-to-infant transmission of pertussis remains an issue in France. Although adult booster vaccination was introduced in 2004 as part of a cocooning strategy targeted primarily to parents of young infants, vaccination coverage in this population has remained low. The aim of this study was to evaluate the impact on ...


    pub_type: 杂志文章


    authors: Leboucher B,Sentilhes L,Abbou F,Henry E,Grimprel E,Descamps P

    更新日期:2012-08-10 00:00:00

  • Comparison of pertussis surveillance systems in Europe.

    abstract::We compared pertussis surveillance systems of 16 European countries in the period 1998-2002. In twelve out of sixteen countries the system covered the general population. Ten countries relied on WHO case definition for surveillance of pertussis. Eleven countries applied laboratory tests, and eight of them used PCR for...


    pub_type: 杂志文章


    authors: Tozzi AE,Pandolfi E,Celentano LP,Massari M,Salmaso S,Ciofi degli Atti ML,EUVAC-NET Study Group.

    更新日期:2007-01-04 00:00:00

  • Influenza vaccine production for Brazil: a classic example of successful North-South bilateral technology transfer.

    abstract::Technology transfer is a promising approach to increase vaccine production at an affordable price in developing countries. In the case of influenza, it is imperative that developing countries acquire the technology to produce pandemic vaccines through the transfer of know-how, as this will be the only way for the majo...


    pub_type: 杂志文章,评审


    authors: Miyaki C,Meros M,Precioso AR,Raw I

    更新日期:2011-07-01 00:00:00

  • Factors associated with the immune response to hepatitis A vaccination in HIV-infected patients in the era of highly active antiretroviral therapy.

    abstract:INTRODUCTION:HIV seropositivity is considered a risk factor for complications in hepatitis A virus (HAV) infection. HAV vaccination schedules are widely implemented in HIV-infected patients, but the immune response remains impaired. METHODS:We analysed the response to vaccination (antiHAV titres ≥20IU/l) in 282 HIV-in...


    pub_type: 杂志文章


    authors: Mena G,García-Basteiro AL,Llupià A,Díez C,Costa J,Gatell JM,García F,Bayas JM

    更新日期:2013-08-12 00:00:00

  • Plasmodium falciparum serine repeat antigen 5 (SE36) as a malaria vaccine candidate.

    abstract::A devastating disease spread by mosquitoes with high-efficiency, malaria imposes an enormous burden for which no licensed vaccine currently exists. Although the genome complexity of the parasite has made vaccine development tenuous, an effective malaria vaccine would be a valuable tool for control, elimination and eve...


    pub_type: 杂志文章,评审


    authors: Palacpac NM,Arisue N,Tougan T,Ishii KJ,Horii T

    更新日期:2011-08-11 00:00:00

  • Potential T cell epitopes within swine-origin triple reassortant influenza A (H3N2) variant virus which emerged in 2011: an immunoinformatics study.

    abstract::An immuno-informatics study was conducted to determine possible pre-existing T cellular immunity to the recently emerged swine-origin triple reassortant H3N2 variant (S-OtrH3N2v-2011) which acquired the matrix gene of influenza A (H1N1)pdm09. Given the genetic origin of S-OtrH3N2v-2011, our study focused on the hemagg...


    pub_type: 杂志文章


    authors: Duvvuri VR,Marchand-Austin A,Eshaghi A,Patel SN,Low DE,Gubbay JB

    更新日期:2012-09-14 00:00:00

  • Socioeconomic factors play a more important role in childhood vaccination coverage than parental perceptions: a cross-sectional study in Greece.

    abstract::To identify predictive factors of complete and age-appropriate vaccination status in Greece, we conducted a cross-sectional study, using stratified cluster sampling, among children attending the first year of the Greek Grammar school (about 6 years of age) and their parents/guardians. Almost 88% (N=3878) of pupils in ...


    pub_type: 杂志文章


    authors: Danis K,Georgakopoulou T,Stavrou T,Laggas D,Panagiotopoulos T

    更新日期:2010-02-17 00:00:00

  • Ultraviolet-C irradiation for inactivation of viruses in foetal bovine serum.

    abstract::Foetal Bovine Serum (FBS) and porcine trypsin are one of the essential raw materials used in the manufacturing of cell culture based viral vaccines. Being from animal origin, these raw materials can potentially contaminate the final product by known or unknown adventitious agents. The issue is more serious in case of ...


    pub_type: 杂志文章


    authors: Vaidya V,Dhere R,Agnihotri S,Muley R,Patil S,Pawar A

    更新日期:2018-07-05 00:00:00

  • Changes in Streptococcus pneumoniae serotype distribution in invasive disease and nasopharyngeal carriage after the heptavalent pneumococcal conjugate vaccine introduction in Bogotá, Colombia.

    abstract:BACKGROUND:In Bogotá, the Heptavalent Conjugate Vaccine (PCV7) was introduced into childhood immunization schedule since 2009. The aim of this study was to assess the changes in serotype distribution and penicillin susceptibility of Streptococcus pneumoniae isolates recovered from nasopharyngeal samples and invasive di...


    pub_type: 杂志文章


    authors: Parra EL,De La Hoz F,Díaz PL,Sanabria O,Realpe ME,Moreno J

    更新日期:2013-08-20 00:00:00

  • Improved immunogenicity of high-dose influenza vaccine compared to standard-dose influenza vaccine in adult oncology patients younger than 65 years receiving chemotherapy: A pilot randomized clinical trial.

    abstract:PURPOSE:Patients undergoing chemotherapy often fail to develop robust responses to influenza vaccination. Compared to standard-dose influenza vaccine (SD), high-dose influenza vaccine (HD) has shown improved immunogenicity and protection against influenza illness in adults 65 years and older. This study compared the im...


    pub_type: 杂志文章,随机对照试验


    authors: Jamshed S,Walsh EE,Dimitroff LJ,Santelli JS,Falsey AR

    更新日期:2016-01-27 00:00:00

  • The effect of diabetes mellitus on immunological response to hepatitis B virus vaccine in individuals with chronic kidney disease: A meta-analysis of current literature.

    abstract:BACKGROUND:Patients with chronic kidney disease (CKD) often fail to produce protective antibodies to hepatitis B virus (HBV) surface antigen after vaccination. Diabetes mellitus (DM) is the most common cause of CKD; however it is not clear whether it affects immunological response to HBV vaccine in these patients. AIM...


    pub_type: 杂志文章,meta分析,评审


    authors: Alavian SM,Tabatabaei SV

    更新日期:2010-05-14 00:00:00

  • A DNA vaccine encoding ubiquitinated Rift Valley fever virus nucleoprotein provides consistent immunity and protects IFNAR(-/-) mice upon lethal virus challenge.

    abstract::Current vaccine candidates against Rift Valley fever virus (RVFV) incorporate the viral structural glycoproteins as antigens, since triggering antibody responses against them usually correlates with protection. Here, we have focused solely on the nucleoprotein of RVFV as a potential target for vaccine development. Pre...


    pub_type: 杂志文章


    authors: Boshra H,Lorenzo G,Rodriguez F,Brun A

    更新日期:2011-06-15 00:00:00

  • Immunogenicity of dengue virus type 1 DNA vaccines expressing truncated and full length envelope protein.

    abstract::Recombinant plasmid DNA constructs expressing truncated or full-length dengue-1 envelope (E) with or without the pre-membrane (prM) were tested for immunogenicity in mice, as candidate dengue DNA vaccines. Two plasmids, one expressing the N-terminal 80% E and the other expressing prM and full length E were immunogenic...


    pub_type: 杂志文章


    authors: Raviprakash K,Kochel TJ,Ewing D,Simmons M,Phillips I,Hayes CG,Porter KR

    更新日期:2000-05-08 00:00:00

  • N-fragment of edema factor as a candidate antigen for immunization against anthrax.

    abstract::The nontoxic N-terminal fragment of Bacillus anthracis edema factor (EF) was evaluated as a candidate antigen in an anthrax vaccine using a replication-incompetent adenoviral vector. An E1/E3 deleted adenovirus (Ad/EFn) encoding the N-terminal region 1-254 amino acids of the edema factor (EFn) was constructed using th...


    pub_type: 杂志文章


    authors: Zeng M,Xu Q,Hesek ED,Pichichero ME

    更新日期:2006-01-30 00:00:00

  • Synthetic luteinizing hormone releasing hormone (LHRH) vaccine for effective androgen deprivation and its application to prostate cancer immunotherapy.

    abstract::We have designed a peptide-based immunotherapeutic vaccine for treatment of androgen-responsive prostate cancer. The vaccine targets the luteinizing hormone-releasing hormone (LHRH) decapeptide that results in an androgen-deprivation immunotherapy. The design elements of the peptide immunogens are the LHRH peptide or ...


    pub_type: 杂志文章


    authors: Finstad CL,Wang CY,Kowalski J,Zhang M,Li ML,Li XM,Xia WG,Bosland MC,Murthy KK,Walfield AM,Koff WC,Zamb TJ

    更新日期:2004-03-12 00:00:00

  • Recent advances in the study of human antibody responses to influenza virus using optimized human hybridoma approaches.

    abstract::Influenza viruses exhibit a fascinating level of antigenic heterogeneity that facilitates re-infection in the human population. The human antibody repertoire also manifests endless capability for variation in the genes that specify the portion of antibody molecules interacting with epitopes. A recent explosion of tech...


    pub_type: 杂志文章


    authors: Crowe JE Jr

    更新日期:2009-12-30 00:00:00

  • Algammulin, a new vaccine adjuvant comprising gamma inulin particles containing alum: preparation and in vitro properties.

    abstract::Crystallization of inulin with alum forms a fine (1-2 micron) suspension of electron-dense ovoids; the alum is embedded in inulin particles, which are then converted to the immune stimulant polymorphic form, gamma inulin. This very stable hybrid preparation is termed Algammulin. Preferred conditions for its preparatio...


    pub_type: 杂志文章


    authors: Cooper PD,Steele EJ

    更新日期:1991-05-01 00:00:00

  • Immunisation status in the public care system: a comparative study.

    abstract::Children in public care have poor health outcomes despite statutory health assessments. Incomplete immunisation of children entering the care system has been reported. Does this health disadvantage persist for those established in the care system? The immunisation status of 119 children in public care for at least 6 m...


    pub_type: 杂志文章


    authors: Barnes P,Price L,Maddocks A,Cheung WY,Williams J,Jackson S,Mason B

    更新日期:2005-04-15 00:00:00

  • Correlates of protection of serotype-specific capsular antibody and invasive Group B Streptococcus disease in South African infants.

    abstract:BACKGROUND:Vaccinating pregnant women may prevent invasive Group B Streptococcus (GBS) disease in their young infants. In a low-middle income setting, we sought to determine an association between natural maternal antibody responses and the development of invasive GBS disease. METHODS:We undertook a matched case-contr...


    pub_type: 杂志文章


    authors: Dangor Z,Kwatra G,Izu A,Adrian P,Cutland CL,Velaphi S,Ballot D,Reubenson G,Zell ER,Lala SG,Madhi SA

    更新日期:2015-11-27 00:00:00

  • Clinical proof of principle for ChimeriVax: recombinant live, attenuated vaccines against flavivirus infections.

    abstract::ChimeriVax is a live, attenuated recombinant virus constructed from yellow fever (YF) 17D in which the envelope protein genes of YF 17D are replaced with the corresponding genes of another flavivirus. A ChimeriVax vaccine was developed against Japanese encephalitis (JE). A randomized, double-blind, outpatient study wa...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Monath TP,McCarthy K,Bedford P,Johnson CT,Nichols R,Yoksan S,Marchesani R,Knauber M,Wells KH,Arroyo J,Guirakhoo F

    更新日期:2002-01-15 00:00:00

  • Vaccination against hepatitis A during outbreaks starting in schools: what can we learn from experiences in central Italy?

    abstract::Two outbreaks of hepatitis A started almost simultaneously in a maternal school and in a day care centre located at opposite sides of Florence, Italy, at the end of 2002. Both of them originated from immigrant children, and in both cases, hepatitis A was initially not recognised due to aspecific symptoms. While vaccin...


    pub_type: 杂志文章


    authors: Bonanni P,Franzin A,Staderini C,Pitta M,Garofalo G,Cecconi R,Santini MG,Lai P,Innocenti B

    更新日期:2005-03-18 00:00:00

  • Neutralization epitopes on the antigenic domain II of the Orientia tsutsugamushi 56-kDa protein revealed by monoclonal antibodies.

    abstract::Monoclonal antibodies (MoAbs) reactive with the authentic Orientia tsutsugamushi 56-kDa protein were generated. MoAb FS10 and FS15 showed in vitro, as well as, in vivo neutralizing activity upon O. tsutsugamushi infection. Deletion mutants of the gene for 56-kDa protein of O. tsutsugamushi Boryong were expressed to ma...


    pub_type: 杂志文章


    authors: Seong SY,Kim MK,Lee SM,Odgerel Z,Choi MS,Han TH,Kim IS,Kang JS,Lim BU

    更新日期:2000-08-15 00:00:00

  • Awareness of and attitude towards human papillomavirus infection and vaccination for cervical cancer prevention among adult males and females in Korea: a nationwide interview survey.

    abstract::We assessed adult male and female awareness and acceptance of human papillomavirus (HPV) infection and vaccination for cervical cancer prevention, as well as factors associated with willingness to be administered the HPV vaccine. A nationwide population-based interview survey was conducted in Korea. One thousand male ...


    pub_type: 杂志文章


    authors: Oh JK,Lim MK,Yun EH,Lee EH,Shin HR

    更新日期:2010-02-17 00:00:00

  • A method for estimating vaccine-preventable pediatric influenza pneumonia hospitalizations in developing countries: Thailand as a case study.

    abstract::The burden of influenza in children is increasingly appreciated; some middle-income countries are considering support for influenza vaccine programs. To support decision-making, methods to estimate the potential impact of proposed programs are needed. Using Thailand as a case-study, we present a model that uses survei...


    pub_type: 杂志文章


    authors: Dawood FS,Fry AM,Muangchana C,Sanasuttipun W,Baggett HC,Chunsuttiwat S,Maloney SA,Simmerman JM

    更新日期:2011-06-10 00:00:00

  • Five winters of pneumococcal serotype replacement in UK carriage following PCV introduction.

    abstract::The seven-valent pneumococcal conjugate vaccine (PCV7) was added to the UK national immunisation programme in September 2006. PCV13 replaced PCV7 in April 2010. As carriage precedes disease cases this study collected carried pneumococci from children each winter from 2006/7 to 2010/11 over PCV introduction. Convention...


    pub_type: 杂志文章


    authors: Gladstone RA,Jefferies JM,Tocheva AS,Beard KR,Garley D,Chong WW,Bentley SD,Faust SN,Clarke SC

    更新日期:2015-04-21 00:00:00

  • fH-dependent complement evasion by disease-causing meningococcal strains with absent fHbp genes or frameshift mutations.

    abstract::Meningococci bind human fH to down-regulate complement, which enhances survival of the bacteria in serum. A major fH ligand is the vaccine candidate, factor H-binding protein (fHbp). Although fHbp has been considered an essential meningococcal virulence factor, rarely, invasive isolates with absent fHbp genes or frame...


    pub_type: 杂志文章


    authors: Giuntini S,Vu DM,Granoff DM

    更新日期:2013-08-28 00:00:00

  • New Wisdom to Defy an Old Enemy: Summary from a scientific symposium at the 4th Influenza Vaccines for the World (IVW) 2012 Congress, 11 October, Valencia, Spain.

    abstract::Both seasonal and pandemic influenza cause considerable morbidity and mortality globally. In addition, the ongoing threat of new, unpredictable influenza pandemics from emerging variant strains cannot be underestimated. Recently bioCSL (previously known as CSL Biotherapies) sponsored a symposium 'New Wisdom to Defy an...


    pub_type: 杂志文章


    authors: Poland GA,Fleming DM,Treanor JJ,Maraskovsky E,Luke TC,Ball EM,Poland CM

    更新日期:2013-04-17 00:00:00

  • Estimated acceptance of HPV vaccination among Italian women aged 18-26 years.

    abstract::In Italy vaccination against human papillomavirus (HPV) was introduced in the national immunization programme in 2007; the primary target for this vaccination is 11-year-old females, whereas vaccination for older age groups is still a matter of debate. This project was carried out in the period 2007-2009 to estimate t...


    pub_type: 杂志文章


    authors: Giambi C,Donati S,Declich S,Salmaso S,Ciofi Degli Atti ML,Alibrandi MP,Brezzi S,Carozzi F,Collina N,Franchi D,Lattanzi A,Meda M,Minna MC,Nannini R,Scherillo I,Bella A,PreGio Working Group.

    更新日期:2011-10-26 00:00:00

  • Hepatitis B vaccination: universal vaccination of newborn babies and children at 12 years of age versus high risk groups. A comparison in the field.

    abstract::From 1983 to 1993 two anti-hepatitis B vaccinal strategies were adopted in two small towns of Southern Italy at high incidence for HBV infections: Afragola (prevalence of HBsAg carriers of 13.4%) and Frattamaggiore (prevalence of HBsAg carriers of 12.9%). In Afragola, the universal vaccination of infants in their firs...


    pub_type: 临床试验,杂志文章


    authors: Da Villa G,Picciottoc L,Elia S,Peluso F,Montanaro F,Maisto T

    更新日期:1995-09-01 00:00:00