Induction of mucosal immunity with a replication-defective adenoviral recombinant.

abstract：:Myxoma virus, a member of the Poxviridae family (genus Leporipoxvirus) is the agent responsible for myxomatosis in the European rabbit. Recombinant myxoma viruses expressing the capsid gene of an F9 strain of feline calicivirus (FCV) were constructed from an apathogenic, laboratory attenuated, isolate of myxoma virus....

journal_title：Vaccine

authors： McCabe VJ,Tarpey I,Spibey N

更新日期：2002-06-07 00:00:00

abstract：:Recognition of the acute and chronic burden of respiratory syncytial virus (RSV) lower respiratory tract infections (LRTI) sparked a wave of initiatives to develop preventive and therapeutic products against the pathogen in recent years. RSV is a leading cause of hospitalization in infants in industrialized and develo...

journal_title：Vaccine

authors： Polack FP

更新日期：2015-11-25 00:00:00

abstract：:Dengue fever is a growing public health concern around the world and despite vaccine development efforts, there are currently no effective dengue vaccines. In the present study we report the induction of protective antibodies against dengue virus by DNA immunization with domain III (DIII) region of the envelope protei...

journal_title：Vaccine

authors： Mota J,Acosta M,Argotte R,Figueroa R,Méndez A,Ramos C

更新日期：2005-05-16 00:00:00

abstract：:Historical evidence demonstrates the validity of the concept "Grand Convergence". The Lancet commission identified the major challenges facing low and lower middle income countries including the unfinished agenda, non-communicable diseases and injuries and an approach to funding and achieving these objectives along wi...

journal_title：Vaccine

authors： Mahmoud A

更新日期：2017-01-20 00:00:00

abstract：:Forty-four adult patients with cutaneous leishmaniasis (CL) were enrolled in a randomized, double-blind, controlled, dose-escalating clinical trial and were randomly assigned to receive three injections of either the LEISH-F1+MPL-SE vaccine (consisting of 5, 10, or 20 μg recombinant Leishmania polyprotein LEISH-F1 ant...

journal_title：Vaccine

authors： Nascimento E,Fernandes DF,Vieira EP,Campos-Neto A,Ashman JA,Alves FP,Coler RN,Bogatzki LY,Kahn SJ,Beckmann AM,Pine SO,Cowgill KD,Reed SG,Piazza FM

更新日期：2010-09-14 00:00:00

abstract：:Reaseheath line C chicks produced IgA, IgG and IgM in their serum, tears, spleen and Harderian gland (HG) as a consequence of oculotopical vaccination with the Hitchner B1 strain of Newcastle disease virus. The IgM response was seen first, at 5 days after vaccination, and antiviral IgM levels in the tears and serum we...

journal_title：Vaccine

authors： Russell PH,Ezeifeka GO

更新日期：1995-01-01 00:00:00

abstract：:Our initial results with a bovine papilloma virus (BPV) vector expression system indicated that we could produce significant amounts of Epstein-Barr virus (EBV) gp340/220 in the supernatant of a mouse fibroblast cell line. We have now extended these findings to show that the truncated version of gp340/220, where the m...

journal_title：Vaccine

authors： Madej M,Conway MJ,Morgan AJ,Sweet J,Wallace L,Qualtiere LF,Arrand JR,Mackett M

更新日期：1992-01-01 00:00:00

abstract：:The persistence of anti-HBs protective levels in groups of children who had been immunized against Hepatitis B 5 and 10 years earlier, in their first year of life, has been studied. The results were analyzed according to the type of vaccine (both plasma-derived and DNA recombinant) and the number of doses administered...

journal_title：Vaccine

authors： Da Villa G,Peluso F,Picciotto L,Bencivenga M,Elia S,Pelliccia MG

更新日期：1996-11-01 00:00:00

abstract：:With tuberculosis continuing to be a major cause of global morbidity and mortality, a new vaccine is urgently needed. Tuberculosis subunit vaccines have been shown to induce robust immune responses in humans and are a potentially safer alternative to BCG for use in HIV-endemic areas. In this study, we investigated the...

journal_title：Vaccine

authors： Derrick SC,Yabe IM,Yang A,Kolibab K,Hollingsworth B,Kurtz SL,Morris S

更新日期：2013-09-23 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV) is the etiological agent of a highly contagious disease that affects cloven-hoofed animal species. The FMDV capsid is highly acid labile and viral particles lose their immunogenicity when they disassemble at mildly acidic pHs. The viral capsid of FMDV serotype O is more sensitive th...

journal_title：Vaccine

authors： Xie Y,Li H,Qi X,Ma Y,Yang B,Zhang S,Chang H,Yin X,Li Z

更新日期：2019-03-28 00:00:00

abstract：:Eight different vaccination schemes using four commercially available inactivated Bluetongue vaccines against serotypes 4 and 8 in three different combinations (setting 1-3) were tested under field conditions for their ability to generate a measurable immune response in sheep. Animals of setting 1 (groups A-D) were si...

journal_title：Vaccine

authors： Hilke J,Strobel H,Woelke S,Stoeter M,Voigt K,Grimm L,Meilwes J,Punsmann T,Blaha I,Salditt A,Rohn K,Bastian M,Ganter M

更新日期：2019-09-16 00:00:00

abstract：:The incidence of Lyme disease has continued to rise despite attempts to control its spread. Vaccination of zoonotic reservoirs of human pathogens has been successfully used to decrease the incidence of rabies in raccoons and foxes. We have previously reported on the efficacy of a vaccinia virus vectored vaccine to red...

journal_title：Vaccine

authors： Kern A,Zhou CW,Jia F,Xu Q,Hu LT

更新日期：2016-08-31 00:00:00

abstract：:We estimated the sensitivity, i.e., the proportion of all cases of adverse events following immunization (AEFIs) reported to the Brazilian passive surveillance for adverse events following immunization (PSAEFI) with the diphtheria-tetanus-whole-cell pertussis-Haemophilus influenzae type b (DTwP/Hib) vaccine, as well a...

journal_title：Vaccine

authors： Monteiro SA,Takano OA,Waldman EA

更新日期：2010-04-19 00:00:00

abstract：:Enterovirus type 71 (EV71) and coxsackievirus A 16 (CA16) are recognized as the major pathogens responsible for human hand-foot-mouth disease. To develop a bivalent EV71-CA16 vaccine, rhesus macaques immunized with two doses of this vaccine via the intradermal route were challenged with EV71 or CA16, and their clinica...

journal_title：Vaccine

authors： Fan S,Liao Y,Jiang G,Jiang L,Wang L,Xu X,Feng M,Yang E,Zhang Y,Cui W,Li Q

更新日期：2020-02-18 00:00:00

abstract：:This commentary is a response to a systematic review, recently published in Vaccine, which investigates the effectiveness of educational interventions in increasing uptake of the human papillomavirus vaccine. The systematic review by Fu et al. (2014) enhances the field's understanding of human papillomavirus vaccine i...

journal_title：Vaccine

authors： Shapiro GK,Joyal-Desmarais K,Perez S,Rosberger Z

更新日期：2014-11-12 00:00:00

abstract：:Since many years Afssaps applies the 3R's strategy (replacement, reduction and refinement) for the use of laboratory animal testing in the framework of vaccine batch release. In this context, for Hepatitis A vaccines, a study was carried out to assess the feasibility of replacing the in vivo "Gold Standard" potency as...

journal_title：Vaccine

authors： Poirier B,Variot P,Delourme P,Maurin J,Morgeaux S

更新日期：2010-02-17 00:00:00

abstract：:The proteolytic enzyme bromelain has been traditionally used to cleave the hemagglutinin (HA) protein at the C-terminus of the HA2 region to release the HA proteins from influenza virions. The bromelain cleaved HA (BHA) has been routinely used as an antigen to generate antiserum that is essential for influenza vaccine...

journal_title：Vaccine

authors： Wang W,Suguitan AL Jr,Zengel J,Chen Z,Jin H

更新日期：2012-01-20 00:00:00

abstract：OBJECTIVE:To assess the efficacy and safety of whole-cell and acellular pertussis vaccines administered to children singly or within diphtheria, tetanus and pertussis (DTP) vaccines. DATA SOURCES:We searched the Cochrane Library, MEDLINE, EMBASE, Biological Abstracts and Science Citation Index to December 2001. Specia...

journal_title：Vaccine

authors： Jefferson T,Rudin M,DiPietrantonj C

更新日期：2003-05-16 00:00:00

abstract：:Financial sustainability plans (FSPs) were developed by over 50 of the world's poorest countries receiving funding support from the Global Alliance for Vaccines and Immunization (GAVI) to introduce new and underused vaccines, injection safety and immunization service support between 2000 and 2006. These plans were ana...

journal_title：Vaccine

authors： Kamara L,Milstien JB,Patyna M,Lydon P,Levin A,Brenzel L

更新日期：2008-12-02 00:00:00

abstract：BACKGROUND:Tuberculosis is a major challenge for health care, as options for its treatment and prevention are limited. Therefore, novel approaches, such as DNA vaccination, to both prevent primary infections and the reactivation of latent infections need to be developed. A Mycobacterium marinum infection in adult zebra...

journal_title：Vaccine

authors： Niskanen M,Myllymäki H,Rämet M

更新日期：2020-07-31 00:00:00

abstract：:Adjuvants are substances that enhance adaptive immune response to antigen. Development of a safe and effective immunostimulant adjuvant is essential for the efficacy of a vaccine to protect against infectious pathogens. Purple non-sulfur photosynthetic bacteria exhibited nontoxic natural lipid A variants that are dist...

journal_title：Vaccine

authors： Masoud H

更新日期：2019-06-06 00:00:00

abstract：BACKGROUND:We aim to determine the vaccination coverage of social and healthcare workers in International sites of Samusocial, providing emergency care to homeless people, and to assess factors associated with having received necessary doses at adulthood. METHODS:Data on immunization coverage of social and healthcare ...

journal_title：Vaccine

authors： Marshall E,Salmon D,Bousfiha N,Togola Y,Ouedraogo F,Santantonio M,Dieng CK,Tartière S,Emmanuelli X

更新日期：2017-09-18 00:00:00

abstract：OBJECTIVE:Informed decision making requires transparent and evidence-based (=balanced) information on the potential benefit and harms of medical preventions. An analysis of German HPV vaccination leaflets revealed, however, that none met the standards of balanced risk communication. METHODS:We surveyed a sample of 225...

journal_title：Vaccine

authors： Wegwarth O,Kurzenhäuser-Carstens S,Gigerenzer G

更新日期：2014-03-10 00:00:00

abstract：BACKGROUND:Measles-containing vaccine (MCV) was introduced in 1965 in Beijing and given to the children aged 8m-14y. In population-based surveillance system, real-time polymerase chain reaction (RT-PCR) and immunoglobulin M(IgM) serology tests have been conducted for each suspected case since 2013. We used the surveill...

journal_title：Vaccine

authors： Ma R,Lu L,Suo L,Zhangzhu J,Chen M,Pang X

更新日期：2019-06-27 00:00:00

abstract：:Binding of antibodies to oligomeric envelope glycoprotein of R5-tropic primary isolates of human immunodeficiency virus type 1 (HIV-1) was studied by flow cytometry using sera from HIV-1 vaccine recipients and clade B and C HIV-1-infected patients, and monoclonal and polyclonal antibodies to neutralizing epitopes of H...

journal_title：Vaccine

authors： Gorse GJ,Patel GB,Arbuckle JA,Belshe RB

更新日期：2004-01-02 00:00:00

abstract：:Immunologic tolerance to endogenous antigens reduces antitumor responses. Gp70 is an endogenous tumor-associated antigen (TAA) of the BALB/c-derived colon carcinoma CT26. We found that expression of gp70 mRNA is detectable in tissues of mice 8 months of age and older. We showed that expression of gp70 establishes immu...

journal_title：Vaccine

authors： McWilliams JA,Sullivan RT,Jordan KR,McMahan RH,Kemmler CB,McDuffie M,Slansky JE

更新日期：2008-03-28 00:00:00

abstract：:Sodium periodate (10 mM, 4 degrees C) inactivated murine cytomegalovirus (MCMV) very rapidly (loss of 2 to 3 log of viral infectivity per minute). Periodate-treated MCMV (PI-MCMV) was shown to be innocuous in mice, as determined by the inability of the virus to replicate. PI-MCMV induced a strong humoral immune respon...

journal_title：Vaccine

authors： Geoffroy F,Moachon N,Rodwell J,Quash GA

更新日期：1996-12-01 00:00:00

abstract：:Domestic dogs constitute the main reservoir of Leishmania infantum and play a key role in transmission to humans. The main tool for controlling infection spread is a safe and effective vaccine, as successful immunization of dogs could significantly reduce the incidence of human visceral leishmaniosis (VL) and is the m...

journal_title：Vaccine

authors： Cacheiro-Llaguno C,Parody N,Renshaw-Calderón A,Osuna C,Alonso C,Carnés J

更新日期：2020-01-22 00:00:00

abstract：:In this study we have investigated the immunogenicity and antigenicity of synthetic immunocontraceptive vaccine candidates containing T- and B-cell epitopes arranged in different geometries. Two epitopes were selected, a B-cell epitope from fox sperm lactate dehydrogenase C(4) and a B-cell epitope from murine zona pel...

journal_title：Vaccine

authors： Sadler K,Bird PH,Brown LE,Jackson DC

更新日期：1999-10-14 00:00:00

abstract：:Serum specimens of 1075 young adults representing nursing and medical staff were collected for determination of rubella immunity using the radial haemolysis (RH) technique, also know as the haemolysis in gel (HIG) test. Of the sera 84 (7.8%) were negative (RH titre less than 4 mm) and an additional 93 (8.7%) gave an R...

journal_title：Vaccine

authors： Väänänen P,Mäkelä P,Vaheri A

更新日期：1986-03-01 00:00:00