Abstract:
:Conferols A (1) and B (2), the new 4-hydroxyisoflavones, have been isolated from the dichloromethane sub-fraction of the methanolic extract of Caragana conferta along with 3',5'-dihydroxy, 7,4'-dimethoxyisoflavone (3), E-cinnamic acid (4), tetracosyl 3,4-dihydroxy-E-cinnamate (5), docosyl 3,4-dihydroxy-E-cinnamate (6), beta-sitosterol (7), beta-sitostrerol 3-O-beta-D-glucopyranoside (8), stigmasterol (9) and lupeol (10), respectively, reported for the first time from this species. The structures of the new compounds were elucidated through spectroscopic techniques including MS and 2D-NMR. The compounds 1-3 showed significant anti-inflammatory activity in the respiratory burst assay.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Khan R,Malik A,Adhikari A,Qadir MI,Choudhary MIdoi
10.1248/cpb.57.415subject
Has Abstractpub_date
2009-04-01 00:00:00pages
415-7issue
4eissn
0009-2363issn
1347-5223pii
JST.JSTAGE/cpb/57.415journal_volume
57pub_type
杂志文章abstract::The effect of metal ions on transcription of the ada gene of Escherichia coli which is promoted by Ada protein in the presence of methylated deoxyribonucleic acid (DNA) was examined in a reconstituted system. Their effect on the O6-methylguanine-DNA methyltransferase (MGTase) activity of Ada protein was also examined....
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journal_title:Chemical & pharmaceutical bulletin
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