Abstract:
:Novel 9alpha and 9beta-hydroxy grayanotoxin II derivatives were prepared by photo-sensitized oxygenation of iso-grayanotoxin II and oxidation of grayanotoxin II tetraacetate with selenium dioxide respectively. The lethal dosage of 9alpha and 9beta-hydroxy grayanotoxin II were lower than that of grayanotoxin II. In addition, the lethal dosage of 9beta-hydroxy-dihydro grayanotoxin II was higher than that of dihydro grayanotoxin II.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Terai T,Osakabe K,Katai M,Sakaguchi K,Narama I,Matsuura T,Katakawa J,Tetsumi Tdoi
10.1248/cpb.51.351subject
Has Abstractpub_date
2003-03-01 00:00:00pages
351-3issue
3eissn
0009-2363issn
1347-5223journal_volume
51pub_type
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