Abstract:
:An effective procedure for decontamination of beta-lactam antibiotic residues or contaminants in the pharmaceutical manufacturing environment was investigated. Decontamination with solutions of hydrochloric acid, sodium hydroxide, hydrogen peroxide and hydroxylamine as agents for degradation was assessed. According to the results, the beta-lactam antibiotics were significantly degraded with sodium hydroxide and hydroxylamine. From the structural analysis of the degradation products of a cephem antibiotic, cefpodoxime proxetil, it was found that hydroxylamine degraded the beta-lactam structure under mild conditions, while sodium hydroxide did not. Therefore, hydroxylamine was considered an appropriate decontamination agent for beta-lactam antibiotics.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Fukutsu N,Kawasaki T,Saito K,Nakazawa Hdoi
10.1248/cpb.54.1340subject
Has Abstractpub_date
2006-09-01 00:00:00pages
1340-3issue
9eissn
0009-2363issn
1347-5223pii
JST.JSTAGE/cpb/54.1340journal_volume
54pub_type
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