Synthesis of new immunosuppressive myriocin analogs, 2-epi-myriocin, 14-deoxomyriocin, Z-14-deoxomyriocin, and nor-deoxomyriocins: their structure-activity relationships.


:Eight new myriocin analogs, 2-epi-myriocin, Z-14-deoxomyriocin, and nor-deoxomyriocins, and a known myriocin derivative, 14-deoxomyriocin, were synthesized from 2-deoxy-D-glucose via common intermediates in previous myriocin and Z-myriocin syntheses. The immunosuppressive activities of new myriocin analogs and Z-myriocin on mouse allogeneic mixed lymphocyte reaction were examined, and, by comparing with those of myriocin and 14-deoxomyriocin, some structure-activity relationships have been found.


Yoshikawa M,Yokokawa Y,Okuno Y,Yagi N,Murakami N




Has Abstract


1994-12-01 00:00:00












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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章,评审


    authors: Shishido K

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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Miyauchi M,Kurihara H,Fujimoto K,Kawamoto I,Ide J,Nakao H

    更新日期:1989-09-01 00:00:00

  • Enantioselective synthesis of the key intermediate of the acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor (R-106578) using 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP)-Ru(OAc)2 as a catalyst.

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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Murakami M,Kobayashi K,Hirai K

    更新日期:2000-10-01 00:00:00

  • A hepatitis B virus inhibitory neolignan from Herpetospermum caudigerum.

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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Yang F,Zhang HJ,Zhang YY,Chen WS,Yuan HL,Lin HW

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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kubota H,Kakefuda A,Nagaoka H,Yamamoto O,Ikeda K,Takeuchi M,Shibanuma T,Isomura Y

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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Preeprame S,Hayashi K,Lee JB,Sankawa U,Hayashi T

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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Miura T,Ogiso T

    更新日期:1991-06-01 00:00:00

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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Wang G,Luo JG,Yang MH,Wang XB,Kong LY

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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Matsuhama M,Saito R,Miyazaki S

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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Shibasaki M,Takahashi A,Aoki T,Sato H,Narita S

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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Konishi K,Ikeda K,Achiwa K,Hoshino H,Tanaka K

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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Onodera S

    更新日期:1991-04-01 00:00:00

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    journal_title:Chemical & pharmaceutical bulletin

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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


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    journal_title:Chemical & pharmaceutical bulletin

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    journal_title:Chemical & pharmaceutical bulletin

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    journal_title:Chemical & pharmaceutical bulletin

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    journal_title:Chemical & pharmaceutical bulletin

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    journal_title:Chemical & pharmaceutical bulletin

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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Nanbo T

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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Fathi-Azarbayjani A,Chan SY

    更新日期:2010-02-01 00:00:00

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    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Asada S,Nagamine S,Nakae H

    更新日期:1989-03-01 00:00:00