Synthesis of new immunosuppressive myriocin analogs, 2-epi-myriocin, 14-deoxomyriocin, Z-14-deoxomyriocin, and nor-deoxomyriocins: their structure-activity relationships.

Abstract:

:Eight new myriocin analogs, 2-epi-myriocin, Z-14-deoxomyriocin, and nor-deoxomyriocins, and a known myriocin derivative, 14-deoxomyriocin, were synthesized from 2-deoxy-D-glucose via common intermediates in previous myriocin and Z-myriocin syntheses. The immunosuppressive activities of new myriocin analogs and Z-myriocin on mouse allogeneic mixed lymphocyte reaction were examined, and, by comparing with those of myriocin and 14-deoxomyriocin, some structure-activity relationships have been found.

authors

Yoshikawa M,Yokokawa Y,Okuno Y,Yagi N,Murakami N

doi

10.1248/cpb.42.2662

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

2662-4

issue

12

eissn

0009-2363

issn

1347-5223

journal_volume

42

pub_type

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