Effects of several dithiocarbamates on tissue distribution and excretion of inorganic mercury in rats.


:The effects of various chelating agents, sodium N-benzyl-D-glucamine dithiocarbamate (BGD), sodium N-p-methylbenzyl-D-glucamine dithiocarbamate (MBGD), sodium N-p-hydroxymethylbenzyl-D-glucamine dithiocarbamate (HBGD), and N-p-carboxybenzyl-D-glucamine dithiocarbamate (CBGD), which were newly synthesized, and sodium N-methyl-D-glucamine dithiocarbamate (MGD), on the distribution and excretion of inorganic mercury were compared in rats exposed to HgCl2. Rats were injected i.p. with 203HgCl2 (300 micrograms of Hg and 74 kBq of 203Hg/kg) and 30 min or 24 h later, they were injected with a dithiocarbamate (1200 mumol/kg). At 30 min after mercury administration, BGD and MBGD significantly enhanced the biliary excretion of mercury, while CBGD, MGD, and HBGD enhanced the urinary excretion of mercury to a small extent. At 24 h after mercury injection, BGD was the most effective on the biliary excretion of the metal, while MGD and HBGD significantly enhanced the urinary excretion of the metal. All of these dithiocarbamates were effective in mobilizing mercury from the kidney at 30 min after mercury treatment. At 24 h after mercury treatment, HBGD and BGD effectively depressed mercury content in the kidney. These results show that the injection of BGD and HBGD at both 30 min and 24 h after mercury treatment can much more effectively mobilize mercury from the kidney without redistribution of mercury to other tissues, such as brain, heart, and lung, when compared with injection of other chelating agents. The pattern of mobilization and excretion of mercury following treatment with each chelating agent was related to the organic/aqueous partition coefficient of each dithiocarbamate-mercury complex.


Shimada H,Kiyozumi M,Kawagoe M,Fukudome S,Kojima S




Has Abstract


1990-03-01 00:00:00












  • Antioxidant constituents of Caragana tibetica.

    abstract::Caragana tibetica KOM. (Fabaceae) is a medicinal plant that has been traditionally used in western part of China. In the course of our screening study on antioxidant activity of medicinal plants, the 70% acetone extract of the stems of C. tibetica was found to have a potent superoxide anion scavenging activity. Tibeti...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Xiang T,Uno T,Ogino F,Ai C,Duo J,Sankawa U

    更新日期:2005-09-01 00:00:00

  • Efficient identification and quantification of peptides containing nitrotyrosine by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry after derivatization.

    abstract::Protein nitration at tyrosine residues proceeds to form 3-nitrotyrosine; this product is today used as a biomarker of nitrative stress. We have developed an efficient method with which to identify nitrated peptides and to quantify protein nitration levels in different biological samples by a combination of the chemica...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Tsumoto H,Taguchi R,Kohda K

    更新日期:2010-04-01 00:00:00

  • Proton nuclear magnetic resonance studies of the complexation of zinc(II) with glycyl-L-histidylglycine.

    abstract::The complexation of Zn(II) with glycyl-L-histidylglycine and its deuterated derivatives, glycyl-d2-L-histidylglycine and glycyl-L-histidylglycine-d2, was studied by proton nuclear magnetic resonance spectroscopy over the pD range, from 3.4 to 11.0, at 25 degrees C. Addition of Zn(II) to the peptide made the resonances...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ueda J,Hanaki A,Yoshida N,Nakajima T

    更新日期:1995-12-01 00:00:00

  • Synthesis of dibenzofurans directly from aryl halides and ortho-bromophenols via one-pot consecutive SNAr and intramolecular palladium-catalyzed aryl-aryl coupling reactions.

    abstract::A series of dibenzofurans were efficiently and conveniently synthesized via one-pot consecutive C(sp(2))-O bond formation reaction (SNAr) in the presence of anhydrous K(2)CO(3), followed by C(sp(2))-C(sp(2)) bond formation reaction (intramolecular palladium-catalyzed aryl-aryl coupling reaction) between aryl halides a...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Xu H,Fan LL

    更新日期:2008-10-01 00:00:00

  • Synthesis and azannulation of pyridinylaminohexadienones.

    abstract::4-(2-Pyridinylamino)-1,1,1-trifluoro-3-penten-2-ones 3, obtained from the reaction of commercially available 2-aminopyridine derivatives and 4-methoxy-1,1,1-trifluoro-3-penten-2-one 2, were converted to 6-(dimethylamino)-4-(2-pyridinylamino)-3,5-hexadien-2-ones 4 by treatment with dimethylformamide dimethyl acetal. Az...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Cocco MT,Conglu C,Onnis V

    更新日期:2001-06-01 00:00:00

  • Cytotoxic activity and DNA-binding properties of isoeuxanthone derivatives.

    abstract::In this study, the interactions of different groups substituted isoeuxanthone derivatives with calf thymus DNA (ct DNA) were investigated by spectrophotometric methods and viscosity measurements. Results indicated that the xanthone derivatives could intercalate into the DNA base pairs by the plane of xanthone ring and...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Wang HF,Yan H,Gao X,Niu B,Guo R,Wei L,Xu B,Tang N

    更新日期:2014-01-01 00:00:00

  • Tyrokeradines C-F, new bromotyrosine alkaloids from the Verongid sponges.

    abstract::Four new bromotyrosine alkaloids, tyrokeradines C-F (1-4), have been isolated from Okinawan marine sponges of the order Verongidae. The structures of 1-4 were elucidated on the basis of spectroscopic data. Tyrokeradines C (1) and D (2) are new bromotyrosine alkaloids possesing an imidazole ring, while tyrokeradines E ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kubota T,Watase S,Mukai H,Fromont J,Kobayashi J

    更新日期:2012-01-01 00:00:00

  • Two new C21 steroidal glycosides from Marsdenia tenacissima (ROXB.) WIGHT et ARN.

    abstract::Two new C(21) steroidal glycosides, tenacissoside L (1), tenacissoside M (2), were isolated from the stems of Marsdenia tenacissima (ROXB.) WIGHT et ARN. Their structures were elucidated, respectively, by means of chemical and spectral data, including ESI-MS, HR-ESI-MS, 1D-NMR and 2D-NMR. ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Wang S,Lai YH,Tian B,Yang L

    更新日期:2006-05-01 00:00:00

  • Design, Synthesis and Biological Evaluation of Novel Pyrazole Sulfonamide Derivatives as Potential AHAS Inhibitors.

    abstract::Acetohydroxy acid synthase (AHAS; EC, also referred to as acetolactate synthase, ALS) has been considered as an attractive target for the design of herbicides. In this work, an optimized pyrazole sulfonamide base scaffold was designed and introduced to derive novel potential AHAS inhibitors by introducing a py...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Lv XH,Ren ZL,Liu H,Li HD,Li QS,Wang L,Zhang LS,Yao XK,Cao HQ

    更新日期:2018-01-01 00:00:00

  • Studies on the constituents of Gardenia species. III. New iridoid glycosides from the leaves of Gardenia jasminoides cv. fortuneana Hara.

    abstract::Two new iridoid glycosides, 7 beta,8 beta-epoxy-8 alpha-dihydrogeniposide (1) and 8-epiapodantheroside (2), were isolated, together with six known (3-8) and three artifact (9-11) iridoids, from the leaves of Gardenia jasminoides cv. fortuneana Hara. Their structures were established based on chemical and spectral data...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Machida K,Takehara E,Kobayashi H,Kikuchi M

    更新日期:2003-12-01 00:00:00

  • Triterpenoid saponins from the seeds of Pharbitis nil.

    abstract::From the seeds of Pharbitis nil (Convolvulaceae), two new oleanene-type triterpene glycosides, pharbitosides A (1) and B (2), together with beta-sitosterol, beta-sitosterol glucoside (daucosterol), caffeic acid, and methyl caffeate were isolated. The structure of pharbitoside A (1) was elucidated to be queretaroic aci...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Jung DY,Ha H,Lee HY,Kim C,Lee JH,Bae K,Kim JS,Kang SS

    更新日期:2008-02-01 00:00:00

  • New lanostane triterpene lactones from the Vietnamese mushroom Ganoderma colossum (FR.) C. F. BAKER.

    abstract::Four new lanostane triterpene lactones (colossolactone I, colossolactone II, colossolactone III and colossolactone IV) were isolated from the Vietnamese mushroom Ganoderma colossum (FR.) C. F. BAKER along with five known compounds. The structures of the new compounds were determined on the basis of MS, NMR and circula...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: El Dine RS,El Halawany AM,Nakamura N,Ma CM,Hattori M

    更新日期:2008-05-01 00:00:00

  • Binding properties of adenosine deaminase interacted with theophylline.

    abstract::Thermodynamic studies were carried out to evaluate the binding of theophylline on adenosine deaminase (ADA) in 50 mM sodium phosphate buffer pH 7.5, at 300 K, using isothermal titration calorimetry (ITC). A simple method for determination of binding isotherm in the drug--ADA interaction was applied using ITC data. ADA...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Saboury AA,Bagheri S,Ataie G,Amanlou M,Moosavi-Movahedi AA,Hakimelahi GH,Cristalli G,Namaki S

    更新日期:2004-10-01 00:00:00

  • Constituents of Crinoidea. 5. Isolation and structure of a new glycosyl inositolphosphoceramide-type ganglioside from the feather star Comanthina schlegeli.

    abstract::A new glycosyl inositolphosphoceramide-type ganglioside, CSP2, was obtained from the polar lipid fraction of the chloroform/methanol extract of the feather star Comanthina schlegeli together with a known same type of ganglioside CJP2. The structure of this ganglioside has been determined on the basis of chemical and s...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Inagaki M,Shiizaki M,Hiwatashi T,Miyamoto T,Higuchi R

    更新日期:2007-11-01 00:00:00

  • Studies on the synthesis of compounds related to adenosine 3',5'-cyclic phosphate. VII. Synthesis and cardiac effects of N6,N6-dialkyl adenosine 3',5'-cyclic phosphates.

    abstract::A series of novel N6,N6-dialkyl adenosine 3',5'-cyclic phosphates N6,N6-dialkyl cAMPs) was synthesized from 2'-O-p-toluenesulfonyl cAMP (2'-O-tosyl cAMP, 2) and tested for inotropic and chronotropic activities in vitro. Treatment of 2 with excess alkyl halides and sodium hydride followed by detosylation with aqueous N...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kataoka S,Yamaji N,Kato M,Kawada T,Imai S

    更新日期:1990-11-01 00:00:00

  • Electronic structure of brain: structure-activity relationships between electronic structure and neurotransmitters based on molecular hardness concept.

    abstract::In order to understand the relation between the electronic structure of neurotransmitters and the brain, a model of the brain based on absolute hardness (eta) and absolute electronegativity (chi) is described. It was found that the coordinate r(chi, eta) of electronic structures of neurotransmitters obtained using the...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kobayashi S,Terao Y

    更新日期:2004-05-01 00:00:00

  • Syntheses of cerulenin and its analogs. II. Synthesis and biological activity of dl-carbacerulenin, a carbocyclic analog of cerulenin.

    abstract::2,3-Epoxy-4-hydroxy-4-((E,E)-3,6-octadienyl)cyclopentanone (dl-carbacerulenin 5) was synthesized via the epoxyketones 15a and 15b as a mimic of the active form of the antibiotics cerulenin 1, a potent inhibitor of fatty acid synthetase (FAS). The monobenzyl ethers (12 and 13), synthetic intermediates of 15, were prepa...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Shimazawa R,Ogawa Y,Morisaki N,Funabashi H,Kawaguchi A,Iwasaki S

    更新日期:1992-11-01 00:00:00

  • Synthesis and structure-activity relationships of new (5R,8R,10R)-ergoline derivatives with antihypertensive or dopaminergic activity.

    abstract::A series of new (5R,8R,10R)-ergoline derivatives was synthesized, and their antihypertensive and dopaminergic activities were tested in conscious spontaneously hypertensive rats and in rats with unilateral 6-hydroxydopamine-induced lesions of the substantia nigra. (5R,8R,10R)-6-Alkyl-8-ergolinemethanols, prepared from...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ohno S,Adachi Y,Koumori M,Mizukoshi K,Nagasaka M,Ichihara K,Kato E

    更新日期:1994-07-01 00:00:00

  • Constituents of Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activity.

    abstract::A new sesquiterpene 2,9-humuladien-6-ol-8-one (1) was isolated from methanol extract of Zingiber aromaticum, along with 15 known compounds. The structures of the isolated compounds were elucidated on the basis of spectroscopic analyses. The isolated compounds were tested for their inhibitory activity on the metabolism...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Subehan,Usia T,Kadota S,Tezuka Y

    更新日期:2005-03-01 00:00:00

  • Synthesis and antibacterial activity of novel 7-substituted-6-fluoro-1- fluoromethyl-4-oxo-4H-[1,3thiazeto[3,2-a]quinoline-3-carboxylic acid derivatives.

    abstract::A series of 7-substituted-6-fluoro-1-fluoromethyl-4-oxo-4H- [1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid derivatives (2a-1) was prepared and evaluated for antibacterial activity. These compounds were obtained by deacylation of 4-benzoyloxy-2-(1-chloro-2-fluoroethyl)thio-6,7- difluoroquinoline-3-carboxylate (10) and...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Matsuoka M,Segawa J,Amimoto I,Masui Y,Tomii Y,Kitano M,Kise M

    更新日期:1999-12-01 00:00:00

  • Synthesis and testosterone 5 alpha-reductase-inhibitory activity of 4-aza-5 alpha-androstane-17-carboxamide compound with an aromatic moiety in the C-17 carbamoyl group.

    abstract::A series of 4-aza-5 alpha-androstane compounds with one or two aromatic moieties in the carbamoyl group at the C-17 position were synthesized and their inhibitory activities for rat and human prostatic testosterone 5 alpha-reductase were tested in vitro. Compounds with one aromatic moiety in the carbamoyl group showed...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kurata H,Ishibashi K,Saito S,Hamada T,Horikoshi H,Furukawa Y,Kojima K

    更新日期:1996-01-01 00:00:00

  • Synthesis and pharmacological activity of 4-amino-5-chloro-2-methoxy-N-[(2S,4S)-1-ethyl-2-hydroxymethyl-4- pyrrolidinyl]benzamide (TKS159) and its optical isomers.

    abstract::Of 4-amino-5-chloro-2-methoxy-N-(1-ethyl-2-hydroxymethyl-4- pyrrolidinyl)benzamide, four optical isomers, (2S,4S)-1 (TKS159), (2S,4R)-25, (2R,4S)-26 and (2R,4R)-27, were prepared from optically active 4-amino-1-ethyl-2-hydroxymethylpyrrolidine di-p-toluenesulfonate [(2S,4S)-14, (2S,4R)-17, (2R,4S)-20 and (2R,4R)-23, r...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Yanagi T,Kitajima A,Anzai K,Kodama K,Mizoguchi J,Fujiwara H,Sakiyama H,Kamoda O,Kamei C

    更新日期:1999-11-01 00:00:00

  • Detection and identification of loline and its analogues in horse urine.

    abstract::Several kinds of loline-type alkaloids, norloline, loline, N-acetylnorloline, N-acetylloline, N-formylnorloline, N-formylloline and N-methylloline were detected in the urine of race-horses. Furthermore, a new compound of the alkaloids, N-senecioylnorloline, was also found and identified. These compounds were mainly id...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Takeda A,Suzuki E,Kamei K,Nakata H

    更新日期:1991-04-01 00:00:00

  • Aromaticity of Phenylalanine Residues Is Essential for Amyloid Formation by Alzheimer's Amyloid β-Peptide.

    abstract::The abnormal aggregation of amyloid β-peptide (Aβ) is central to the pathogenesis of Alzheimer's disease, the major form of dementia. Aromatic π-π interactions have been suggested to play a crucial role in the aggregation of not only Aβ, but also other amyloidogenic proteins. In this study, each or all phenylalanine (...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Genji M,Yano Y,Hoshino M,Matsuzaki K

    更新日期:2017-01-01 00:00:00

  • Green and efficient synthesis of quinoxaline derivatives via ceric ammonium nitrate promoted and in situ aerobic oxidation of alpha-hydroxy ketones and alpha-keto oximes in aqueous media.

    abstract::The direct conversion of alpha-hydroxy ketones and alpha-keto oximes into quinoxaline derivatives in the presence of a catalytic amount of ceric ammonium nitrate via metal-catalyzed aerobic oxidation followed by in situ trapping with aromatic 1,2-diamines in water as a green and efficient reaction media, is reported. ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Shaabani A,Maleki A

    更新日期:2008-01-01 00:00:00

  • Analysis of the phase solubility diagram of a phenacetin/competitor/beta-cyclodextrin ternary system, involving competitive inclusion complexation.

    abstract::The competitive inclusion complexations in the ternary phenacetin/competitors/beta-cyclodextrin (beta-CyD) systems were investigated by the solubility method, where m-bromobenzoic acid (m-BBA) and o-toluic acid (o-TA) were used as competitors. The solubility changes of the drug and competitors as a function of beta-Cy...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ono N,Hirayama F,Arima H,Uekama K

    更新日期:2001-01-01 00:00:00

  • Synthesis of (±)-8-deisopropyladunctin B.

    abstract::(±)-8-Deisopropyladunctin B, the deisopropyl form of adunctin B, which was isolated from the leaves of Piper aduncum (Piperaceae) collected in Papua New Guinea, was synthesized in 0.77% overall yield in 17 steps from 5,7-dimethoxycoumarin-3-carboxylate. The key step was our original stereoconvergent skeleton transform...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Nomura S,Arimitsu K,Yamaguchi S,Kosuga Y,Kakimoto Y,Komai T,Hasegawa K,Nakanishi A,Miyoshi T,Iwasaki H,Ozeki M,Kawasaki I,Kurume A,Ohta S,Yamashita M

    更新日期:2012-01-01 00:00:00

  • Chemical constituents of a marine soft coral of the genus Lobophytum.

    abstract::Chemical investigations on the marine soft coral Lobophytum sp., collected from the Andaman and Nicobar Islands, yielded two new acyl glycerol monoalkyl ethers along with two known compounds of this series (1a-d), and a new ceramide (4a). The structures of the new and known compounds were elucidated on the basis of ex...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Radhika P,Rao VL,Laatsch H

    更新日期:2004-11-01 00:00:00

  • Synthesis of an immunologically active fragment analog of prothymosin alpha with enhanced enzymatic stability.

    abstract::A fragment analog, [D-Arg30]prothymosin alpha fragment 1-30, containing D-arginine in place of arginine residue at position 30 was synthesized by the liquid phase procedure and studied for immunological effect on the impaired blastogenic response of T-lymphocytes isolated from uremic patients after treatment of human ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Abiko T,Sekino H

    更新日期:1991-03-01 00:00:00

  • A cytotoxic and apoptosis-inducing sesquiterpenoid isolated from the aerial parts of Artemisia princeps PAMPANINI (Sajabalssuk).

    abstract::Repeated silica gel and octadecyl silica gel (ODS) column chromatography of the aerial parts of Artemisia princeps PAMPANINI (Sajabalssuk) led to the isolation of a new sesquiterpenoid, 3-((S)-2-methylbutyryloxy)-costu-1(10),4(5)-dien-12,6 alpha-olide (2), along with two previously reported sesquiterpenoids: 8 alpha-a...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Bang MH,Han MW,Song MC,Cho JG,Chung HG,Jeong TS,Lee KT,Choi MS,Kim SY,Baek NI

    更新日期:2008-08-01 00:00:00