Studies on the constituents of Solidago virga-aurea L. III. Structures of solidagosaponins XXI-XXIX.


:From the most polar fractions of Solidago virga-aurea L. (Compositae), 9 oleanane-type triterpene saponins named solidagosaponins XXI-XXIX (1-9) were isolated, together with a known saponin, virgaureasaponin 2 (10). These saponins are bisdesmosidic glycosides having two monosaccharides at C-3 and four or five monosaccharides at C-28. Their structures were established on the basis of spectroscopic and chemical evidence.


Miyase T,Inose Y,Ueno A




Has Abstract


1994-03-01 00:00:00












  • A new ent-kaurane diterpenoid glycoside from the leaves of Cussonia bojeri, a Malagasy endemic plant.

    abstract::A new ent-kaurane diterpene glycoside, beta-D-glucopyranosyl 17-hydroxy-ent-kauran-19-oate-16-O-beta-D-glucopyranoside (4) was isolated from the dried leaves of Cussonia bojeri SEEM., together with four known compounds identified as 16beta,17-dihydroxy-kauran-19-oic acid (1), beta-D-glucopyranosyl 16beta,17-dihydroxy-...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Harinantenaina L,Kasai R,Yamasaki K

    更新日期:2002-08-01 00:00:00

  • Synthesis, in Vivo Anti-inflammatory, and in Vitro Antimicrobial Activity of New 5-Benzofuranyl Fused Pyrimidines.

    abstract::Chalcone (3) has been synthesized as a new chalcone derivative bearing benzofuran moiety at 1 position. Such chalcone was used as a model dielectrophile applied to react with some nucleophiles such as 5-amino pyrazoles, 5-amino-1,2,4-triazole, 2-aminobenzimidazole, and 6-uraciles under Michael reaction conditions and ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Nassar E,El-Badry YA,El Kazaz H

    更新日期:2016-01-01 00:00:00

  • Nateglinide controlled release tablet containing compressionable enteric coated granules.

    abstract::We designed a single unit type controlled release tablet containing nateglinide to decrease both postprandial blood glucose level (PBG) and fasting blood glucose level (FBG) in normal beagle dogs. The tablet contains 60 mg of nateglinide in an immediate release portion, and 90 mg of nateglinide in a controlled release...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Makino C,Sakai H,Yabuki A

    更新日期:2010-09-01 00:00:00

  • Highly-oxygenated isopimarane-type diterpenes from Orthosiphon stamineus of Indonesia and their nitric oxide inhibitory activity.

    abstract::From the methanolic extract of Indonesian Orthosiphon stamineus, nine new highly-oxygenated isopimarane-type diterpenes [7-O-deacetylorthosiphol B (1), 6-hydroxyorthosiphol B (2), 3-O-deacetylorthosiphol I (3), 2-O-deacetylorthosiphol J (4), siphonols A-E (5-9)] have been isolated together with nine known diterpenes [...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Awale S,Tezuka Y,Banskota AH,Adnyana IK,Kadota S

    更新日期:2003-03-01 00:00:00

  • Lipase-catalyzed hydrolysis of some racemic 1-acetoxy-2-arylpropanes.

    abstract::Racemic 1-acetoxy-2-phenylpropane (12) and 1-acetoxy-2-(2-naphthyl)propane (33) were hydrolyzed with lipase at 35-36 degrees C for 2 and 24 h to give predominantly (S)-2-phenyl-1-propanol (11) and (S)-2-(2-naphthyl)-1-propanol (32), respectively. However, racemic 1-acetoxy-2-(1-naphthyl)propane (25) was recovered inta...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Matsumoto T,Takeda Y,Iwata E,Sakamoto M,Ishida T

    更新日期:1994-06-01 00:00:00

  • Generation of a different type of beta-kallikrein from porcine pancreatic alpha-kallikrein by the action of chymotrypsin--observation of proteolytic processing occurring around "kallikrein autolysis loop" region.

    abstract::The generation of a different type of beta-kallikrein, designated C beta-kallikrein, from alpha-kallikrein by chymotryptic action was ascertained by the following observations: 1) When alpha-kallikrein was incubated with chymotrypsin, an increase of esterolytic activity of kallikrein was observed. 2) In sodium dodecyl...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kamada M,Ikekita M,Kurahashi T,Aoki K,Kizuki K,Moriya H,Sweeley CC,Kamo M,Tsugita A

    更新日期:1990-04-01 00:00:00

  • Preparation and properties of a mitomycin C-albumin conjugate.

    abstract::Mitomycin C, an anti-neoplastic agent, was covalently attached to bovine serum albumin through various kinds of spacers such as glutaryl, succinyl, trans-aconityl, methylsuccinyl and the trimellityl group. The prior acylation of albumin not only prevented protein polymerization in the presence of carbodiimide, but als...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kaneo Y,Tanaka T,Iguchi S

    更新日期:1990-09-01 00:00:00

  • Transport of harman alkaloids across Caco-2 cell monolayers.

    abstract::This study examined the intestinal transport of five harman alkaloids using the Caco-2 cell monolayer as a model of the human intestinal mucosa. Transport parameters, permeability coefficients and percent transports, were calculated and compared under identical conditions with atenolol. Permeability coefficients were ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Khan SI,Abourashed EA,Khan IA,Walker LA

    更新日期:2004-04-01 00:00:00

  • Comparative pharmacokinetics of acetohexamide and its metabolite, hydroxyhexamide in laboratory animals.

    abstract::The pharmacokinetic profiles of the hypoglycemic agent, acetohexamide (AH) and its major active metabolite, hydroxyhexamide (HH) were studied in three species of laboratory animals after intraperitoneal (ipl) administration in comparison with those after intravenous (iv) administration of AH and of the preformed metab...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Asada S,Nagamine S,Nakae H

    更新日期:1989-03-01 00:00:00

  • Medicinal flowers. XI. Structures of new dammarane-type triterpene diglycosides with hydroperoxide group from flower buds of Panax ginseng.

    abstract::Six new dammarane-type triterpene diglycosides with a hydroperoxide group, floralginsenosides A, B, C, D, E, and F, were isolated from ginseng flower, the flower buds of Panax ginseng C. A. MEYER, together with seven known dammarane-type triterpene oligoglycosides. The structures of new floralginsenosides were elucida...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Yoshikawa M,Sugimoto S,Nakamura S,Matsuda H

    更新日期:2007-04-01 00:00:00

  • Cytotoxic cardenolides from woods of Euonymus alata.

    abstract::Three cytotoxic cardenolides, acovenosigenin A 3-O-alpha-L-ramnopyranoside (1), euonymoside A (2) and euonymusoside A (3), were isolated from the woods of Euonymus alata (Celastraceae). The chemical structure of a new cardenolide, euonymusoside A (3) has been elucidated on the basis of extensive spectral analysis and ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kitanaka S,Takido M,Mizoue K,Nakaike S

    更新日期:1996-03-01 00:00:00

  • The role of Fe3+ on Fe2+-dependent lipid peroxidation in phospholipid liposomes.

    abstract::Fe2+-dependent lipid peroxidation in phosphatidylcholine (PC) liposomes, assessed by thiobarbituric acid-reactive substances (TBARS) production, was stimulated in the presence of Fe3+ in a concentration-dependent manner. The rates of nitroblue tetrazolium (NBT) reduction and Fe2+ oxidation (Fe2+ disappearance and Fe3+...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ohyashiki T,Kadoya A,Kushida K

    更新日期:2002-02-01 00:00:00

  • Nanoparticle formation of poorly water-soluble drugs from ternary ground mixtures with PVP and SDS.

    abstract::Poorly water-soluble drugs N-5159, griseofulvin (GFV), glibenclamide (GBM) and nifedipine (NFP) were ground in a dry process with polyvinylpyrrolidone (PVP) and sodium dodecyl sulfate (SDS). Different crystallinity behavior of each drug during grinding was shown in the ternary Drug/PVP/SDS system. However, when each t...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Itoh K,Pongpeerapat A,Tozuka Y,Oguchi T,Yamamoto K

    更新日期:2003-02-01 00:00:00

  • New diarylheptanoids from Amomum muricarpum ELMER.

    abstract::Two new diarylheptanoids, designated muricarpones A and B, together with three known diarylheptanoids, 1,7-di-(3',4'-dihydroxyphenyl)-4-hepten-3-one, 1-(3',4'-dihydroxyphenyl)-7-(4''-hydroxyphenyl)-4-hepten-3-one, and 1,7-bis(p-hydroxyphenyl)-4-hepten-3-one, were isolated from the rhizomes of Amomum muricarpum ELMER (...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Giang PM,Son PT,Matsunami K,Otsuka H

    更新日期:2006-01-01 00:00:00

  • Russuphelin A, a new cytotoxic substance from the mushroom Russula subnigricans Hongo.

    abstract::A new cytotoxic substance, designated russuphelin A (1), has been isolated from the mushroom Russula subnigricans Hongo (Basidiomycetes). The structure was elucidated as 2,6-bis(2,6-dichloro-4-hydroxyphenyloxy)-1,4-dimethoxy-benzene on the basis of spectroscopic data and confirmed by total synthesis. ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Takahashi A,Agatsuma T,Matsuda M,Ohta T,Nunozawa T,Endo T,Nozoe S

    更新日期:1992-12-01 00:00:00

  • Novel method to control release of lipophilic drugs with high potency from silicone.

    abstract::Silicone has been utilized as a carrier material for sustained release system of lipophilic drugs. Extensive studies revealed that drug release rate is influenced by factors such as physicochemical properties of the drug and additives.(1-5)) When a lipophilic drug is highly potent at low concentrations, the drug relea...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kajihara M,Sugie T,Sano A,Fujioka K,Urabe Y,Tanihara M,Imanishi Y

    更新日期:2003-01-01 00:00:00

  • Novel Orally Disintegrating Tablets Produced Using a High-Pressure Carbon Dioxides Process.

    abstract::It is well known that high-pressure carbon dioxide (CO2) lowers the glass transition temperature (Tg) of polymers. We therefore investigated whether Tg depression of high-pressure CO2 results in interparticle bridging of a polymer and the tablet characteristics that makes the manufacture of an orally disintegrating ta...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kobayashi M,Shinozuka D,Kondo H,Sako K,Otake K

    更新日期:2018-01-01 00:00:00

  • Rupestines F-M, new guaipyridine sesquiterpene alkaloids from Artemisia rupestris.

    abstract::Eight new guaipyridine sesquiterpene alkaloids, rupestines F-M (1-8) were isolated from the leaves of Artemisia rupestris and their structures were elucidated on the basis of 2D-NMR data. The absolute configurations of 1-8 have been assigned by comparison of their experimental and calculated circular dichroism (CD) sp...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: He F,Nugroho AE,Wong CP,Hirasawa Y,Shirota O,Morita H,Aisa HA

    更新日期:2012-01-01 00:00:00

  • Stereoselective oxidation at C-4 of flavans by the endophytic fungus Diaporthe sp. isolated from a tea plant.

    abstract::The microbial transformation of five flavans (1-5) by endophytic fungi isolated from the tea plant Camellia sinensis was investigated. It was found that the endophytic filamentous fungus Diaporthe sp. oxidized stereoselectively at C-4 position of (+)-catechin (1) and (-)-epicatechin (2) to give the correspondent 3,4-c...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Agusta A,Maehara S,Ohashi K,Simanjuntak P,Shibuya H

    更新日期:2005-12-01 00:00:00

  • Physical characteristics of freeze-dried griseofulvin-lipids nanoparticles.

    abstract::We have attempted to prepare micronized drug particles and to maintain the micronized state long-term in order to improve the solubility of a practically insoluble drug, griseofulvin (GF). GF nanoparticles (GFNPs) prepared by high-pressure homogenization were micronized to about 45 nm (mean particle size). GFNPs were ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kamiya S,Nozawa Y,Miyagishima A,Kurita T,Sadzuka Y,Sonobe T

    更新日期:2006-02-01 00:00:00

  • Hydronaphthalenones and a dihydroramulosin from the endophytic fungus PSU-N24.

    abstract::Three new hydronaphthalenone derivatives (1-3) and one new dihydroramulosin derivative (4), were isolated from the endophytic fungus PSU-N24 together with eight known compounds. Their structures were elucidated by spectroscopic methods. Griseofulvin (9) displayed strong antifungal activity against Microsporum gypseum ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Sommart U,Rukachaisirikul V,Sukpondma Y,Phongpaichit S,Sakayaroj J,Kirtikara K

    更新日期:2008-12-01 00:00:00

  • N-Methylniphatyne A, a New 3-Alkylpyridine Alkaloid as an Inhibitor of the Cancer Cells Adapted to Nutrient Starvation, from an Indonesian Marine Sponge of Xestospongia sp.

    abstract::In the course of searching for selective growth inhibitors of the cancer cells adapted to nutrient starvation, a new 3-alkylpyridine alkaloid named N-methylniphatyne A (1) was isolated from an Indonesian marine sponge of Xestospongia sp. The chemical structure of 1 was determined on the basis of the spectroscopic anal...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Arai M,Kamiya K,Shin D,Matsumoto H,Hisa T,Setiawan A,Kotoku N,Kobayashi M

    更新日期:2016-01-01 00:00:00

  • Lembehsterols A and B, novel sulfated sterols inhibiting thymidine phosphorylase, from the marine sponge Petrosia strongylata.

    abstract::Lembehsterols A (1) and B (2), two novel sulfated sterols, were isolated from the marine sponge Petrosia strongylata. Both sterols showed inhibitory activity against thymidine phosphorylase, which is an enzyme related to angiogenesis in solid tumors. The structures of these sulfated sterols were established on the bas...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Aoki S,Naka Y,Itoh T,Furukawa T,Rachmat R,Akiyama S,Kobayashi M

    更新日期:2002-06-01 00:00:00

  • High entrapment of insulin and bovine serum albumin into neutral and positively-charged liposomes by the remote loading method.

    abstract::Remote loading of insulin and bovine serum albumin (BSA) into neutral or positively-charged liposomes by incubation under a transmembrane pH gradient or non-pH gradient was investigated. Trapping efficiencies in several incubation conditions were compared with those of the conventional reverse-phase evaporation vesicl...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Hwang SH,Maitani Y,Takayama K,Nagai T

    更新日期:2000-03-01 00:00:00

  • Effect of Drug Combination on Omeprazole Metabolism by Cytochrome P450 2C19 in Helicobacter pylori Eradication Therapy.

    abstract::Helicobacter pylori (H. pylori) infection is common and can result in gastric and duodenal ulcers, and in some cases, gastric lymphoma and cancer. Omeprazole (OMP)-in combination with clarithromycin (CLR), amoxicillin (AMX), tinidazole (TND), or metronidazole (MET)-is used in double or triple combination therapy for e...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Attia TZ,Yamashita T,Tsujino H,Derayea SM,Tsutsumi Y,Uno T

    更新日期:2019-01-01 00:00:00

  • Oxygenated hexylitaconates from a marine sponge-derived fungus Penicillium sp.

    abstract::In the course of our search for bioactive metabolites from marine organisms, new hexylitaconic acid derivatives (1-4), along with (3S)-hexylitaconic acid (5), were isolated from a sponge-derived fungus Penicillium sp. Based on the NMR and MS data, the structures of compounds 1-4 were defined as α,β-dicarboxylic acid d...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Li JL,Zhang P,Lee YM,Hong J,Yoo ES,Bae KS,Jung JH

    更新日期:2011-01-01 00:00:00

  • Hapten synthesis for (+)-6-(2-chlorophenyl)-3-cyclopropanecarbonyl-8,11-dimethyl-2,3,4,5-tet rahydro-8H-pyrido[4',3':4,5]thieno[3,2-f] triazolo[4,3-a][1,4]diazepine (E6123).

    abstract::(+)-6-(2-Chlorophenyl)-3-cyclopropanecarbonyl-8,11-dimethyl-2,3,4, 5-tetrahydro-8H-pyrido[4',3':4,5]thieno[3,2-f]triazolo[4,3-a] [1,4]diazepine (E6123) is a very potent platelet-activating factor (PAF) receptor antagonist and shows potent anti-PAF activities at the microgram level in a variety of animal models. In ord...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Miyazawa S,Okano K,Kawahara T,Machida Y,Yamatsu I

    更新日期:1992-03-01 00:00:00

  • Effect of Solution Composition on Impurity Profile of the Crystallized Product in Oiling-Out Crystallization.

    abstract::Oiling-out is a unique phenomenon that the liquid phase is separated into two parts during crystallization. The emergence of new liquid phase changes the environment where crystals nucleate and grow, we call "mother phase," because target material and impurities become distributed to each phase according to their own ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Tanaka K,Takiyama H

    更新日期:2020-01-01 00:00:00

  • Chemical Synthetic Platform for Chlorpromazine Oligomers That Were Reported as Photo-degradation Products of Chlorpromazine.

    abstract::A synthetic platform for chlorpromazine (CPZ) oligomers, which could be generated via photo-reaction of CPZ, is essential to promote their biological and structural studies. In this paper, the first synthetic platform for CPZ oligomers is described. A photo-irradiation experiment of CPZ to confirm whether the structur...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kohiki T,Nishikawa Y,Inokuma T,Shigenaga A,Otaka A

    更新日期:2017-01-01 00:00:00

  • Synthesis of an immunologically active fragment analog of prothymosin alpha with enhanced enzymatic stability.

    abstract::A fragment analog, [D-Arg30]prothymosin alpha fragment 1-30, containing D-arginine in place of arginine residue at position 30 was synthesized by the liquid phase procedure and studied for immunological effect on the impaired blastogenic response of T-lymphocytes isolated from uremic patients after treatment of human ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Abiko T,Sekino H

    更新日期:1991-03-01 00:00:00