Abstract:
:Adipocyte fatty acid binding protein (A-FABP; FABP4), which is predominantly expressed in macrophages and adipose tissue, regulates fatty acid storage and lipolysis, and is also an important mediator of inflammation. Here, we report a synthesis of (14)C-labeled 2-[2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)biphenyl-3-yloxy]acetic acid (BMS309403), a potent and selective small-molecular FABP4 inhibitor, as a chemical tool for investigating the roles of FABP4 in inflammatory and metabolic disorders. The structure-activity relationship of several BMS derivatives for inhibition of FABP4 is also reported.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Okada T,Hiromura M,Otsuka M,Enomoto S,Miyachi Hdoi
10.1248/cpb.60.164subject
Has Abstractpub_date
2012-01-01 00:00:00pages
164-8issue
1eissn
0009-2363issn
1347-5223pii
JST.JSTAGE/cpb/60.164journal_volume
60pub_type
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