Cytotoxic and anti-oxidant activities of lanostane-type triterpenes isolated from Poria cocos.

Abstract:

:A new lanostane-type triterpene, 29-hydroxypolyporenic acid C (8), was isolated from the dried sclerotia of Poria cocos together with eight other known compounds pachymic acid (1), dehydropachymic acid (2), 3-acetyloxy-16alpha-hydroxytrametenolic acid (3), polyporenic acid C (4), 3-epi-dehydropachymic acid (5), 3-epi-dehydrotumulosic acid (6), tumulosic acid (7), and dehydrotumulosic acid (9). The compounds were identified by spectral analysis and comparison with spectroscopic data reported in the literatures. Although none of the nine (1 to 9) compounds showed promising antioxidant activity, 1 through 6 and 8 showed good cytotoxicity against human lung cancer cell line A549 and human prostate cancer cell line DU145. Interestingly, all these compounds exhibited better cytotoxicity towards A549 than DU145 cells.

authors

Zhou L,Zhang Y,Gapter LA,Ling H,Agarwal R,Ng KY

doi

10.1248/cpb.56.1459

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

1459-62

issue

10

eissn

0009-2363

issn

1347-5223

pii

JST.JSTAGE/cpb/56.1459

journal_volume

56

pub_type

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