Two new cycloartane glycosides from the underground parts of Aquilegia vulgaris.


:Two new cycloartane glycosides, named aquilegiosides K and L, have been isolated from the dried underground parts of Aquilegia vulgaris. Their structures were determined by two dimensional (2D) NMR spectroscopic analysis and chemical evidence.


Yoshimitsu H,Nishida M,Nohara T




Has Abstract


2008-11-01 00:00:00














  • Acridine derivatives. III. Preparation and antitumor activity of the novel acridinyl-substituted uracils.

    abstract::In an investigation of a new class of deoxyribonucleic acid (DNA)-intercalating antitumor agents, novel acridinyl-substituted uracils have been synthesized and evaluated for activity against L1210 leukemia in vivo, and against bacteria and fungus. These compounds were prepared by the novel enamine reaction between 9-c...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kimura M,Okabayashi I,Kato A

    更新日期:1989-03-01 00:00:00

  • Progress in Development of Interventions to Prevent Birth Defects in Diabetic Pregnancies.

    abstract::Diabetic embryopathy is a diabetic complication, in which maternal hyperglycemia in early pregnancy causes birth defects in newborn infants. Under maternal diabetic conditions, hyperglycemia disturbs intracellular molecular activities and organelles functions. These include protein misfolding in the endoplasmic reticu...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章,评审


    authors: Han L,Jiang Z,Zheng X,Qiu J,Hu Y,Li X

    更新日期:2019-01-01 00:00:00

  • Preparation and evaluation of proliposomes containing clotrimazole.

    abstract::Clotrimazole (CT)-containing proliposomes were prepared by penetrating an ethanol solution of CT and Egg phosphatidylcholine (PC) into microporous sorbitol particles, followed by vacuum evaporation of the solvent. As a result, CT proliposomes with free-flowing flowability were obtained. On contact with water, the prol...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ning MY,Guo YZ,Pan HZ,Yu HM,Gu ZW

    更新日期:2005-06-01 00:00:00

  • Minor saponins from Tetrapanax papyriferum.

    abstract::Four new minor saponins, papyrioside LE-LH, were isolated from the leaves of Tetrapanax papyriferum, and their structures were determined on the basis of spectroscopic evidence. ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Mutsuga M,Kojima K,Saracoglu I,Ogihara Y

    更新日期:1997-03-01 00:00:00

  • Studies on the constituents of Luffa acutangula Roxb. I. Structures of acutosides A--G, oleanane-type triterpene saponins isolated from the herb.

    abstract::From the herb of Luffa acutangula ROXB. (Cucurbitaceae), seven oleanane-type triterpene saponins, acutosides A--G, were isolated and their structures were determined. Acutoside A is oleanolic acid 3-O-beta-D-glucopyranosyl-(1----2)-beta-D-glucopyranoside. Acutosides B, D, E, F and G have a common prosapogenin structur...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Nagao T,Tanaka R,Iwase Y,Hanazono H,Okabe H

    更新日期:1991-03-01 00:00:00

  • Is the thiobarbituric acid-reactivity of blood plasma specific to lipid peroxidation?

    abstract::The fluorometric thiobarbituric acid (TBA) assay of blood plasma was performed under various conditions in order to assess whether the assay reflects lipid peroxidation. The TBA-reactivity of malonaldehyde was not dependent on the pH values of the reaction and was little affected by tert-butyl hydroperoxide (tert-BuOO...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kojima T,Kikugawa K,Kosugi H

    更新日期:1990-12-01 00:00:00

  • Electrochemical study of zolpidem at glassy carbon electrode and its determination in a tablet dosage form by differential pulse voltammetry.

    abstract::The oxidative behaviour of, a hypnotic drug, zolpidem was studied at glassy carbon electrode in Britton-Robinson buffer over the pH range 2.0-11.0 using cyclic, linear sweep and differential pulse voltammetry. Oxidation of the drug was effected in a single irreversible, diffusion-controlled step. Using differential pu...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Radi AE,Bekhiet G,Wahdan T

    更新日期:2004-09-01 00:00:00

  • Electrochemical oxidation of catechols in the presence of phenyl-Meldrum's acid. Synthesis and kinetic evaluation.

    abstract::Electrochemical oxidation of catechols in the presence of phenyl-Meldrum's acid as a nucleophile in aqueous solution has been studied in detail by means of cyclic voltammetry and controlled potential coulometry. The results indicate that the o-benzoquinone derived from catechols participates in Michael addition reacti...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Nematollahi D,Bamzadeh M,Shayani-Jam H

    更新日期:2010-01-01 00:00:00

  • Chemical constituents of malagasy liverworts, part V: prenyl bibenzyls and clerodane diterpenoids with nitric oxide inhibitory activity from Radula appressa and Thysananthus spathulistipus.

    abstract::3Beta,4beta:15,16-diepoxy-13(16),14-clerodadiene (1) and a new clerodane diterpenoid designated thysaspathone (2) were isolated from the liverwort Thysananthus spathulistipus, while Radula appressa produced radulannin A (3), radulannin L (4), 2-geranyl-3,5-dihydroxybibenzyl (5), 2(S)-2-methyl-2-(4-methyl-3-pentenyl)-7...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Harinantenaina L,Takahara Y,Nishizawa T,Kohchi C,Soma G,Asakawa Y

    更新日期:2006-07-01 00:00:00

  • Quantitative Analysis of Salidroside and p-Tyrosol in the Traditional Tibetan Medicine Rhodiola crenulata by Fourier Transform Near-Infrared Spectroscopy.

    abstract::A nondestructive, efficient, and rapid method for quantitative analysis of two bioactive components (salidroside and p-tyrosol) in Rhodiola crenulata, a traditional Tibetan medicine, by Fourier transform near-infrared (FT-NIR) spectroscopy was developed. Near-infrared diffuse reflectance spectra in the range of 4000 t...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Li T,He X

    更新日期:2016-01-01 00:00:00

  • Formulation Optimization and in Vitro Characterization of Orally Disintegrating Films Using a Factorial Design and Mathematical Modeling for Drug Release.

    abstract::Even though experimental designs are becoming popular especially for conventional dosage forms, limited studies have been performed to optimize formulations of orally disintegrating films (ODFs). This study aimed to evaluate sildenafil citrate-loaded ODFs for a controlled release with hydroxypropyl methylcellulose as ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Lee Y,Thapa P,Jeong SH,Woo MH,Choi DH

    更新日期:2017-02-01 00:00:00

  • Hapten synthesis for (+)-6-(2-chlorophenyl)-3-cyclopropanecarbonyl-8,11-dimethyl-2,3,4,5-tet rahydro-8H-pyrido[4',3':4,5]thieno[3,2-f] triazolo[4,3-a][1,4]diazepine (E6123).

    abstract::(+)-6-(2-Chlorophenyl)-3-cyclopropanecarbonyl-8,11-dimethyl-2,3,4, 5-tetrahydro-8H-pyrido[4',3':4,5]thieno[3,2-f]triazolo[4,3-a] [1,4]diazepine (E6123) is a very potent platelet-activating factor (PAF) receptor antagonist and shows potent anti-PAF activities at the microgram level in a variety of animal models. In ord...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Miyazawa S,Okano K,Kawahara T,Machida Y,Yamatsu I

    更新日期:1992-03-01 00:00:00

  • Estimating tissue permeability and other bioelectrical parameters using membrane voltage and short-circuit current.

    abstract::Evaluating the acute toxic effects of drugs or toxins is based mainly on studies which require the use of light microscopy. Recently, the effects of such substances on biological membranes, such as the nasal membrane, has been studied using the traditional Ussing chambers, which make it possible to study the transepit...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Gizurarson S,Tamura S,Kurata T

    更新日期:1991-06-01 00:00:00

  • Inner-hydrogen tautomerism in some 5,15-unsymmetrically disubstituted and beta-unsubstituted porphyrins.

    abstract::5,15-Unsymmetrically disubstituted and beta-unsubstituted porphyrins such as 5-R, 15-(3,5-dimethoxyphenyl) porphyrins [where R=2-benzyloxy-1-naphthyl (1), 2-(2-naphthylmethoxy)-1-naphthyl (2), anthryl (3), or 2,4,6-triphenylphenyl (4)] and 5-(2-benzyloxy-1-naphthyl), 10,15,20-tri(3,5-dimethoxyphenyl) porphyrin (1') we...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Tohara A,Sato M

    更新日期:2008-07-01 00:00:00

  • Potential of Enzymomics Methodologies to Characterize Disease-Related Protein Functions.

    abstract::Enzymatic functions are often altered during disease onset and progression, and therefore chemical-biological studies, which utilize chemical knowledge to discover novel protein functions, are often employed to find proteins with functions closely related to disease phenotypes. Such studies are known as forward chemic...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章,评审


    authors: Komatsu T

    更新日期:2017-01-01 00:00:00

  • Synthesis of all-methylated isorugosin B.

    abstract::All-methylated isorugosin B was synthesized via two-step esterification between optically active valoneic acid and glucose derivatives. ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Shioe K,Takeuchi Y,Harayama T,Abe H

    更新日期:2010-03-01 00:00:00

  • Importance of Proton-Coupled Electron Transfer from Natural Phenolic Compounds in Superoxide Scavenging.

    abstract::The superoxide O2(·-) scavenging reaction of (+)-catechin (Cat), quercetin (Que), rutin, and α-tocopherol (α-TOH) as natural phenolic compounds is investigated on the basis of electrochemical and ESR spectral measurements with the aid of density functional theory (DFT) calculations. Reversibility of the O2/O2(·-) redo...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Nakayama T,Uno B

    更新日期:2015-01-01 00:00:00

  • Synthesis and HIV-1 integrase inhibition of novel bis- or tetra-coumarin analogues.

    abstract::Present studies were undertaken on the preparation of synthetic analogues of bis- or tetra-coumarins and their activity against HIV-1 integrase (HIV-1 IN). Among these coumarin analogues, compounds 14, 16 and 18 were found to be potent molecules against HIV-1 IN at IC50 values of 0.96, 0.58, and 0.49 microM, respectiv...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Chiang CC,Mouscadet JF,Tsai HJ,Liu CT,Hsu LY

    更新日期:2007-12-01 00:00:00

  • Studies towards the synthesis of the hypermodified nucleoside of rat liver phenylalanine transfer ribonucleic acid: improved synthesis of the base beta-hydroxywybutine.

    abstract::An improved synthesis of the key intermediates (3 and 8) for the synthesis of beta-hydroxywybutines [[R-(R*,S*)]- and [S-(R*,R*)]-4], the most probable structures for the minor base from rat liver tRNA(Phe), has been achieved by the Wittig reaction between 1-benzyl-7-formylwye (1) and the phosphorane derived from (R)-...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Itaya T,Kanai T

    更新日期:1998-08-01 00:00:00

  • Plasma-polymerized allylamine film used as a new solid phase in immunoradiometric assay (IRMA): effect of antibody (F(ab')2 fragment) concentration on dose response in two-site IRMA.

    abstract::Allylamine (ALAM) film was plasma-polymerized on a flat glass (referred to as ALAM(GLA): GLA refers to a flat glass plate) for use as a solid phase in two-site immunoradiometric assay (two-site IRMA). Adsorption of F(ab')2 anti-human immunoglobulin G [formula: see text] to ALAM(GLA) was larger than adsorption on a pol...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Muratsugu M,Kurosawa S,Mori Y,Kamo N

    更新日期:1992-02-01 00:00:00

  • Cytotoxic activity and DNA-binding properties of isoeuxanthone derivatives.

    abstract::In this study, the interactions of different groups substituted isoeuxanthone derivatives with calf thymus DNA (ct DNA) were investigated by spectrophotometric methods and viscosity measurements. Results indicated that the xanthone derivatives could intercalate into the DNA base pairs by the plane of xanthone ring and...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Wang HF,Yan H,Gao X,Niu B,Guo R,Wei L,Xu B,Tang N

    更新日期:2014-01-01 00:00:00

  • Design, synthesis and biological evaluation of hydroxy- or methoxy-substituted phenylmethylenethiosemicarbazones as tyrosinase inhibitors.

    abstract::A series of hydroxy- or methoxy-substituted phenylmethylenethiosemicarbazones were designed, synthesized and evaluated as mushroom tyrosinase inhibitors. The results demonstrated that most of target compounds had remarkable inhibitory activities on mushroom tyrosinase. Interestingly, compound 2h was found to be the mo...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Yi W,Cao RH,Chen ZY,Yu L,Ma L,Song HC

    更新日期:2009-11-01 00:00:00

  • Nateglinide controlled release tablet containing compressionable enteric coated granules.

    abstract::We designed a single unit type controlled release tablet containing nateglinide to decrease both postprandial blood glucose level (PBG) and fasting blood glucose level (FBG) in normal beagle dogs. The tablet contains 60 mg of nateglinide in an immediate release portion, and 90 mg of nateglinide in a controlled release...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Makino C,Sakai H,Yabuki A

    更新日期:2010-09-01 00:00:00

  • Magnolin Inhibits Proliferation and Invasion of Breast Cancer MDA-MB-231 Cells by Targeting the ERK1/2 Signaling Pathway.

    abstract::The aim of this study was to evaluate the effects of Magnolin (MGL) on inhibition of human breast cancer cells, and explore the underlying molecular mechanisms. The viability of the treated cells was assessed with the Cell Counting Kit-8 (CCK-8) assay, and the proliferation was analyzed in terms of EdU uptake, colony ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Wang J,Zhang S,Huang K,Shi L,Zhang Q

    更新日期:2020-01-01 00:00:00

  • Efficient synthesis of trans- or cis-4(5)-(5-aminomethyltetrahydrofuran-2-yl)imidazoles via diazafulvene intermediates: synthetic approach toward human histamine H4)-ligands.

    abstract::(+)-4(5)-[(2R,5R)-5-aminomethyltetrahydrofuran-2-yl]imidazole [(+)-1, imifuramine] and its 2R,5S-stereoisomer (+)-2 were expected as base compounds to develop selective human histamine H4-receptor ligands. The improved synthesis of (+)-1 was done via cyclization of a diazafulvene intermediate generated by Bu3P/N,N,N',...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Harusawa S,Araki L,Terashima H,Kawamura M,Takashima S,Sakamoto Y,Hashimoto T,Yamamoto Y,Yamatodani A,Kurihara T

    更新日期:2003-07-01 00:00:00

  • Tandem enzymatic resolution yielding L-alpha-aminoalkanedioic acid omega-esters.

    abstract::The tandem action of serine protease (alpha-chymotrypsin or subtilisin BPN') and Aspergillus genus aminoacylase on racemic N-acetyl-alpha-aminoalkanedioic acid alpha,omega-diester produced L-alpha-aminoalkanedioic acid omega-ester in good yield and high optical purity. L-alpha-Aminosuberic acid omega-ester thus obtain...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Nishino N,Arai T,Ueno Y,Ohba M

    更新日期:1996-01-01 00:00:00

  • Structural Optimization of Ghrelin Receptor Inverse Agonists to Improve Lipophilicity and Avoid Mechanism-Based CYP3A4 Inactivation.

    abstract::Structural optimization of 2-aminonicotinamide derivatives as ghrelin receptor inverse agonists is reported. So as to avoid mechanism-based inactivation (MBI) of CYP3A4, 1,3-benzodioxol ring of the lead compound was modified. Improvement of the main activity and lipophilicity was achieved simultaneously, leading to co...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Takahashi B,Funami H,Shibata M,Maruoka H,Koyama M,Kanki S,Muto T

    更新日期:2015-01-01 00:00:00

  • Prolonged Distribution of Tranilast in the Eyes after Topical Application onto Eyelid Skin.

    abstract::Tranilast, a lipophilic drug with various ophthalmic applications, was used as a model drug to establish the possibility of delivering lipophilic drugs through the eyelid skin. Pharmacokinetics and tissue distribution studies were conducted employing three application methods (topical application onto eyelid skin, eye...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: See GL,Arce F Jr,Itakura S,Todo H,Sugibayashi K

    更新日期:2020-01-01 00:00:00

  • Studies on the number of contacts between ibuprofen and ethenzamide using thermal analysis.

    abstract::We studied a method of estimating the number of contacts in a solid dosage form using thermal analysis. Ibuprofen (IB) and Ethenzamide (ET) were used as model actives. IB and ET were granulated and sieved with each other. We prepared mixtures of IB and ET using different diameter granules. The number of contacts betwe...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Aoki S,Mizutani T,Danjo K

    更新日期:2000-01-01 00:00:00

  • Partial purification, and some properties and reactivities of cetraxate benzyl ester hydrochloride-hydrolyzing enzyme.

    abstract::Debenzylating enzyme from Aspergillus niger enzyme (commercial crude cellulase) catalyzes the hydrolysis of cetraxate benzyl ester hydrochloride (2), a precursor of the antiulcer agent (1). The enzyme was highly purified by three kinds of chromatographies (hydrophobic, ion exchange, gel filtration) with a recovery of ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kuroda H,Miyadera A,Imura A,Suzuki A

    更新日期:1989-11-01 00:00:00