Estimation of the relative excess risk due to interaction and associated confidence bounds.

Abstract:

:The relative excess risk due to interaction (RERI) provides a useful metric of departure from additivity of effects on a relative risk scale. In this paper, the authors show that RERI is identical to the product term in a linear odds ratio or a linear relative risk model. SAS and STATA codes are provided for fitting a linear odds ratio model that directly parameterizes RERI. In addition, this paper presents a method for obtaining likelihood-based 95% confidence bound estimates for RERI. The authors show that likelihood-based confidence intervals may differ substantially from the asymptotic confidence interval estimates advocated by previous authors. The approach presented in this paper should facilitate estimation of RERI and associated likelihood-based confidence bounds, by using standard statistical packages.

journal_name

Am J Epidemiol

authors

Richardson DB,Kaufman JS

doi

10.1093/aje/kwn411

subject

Has Abstract

pub_date

2009-03-15 00:00:00

pages

756-60

issue

6

eissn

0002-9262

issn

1476-6256

pii

kwn411

journal_volume

169

pub_type

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