How many well vs. unwell days can you expect over 10 years, once you become depressed?

Abstract:

OBJECTIVE:Prognostic studies of major depression have mainly focused on episode remission and relapse, and only a limited number of studies have examined long-term course of depressive symptomatology at threshold and subthreshold levels. METHOD:The Group for Longitudinal Affective Disorders Study has conducted prospective serial assessments of a cohort of heretofore untreated major depressive episodes for 10 years under naturalistic conditions. RESULTS:Of the 94 patients in the cohort, the follow-up rate was 70% of the 11,280 person-months. Around 77% of the follow-up months were spent in euthymia, 16% in subthreshold depression and 7% in major depression. Duration of the index episode before reaching recovery was the only significant predictor of the ensuing well time. CONCLUSION:On average, patients with major depression starting treatment today may expect to spend three quarters of the next decade in euthymia but the remaining one quarter in subthreshold or threshold depression.

journal_name

Acta Psychiatr Scand

authors

Furukawa TA,Yoshimura R,Harai H,Imaizumi T,Takeuchi H,Kitamura T,Takahashi K

doi

10.1111/j.1600-0447.2008.01288.x

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

290-7

issue

4

eissn

0001-690X

issn

1600-0447

pii

ACP1288

journal_volume

119

pub_type

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