A1-adenosine receptor inhibition of adenylate cyclase in failing and nonfailing human ventricular myocardium.

abstract：:Composite graft replacement of the ascending aorta and aortic valve was performed in 78 patients over an 8 1/2-year period. Degenerative lesions of the aortic root in Marfan's syndrome (annuloaortic ectasia) was the indication for operation in 56 cases; the other 22 patients had other causes of aortic root dilatation ...

journal_title：Circulation

authors： Donaldson RM,Ross DN

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND:There has been considerable speculation about the role of lesion microvessels in the accumulation of leukocytes in atherosclerosis. However, direct study of microvascular recruitment of leukocytes in lesions has not been performed, and the quantitative role for this route of entry is unclear. METHODS AND RE...

journal_title：Circulation

authors： Eriksson EE

更新日期：2011-11-08 00:00:00

abstract：BACKGROUND:Adverse cardiovascular events associated with thrombotic occlusion occur in 4% to 12.8% of patients after coronary angioplasty. Recently, potent antiplatelet agents have been used to reduce those thrombotic complications. Tirofiban is a highly selective, short-acting inhibitor of fibrinogen binding to platel...

journal_title：Circulation

authors：

更新日期：1997-09-02 00:00:00

abstract：BACKGROUND:Heat shock protein (HSP)60 is an abundant protein found primarily in the mitochondria, though 15% to 20% is found in the cytosol. Previously we observed that HSP60 complexes with bax in the cytosol. Reduction in HSP60 precipitates translocation of bax to the mitochondria and apoptosis. We hypothesized that H...

journal_title：Circulation

authors： Gupta S,Knowlton AA

更新日期：2002-11-19 00:00:00

abstract：BACKGROUND:Electric stimulation of mediastinal sympathetic cardiac nerves increases cardiac contractility but is not selective for the left ventricle because it elicits sinus tachycardia and enhanced atrioventricular conduction. The aim of this study was to identify sympathetic neural structures inside the heart that s...

journal_title：Circulation

authors： Meyer C,Rana OR,Saygili E,Gemein C,Becker M,Nolte KW,Weis J,Schimpf T,Knackstedt C,Mischke K,Hoffmann R,Kelm M,Pauza D,Schauerte P

更新日期：2010-03-23 00:00:00

abstract：BACKGROUND:Although prospective studies, systematic reviews, and meta-analyses have documented an association between depression and increased morbidity and mortality in a variety of cardiac populations, depression has not yet achieved formal recognition as a risk factor for poor prognosis in patients with acute corona...

journal_title：Circulation

authors： Lichtman JH,Froelicher ES,Blumenthal JA,Carney RM,Doering LV,Frasure-Smith N,Freedland KE,Jaffe AS,Leifheit-Limson EC,Sheps DS,Vaccarino V,Wulsin L,American Heart Association Statistics Committee of the Council on Epidemiology an

更新日期：2014-03-25 00:00:00

abstract：BACKGROUND:Ultrasonic angioplasty was recently shown to ablate thrombi and atherosclerotic plaques in vitro and to recanalize occluded arteries in experimental animal models. The goal of the present study was to examine the clinical feasibility of ultrasonic angioplasty. METHODS AND RESULTS:Intraoperative ultrasonic a...

journal_title：Circulation

authors： Rosenschein U,Rozenszajn LA,Kraus L,Marboe CC,Watkins JF,Rose EA,David D,Cannon PJ,Weinstein JS

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Clinical cardiac volumetric measurement techniques are essential for assessing cardiac performance but produce significant inaccuracies in extrapolation of the volume of a three-dimensional (3D) object from two-dimensional images and lack the ability to associate cardiac electrical and mechanical activities....

journal_title：Circulation

authors： Gepstein L,Hayam G,Shpun S,Ben-Haim SA

更新日期：1997-11-18 00:00:00

abstract：:To assess the impact of operative reduction of left ventricular outflow obstruction in hypertrophic cardiomyopathy, measurements of great cardiac vein flow, oxygen and lactate content, left ventricular pressures, and cardiac index were measured at rest and during pacing stress in 20 consecutive patients (13, myotomy-m...

journal_title：Circulation

authors： Cannon RO 3rd,McIntosh CL,Schenke WH,Maron BJ,Bonow RO,Epstein SE

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:The role of infections and inflammation in the pathophysiology of coronary heart disease is emerging. We studied the independent and joint effects of these 2 components on coronary risk. METHODS AND RESULTS:We measured baseline levels of C-reactive protein (CRP) and antibodies to adenovirus, enterovirus, cy...

journal_title：Circulation

authors： Roivainen M,Viik-Kajander M,Palosuo T,Toivanen P,Leinonen M,Saikku P,Tenkanen L,Manninen V,Hovi T,Mänttäri M

更新日期：2000-01-25 00:00:00

abstract：:Minoxidil, a potent predominant arterial dilator, improves hemodynamics over the short term in patients with heart failure. In random double-blind fashion 17 patients with chronic left heart failure were given minoxidil (nine patients) or placebo (eight patients) in addition to digoxin and diuretics for 3 months. Card...

journal_title：Circulation

authors： Franciosa JA,Jordan RA,Wilen MM,Leddy CL

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:Immunization with cardiac myosin induces experimental autoimmune heart disease in genetically predisposed mice. These mice produce heart-specific autoantibodies, some of which are directed against the cardiac myosin isoform. METHODS AND RESULTS:We have reported the presence of circulating heart-specific aut...

journal_title：Circulation

authors： Caforio AL,Grazzini M,Mann JM,Keeling PJ,Bottazzo GF,McKenna WJ,Schiaffino S

更新日期：1992-05-01 00:00:00

abstract：:To assess the results of cardiac repair utilizing a right ventricular to pulmonary artery conduit, we reviewed postoperative hemodynamic data in 16 patients catheterized 0.5 to 5 years after repair. In 12 patients, a Hancock conduit (dacron conduit with porcine valve) was used; the conduit in the remaining four patien...

journal_title：Circulation

authors： Rocchini AP,Rosenthal A,Keane JF,Castaneda AR,Nadas AS

更新日期：1976-12-01 00:00:00

abstract：:The outlook for patients with double-outlet right ventricle has improved since the development of corrective operations. Late arrhythmic deaths after successful procedures have been reported; however, the magnitude remains unknown. This study was undertaken to identify the magnitude of late sudden death and the signif...

journal_title：Circulation

authors： Shen WK,Holmes DR Jr,Porter CJ,McGoon DC,Ilstrup DM

更新日期：1990-01-01 00:00:00

abstract：:The quantitative approaches to the assessment of regional left ventricular (LV) function described in the preceding paper were applied in a well-defined population of patients with coronary artery disease. Two groups were chosen by electrocardiographic and angiographic criteria: group 1 had infarction and regional wal...

journal_title：Circulation

authors： Parisi AF,Moynihan PF,Folland ED,Feldman CL

更新日期：1981-04-01 00:00:00

abstract：BACKGROUND:The Ross procedure and aortic homografts have both been shown to have superior hemodynamic performance after valve replacement, but there have been few comparisons. METHODS:Sequential Doppler echocardiograms were performed up to 5 years after aortic valve replacement in 132 patients with the Ross procedure ...

journal_title：Circulation

authors： Laforest I,Dumesnil JG,Briand M,Cartier PC,Pibarot P

更新日期：2002-09-24 00:00:00

abstract：:Lidocaine is a commonly used antiarrhythmic drug that causes use-dependent blockade of sodium channels in vitro and reduces conduction velocity in vitro and in vivo. According to the modulated receptor hypothesis of antiarrhythmic drug action, lidocaine has a low affinity for rested sodium channels but a high affinity...

journal_title：Circulation

authors： Davis J,Matsubara T,Scheinman MM,Katzung B,Hondeghem LH

更新日期：1986-07-01 00:00:00

abstract：:For the past 5 years, investigators from many different laboratories have contributed to a greatly increased understanding of two very important lipid-carrying proteins in plasma--apo B-100 and apo B-48. Apo B-100, an extremely large protein composed of 4,536 amino acids, is synthesized by the liver and is crucial for...

journal_title：Circulation

authors： Young SG

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to evaluate dynamic changes in aortic regurgitant (AR) orifice area with the use of calibrated electromagnetic (EM) flowmeters and to validate a color Doppler flow convergence (FC) method for evaluating effective AR orifice area and regurgitant volume. METHODS AND RESULTS:In...

journal_title：Circulation

authors： Shiota T,Jones M,Yamada I,Heinrich RS,Ishii M,Sinclair B,Holcomb S,Yoganathan AP,Sahn DJ

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:Dual antiplatelet therapy with aspirin and a P2Y12 inhibitor has been shown to reduce the risk of major adverse cardiovascular events (MACE) compared with aspirin alone after percutaneous coronary intervention (PCI) or acute coronary syndrome but with increased risk of bleeding. The safety of discontinuing a...

journal_title：Circulation

authors： O'Donoghue ML,Murphy SA,Sabatine MS

更新日期：2020-08-11 00:00:00

abstract：BACKGROUND:Elevated asymmetrical dimethylarginine (ADMA) is a novel risk factor for atherosclerosis that may impair endothelial function by interfering with endothelial nitric oxide synthesis. To gain insight into the effects of ADMA on systemic endothelial function, we examined the association between ADMA and brachia...

journal_title：Circulation

authors： Juonala M,Viikari JS,Alfthan G,Marniemi J,Kähönen M,Taittonen L,Laitinen T,Raitakari OT

更新日期：2007-09-18 00:00:00

abstract：:Background: Vascular smooth muscle cells (VSMCs) show a remarkable phenotypic plasticity allowing acquisition of contractile or synthetic states but critical information is missing about the physiological signals, promoting formation and maintenance of contractile VSMCs in vivo. BMP9 and BMP10 are known to regulate en...

journal_title：Circulation

authors： Wang L,Rice M,Swist S,Kubin T,Wu F,Wang S,Kraut S,Weissmann N,Böttger T,Wheeler M,Schneider A,Braun T

更新日期：2020-12-18 00:00:00

abstract：BACKGROUND:Recombinant staphylokinase (STAR) was shown recently to offer promise for coronary arterial thrombolysis in patients with evolving myocardial infarction. The present multicenter randomized open trial was designed to assess the thrombolytic efficacy, safety, and fibrin specificity of STAR relative to accelera...

journal_title：Circulation

authors： Vanderschueren S,Barrios L,Kerdsinchai P,Van den Heuvel P,Hermans L,Vrolix M,De Man F,Benit E,Muyldermans L,Collen D

更新日期：1995-10-15 00:00:00

abstract：BACKGROUND:Diagnostic strategies with ECG and serum cardiac markers have been used to rule out acute myocardial infarction in 6 to 12 hours. The present study evaluated whether a multimarker strategy that used point-of-care measurement of myoglobin, creatine kinase (CK)-MB, and troponin I could exclude acute myocardial...

journal_title：Circulation

authors： McCord J,Nowak RM,McCullough PA,Foreback C,Borzak S,Tokarski G,Tomlanovich MC,Jacobsen G,Weaver WD

更新日期：2001-09-25 00:00:00

abstract：BACKGROUND:Vascular endothelial cell growth factor plays a pivotal role in angiogenesis via regulating endothelial cell proliferation. The X-box binding protein 1 (XBP1) is believed to be a signal transducer in the endoplasmic reticulum stress response. It is unknown whether there is crosstalk between vascular endothel...

journal_title：Circulation

authors： Zeng L,Xiao Q,Chen M,Margariti A,Martin D,Ivetic A,Xu H,Mason J,Wang W,Cockerill G,Mori K,Li JY,Chien S,Hu Y,Xu Q

更新日期：2013-04-23 00:00:00

abstract：BACKGROUND:Recent studies of beta-adrenergic receptor (beta-AR) subtype signaling in in vitro preparations have raised doubts as to whether the cAMP/protein kinase A (PKA) signaling is activated in the same manner in response to beta2-AR versus beta1-AR stimulation. METHODS AND RESULTS:The present study compared, in t...

journal_title：Circulation

authors： Kuschel M,Zhou YY,Spurgeon HA,Bartel S,Karczewski P,Zhang SJ,Krause EG,Lakatta EG,Xiao RP

更新日期：1999-05-11 00:00:00

abstract：:It is generally agreed that the conditions leading to myocardial ischemia occur when the oxygen demands of the myocardium exceed the oxygen supply. The major limitations of oxygen supply to the myocardium are atherogenic disease and vasospasm of the coronary arteries. The major hemodynamic determinants of myocardial o...

journal_title：Circulation

authors： Frishman WH

更新日期：1983-06-01 00:00:00

abstract：BACKGROUND:Decreased renal function has been found to be an independent risk factor for cardiovascular outcomes in patients with chronic heart failure (CHF) with markedly reduced left ventricular ejection fraction (LVEF). The aim of this analysis was to evaluate the prognostic importance of renal function in a broader ...

journal_title：Circulation

authors： Hillege HL,Nitsch D,Pfeffer MA,Swedberg K,McMurray JJ,Yusuf S,Granger CB,Michelson EL,Ostergren J,Cornel JH,de Zeeuw D,Pocock S,van Veldhuisen DJ,Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity

更新日期：2006-02-07 00:00:00

abstract：:Myocardial ischemia has, for many decades, been viewed as an all-or-none process that causes myocardial necrosis when prolonged and severe, but whose effects are transient when it is brief or mild. In view of the evidence that the ischemic process may "hit, run and stun," perhaps our thinking about the consequences of...

journal_title：Circulation

authors： Braunwald E,Kloner RA

更新日期：1982-12-01 00:00:00

abstract：BACKGROUND:We examined the relationship between hypertension subtype and cardiovascular disease incidence and mortality in Chinese adults. METHODS AND RESULTS:We conducted a prospective cohort study in a nationally representative sample of 169 871 Chinese men and women aged >or=40 years. Data on systolic (SBP) and dia...

journal_title：Circulation

authors： Kelly TN,Gu D,Chen J,Huang JF,Chen JC,Duan X,Wu X,Yau CL,Whelton PK,He J

更新日期：2008-10-07 00:00:00