Abstract：
:This study evaluated independent effects of maternal and paternal age on risk of autism spectrum disorder. A case-cohort design was implemented using data from 10 US study sites participating in the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring Network. The 1994 birth cohort included 253,347 study-site births with complete parental age information. Cases included 1,251 children aged 8 years with complete parental age information from the same birth cohort and identified as having an autism spectrum disorder based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria. After adjustment for the other parent's age, birth order, maternal education, and other covariates, both maternal and paternal age were independently associated with autism (adjusted odds ratio for maternal age > or =35 vs. 25-29 years = 1.3, 95% confidence interval: 1.1, 1.6; adjusted odds ratio for paternal age > or =40 years vs. 25-29 years = 1.4, 95% confidence interval: 1.1, 1.8). Firstborn offspring of 2 older parents were 3 times more likely to develop autism than were third- or later-born offspring of mothers aged 20-34 years and fathers aged <40 years (odds ratio = 3.1, 95% confidence interval: 2.0, 4.7). The increase in autism risk with both maternal and paternal age has potential implications for public health planning and investigations of autism etiology.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Durkin MS,Maenner MJ,Newschaffer CJ,Lee LC,Cunniff CM,Daniels JL,Kirby RS,Leavitt L,Miller L,Zahorodny W,Schieve LAdoi
10.1093/aje/kwn250subject
Has Abstractpub_date
2008-12-01 00:00:00pages
1268-76issue
11eissn
0002-9262issn
1476-6256pii
kwn250journal_volume
168pub_type
杂志文章,多中心研究abstract：:The Baltimore-Washington Infant Study is a regional epidemiologic study of congenital heart disease. Among Infants born in the study area in 1981 and 1982, 664 had a diagnosis of congenital heart disease confirmed in the first year of life by echocardiography, cardiac catheterization, cardiac surgery, or autopsy. The ...
journal_title：American journal of epidemiology
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更新日期：1985-01-01 00:00:00
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journal_title：American journal of epidemiology
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doi：10.1093/oxfordjournals.aje.a113389
更新日期：1982-07-01 00:00:00
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journal_title：American journal of epidemiology
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更新日期：1998-04-15 00:00:00
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journal_title：American journal of epidemiology
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journal_title：American journal of epidemiology
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更新日期：2013-05-15 00:00:00
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更新日期：1978-04-01 00:00:00
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更新日期：2018-02-01 00:00:00
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更新日期：2009-04-15 00:00:00
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更新日期：2014-04-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：2008-03-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a008869
更新日期：1996-11-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112113
更新日期：1975-05-01 00:00:00
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doi：10.1093/oxfordjournals.aje.a114205
更新日期：1986-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112498
更新日期：1977-12-01 00:00:00
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journal_title：American journal of epidemiology
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更新日期：2002-07-01 00:00:00
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更新日期：1999-04-15 00:00:00
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更新日期：2004-01-15 00:00:00
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更新日期：1990-12-01 00:00:00
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更新日期：1984-04-01 00:00:00
