Rheumatoid arthritis in the Women's Health Initiative: methods and baseline evaluation.


:Second-generation assays for anti-cyclic citrullinated peptide (anti-CCP), a highly sensitive and specific marker for rheumatoid arthritis (RA), have redefined the epidemiology of RA. In the Women's Health Initiative (WHI) RA study (2009-2011), we evaluated the prevalence of anti-CCP positivity among 15,691 (10.2% of 161,808) WHI participants aged 50-79 years who reported RA. Using stored baseline specimens, we measured serum anti-CCP, rheumatoid factor (RF), and antinuclear antibody in a defined sample of 9,988 of black, white, and Hispanic women. In a subset of women, we measured plasma cytokine levels and number of copies of the human leukocyte antigen (HLA)-DRB1 (HLA-DRB1) shared epitope in DNA by means of Luminex polymerase chain reaction typing (Luminex Corporation, Austin, Texas). We validated classification of probable clinical RA in 2 clinics as anti-CCP positivity or self-reported validated use of disease-modifying antirheumatic drugs (DMARDs). The prevalence of anti-CCP positivity was 8.1%, and the prevalence of RF positivity was approximately 16.0%. DMARD use including prednisone was reported by 1,140 (11.4%) participants (841 excluding prednisone) but by 57.5% of anti-CCP-positive women. The prevalence of 2 shared epitopes was also much higher for anti-CCP-positive women (18.2%, as opposed to only 5.5% for women with anti-CCP-negative DMARD-positive RA and 6.6% for anti-CCP-negative, RF-negative DMARD nonusers). Median cytokine levels were much higher for anti-CCP-positive/RF-positive women. Women with anti-CCP-positive RA and anti-CCP-negative RA had different characteristics with regard to HLA shared epitope, cigarette smoking, and inflammation (cytokines).


Am J Epidemiol


Kuller LH,Mackey RH,Walitt BT,Deane KD,Holers VM,Robinson WH,Sokolove J,Chang Y,Moreland LW




Has Abstract


2014-04-01 00:00:00














  • Mood Disorders and Risk of Herpes Zoster in 2 Population-Based Case-Control Studies in Denmark and the United Kingdom.

    abstract::We examined the association between mood disorders and risk of herpes zoster in two case-control studies using data from nationwide Danish registries and practices in the UK Clinical Practice Research Datalink. We included incident zoster cases diagnosed in general practice (using systemic antivirals as a proxy in Den...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Schmidt SAJ,Langan SM,Pedersen HS,Schønheyder HC,Thomas SL,Smeeth L,Mansfield KE,Sørensen HT,Forbes HJ,Vestergaard M

    更新日期:2018-05-01 00:00:00

  • Sensitivity analysis using elicited expert information for inference with coarsened data: illustration of censored discrete event times in the AIDS Link to Intravenous Experience (ALIVE) Study.

    abstract::In this paper, the authors use the rubric of "coarsened data," of which missing and censored data are special cases, to motivate the elicitation and use of expert information for performing sensitivity analyses of censored event-time data. Elicited information is important because observed data are insufficient to est...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,评审


    authors: Shardell M,Scharfstein DO,Vlahov D,Galai N

    更新日期:2008-12-15 00:00:00

  • Epidemiology and long-term consequences of hepatitis delta virus infection in the Yucpa Indians of Venezuela.

    abstract::To define better the epidemiology and clinical impact of hepatitis delta virus (HDV) infection among hepatitis B virus (HBV) carriers in less developed countries, the authors prospectively studied a cohort of 216 Yucpa Indian HBV carriers in Venezuela. HBV carriers were followed regularly between 1983 and 1988 by phys...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Hadler SC,Alcala de Monzon M,Rivero D,Perez M,Bracho A,Fields H

    更新日期:1992-12-15 00:00:00

  • Genetic Epidemiology and Public Health: The Evolution From Theory to Technology.

    abstract::Genetic epidemiology represents a hybrid of epidemiologic designs and statistical models that explicitly consider both genetic and environmental risk factors for disease. It is a relatively new field in public health; the term was first coined only 35 years ago. In this short time, the field has been through a major e...

    journal_title:American journal of epidemiology

    pub_type: 历史文章,杂志文章


    authors: Fallin MD,Duggal P,Beaty TH

    更新日期:2016-03-01 00:00:00

  • Lyme disease in outdoor workers: risk factors, preventive measures, and tick removal methods.

    abstract::A statewide cross-sectional study of risk factors for seropositivity for antibody to Borrelia burgdorferi in outdoor workers in New Jersey was performed in September and October 1988. The crude odds ratio associated with exposure to ticks on the primary state job was 2.2 (95% confidence interval (CI) 0.7-9.0). After a...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Schwartz BS,Goldstein MD

    更新日期:1990-05-01 00:00:00

  • Menarcheal age and spontaneous abortion: a causal connection?

    abstract::Data from a Norwegian investigation on family planning were used to study the relation between menarcheal age and spontaneous abortion rate. Abortion rates were found to be 1.5-2 times higher among women with a menarcheal age of 12 years or less than among those with a menarcheal age of 14 years or more. The possibili...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Liestøl K

    更新日期:1980-06-01 00:00:00

  • Magnesium in drinking water and death from acute myocardial infarction.

    abstract::The relation between death from acute myocardial infarction and the level of magnesium in drinking water was examined using mortality registers and a case-control design. The study area comprised 17 municipalities in the southern part of Sweden that have different magnesium levels in the drinking water. Cases were men...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Rubenowitz E,Axelsson G,Rylander R

    更新日期:1996-03-01 00:00:00

  • Using Web-Based Questionnaires to Assess Medication Use During Pregnancy: A Validation Study in 2 Prospectively Enrolled Cohorts.

    abstract::Medication use is often underreported in paper-based questionnaires or interviews. Web-based questionnaires may improve recall of medication use, but data on their validity are currently lacking. Participants in the Pregnancy and Infant Development (PRIDE) Study (2014-2016; n = 557) and the Pregnancy Drug Registry (pR...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: van Gelder MMHJ,Vorstenbosch S,Te Winkel B,van Puijenbroek EP,Roeleveld N

    更新日期:2018-02-01 00:00:00

  • Misclassification bias arising from random error in exposure measurement: implications for dual measurement strategies.

    abstract::Despite the resulting loss of information, continuous exposure variables are often categorized in epidemiologic data analysis. It has been shown that nondifferential measurement error of exposure can lead to differential misclassification under these circumstances. This paper extends these findings to the misclassific...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Brenner H,Blettner M

    更新日期:1993-09-15 00:00:00

  • Immunoglobulin M-specific serologic testing in an outbreak of foodborne viral hepatitis, type A.

    abstract::Ninety-seven symptomatic and five asymptomatic infections with viral hepatitis, type A (102 cases) were identified in members, guests and employees of a private country club in an outbreak associated with consuming food and ice prepared or handled by an employee of the club's kitchen pantry. Twenty-three symptomatic p...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Osterholm MT,Kantor RJ,Bradley DW,Hall WN,Francis DP,Aaron HC,Washburn JW,Velde D

    更新日期:1980-07-01 00:00:00

  • Amyotrophic Lateral Sclerosis and Exposure to Diesel Exhaust in a Danish Cohort.

    abstract::Previous studies have suggested an increased risk of amyotrophic lateral sclerosis (ALS) and other motor neuron diseases for persons in occupations commonly involving exposure to diesel exhaust (DE). In this study, we investigated the association between occupational exposure to DE and odds of ALS. ALS cases were iden...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Dickerson AS,Hansen J,Gredal O,Weisskopf MG

    更新日期:2018-08-01 00:00:00

  • Vitamin measurements in pooled blood samples.

    abstract::From 610 blood samples collected in September 1983 in an intervention trial in Huixian, Henan Province, People's Republic of China, which were individually analyzed for retinol, beta-carotene, and alpha-tocopherol levels, 10 pools were formed from 50 individual samples, and the vitamin levels in the merged pools were ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Wahrendorf J,Hanck AB,Muñoz N,Vuilleumier JP,Walker AM

    更新日期:1986-03-01 00:00:00

  • Air pollution and hospital admissions for cardiovascular disease in Detroit, Michigan.

    abstract::In the December 1952 smog disaster in London, a substantial increase in mortality was closely associated with the increase in air pollution. Deaths from cardiovascular causes were elevated as well as respiratory deaths. The increase was greatest in the elderly. Hospital admissions were increased for both respiratory a...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Schwartz J,Morris R

    更新日期:1995-07-01 00:00:00

  • Identifying genetic susceptibilities to diabetes-related complications among individuals at low risk of complications: An application of tree-structured survival analysis.

    abstract::The authors hypothesized that genetic predisposition to diabetes complications would be more evident among low-risk individuals and aimed to identify genes related to developing complications (confirmed distal symmetric polyneuropathy, overt nephropathy, or coronary artery disease) in low-risk groups. Participants in ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Costacou T,Chang Y,Ferrell RE,Orchard TJ

    更新日期:2006-11-01 00:00:00

  • Seroepidemiology of California and Bunyamwera serogroup bunyavirus infections in humans in California.

    abstract::Several human populations in California were surveyed cross-sectionally and longitudinally for neutralizing antibodies to selected arthropod-borne bunyaviruses in the California and Bunyamwera serogroups. Overall, the prevalence of antibodies to California serogroup viruses was 6.4% in 702 individuals sampled during 1...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,评审


    authors: Campbell GL,Reeves WC,Hardy JL,Eldridge BF

    更新日期:1992-08-01 00:00:00

  • Education and the risk for Alzheimer's disease: sex makes a difference. EURODEM pooled analyses. EURODEM Incidence Research Group.

    abstract::The hypothesis that a low educational level increases the risk for Alzheimer's disease remains controversial. The authors studied the association of years of schooling with the risk for incident dementia and Alzheimer's disease by using pooled data from four European population-based follow-up studies. Dementia cases ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Letenneur L,Launer LJ,Andersen K,Dewey ME,Ott A,Copeland JR,Dartigues JF,Kragh-Sorensen P,Baldereschi M,Brayne C,Lobo A,Martinez-Lage JM,Stijnen T,Hofman A

    更新日期:2000-06-01 00:00:00

  • Silicosis mortality with respiratory tuberculosis in the United States, 1968-2006.

    abstract::The presence of tuberculosis (TB) in patients with silicosis increases mortality risk. To characterize silicosis-respiratory TB comortality in the United States, the authors used 1968-2006 National Center for Health Statistics multiple cause-of-death data for decedents aged ≥25 years. The authors calculated proportion...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Nasrullah M,Mazurek JM,Wood JM,Bang KM,Kreiss K

    更新日期:2011-10-01 00:00:00

  • Reye's syndrome: epidemiologic and viral studies, 1963-1974.

    abstract::Fifty-eight children with Reye's syndrome (RS) confirmed by liver biopsy were treated at the University of Cincinnati between 1963 and 1974. Cases were clustered in the winter and spring with the peak in February and March. These coincided with the occurrence of influenza and, numerically, were associated more closely...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Linnemann CC Jr,Shea L,Partin JC,Schubert WK,Schiff GM

    更新日期:1975-06-01 00:00:00

  • Calcium and vitamin D intake and risk of colorectal cancer: the Multiethnic Cohort Study.

    abstract::The associations of intakes of calcium and vitamin D with colorectal cancer risk were examined in the Multiethnic Cohort Study (Hawaii and Los Angeles, California). In 1993-1996, 85,903 men and 105,108 women aged > or =45 years completed a quantitative food frequency questionnaire. A total of 2,110 incident cases of c...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Park SY,Murphy SP,Wilkens LR,Nomura AM,Henderson BE,Kolonel LN

    更新日期:2007-04-01 00:00:00

  • Acquired immunodeficiency syndrome (AIDS) risk in recent and long-standing human immunodeficiency virus type 1 (HIV-1)-infected patients with similar CD4 lymphocyte counts.

    abstract::The loss of CD4 lymphocytes is known to be an important component of human immunodeficiency virus type 1 (HIV-1) pathogenesis. It remains unclear, however, whether the importance of the CD4 lymphocyte count is such that individuals who have been infected for widely different lengths of time, but for whom the CD4 lymph...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Phillips AN,Sabin CA,Elford J,Bofill M,Janossy G,Lee CA

    更新日期:1993-11-15 00:00:00

  • Neighborhood contextual influences on depressive symptoms in the elderly.

    abstract::To understand whether neighborhood contexts contribute to the onset or maintenance of mental health problems independently of individual characteristics requires the use of multilevel study designs and analytical strategies. This study used a multilevel analytical framework to examine the relation between neighborhood...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Kubzansky LD,Subramanian SV,Kawachi I,Fay ME,Soobader MJ,Berkman LF

    更新日期:2005-08-01 00:00:00

  • Diarrheal disease in Cambodian children at a camp in Thailand.

    abstract::The etiology of acute diarrhea (less than or equal to 3 days duration) and persistent diarrhea (greater than or equal to 14 days duration) was determined in Cambodian children under age 5 years in a refugee camp on the Thai-Cambodian border between May and October 1989; potential risk factors associated with persisten...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Arthur JD,Bodhidatta L,Echeverria P,Phuphaisan S,Paul S

    更新日期:1992-03-01 00:00:00

  • Risk of other cancers following Kaposi's sarcoma: relation to acquired immunodeficiency syndrome.

    abstract::To evaluate the risk of another cancer among persons who initially developed Kaposi's sarcoma, the authors used data from the Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer Institute for the years 1973-1990. In persons under 70 years of age, 4,946 cases of Kaposi's sarcoma were obser...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Biggar RJ,Curtis RE,Cote TR,Rabkin CS,Melbye M

    更新日期:1994-02-15 00:00:00

  • Prospective study of human papillomavirus seropositivity and risk of nonmelanoma skin cancer.

    abstract::Cutaneous human papillomaviruses (HPVs) have been associated with squamous cell carcinoma (SCC) in case-control studies, but there are limited data from prospective studies assessing whether virus exposure predicts risk of future cancer development. Two major biobanks, the Southern Sweden Microbiology Biobank (1971-20...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Andersson K,Michael KM,Luostarinen T,Waterboer T,Gislefoss R,Hakulinen T,Forslund O,Pawlita M,Dillner J

    更新日期:2012-04-01 00:00:00

  • Validation of a method to estimate age-specific human immunodeficiency virus (HIV) incidence rates in developing countries using population-based seroprevalence data.

    abstract::The authors have conducted an analysis to validate a computer model that uses age-specific human immunodeficiency virus (HIV) prevalence data to estimate age-specific HIV incidence rates. Data for the analysis are from a cohort study of volunteer male workers in Bujumbura, the capital city of Burundi. Testing for HIV ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Saidel T,Sokal D,Rice J,Buzingo T,Hassig S

    更新日期:1996-08-01 00:00:00

  • Proxy respondents in reproductive research: a comparison of self- and partner-reported data.

    abstract::The quality of proxy reporting was assessed among 136 prenatal patients and their spouse/partners recruited from the obstetric services of a New Jersey hospital between 1985 and 1987. The concordance, sensitivity, and specificity of proxy reports about partners' occupation, smoking, and drinking were examined in relat...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Hatch MC,Misra D,Kabat GC,Kartzmer S

    更新日期:1991-04-15 00:00:00

  • Receiver operating characteristic curve inference from a sample with a limit of detection.

    abstract::The receiver operating characteristic curve is a commonly used tool for evaluating biomarker usefulness in clinical diagnosis of disease. Frequently, biomarkers being assessed have immeasurable or unreportable samples below some limit of detection. Ignoring observations below the limit of detection leads to negatively...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Perkins NJ,Schisterman EF,Vexler A

    更新日期:2007-02-01 00:00:00

  • Factor XIII Val34Leu variant is protective against venous thromboembolism: a HuGE review and meta-analysis.

    abstract::It has been suggested that a G-to-T transition in exon 2 of the factor XIIIA gene resulting in a substitution of leucine for valine at amino acid 34 (FXIII Val34Leu) protects against venous thromboembolism (VTE). However, the evidence to date is insufficient to incorporate testing for the FXIII Val34Leu variant into c...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,meta分析


    authors: Wells PS,Anderson JL,Scarvelis DK,Doucette SP,Gagnon F

    更新日期:2006-07-15 00:00:00

  • Alcohol concentration and risk of oral cancer in Puerto Rico.

    abstract::Alcohol consumption is a major risk factor for cancers of the mouth and pharynx (oral cancer), but the differential risks by beverage type are unclear. In this 1992-1995 study, the authors examined oral cancer risk in Puerto Rico, comparing alcohol intake among 286 male cases aged 21-79 years and 417 population-based ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Huang WY,Winn DM,Brown LM,Gridley G,Bravo-Otero E,Diehl SR,Fraumeni JF Jr,Hayes RB

    更新日期:2003-05-15 00:00:00

  • Reproductive risk factors for cutaneous melanoma in women: a case-control study.

    abstract::Reproductive hormonal factors may have a potential role in cutaneous melanoma. This study estimated the risk of melanoma in women related to self-reported changes in nevi during pregnancy, while using oral contraceptives and/or hormone replacement therapy. Trained interviewers administered a questionnaire obtaining in...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章


    authors: Lea CS,Holly EA,Hartge P,Lee JS,Guerry D 4th,Elder DE,Halpern A,Sagebiel RW,Tucker MA

    更新日期:2007-03-01 00:00:00