Abstract:
OBJECTIVE:Cross validation study of the MoCA for the detection of Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) in a community-based cohort residing in the Southeastern United States. METHODS:One hundred and eighteen English-speaking older adults, who underwent diagnostic evaluation as part of an on-going prospective study, were administered the MoCA and MMSE. Twenty were diagnosed with AD, 24 met criteria for amnestic MCI and 74 were considered cognitively normal. Sensitivities and specificities were calculated using the recommended cut-off scores and ROC curve analyses were performed to determine optimal sensitivity and specificity. The influence of age, education and gender on MoCA score was also examined. RESULTS:Using a cut-off score of 24 or below, the MMSE was insensitive to cognitive impairment. Using the recommended cut-off score of 26, the MoCA detected 97% of those with cognitive impairment but specificity was fair (35%). Using a lower cut-off score of 23, the MoCA exhibited excellent sensitivity (96%) and specificity (95%). CONCLUSION:The MoCA appears to have utility as a cognitive screen for early detection of AD and for MCI and warrants further investigation regarding its applicability in primary care settings, varying ethnic groups, and younger at-risk individuals.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Luis CA,Keegan AP,Mullan Mdoi
10.1002/gps.2101subject
Has Abstractpub_date
2009-02-01 00:00:00pages
197-201issue
2eissn
0885-6230issn
1099-1166journal_volume
24pub_type
杂志文章abstract:OBJECTIVES:The post-hoc analyses reported here evaluate the specific effects of memantine treatment on ADAS-cog single-items or SIB subscales for patients with moderate to severe AD. METHODS:Data from six multicentre, randomised, placebo-controlled, parallel-group, double-blind, 6-month studies were used as the basis ...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2226
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the cost-consequences of an intervention for the management of neuropsychiatric symptoms in nursing home residents with young-onset dementia. METHODS:A stepped wedge design was used. The intervention consisted of an educational program and a multidisciplinary care program and was implemented in 1...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1002/gps.5229
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Acetyl Cholinesterase Inhibitors (AChEIs) have been in clinical use for the past five years in the UK for the symptomatic treatment of Alzheimer's disease (AD). There are few data on the patterns and predictors of response to AChEI therapy in routine clinical practice. We therefore investigated clinical vari...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.928
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Vascular dementia (VaD) is associated with impairments in cognitive, motor, and functional domains. Patients with VaD display diverse cognitive and motor deficits, however, and relationships between these impairments and independent living abilities remain unclear. OBJECTIVES:The purpose of the present stud...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.539
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:Alzheimer's disease (AD) causes progressive loss of memory and disability, especially in older people. As worldwide population grows older, AD is responsible for an important social and economical burden in many nations. People suffering from AD may experience health-related stigma that influences their atti...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.3903
更新日期:2013-09-01 00:00:00
abstract::Surveys of older populations reveal rates of senile dementia varying from 5.2% to 25%. The specialist branch of psychiatry dealing with the elderly advocates that services for these patients and their carers should predominantly be based outside hospital. The following study was conducted in Limerick, Ireland before t...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(199701)12:1<27::aid-gps446
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:Limited data are available on how older adults access public mental health systems. This study examines how uninsured or publicly insured older adults with severe mental illness in San Diego County initially accessed the public mental health system, as well as their subsequent use of public mental health serv...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2123
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Cultural differences in how the symptoms, causes, consequences, and treatments of dementia are understood and interpreted by South Asian people are a commonly expressed reason for late- or nonuse of mental health and care services. However, systematic collection of information on South Asian perceptions of d...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.5313
更新日期:2020-08-01 00:00:00
abstract:INTRODUCTION:Dementia Care Mapping (DCM) was originally developed as a clinical tool but has attracted interest as a potential observational measure of quality of life (QOL) and well-being of long-term care residents with dementia. DCM coding involves continuous observation over a 6-h period, with observers recording a...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1721
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:Apathy is one of the most frequent symptoms of dementia, whose underlying neurobiology is not well understood. The objective was to analyze the correlations of apathy and its dimensions with gray and white matter damage in the brain of patients with advanced Alzheimer's disease (AD). METHODS:The setting of t...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4548
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:Psychosis, like other neuropsychiatric symptoms of dementia, has many features that make predictive modeling of its onset difficult. For example, psychosis onset is associated with both the absolute degree of cognitive impairment and the rate of cognitive decline. Moreover, psychotic symptoms, while more like...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4326
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVES:The ventrolateral prefrontal cortex (vlPFC) has been speculated to play an important role in complex processes that allow emotional factors to influence human cognition. Accumulating evidence from human neuroimaging studies, in conjunction with studies of patients with lesions and animal models, shed light o...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:10.1002/gps.4982
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVES:To identify factors which may contribute to prolonged length of stay in an elderly psychiatric inpatient setting. DESIGN:Retrospective case note study. METHODS:A list of all patients over the age of 65 discharged from a private psychiatric hospital over a three-year period excluding those with a length of ...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.463
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:To examine whether intensive care unit (ICU) admission is independently associated with increased risk of major depression in patients with diabetes. METHODS:This prospective cohort study included 3596 patients with diabetes enrolled in the Pathways Epidemiologic Follow-Up Study, of whom 193 had at least one...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2684
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:An economic evaluation of dementia-related interventions from a societal perspective should take account of informal caregiving. We assessed informal caregiving time and report our findings on the validity and stability of our results. METHODS:Within the German IDA study ('Dementia Care Initiative in Primary...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2103
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:To measure depressive symptomatology in a largely illiterate elderly population in India, using a new Hindi version of the Geriatric Depression Scale (GDS-H), and to examine its distribution and associations with age, gender, literacy, cognitive impairment and functional impairment. DESIGN:A Hindi version of...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVES:While a recent task force report recommended that remission from major depression be defined according to DSM criteria, most previous work has used depressive symptom rating scales. The current study sought to identify baseline factors associated with treatment outcome in major depression, diagnosed accordin...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1002/gps.2485
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Research has highlighted the influence of psychosocial factors on the wellbeing of carers of people with dementia. This study aimed to investigate the interrelationships between life events, depression and social support in carers of people with dementia. METHOD:Participants were 72 carers of people with de...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1136
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:To examine health behaviour, severity of depression, gender differences and religiosity in older patients admitted to intermediate care for further rehabilitation. DESIGN:Cross-sectional survey. PARTICIPANTS:A research physiotherapist interviewed 173 older patients (113 female), 60 and older consecutively a...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1968
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to examine the association between physical frailty and neurocognitive performance in late-life depression (LLD). METHODS:Cross-sectional design using baseline data from a treatment study of late-life depression was used in this study. Individuals aged 60 years and older were diagno...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4351
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:Memory complaints in the absence of objective test impairments are common. Only a subset of these subjects seeks medical attention for these complaints. The aim of the present study was to investigate which factors determine why people with subjective memory complaints (SMC) seek medical attention. METHODS:T...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2092
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:Elderly persons with mild cognitive impairment (MCI) are at increased risk of dementia and functional impairments. The present study investigated the contribution of three domains of executive cognition to everyday functioning among persons with MCI. METHODS:124 MCI patients and 68 cognitively normal elderly...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2325
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:To study performance of DSM-III-R, ICD-10 and CAMDEX diagnoses of delirium as predictors of improvement in mental state in survivors, and to develop a brief rating scale which will predict reversibility of cognitive dysfunction. DESIGN:Prospective cohort study. SETTING:Acute geriatric inpatient units. PATI...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(199706)12:6<609::aid-gps55
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVE:To consider the characteristics of first episode psychosis in older adults in a county in North East England. METHOD/DESIGN:The present study used a naturalistic design to compare individuals aged 65 years and over with those under 65, with a first episode psychosis. Data were collected on demographics, diag...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2437
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Associations between low levels of folate and vitamin B12 and cognitive impairment in patients with dementia have been reported. Some studies revealed correlations between low levels of vitamin B12 and behavioural and psychological signs and symptoms of dementia (BPSD) in Alzheimer's disease (AD) patients. G...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1092
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVES:The Rare Dementia Support (RDS) Impact study will be the first major study of the value of multicomponent support groups for people living with or supporting someone with a rare form of dementia. The multicentre study aims to evaluate the impact of multicomponent support offered and delivered to people livin...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.5253
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:In an earlier report, response inhibition predict antidepressant non-response in late-life depression (Sneed et al., 2007). The purpose of this study was to ascertain whether this effect is specific to response inhibition or whether impairment in other cognitive domains also predicts non-response. METHOD:Old...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/gps.1889
更新日期:2008-03-01 00:00:00
abstract:INTRODUCTION:Short-form versions of the Montreal Cognitive Assessment (SF-MoCA) are increasingly used to screen for dementia in research and practice. We sought to collate evidence on the accuracy of SF-MoCAs and to externally validate these assessment tools. METHODS:We performed systematic literature searching across...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.5162
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:This paper provides an initial evaluation of the impact of the Single Assessment Process (SAP) in England upon practice regarding multidisciplinary assessment. OBJECTIVES:To investigate changes in recorded health needs of older people and in the number of multidisciplinary assessments undertaken using socia...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2069
更新日期:2008-12-01 00:00:00
abstract::Residents of nursing and residential homes are often prescribed medication for physical and mental ill-health with resultant polypharmacy and the possibility of iatrogenic disorders. Sometimes drugs are prescribed inappropriately and a number of studies have highlighted the overuse of psychotropic drugs. Legislation i...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:10.1002/(sici)1099-1166(199807)13:7<433::aid-gps79
更新日期:1998-07-01 00:00:00