Abstract：
PURPOSE:To compare apolipoprotein A1 (ApoA1) expression in the retina from diabetic and nondiabetic donors. DESIGN:Case-control study. METHODS:Diabetic postmortem eyes (n = 8) were compared with eyes (n = 8) from nondiabetic donors matched by age. Messenger ribonucleic acid (mRNA) of ApoA1 (quantitative reverse-transcriptase polymerase chain reaction) was measured separately in the neuroretina and retinal pigment epithelium (RPE). ApoA1 was assessed by immunofluorescence (confocal laser microscopy) and Western blot analysis. The presence of early diabetic retinal damage was evaluated by measuring the rate of apoptosis and glial activation. RESULTS:ApoA1 mRNA levels and ApoA1 immunofluorescence obtained in RPEs and in neuroretinas from diabetic donors were significantly higher than those obtained from nondiabetic donors. ApoA1 was expressed in all retina layers and it was more abundant in RPE than in the neuroretina in both diabetic and nondiabetic donors. In addition, ApoA1 immunofluorescence was significantly higher in all the layers of the neuroretina from diabetic patients. Densitometric analysis of immunoblots showed higher ApoA1 in the retinas from diabetic donors in comparison with nondiabetic donors, but the differences were at significant levels only for the RPE. CONCLUSIONS:ApoA1 overexpression is an early event in the retina of diabetic patients and can be involved in the physiopathology of diabetic retinopathy. In addition, RPE is the main source of ApoA1 within the retina. These findings my be relevant to aiming new treatment strategies toward reducing the development of diabetic retinopathy.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Simó R,García-Ramírez M,Higuera M,Hernández Cdoi
10.1016/j.ajo.2008.08.009subject
Has Abstractpub_date
2009-02-01 00:00:00pages
319-325.e1issue
2eissn
0002-9394issn
1879-1891pii
S0002-9394(08)00652-1journal_volume
147pub_type
杂志文章abstract：PURPOSE:To compare immunocytochemical and ultrastructural characteristics of "lamellar hole-associated epiretinal proliferation" in lamellar macular holes with "conventional epiretinal membrane" in macular pseudoholes. DESIGN:A consecutive observational case series, laboratory investigation. METHODS:We analyzed surgi...
journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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更新日期：1978-09-01 00:00:00
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更新日期：2015-05-01 00:00:00
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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更新日期：2004-11-01 00:00:00
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(89)90667-3
更新日期：1989-04-15 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：2008-04-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：1985-03-15 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00582-1
更新日期：2000-10-01 00:00:00
abstract：:To study the retinal surface in the human eye in normal and diseased states we used laser scanning tomography. The confocal arrangement of the laser tomographic scanner permits examination of retinal topography in the axis perpendicular to the retinal surface. The eyes examined with the laser tomographic scanner inclu...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1989-09-15 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2013-07-01 00:00:00
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2005-07-01 00:00:00
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1994-08-15 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.06.005
更新日期：2006-11-01 00:00:00
abstract：:To determine the hereditary pattern of acute anterior uveitis, we examined seven families-one family with four cases, one family with three cases, and four families with two cases of acute anterior uveitis. A total of 16 patients with uveitis and 28 relatives underwent ocular examinations and serologic determination o...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1981-06-01 00:00:00
abstract：PURPOSE:To report atypical kerato-conjunctivitis as a manifestation of Hodgkin disease. METHODS:Case report. RESULTS:A 19-year old woman presented with conjunctival nodules and corneal infiltrates. Diffuse lymph node enlargement occurred, but not in the preauricular or submandibular areas. Extensive microbiologic exa...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2001-06-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.11.043
更新日期：2007-04-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
