Thalassaemia trait and myocardial infarction: low infarction incidence in male subjects confirmed.

abstract：INTRODUCTION:The bb genotype of the BsmI polymorphism of the vitamin D receptor (VDR) is more common in primary hyperparathyroidism (HPT) than in the general population in Swedish and German women. However, little is known about the association of HPT with the start codon polymorphism of the VDR (defined by FokI). OBJ...

journal_title：Journal of internal medicine

authors： Sosa M,Torres A,Martín N,Salido E,Limiñana JM,Barrios Y,De Miguel E,Betancor P

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Gallium-67 (67Ga) scintigraphy may be useful in evaluating patients with retroperitoneal fibrosis (RPF), but a systematic assessment of its value is lacking. OBJECTIVE:Prospective evaluation of the value of 67Ga scintigraphy in assessing active RPF disease and in predicting treatment response. METHODS:Thir...

journal_title：Journal of internal medicine

authors： van Bommel EF,Siemes C,van der Veer SJ,Han SH,Huiskes AW,Hendriksz TR

更新日期：2007-08-01 00:00:00

abstract：:Chances are that you have come across membrane proteins many times in your professional life: ion channels, aquaporins, G-protein-coupled receptors, drug resistance proteins. But it is also quite likely that you have never bothered to think about what the implications are of being a membrane protein, as opposed to a s...

journal_title：Journal of internal medicine

authors： von Heijne G

更新日期：2007-06-01 00:00:00

abstract：:Cytokine production is necessary to protect against pathogens and promote tissue repair, but excessive cytokine release can lead to systemic inflammation, organ failure and death. Inflammatory responses are finely regulated to effectively guard from noxious stimuli. The central nervous system interacts dynamically wit...

journal_title：Journal of internal medicine

authors： Rosas-Ballina M,Tracey KJ

更新日期：2009-06-01 00:00:00

abstract：:For nearly a decade since the mapping of the multiple endocrine neoplasia type 1 (MEN1) locus to 11q13 and the suggestion that it is a tumour suppressor gene, efforts have been made to identify the gene responsible for this familial cancer syndrome. Recently, we have identified the MEN1 gene by the positional cloning ...

journal_title：Journal of internal medicine

authors： Guru SC,Manickam P,Crabtree JS,Olufemi SE,Agarwal SK,Debelenko LV

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Heart failure is characterized by chronically increased adenosine levels, which are thought to express a protective anti-heart failure activation of the adenosinergic system. The aim of the study was to assess whether the activation of adenosinergic system in idiopathic dilated cardiomyopathy (IDC) can be mi...

journal_title：Journal of internal medicine

authors： Laghi-Pasini F,Guideri F,Petersen C,Lazzerini PE,Sicari R,Capecchi PL,Picano E

更新日期：2003-12-01 00:00:00

abstract：:Developing new pharmacotherapies for autism spectrum disorder (ASD) is a challenge. ASD has a complex genetic architecture, several neurobiological phenotypes and multiple symptom domains. However, new opportunities are emerging that could lead to the development of 'targeted' and individualized pharmacological interv...

journal_title：Journal of internal medicine

authors： Ecker C,Spooren W,Murphy D

更新日期：2013-10-01 00:00:00

abstract：:Coeliac disease (CD) and noncoeliac wheat or gluten sensitivity (NCWS/NCGS) are common gluten-related disorders. Both conditions can present with gastrointestinal and extraintestinal manifestations, which can be a challenge for physicians to discern between. Whilst coeliac serology and histological assessment are requ...

journal_title：Journal of internal medicine

authors： Rej A,Aziz I,Sanders DS

更新日期：2020-11-01 00:00:00

abstract：:Cardiovascular disease remains the most prevalent cause of human morbidity and mortality in ageing Western societies. Basic and translational scientific efforts have focused on the development and improvement of diagnostic and therapeutic strategies to limit the burden of associated diseases, such as stroke and myocar...

journal_title：Journal of internal medicine

authors： Maegdefessel L

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVES:The effect of a second and third generation oral contraceptive and of the progestagens used in these pills on lipid metabolism was studied in the absence or presence of the factor V Leiden mutation. DESIGN:A single centre, double blind randomized trial. SETTING:University Medical Centre. SUBJECTS:A total ...

journal_title：Journal of internal medicine

authors： Kemmeren JM,Algra A,Grobbee DE

更新日期：2001-11-01 00:00:00

abstract：:A five-year follow-up, by means of a personal interview, was performed on patients below the age of 40 years with acute chest pain without obvious organic cause (n = 64). They had been consecutively admitted to the emergency unit over a period of 8 weeks, and had all been subjected to a thorough medical and psychosoci...

journal_title：Journal of internal medicine

authors： Roll M,Kollind M,Theorell T

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Inflammation is involved in the pathogenesis of cardiovascular disease and cognitive decline. Interleukin-6 (IL-6) has a role in cardiovascular disease, but the association of IL-6 concentration and the functional IL-6 -174 polymorphism with cognitive decline has not been demonstrated unequivocally. The obje...

journal_title：Journal of internal medicine

authors： Mooijaart SP,Sattar N,Trompet S,Lucke J,Stott DJ,Ford I,Jukema JW,Westendorp RG,de Craen AJ,PROSPER Study Group.

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:The relationship between physical activity and cognitive function is intriguing but controversial. We performed a systematic meta-analysis of all the available prospective studies that investigated the association between physical activity and risk of cognitive decline in nondemented subjects. METHODS:We con...

journal_title：Journal of internal medicine

authors： Sofi F,Valecchi D,Bacci D,Abbate R,Gensini GF,Casini A,Macchi C

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:To describe types of diabetes treatment in a total, adult population, including those on no antidiabetic medication, and to evaluate use of the defined daily doses in estimation of diabetes prevalence. DESIGN:Cross-sectional epidemiologic survey applying patient-based questionnaires and clinical examination...

journal_title：Journal of internal medicine

authors： Midthjell K,Holmen J,Bjørndal A

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Epidemiological and clinical features of patients with COVID-19 have been reported, but none of them focused on medical staff, and few predictors of the duration of viral shedding have been reported. It is urgent to help healthcare workers prevent and recover quickly from the coronavirus disease 2019 (COVID-...

journal_title：Journal of internal medicine

authors： Liu W,Liu Y,Xu Z,Jiang T,Kang Y,Zhu G,Chen Z

更新日期：2020-12-01 00:00:00

abstract：:In the mitochondrion, inherited defects have been identified in the electron transport system by which ATP is formed, as well as in the transport and metabolism of fuels. Clinical findings in diseases due to these defects can be related to abnormal accumulations of metabolic intermediates and inadequate or inefficient...

journal_title：Journal of internal medicine

authors： Luft R,Landau BR

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVES:To evaluate beneficial effects of postmenopausal hormone replacement therapy (HRT) on endothelial function, measured as intraplatelet cyclic guanosine monophosphate (cGMP, mediator of nitric oxide), cyclic adenosine monophosphate (cAMP, mediator of prostacyclin) and plasma endothelin-1 (ET-1), and on monocyt...

journal_title：Journal of internal medicine

authors： Anwaar I,Rendell M,Gottsäter A,Lindgärde F,Hulthén UL,Mattiasson I

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVE:To investigate influence of whole-body cooling on cyclic GMP (cGMP) in women with Raynaud's phenomenon and in healthy women. DESIGN:The study was performed as an open, parallel-group comparison between women with Raynaud's phenomenon and healthy women during the winter month of February. SETTING:The municip...

journal_title：Journal of internal medicine

authors： Leppert J,Ringqvist A,Ahlner J,Myrdal U,Sørensen S,Ringqvist I

更新日期：1995-05-01 00:00:00

abstract：:Previous studies in patients with peripheral arterial disease (PAD) have shown that the prognosis is relatively good when the distal systolic ankle index (ankle systolic pressure/arm systolic pressure) is above 50% and the distal toe systolic pressure is above 40 mmHg. In 132 patients suspected of PAD in the legs we i...

journal_title：Journal of internal medicine

authors： Christensen JH,Freundlich M,Jacobsen BA,Falstie-Jensen N

更新日期：1989-08-01 00:00:00

abstract：OBJECTIVES:Hip and distal arm fractures are associated with osteoporosis in the postmenopausal female. In diabetic patients, bone mass has been found to be reduced leading to the hypothesis that diabetes is a risk factor for osteoporosis. Whether this has any clinical implication has only been sparsely elucidated. DES...

journal_title：Journal of internal medicine

authors： Melchior TM,Sørensen H,Torp-Pedersen C

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVES:Mild hyperhomocysteinaemia (HHC), fasting or after methionine loading, is associated with an increased risk and severity of atherosclerotic vascular disease. Post-methionine and fasting HHC are responsive to treatment with vitamin B, and folic acid. We performed a prospective cohort study amongst normohomocy...

journal_title：Journal of internal medicine

authors： de Jong SC,Stehouwer CD,van den Berg M,Geurts TW,Bouter LM,Rauwerda JA

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:It has been hypothesized that epicardial adipose tissue (EAT) exerts pathogenic effects on cardiac structures. We analysed the associations between EAT and both cardiovascular (CV) disease risk factors and CV events in patients with chronic kidney disease (CKD). PATIENTS AND METHODS:We included 277 nondialy...

journal_title：Journal of internal medicine

authors： Cordeiro AC,Amparo FC,Oliveira MA,Amodeo C,Smanio P,Pinto IM,Lindholm B,Stenvinkel P,Carrero JJ

更新日期：2015-07-01 00:00:00

abstract：:A major challenge in the growing field of bioelectronic medicine is the development of tissue interface technologies promoting device integration with biological tissues. Materials based on organic bioelectronics show great promise due to a unique combination of electronic and ionic conductivity properties. In this re...

journal_title：Journal of internal medicine

authors： Löffler S,Melican K,Nilsson KPR,Richter-Dahlfors A

更新日期：2017-07-01 00:00:00

abstract：:Helicobacter pylori is one of the most common pathogenic bacterial infections, colonizing an estimated half of all humans. In a subset of individuals, the infection leads to serious gastroduodenal disease such as peptic ulcers and gastric adenocarcinoma. The factors contributing to skewing this, in most cases benign, ...

journal_title：Journal of internal medicine

authors： Björkholm B,Falk P,Engstrand L,Nyrén O

更新日期：2003-02-01 00:00:00

abstract：:Studies of zinc status in insulin-dependent diabetes mellitus (IDDM) have shown contradictory results. Zinc is essential for many enzymes involved in the human metabolism and may play a role in the biosynthesis and storage of insulin in the B-cell. We therefore prospectively followed 26 patients (14 males and 12 femal...

journal_title：Journal of internal medicine

authors： Melchior T,Simonsen KW,Johannessen AC,Binder C

更新日期：1989-07-01 00:00:00

abstract：OBJECTIVES:To determine the possibility of very early prognostic stratification based on electrocardiograms (ECGs) at rest and/or cardiac enzyme levels after an episode of suspected unstable coronary heart disease. DESIGN AND SETTING:Men with suspected unstable angina or non-Q-wave myocardial infarction were studied i...

journal_title：Journal of internal medicine

authors： Nyman I,Areskog M,Areskog NH,Swahn E,Wallentin L

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Atherosclerosis is a multifactorial disease, in part characterized by chronic inflammatory changes in the vessel wall and loss of normal physical and biochemical interactions between endothelial cells and smooth muscle cells. Previous studies [Hu J., Cotgreave IA. J Clin Invest; 99: 1-5] have ...

journal_title：Journal of internal medicine

authors： Boerma M,Forsberg L,Van Zeijl L,Morgenstern R,De Faire U,Lemne C,Erlinge D,Thulin T,Hong Y,Cotgreave IA

更新日期：1999-08-01 00:00:00

abstract：:Somatostatin receptors are expressed on the majority of neuroendocrine tumours. The presence of these receptors is clinically useful. First, long-term treatment with somatostatin analogues controls hormonal hypersecretion, which controls flushing attacks, watery diarrhoea, hypoglycaemia and electrolyte disorders in pa...

journal_title：Journal of internal medicine

authors： Lamberts SW,Hofland LJ,Lely AJ,de Herder WW

更新日期：1998-06-01 00:00:00

abstract：:Type 2 diabetes (T2DM) is a rapidly growing public health problem. It is associated with an increased risk of fracture, particularly of the hip, despite normal or high bone mineral density. Longer duration of disease and poor glycaemic control are both associated with higher fracture risk. The factors underlying incre...

journal_title：Journal of internal medicine

authors： Compston J

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:To compare family physicians' reported practice habits on hypertension in Sweden and Minnesota, and to assess to what extent different national guidelines account for differences. DESIGN:Random samples of family physicians were selected for telephone interviews on their practice of hypertension. SETTING:Pr...

journal_title：Journal of internal medicine

authors： Troein M,Arneson T,Råstam L,Pirie PL,Selander S,Luepker RV

更新日期：1995-09-01 00:00:00