Abstract:
:The possibility of enhancing the biomass productivity of a continuous culture of Saccharomyces cerevisiae growing on a glucose-limited medium is addressed. An unstructured Monod-type model is first identified using steady-state data. The culture is subjected to step changes in dilution rate, and it is seen that the Monod model is unable to predict even qualitatively the dynamic response of the culture. Incorporation of a time delay allows significant improvement in the transient fit. It is found that the culture has a time lag of about 3 h in adapting its growth rate. Cycling the dilution rate with a period of 3 h leads to substantial improvement in the average biomass productivity.
journal_name
Biotechnol Bioengjournal_title
Biotechnology and bioengineeringauthors
Abulesz EM,Lyberatos Gdoi
10.1002/bit.260340603subject
Has Abstractpub_date
1989-09-01 00:00:00pages
741-9issue
6eissn
0006-3592issn
1097-0290journal_volume
34pub_type
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