Fluctuation of fetal rat hepatic histidine decarboxylase activity through the glucocorticoid-ACTH system.

abstract：:SAD-128 was found to be an effective protector of acetylcholinesterase against inhibition by soman, due to its ability to function as a reversible inhibitor and allosteric modifier of the AChE active site. It also attenuated aging of the soman-inhibited enzyme. In order to study the connection between some of these ef...

journal_title：Biochemical pharmacology

authors： Stalc A,Sentjurc M

更新日期：1990-12-01 00:00:00

abstract：:The intraperitoneal injection of methylglyoxal bis(cyclohexylamidinohydrazone) (MGBC), an inhibitor of S-adenosylmethionine decarboxylase and spermidine synthase, markedly increased (7-fold of the basal level at 4 hr) ornithine decarboxylase (ODC) activity in normal mouse liver. ODC activity was also increased 2.5-fol...

journal_title：Biochemical pharmacology

authors： Hibasami H,Maekawa S,Murata T,Nakashima K

更新日期：1988-11-01 00:00:00

abstract：:This study aimed to clarify whether glutathione (GSH) plays a role in the hepatobiliary transport of arsenic. For this purpose, the biliary excretion of 74As was measured in urethane-anaesthetized rats for 2 hr after the administration of labelled sodium arsenite (50 mumol/kg, i.v.) or arsenate (150 mumol/kg, i.v.) an...

journal_title：Biochemical pharmacology

authors： Gyurasics A,Varga F,Gregus Z

更新日期：1991-07-15 00:00:00

abstract：:Increasing evidence supports NLRP3 inflammasome as a new target to control inflammation. Dysregulation of NLRP3 inflammasome has been reported to be involved in the pathogenesis of several human inflammatory diseases. However, no NLRP3 inflammasome inhibitors are available in clinic. Terpenoids are natural products wi...

journal_title：Biochemical pharmacology

authors： Hortelano S,González-Cofrade L,Cuadrado I,de Las Heras B

更新日期：2020-02-01 00:00:00

abstract：:We have demonstrated earlier that a secreted fibroblast growth factor-binding protein (FGF-BP) can enhance angiogenesis and promote tumor growth in vivo. Furthermore, we found that FGF-BP expression in squamous cell carcinoma (SCC) is reduced by concentrations of retinoids that are effective in the treatment of SCC an...

journal_title：Biochemical pharmacology

authors： Boyle BJ,Harris VK,Liaudet-Coopman ED,Riegel AT,Wellstein A

更新日期：2000-12-01 00:00:00

abstract：:L-Carnitine is a key molecule in the transfer of fatty acid across mitochondrial membranes. Bioavailable L-carnitine is either provided by an endogeneous biosynthesis or after intestinal absorption of dietary items containing L-carnitine. After intestinal absorption or hepatic biosynthesis, L-carnitine is transferred ...

journal_title：Biochemical pharmacology

authors： Georges B,Galland S,Rigault C,Le Borgne F,Demarquoy J

更新日期：2003-05-01 00:00:00

abstract：:There is intense interest in the development and application of animal models of CNS disorders to explore pathology and molecular mechanisms, identify potential biomarkers, and to assess the therapeutic utility, estimate safety margins and establish pharmacodynamic and pharmacokinetic parameters of new chemical entiti...

journal_title：Biochemical pharmacology

authors： McGonigle P

更新日期：2014-01-01 00:00:00

abstract：:In recent years, the concept of allosteric modulation of G-protein-coupled receptors (GPCRs) has matured and now represents an increasingly viable approach to drug discovery. This is evident in the fact that allosteric modulators have been reported for every class of GPCR, and several are currently in clinical trials ...

journal_title：Biochemical pharmacology

authors： Raddatz R,Schaffhauser H,Marino MJ

更新日期：2007-08-01 00:00:00

abstract：:Homocysteine has been shown to increase glutathione levels in C3H/10T1/2 Cl 8 cells. The present paper confirms that this increase was specific for non-dividing cells. Several other thiols and disulfides, including cysteamine, mercaptoethanol and dithioerythritol, also increased glutathione, but the specificity for qu...

journal_title：Biochemical pharmacology

authors： Djurhuus R,Svardal AM,Ueland PM

更新日期：1990-02-01 00:00:00

abstract：:In this study, using a combination of immunological and enzymatic characterizations, we compared the forms of cytochrome P-450 induced by ethanol and glutethimide in primary cultures of chicken embryo hepatocytes. Recently we purified a cytochrome P-450 of 50K molecular weight from chicken embryo liver using glutethim...

journal_title：Biochemical pharmacology

authors： Sinclair JF,Wood SG,Smith EL,Sinclair PR,Koop DR

更新日期：1989-02-15 00:00:00

abstract：:The aim of this study was to test if human platelet leukotriene C4-synthase (LTC4-S) is pharmacologically different from cloned and expressed LTC4-S and, in light of the significant homologies between 5-lipoxygenase activating protein (FLAP) and LTC4-S, if different potencies of leukotriene synthesis inhibitors acting...

journal_title：Biochemical pharmacology

authors： Sala A,Folco G,Henson PM,Murphy RC

更新日期：1997-03-21 00:00:00

abstract：:Nicotine has been shown in a variety of studies to improve cognitive function including learning, memory and attention. Nicotine both stimulates and desensitizes nicotinic receptors, thus acting both as an agonist and a net antagonist. The relative roles of these two actions for nicotine-induced cognitive improvement ...

journal_title：Biochemical pharmacology

authors： Levin ED

更新日期：2013-10-15 00:00:00

abstract：:Raf kinase inhibitor protein (RKIP) is a member of the phosphatidylethanolamine-binding protein (PEBP) family. RKIP plays a pivotal modulatory role in several protein kinase signaling cascades. RKIP binds inhibits Raf-1-mediated phosphorylation of MEK through binding to Raf-1. Protein kinase C (PKC) phosphorylates RKI...

journal_title：Biochemical pharmacology

authors： Keller ET,Fu Z,Brennan M

更新日期：2004-09-15 00:00:00

abstract：:Selective removal of sialic acid from isolated guinea pig left atrial strips and rabbit thoracic aortic ring segments was performed by neuraminidase prepared from Clostridium perfringens and was controlled electron microscopically. Preincubation of these organs (2 units/mL; 2 hr) resulted in enzyme mediated hydrolysis...

journal_title：Biochemical pharmacology

authors： Werner G,Addicks K,Fricke U,Klaus W,Sarram M,Gielen W

更新日期：1991-12-11 00:00:00

abstract：:Evasion of cell death by overexpression of anti-apoptotic proteins, such as Bcl-2, is commonly observed in cancer cells leading to a lack of response to chemotherapy. Hence, there is a need to find new chemotherapeutic agents that are able to overcome chemoresistance mediated by Bcl-2 and to understand their mechanism...

journal_title：Biochemical pharmacology

authors： Hoffmann R,von Schwarzenberg K,López-Antón N,Rudy A,Wanner G,Dirsch VM,Vollmar AM

更新日期：2011-09-01 00:00:00

abstract：:The effects of 2-[(4-acetylphenyl)amino]-3-chloro-1,4-naphthalenedione (NQ-Y15), a synthetic 1,4-naphthoquinone derivative, on platelet activity and its mechanism of action were investigated. NQ-Y15 caused a concentration-dependent inhibition of the aggregation induced by thrombin, collagen, arachidonic acid (AA), and...

journal_title：Biochemical pharmacology

authors： Chang TS,Kim HM,Lee KS,Khil LY,Mar WC,Ryu CK,Moon CK

更新日期：1997-07-15 00:00:00

abstract：:Repertaxin is a new non-competitive allosteric blocker of interleukin-8 (CXCL8/IL-8) receptors (CXCR1/R2), which by locking CXCR1/R2 in an inactive conformation prevents receptor signaling and human polymorphonuclear leukocyte (PMN) chemotaxis. Given the unique mode of action of repertaxin it was important to examine ...

journal_title：Biochemical pharmacology

authors： Casilli F,Bianchini A,Gloaguen I,Biordi L,Alesse E,Festuccia C,Cavalieri B,Strippoli R,Cervellera MN,Di Bitondo R,Ferretti E,Mainiero F,Bizzarri C,Colotta F,Bertini R

更新日期：2005-02-01 00:00:00

abstract：:The effects of propranolol or phentolamine on the metabolism of phospholipids, diacylglycerol, and triacylglycerol were studied in the bovine retina in vitro. Lipid labeling was followed during short-term incubation of intact bovine retinas with [U-14C]glycerol and [1-14C]palmitic acid. Each of these precursors was re...

journal_title：Biochemical pharmacology

authors： de Boschero MG,Bazan NG

更新日期：1982-03-15 00:00:00

abstract：:As our knowledge on the mechanisms that control cell function increases, more complex signaling pathways and quite intricate cross-talks among regulatory proteins are discovered. Establishing accurate interactions between cellular networks is essential for a healthy cell and different alterations in signaling are know...

journal_title：Biochemical pharmacology

authors： Gomez-Duran A,Carvajal-Gonzalez JM,Mulero-Navarro S,Santiago-Josefat B,Puga A,Fernandez-Salguero PM

更新日期：2009-02-15 00:00:00

abstract：:Neurotoxic esterase (NTE) is a membrane-bound protein found in highest concentration in brain and lymphocytes. The enzyme has no known physiological function, but its organophosphorylation and aging in neural tissue are thought to trigger the pathogenesis of organophosphorus-induced delayed neuropathy (OPIDN). Solubil...

journal_title：Biochemical pharmacology

authors： Davis CS,Richardson RJ

更新日期：1987-05-01 00:00:00

abstract：:Two pyrophosphate analogues, dichloromethane diphosphonate (Cl2MDP), and 1-hydroxyethane-1,1-diphosphonate (EHDP), at concentrations of 0.5-1 mM, efficiently inhibited the growth of amoebae of the slime mould Dictyostelium discoideum. Cell viability decreased markedly upon incubation with the diphosphonates. The mecha...

journal_title：Biochemical pharmacology

authors： Pelorgeas S,Martin JB,Satre M

更新日期：1992-12-01 00:00:00

abstract：:Hyperphagia (overeating) is often associated with energy over-storage and obesity, which may lead to a myriad of serious health problems, including heart disease, hypertension, and type 2 diabetes. Thus, understanding the complex pathological mechanisms underlying hyperphagia and obesity has an important clinical sign...

journal_title：Biochemical pharmacology

authors： Attele AS,Shi ZQ,Yuan CS

更新日期：2002-05-01 00:00:00

abstract：:The population growth rate of HeLa cells treated with 60 microM 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) in reinforced Eagle's minimum essential medium was directly related to the concentration of fetal bovine serum in the range from 5 to 30%. Control cells proliferated at a maximal rate (doubling time: ...

journal_title：Biochemical pharmacology

authors： Tamm I

更新日期：1984-02-15 00:00:00

abstract：:Interferon and interferon inducers are well known to depress the cytochrome P450-dependent hepatic mixed-function oxidase system and cause a decrease in the capacity of the liver to metabolize drugs and xenobiotics. In this study we have shown that the interferon-mediated changes in an induced form of hepatic cytochro...

journal_title：Biochemical pharmacology

authors： Knickle LC,Spencer DF,Renton KW

更新日期：1992-08-04 00:00:00

abstract：:During tumor progression, hypoxia-inducible factor 1 (HIF-1) plays a critical role in tumor angiogenesis and tumor growth by regulating the transcription of several genes in response to a hypoxic environment and changes in growth factors. This study was designed to investigate the effects of cinnamic aldehyde (CA) on ...

journal_title：Biochemical pharmacology

authors： Bae WY,Choi JS,Kim JE,Jeong JW

更新日期：2015-11-01 00:00:00

abstract：:The use of either methadone or buprenorphine for treatment of the pregnant opiate-dependent patient improves maternal and neonatal outcome. However, patient outcomes are often complicated by neonatal abstinence syndrome (NAS). The incidence and severity of NAS should depend on opiate concentration in the fetal circula...

journal_title：Biochemical pharmacology

authors： Hemauer SJ,Patrikeeva SL,Nanovskaya TN,Hankins GD,Ahmed MS

更新日期：2009-11-01 00:00:00

abstract：:Endosulfan (E) is an organochloric insecticide, which is quickly metabolized and eliminated from the body system. Toxic effects of E and its metabolites have been reported. The influence of E and its metabolites, viz. endosulfan sulfate (ES), endosulfan diol (ED) and endosulfan lactone (EL), has been examined on rat l...

journal_title：Biochemical pharmacology

authors： Dubey RK,Beg MU,Singh J

更新日期：1984-11-01 00:00:00

abstract：:Most studies have reported an up-regulation of retinoic acid receptor (RAR) mRNA expression by all-trans retinoic acid (RA). We aimed to study the effect of RA on RAR protein levels in MCF-7 human breast cancer cells. Incubation of these cells with 10(-6) M RA induced a rapid breakdown of both RARalpha and RARgamma in...

journal_title：Biochemical pharmacology

authors： Tanaka T,Rodríguez de la Concepción ML,De Luca LM

更新日期：2001-06-01 00:00:00

abstract：:Oxysterols possess anti-proliferative properties that may be used with much effect in the treatment of cancer. We have demonstrated previously that 7 beta-hydroxycholesterol (7b-HC) provokes both metabolic stress, as witnessed by AMPK activation, and changes in lipid raft composition in C6 glioblastoma cells. These ob...

journal_title：Biochemical pharmacology

authors： de Weille J,Fabre C,Gaven C,Bakalara N

更新日期：2013-07-01 00:00:00

abstract：:Several tannins with anti-HIV activity have been described previously (Nonaka et al., J Nat Prod 53: 587-595, 1990). We have shown that the tannins chebulinic acid and punicalin were able to block the binding of HIV rgp120 to CD4. These compounds were not toxic to stimulated human peripheral blood lymphocytes at conce...

journal_title：Biochemical pharmacology

authors： Weaver JL,Pine PS,Dutschman G,Cheng YC,Lee KH,Aszalos A

更新日期：1992-06-09 00:00:00