Abstract：
:Increasing evidence supports NLRP3 inflammasome as a new target to control inflammation. Dysregulation of NLRP3 inflammasome has been reported to be involved in the pathogenesis of several human inflammatory diseases. However, no NLRP3 inflammasome inhibitors are available in clinic. Terpenoids are natural products with multi-target activities against inflammation. Recent studies have revealed that these compounds are capable of inhibiting the activation of NLRP3 inflammasome in several mouse models of NLRP3 inflammasome-related pathogenesis. Thus, terpenoids represent an interesting pharmacological approach for the treatment of inflammatory diseases as they are endowed with a dual mechanism of inhibition of NF-KB transcription factor and inflammasome activation, both critically involved in their anti-inflammatory effects. This work provides an overview of the current knowledge on the therapeutic potential of terpenoids as NLRP3 inflammasome inhibitors.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Hortelano S,González-Cofrade L,Cuadrado I,de Las Heras Bdoi
10.1016/j.bcp.2019.113739subject
Has Abstractpub_date
2020-02-01 00:00:00pages
113739eissn
0006-2952issn
1873-2968pii
S0006-2952(19)30438-1journal_volume
172pub_type
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pub_type： 杂志文章,评审
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doi：10.1016/j.bcp.2011.10.012
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/0006-2952(96)00309-7
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2008-01-15 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/0006-2952(95)02104-3
更新日期：1995-12-22 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.bcp.2004.06.017
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更新日期：1986-05-01 00:00:00
