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Vitamin E inhibits hemolysis induced by hemin as a membrane stabilizer.

Abstract：

:Hemin is a potential cytolytic agent. To test the effect of vitamin E on hemin-mediated permeability in cell membranes, sheep erythrocytes were chosen as an appropriate model to study hemolysis induced by hemin. Hemin-induced hemolysis but did not elicit lipid peroxidation in sheep erythrocytes. Vitamin E was effective in inhibiting hemin-mediated hemolysis. Both chromanol ring and the isoprenoid side chain of tocopherols were essential for inhibition of hemin-induced hemolysis. There was a strong correlation between the inhibitory effects of tocopherols on hemin-induced erythrocyte hemolysis and their effects on fluorescence anisotropy of cell membranes. Our results suggested that, in contrast to its antioxidant activity, vitamin E inhibits hemolysis induced by hemin as a membrane stabilizing agent.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Wang F,Wang T,Lai J,Li M,Zou C

doi

10.1016/j.bcp.2005.12.002

subject

Has Abstract

pub_date

2006-03-14 00:00:00

pages

799-805

issue

6

eissn

0006-2952

issn

1873-2968

pii

S0006-2952(05)00809-9

journal_volume

71

pub_type

杂志文章

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