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Glucosyl phosphotriesters of nucleosides: exchange mechanism of transmembrane transport and application to 5-fluoro-deoxyuridine.

Abstract：

:The structure and membrane interactions of lipophilic glucosyl phosphotriester derivatives of thymidine and 5-fluoro-deoxy thymidine are investigated by NMR spectroscopy. The self-association of these molecules, found in different solvents, presents a diastereoisomeric effect which is also observed in the transmembrane transport inside large unilamellar vesicles. The influence of the hydrophobic chain and the nature of the nucleoside in the water-membrane exchange process is discussed.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Debouzy JC,Hervé M,Neumann JM,Gouyette C,Dupraz B,Huynh-Dinh T

doi

10.1016/0006-2952(90)90108-w

subject

Has Abstract

pub_date

1990-06-01 00:00:00

pages

1657-64

issue

11

eissn

0006-2952

issn

1873-2968

pii

0006-2952(90)90108-W

journal_volume

39

pub_type

杂志文章

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