Abstract:
:The multidrug resistance (MDR) phenotype is the major cause of failure of cancer chemotherapy. This phenotype is mainly due to the overexpression of the human MDR1 (hMDR1) gene. Several studies have shown that transcriptional regulation of this gene is unexpectedly complex and is far from being completely understood. Current work is aimed mainly at defining unclear and new control regions in the hMDR1 gene promoter as well as clarifying corresponding signaling pathways. Such studies provide new insights into the mechanisms by which xenobiotic molecules might modify the physiological hMDR1 expression as well as the possible role of oncogenes in the pathological dysregulation of the gene. Here we report recent findings on the regulation of hMDR1 which may help define specific targets aimed at modulating its transcription.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Labialle S,Gayet L,Marthinet E,Rigal D,Baggetto LGdoi
10.1016/s0006-2952(02)01156-5subject
Has Abstractpub_date
2002-09-01 00:00:00pages
943-8issue
5-6eissn
0006-2952issn
1873-2968pii
S0006295202011565journal_volume
64pub_type
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journal_title:Biochemical pharmacology
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