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Differential regulation of a fibroblast growth factor-binding protein by receptor-selective analogs of retinoic acid.

Abstract：

:We have demonstrated earlier that a secreted fibroblast growth factor-binding protein (FGF-BP) can enhance angiogenesis and promote tumor growth in vivo. Furthermore, we found that FGF-BP expression in squamous cell carcinoma (SCC) is reduced by concentrations of retinoids that are effective in the treatment of SCC and that this repression can occur at the transcriptional and post-transcriptional level. To further examine the mechanism of regulation of FGF-BP by retinoids and the role played by retinoid receptor subtypes, we utilized retinoic acid receptor (RAR)-selective (TTNPB) and retinoid X receptor (RXR)-selective (LG100268) ligands. In ME-180 SCC cells, FGF-BP mRNA was down-regulated by TTNPB with an IC(50) value of 1 nM, whereas transcription was only repressed at 10,000-fold higher concentrations (IC(50) > 10 microM). This suggests that the major effects of retinoids on FGF-BP occur at the post-transcriptional level. In four additional SCC cell lines, FGF-BP was also down-regulated by TTNPB with IC(50) values of

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Boyle BJ,Harris VK,Liaudet-Coopman ED,Riegel AT,Wellstein A

doi

10.1016/s0006-2952(00)00507-4

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

1677-84

issue

11

eissn

0006-2952

issn

1873-2968

pii

S0006-2952(00)00507-4

journal_volume

60

pub_type

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