Abstract：
:Cudratricusxanthone G (CTXG), a natural bioactive cudratricusxanthone extracted from C. tricuspidata, has shown anti-cancer properties. However, the function and mechanism of CTXG in tumor invasion have not been elucidated to date. In this study, we investigated the inhibitory effect of CTXG on the proliferation, migration and invasion of SW620 cells. We found that MMP-2, a pivotal factor in tumor invasion, was suppressed in both expression and activation by CTXG in a dose-dependent manner. The suppression of MMP-2 expression by CTXG led to an inhibition of SW620 cells invasion and migration by inactivating Rac1 and Cdc42 but not RhoA GTPase. Furthermore, CTXG also inhibited the transcriptional activity of AP-1 (activator protein-1). In conclusion, our data demonstrate that CTXG exerted anti-invasion action in SW620 cells by targeting MMP-2 though regulating the activities of Rac1, Cdc42 and their downstream transcriptional factor AP-1. These results are the first to reveal the novel functions of CTXG in cancer cell invasion and its molecular basis for the anti-cancer action.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Kuang L,Wang L,Wang Q,Zhao Q,Du B,Li D,Luo J,Liu M,Hou A,Qian Mdoi
10.1016/j.bcp.2011.02.017subject
Has Abstractpub_date
2011-05-15 00:00:00pages
1192-200issue
10eissn
0006-2952issn
1873-2968pii
S0006-2952(11)00121-3journal_volume
81pub_type
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journal_title：Biochemical pharmacology
pub_type： 杂志文章,收录出版
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更新日期：2010-03-01 00:00:00
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更新日期：2004-02-01 00:00:00
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更新日期：2005-05-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2014-05-15 00:00:00
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更新日期：2017-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2004-07-15 00:00:00
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pub_type： 杂志文章
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更新日期：1986-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.bcp.2010.05.024
更新日期：2010-09-15 00:00:00
