Abstract：
:The immediate early genes (IEGs) have been suggested to be implicated in mechanisms of addiction, as well as in learning and memory processes. fosB, which belongs to IEG, has been reported to have pleiotropic impact on response to psychoactive drugs, as well as motivational and stress-related behaviours. In the present study, we used mice with constitutive knock-out of fosB in order to study fosB role in mouse phenotype. We studied rewarding properties of morphine (10mg/kg i.p.) in conditioned place preference (CPP) paradigm. Additionally, we studied fosB role in spatial memory and spatial working memory using elevated plus maze model of spatial learning (EPMSL) and delayed non-match to place task (DNMTP). In further studies, locomotor, depressive-like and anxiety-like behaviours were measured. Rewarding effects of morphine in fosB -/- mice were abolished whereas spatial learning was impaired. On the other hand, we found no significant differences in locomotor activity, depression-like and anxiety-like behaviours. In summary, our results indicate that mice lacking fosB are less sensitive to rewarding properties of morphine and display spatial memory impairment and suggest involvement of fosB and its proteins in motivational aspects of reinforcers as well as in learning and memory processes.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Solecki W,Krowka T,Kubik J,Kaczmarek L,Przewlocki Rdoi
10.1016/j.bbr.2008.02.040subject
Has Abstractpub_date
2008-07-19 00:00:00pages
212-7issue
2eissn
0166-4328issn
1872-7549pii
S0166-4328(08)00117-4journal_volume
190pub_type
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更新日期：1986-11-01 00:00:00
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更新日期：2004-08-31 00:00:00
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更新日期：2001-04-08 00:00:00
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更新日期：2000-02-01 00:00:00
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更新日期：2005-05-28 00:00:00
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更新日期：2010-01-20 00:00:00
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journal_title：Behavioural brain research
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更新日期：2007-08-06 00:00:00
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更新日期：2009-12-07 00:00:00
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pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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更新日期：2018-10-01 00:00:00
abstract：:Rats with lesions in either the fornix or the thalamic nucleus medialis dorsalis were unimpaired on the acquisition of two object discrimination tasks. The same animals were then tested on a concurrent learning task in which various object discriminations were presented at different rates during the same session. This...
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pub_type： 杂志文章
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