Starvation and triglycerides reverse the obesity-induced impairment of insulin transport at the blood-brain barrier.

abstract：:We tested further our postulate that enhanced de novo synthesis of phosphatidic acid is responsible for ACTH- and cAMP-induced increases in adrenal phospholipids in the phosphatidate polyphosphoinositide pathway. During incubation of adrenal sections or cells in vitro, ACTH and cAMP increased the concentrations of and...

journal_title：Endocrinology

authors： Farese RV,Sabir MA,Larson RE

更新日期：1981-12-01 00:00:00

abstract：:The establishment of dominant ovarian follicles that are capable of ovulating fertilizable oocytes is a fundamental determinant of female fertility. This process is governed by pituitary gonadotropins as well as local ovarian factors. Within the follicle, estrogen acts in an autocrine/paracrine manner to enhance FSH a...

journal_title：Endocrinology

authors： Otsuka F,Moore RK,Wang X,Sharma S,Miyoshi T,Shimasaki S

更新日期：2005-08-01 00:00:00

abstract：UNLABELLED:The long-acting glucagon-like peptide-1 receptor (GLP-1R) agonists, exendin-4 and liraglutide, suppress food intake and body weight. The mediating site(s) of action for the anorectic effects produced by peripheral administration of these GLP-1R agonists are not known. Experiments addressed whether food intak...

journal_title：Endocrinology

authors： Kanoski SE,Fortin SM,Arnold M,Grill HJ,Hayes MR

更新日期：2011-08-01 00:00:00

abstract：:Hepcidin plays an essential role in maintaining normal iron homeostasis outside the brain. This recently discovered iron regulation hormone is predominantly expressed in the liver, and regulated by iron and hypoxia. As an antimicrobial peptide, this hormone is also elevated during infections and inflammation. In this ...

journal_title：Endocrinology

authors： Wang Q,Du F,Qian ZM,Ge XH,Zhu L,Yung WH,Yang L,Ke Y

更新日期：2008-08-01 00:00:00

abstract：:Canine renal cortical PTH receptors were solubilized after occupancy of membrane-associated receptors with the agonist ligand [125I]bovine (b) PTH-(1-34). Stabilization of binding during solubilization required the use of high concentrations of BSA (optimally 5%) and appropriate detergents (0.5% 3-[(3-cholamidopropyl)...

journal_title：Endocrinology

authors： Nissenson RA,Mann E,Winer J,Teitelbaum AP,Arnaud CD

更新日期：1986-03-01 00:00:00

abstract：:Studying the mechanisms for the complex pathogenesis of polycystic ovary syndrome (PCOS) requires animal models with endocrine, reproductive, and metabolic features of the syndrome. Hyperandrogenism seems to be a central factor in PCOS, leading to anovulation and insulin resistance. In female rats, continuous administ...

journal_title：Endocrinology

authors： Maliqueo M,Sun M,Johansson J,Benrick A,Labrie F,Svensson H,Lönn M,Duleba AJ,Stener-Victorin E

更新日期：2013-01-01 00:00:00

abstract：:The rate at which the estrogen receptor (ER) is synthesized and degraded (turns over) in target cells is a major factor regulating the levels of ER and cell sensitivity to estrogen. We have used the ability of tamoxifen aziridine [(TAZ)(Z)-1-[4-(2-[N-aziridinyl]ethoxy)phenyl]1,2-diphenyl-1-buten e] to affinity label t...

journal_title：Endocrinology

authors： Nardulli AM,Katzenellenbogen BS

更新日期：1986-11-01 00:00:00

abstract：:Early obesity and late onset of insulin resistance associated with hormonal imbalances occur in FSH receptor-deficient follitropin receptor knockout female mice. This study tests the hypothesis that chronic high-fat diet aggravates obesogenic changes in a depot-specific manner and explores some molecular links of horm...

journal_title：Endocrinology

authors： Zhang H,Chen X,Aravindakshan J,Sairam MR

更新日期：2007-12-01 00:00:00

abstract：:Regulation of galanin gene expression in the anterior pituitary (AP) is positively influenced by estrogen in rodents and undetermined in humans. The objective of this study was to investigate the mechanism behind estrogen induction of galanin by identifying any putative estrogen receptor (ER) binding sequences within ...

journal_title：Endocrinology

authors： Howard G,Peng L,Hyde JF

更新日期：1997-11-01 00:00:00

abstract：:Early-life experiences, including maternal interaction, profoundly influence hormonal stress responses during adulthood. In rats, daily handling during a critical neonatal period leads to a significant and permanent modulation of key molecules that govern hormonal secretion in response to stress. Thus, hippocampal glu...

journal_title：Endocrinology

authors： Avishai-Eliner S,Eghbal-Ahmadi M,Tabachnik E,Brunson KL,Baram TZ

更新日期：2001-01-01 00:00:00

abstract：:The present study was conducted to examine the effect of LH on phospholipid metabolism in corpora luteal tissue. Collagenase-dispersed cells obtained from bovine corpora lutea of early pregnancy were incubated with 32PO4 in the presence or absence of LH and examined for their ability to incorporate this label into pho...

journal_title：Endocrinology

authors： Davis JS,Farese RV,Marsh JM

更新日期：1981-08-01 00:00:00

abstract：:Depletion of hypothalamic norepinephrine (NE) and epinephrine by administration of diethyldithiocarbamate abolished the stimulatory effects of intraventricular (IVT) angiotensin II (AII) on LH release in ovariectomized rats pretreated with estradiol and progesterone. The increase in blood LH produced by IVT NE or iv L...

journal_title：Endocrinology

authors： Steele MK,Ganong WF

更新日期：1986-12-01 00:00:00

abstract：:The aim of this study was to identify and characterize binding sites for inhibin in primary cultures of ovine anterior pituitary cells. Recombinant human 31-kDa inhibin A was iodinated by an optimized lactoperoxidase procedure. Fractionation of the labeled protein by gel filtration chromatography on Sephadex G-100 in ...

journal_title：Endocrinology

authors： Hertan R,Farnworth PG,Fitzsimmons KL,Robertson DM

更新日期：1999-01-01 00:00:00

abstract：:Besides its role in body weight control leptin may also act as a vasoactive hormone. This study was designed to investigate whether leptin modifies angiotensin II (ANG II)-induced vascular responses. The expression of functional leptin receptors (OB-Rb) was detected in vascular smooth muscle cells (VSMCs) from adult W...

journal_title：Endocrinology

authors： Fortuño A,Rodríguez A,Gómez-Ambrosi J,Muñiz P,Salvador J,Díez J,Frühbeck G

更新日期：2002-09-01 00:00:00

abstract：:A side population (SP) has been identified in a number of tissues, where it typically represents a small population enriched in stem/progenitor cells. In this study we show that the adult mouse anterior pituitary (AP) also contains a characteristic SP displaying verapamil-sensitive Hoechst dye efflux capacity. A major...

journal_title：Endocrinology

authors： Chen J,Hersmus N,Van Duppen V,Caesens P,Denef C,Vankelecom H

更新日期：2005-09-01 00:00:00

abstract：:In rat ovary, androgen receptor (AR) is predominantly expressed in granulosa cells and is developmentally regulated. However, the exact mechanism that is responsible for the regulation of AR in granulosa cells has not been elucidated. The aim of this study was to examine 1) the levels of AR messenger RNA (mRNA) expres...

journal_title：Endocrinology

authors： Tetsuka M,Hillier SG

更新日期：1996-10-01 00:00:00

abstract：:Despite the specificity inferred by its name, glycogen synthase kinase (GSK)-3beta is an important kinase with a plethora of significant cellular targets, including cytoskeletal proteins and transcription factors, and its activity is regulated by phosphorylation on tyrosine/serine residues. As part of our efforts to d...

journal_title：Endocrinology

authors： Liao X,Thrasher JB,Holzbeierlein J,Stanley S,Li B

更新日期：2004-06-01 00:00:00

abstract：:Experiments were performed in vitro to examine the possible role of calcium and calmodulin in GRF-induced somatostatin (SRIF) release from the median eminence. Adult male rats were used as tissue donors. The median eminences were first prestimulated in 0.4 ml Krebs Ringer bicarbonate glucose buffer (pH 7.4) containing...

journal_title：Endocrinology

authors： Aguila MC,McCann SM

更新日期：1988-07-01 00:00:00

abstract：:Subcutaneous implantation of a silastic tubing containing crystalline estradiol in castrated female rats results in a circadian rhythm of LH release. Under such conditions, blockade of serotonin (5-HT) biosynthesis by p-chlorophenylalanine (PCPA) completely inhibits the afternoon elevation of plasma LH. Gonadotropin p...

journal_title：Endocrinology

authors： Héry M,Laplante E,Kordon C

更新日期：1976-08-01 00:00:00

abstract：:Activin A is a dimeric protein hormone that regulates numerous cellular functions. A clear physiological role for this molecule in pregnancy is suggested by previous studies in the human, wherein activin A rises dramatically as women approach parturition. To determine whether the rodent is a suitable animal model for ...

journal_title：Endocrinology

authors： Draper LB,Chong H,Wang E,Woodruff TK

更新日期：1997-07-01 00:00:00

abstract：:Isolated renal cortical slices were used to study the conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] and 24,25-dihydroxyvitamin D3 [24,25](OH2)D3] by the rat kidney. Production of 1,25-(OH)2D3 and 24,25-(OH)2D3 was linear with time (30-90 min) and tissue weight (40-250 mg). Production of...

journal_title：Endocrinology

authors： Armbrecht HJ,Zenser TV,Davis BB

更新日期：1981-07-01 00:00:00

abstract：:Transglutaminase (TGase) activity, determined by incorporation of [1,4-14C]putrescine into casein, was demonstrated in a light membrane fraction derived from bovine calf testicular homogenates. In common with other TGases thus far identified, testicular TGase is calcium dependent. A concentration-dependent relationshi...

journal_title：Endocrinology

authors： Grasso P,Dattatreyamurty B,Dias JA,Reichert LE Jr

更新日期：1987-08-01 00:00:00

abstract：:To determine the effect of aromatase inhibitors on peripheral aromatization, male rhesus monkeys were infused with [7-3H]androstenedione and [4-14C]estrone before and during treatment with 4-hdyroxy-androstene-3,17-dione (50 mg/kg each; four monkeys) or 4-acetoxy-androstene-3,17-dione (700 mg each; two monkeys). In al...

journal_title：Endocrinology

authors： Brodie AM,Longcope C

更新日期：1980-01-01 00:00:00

abstract：:There is evidence that the IGF system plays an important role in the growth and function of the thyroid gland. Proteolysis is an important posttranslational process that modulates the affinity of IGF binding proteins (IGFBPs) to IGFs, thus regulating their activity. IGFBP-3 has been shown to be cleaved by members of t...

journal_title：Endocrinology

authors： Wang J,Grünler J,Lewitt MS

更新日期：2004-03-01 00:00:00

abstract：:Kisspeptin neurons play an essential role in the regulation of fertility through direct regulation of the GnRH neurons. However, the relative contributions of the two functionally distinct kisspeptin neuron subpopulations to this critical regulation are not fully understood. Here we analyzed the specific projection pa...

journal_title：Endocrinology

authors： Yip SH,Boehm U,Herbison AE,Campbell RE

更新日期：2015-07-01 00:00:00

abstract：:The regulation of GRF secretion was studied using a fetal rat hypothalamic cell culture system. The cells were subjected to short term release experiments on days 10-18 after plating, and GRF secretion was assessed by RIA. The identity of GRF immunoreactivity in the incubation medium was confirmed by reverse phase liq...

journal_title：Endocrinology

authors： Baes M,Vale WW

更新日期：1989-01-01 00:00:00

abstract：:Our laboratory has previously reported that physiological levels of progestins stimulate growth of the human breast cancer cell line T47D. We have also determined that the antiprogestin RU486 inhibits this stimulation. Here we present the unexpected finding that RU486 alone also stimulates growth of these breast cance...

journal_title：Endocrinology

authors： Bowden RT,Hissom JR,Moore MR

更新日期：1989-05-01 00:00:00

abstract：:We have previously demonstrated that cultured rat thyroid cells do not exhibit constitutive expression of major histocompatibility (MHC) class II antigens. Using reovirus types 1 and 3, we infected 1B-6 cells (a cloned derivative of the Fisher rat cell line FRTL-5), and found a dose-dependent induction of thyroid cell...

journal_title：Endocrinology

authors： Neufeld DS,Platzer M,Davies TF

更新日期：1989-01-01 00:00:00

abstract：:The expression of the proopiomelanocortin (POMC) gene by normal lung and thyroid was examined by measurement of the content of ACTH, beta-lipotropin (beta LPH), and beta-endorphin (beta EP) in porcine lung and thyroid tissue. Acid extracts of normal porcine lung and thyroid tissue each contained appreciable amounts of...

journal_title：Endocrinology

authors： Clements JA,Funder JW,Tracy K,Morgan FJ,Campbell DJ,Lewis P,Hearn MT

更新日期：1982-12-01 00:00:00

abstract：:Des-acyl ghrelin (DAG), the most abundant form of ghrelin in humans, has been found to reduce arterial blood pressure and prevent cardiac and endothelial cell apoptosis. Despite this, data regarding its direct effect on cardiac function and coronary blood flow, as well as the related involvement of autonomic nervous s...

journal_title：Endocrinology

authors： Grossini E,Raina G,Farruggio S,Camillo L,Molinari C,Mary D,Walker GE,Bona G,Vacca G,Moia S,Prodam F,Surico D

更新日期：2016-06-01 00:00:00