Abstract:
:Chemokines and their receptors play a decisive role in tumor progression and metastasis. Here, we describe the expression of the CXCL16-CXCR6-system in human schwannomas of different localization and in malignant peripheral nerve sheath tumors. The transmembrane chemokine CXCL16 and its receptor CXCR6/Bonzo were overexpressed on the mRNA and protein levels in all tumor samples investigated as compared with normal peripheral or 8th cranial nerve tissues. Chromogenic immunostaining and confocal laser microscopy revealed that CXCL16 and CXCR6 were localized mainly on S-100 positive schwannoma cells. Cultured schwannoma cells responded to CXCL16-stimulation by phosphorylation of kinases p42/44 (Erk 2/1) that could be inhibited by the MEK1/2-inhibitor U0126 indicating an involvement of the mitogen-activated protein kinase signal transduction pathway. As a biological response, CXCL16 increased proliferation and induced migration of schwannomas. Hence, CXCL16 appears to be a novel growth factor for schwannomas of different localization.
journal_name
Gliajournal_title
Gliaauthors
Held-Feindt J,Rehmke B,Mentlein R,Hattermann K,Knerlich F,Hugo HH,Ludwig A,Mehdorn HMdoi
10.1002/glia.20651subject
Has Abstractpub_date
2008-05-01 00:00:00pages
764-74issue
7eissn
0894-1491issn
1098-1136journal_volume
56pub_type
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