Abstract:
:In 2004-2005, the antihypertensive effects of telmisartan 80 mg versus valsartan 160 mg combined with hydrochlorothiazide 25 mg were assessed in a large placebo-controlled trial in patients with stages 1 and 2 hypertension and demonstrated that both agents were highly effective in lowering blood pressure (BP) compared with placebo and that telmisartan lowered BP significantly greater than valsartan. To confirm this finding according to Food and Drug Administration guidelines, we performed a second large trial using the same design in an entirely separate patient population. The trial was double-blind with a 4 : 4 : 1 randomization scheme to compare once daily telmisartan 80 mg plus hydrochlorothiazide 25 mg versus once daily valsartan 160 mg plus hydrochlorothiazide 25 mg versus once daily placebo on reductions in seated clinic BP in patients with stages 1 and 2 hypertension. The primary endpoints were the changes from baseline in seated diastolic and systolic BP at the end of the 8-week treatment period. Safety endpoints included adverse events, changes in laboratory parameters and pulse rate. In total, 1185 patients were randomized (of which 1181 were treated and included in the primary analysis: 528 in the telmisartan-hydrochlorothiazide group, 523 in the valsartan-hydrochlorothiazide group, and 130 in the placebo group), changes from baseline in BP following telmisartan-hydrochlorothiazide (-24.6/-18.2 mmHg) were significantly greater than both placebo (-4.1/-6.1 mmHg) and valsartan-hydrochlorothiazide (-22.5/-17.0 mmHg) (versus placebo, P<0.0001 for systolic and diastolic BP; versus valsartan-hydrochlorothiazide, P=0.017 for systolic BP and P=0.025 for diastolic BP). The total number of patients with at least one adverse event reported was similar among the three treatment groups (placebo, 42%, telmisartan-hydrochlorothiazide, 36%, and valsartan-hydrochlorothiazide, 37%). Thus, this large, second trial confirms that telmisartan-hydrochlorothiazide at doses of 80/25 mg lowered both systolic and diastolic BP to a greater extent than valsartan-hydrochlorothiazide at doses of 160/25 mg in stages 1-2 hypertension. Although these are not the highest doses of these agents at present, at the time that the studies were conducted, they were the maximally approved dosages. Both studies support the strategy of using angiotensin receptor blockers with a higher dose of a thazide diuretic (25 mg) for enhancing the control of hypertension.
journal_name
Blood Press Monitjournal_title
Blood pressure monitoringauthors
White WB,Murwin D,Chrysant SG,Koval SE,Davidai G,Guthrie Rdoi
10.1097/MBP.0b013e3282f3859dsubject
Has Abstractpub_date
2008-02-01 00:00:00pages
21-7issue
1eissn
1359-5237issn
1473-5725pii
00126097-200802000-00004journal_volume
13pub_type
杂志文章,随机对照试验abstract::The acute effect of smoking is a rise in blood pressure and heart rate. Nevertheless, in several epidemiologic studies, smokers tend to have a slightly lower office blood pressure than non-smokers. We studied the 24 h ambulatory blood pressure consecutively in hypertensive smokers (> or = 10 cigarettes per day, n = 26...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/00126097-200010000-00004
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND:Ambulatory blood pressure monitoring (ABPM) on the oscillometric method is applicable in patients with atrial fibrillation, but the mean pulse rate is or not similar to the ventricular rate from the Holter in atrial fibrillation patients remains unknown. METHODS:This study included 228 persistent atrial fib...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0000000000000481
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:We have shown that as renal function deteriorates, the circadian blood pressure (BP) rhythm shifts to a nondipper pattern and the duration until nocturnal BP decline [dipping time (DT)] is prolonged. We investigated whether or not morning hypertension (BP 2 h after awakening >135/85 mmHg) in chronic kidney di...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0b013e32835026c6
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:Measurement of office blood pressure using a fully automated sphygmomanometer that takes multiple readings with the patient resting quietly alone has been called automated office blood pressure (AOBP). Almost all AOBP research has involved the patient resting alone in an examining room, which is often impract...
journal_title:Blood pressure monitoring
pub_type: 临床试验,杂志文章
doi:10.1097/MBP.0000000000000133
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVE:To compare the methods of office blood pressure (BP) measurement and ambulatory blood pressure monitoring (ABPM) to ensure optimal BP control in hypertensive anticoagulated patients. PATIENTS AND METHODS:Seventy-eight patients who were receiving antihypertensive drugs and warfarin in a dose-adjusted approach...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0000000000000084
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the physiological variations in arterial blood pressure in normotensive subjects during activity and in relation to the sitting or lying position. METHODS:The subjects were 30 healthy volunteers who were normotensive and receiving no treatment. Blood pressure was measured using the validated moni...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/00126097-200006000-00005
更新日期:2000-06-01 00:00:00
abstract::Current hypertension guidelines continue to base management decisions on the office BP as recorded by mercury sphygmomanometry. The imminent disappearance of mercury from the workplace for environmental and safety reasons provides an opportunity to re-assess how a diagnosis of hypertension is made. There are now sever...
journal_title:Blood pressure monitoring
pub_type: 共识发展会议,杂志文章,评审
doi:10.1097/00126097-200412000-00002
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Waist circumference (WC) and related anthropometric indices have been recognized as useful measures of abdominal obesity. However, little is known about the association of waist-to-sitting-height ratio (WSHtR) with obesity and elevated blood pressure (BP). PARTICIPANTS AND METHODS:Data for this study were o...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0000000000000154
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:It is commonly believed that the associations of left ventricular mass and cardiovascular morbidity/mortality with blood pressure are stronger for 24-h ambulatory pressure than for conventional clinic or casual pressure. METHODS:The investigation comprised a review of relevant studies, with particular empha...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,meta分析
doi:10.1097/00126097-200202000-00006
更新日期:2002-02-01 00:00:00
abstract::OBJECTIVE: To test the SpaceLabs Medical 90217 ambulatory blood pressure monitor for compliance with The Association for the Advancement of Medical Instrumentation's standard and a modification of the British Hypertension Society (BHS) protocol. METHODS: The study concerned 85 subjects aged 17-88 years with various ar...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:The ankle-brachial index (ABI) is the most useful and efficient tool for assessing the presence of peripheral artery disease (PAD). The aim of this study was to evaluate the effect of multiple sequential blood pressure (BP) measurements on the estimation of the ABI and the consequent diagnosis of PAD in a hig...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,随机对照试验
doi:10.1097/MBP.0b013e328351de79
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:Handgrip exercise is an emerging strategy for resting blood pressure (BP) reduction requiring minimal time and exercise effort. However, the research literature is currently limited to handgrip protocol designs predominantly prescribing sustained grip contractions, with little assessment of alternative option...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0000000000000313
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:The objective of this study was to assess the effect of feedback on medium-term blood pressure (BP) measurement skills in medical students versus a control group. METHODS:A randomized controlled trial in first-year medical students was conducted. After theoretical-practical training on measuring BP, the stu...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,随机对照试验
doi:10.1097/MBP.0000000000000433
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:There is a growing tendency for physicians to prescribe exercise in accordance with the 'exercise is medicine' global health initiative. However, the exercise-pharmacologic interactions for controlling blood pressure are not well described. Our purpose was to study whether angiotensin II receptor type 1 block...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,随机对照试验
doi:10.1097/MBP.0000000000000328
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Patients and doctors often use home blood pressure monitoring (HBPM) to assess the control of hypertension. Despite its popularity there has always been some uncertainty with regard to its accuracy, reliability, reproducibility, and comparability. Although there are pre-market HBPM standards of accuracy, the...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/00126097-199904010-00007
更新日期:1999-02-01 00:00:00
abstract:OBJECTIVE:Evaluation of autonomic function responses is increasingly important for risk prediction and hemodynamic evaluation in the ambulant and perioperative setting, but requires a noninvasive arterial blood pressure measurement device. This study describes whether a novel noninvasive beat-to-beat arterial blood pre...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0b013e32834b4431
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:Psoriasis is a chronic inflammatory disorder, which is associated with high risk of metabolic comorbidities. Hypertension (HTN) is among the most common and serious associations. In this study, we aimed to evaluate HTN in psoriatic patients through office and ambulatory blood pressure monitoring (ABPM). MATE...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0000000000000489
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to validate the blood pressure (BP) measurement device Erkameter 125 PRO according to the International Protocol revision 2010 of the European Society of Hypertension (ESH-IP2). PATIENTS AND METHODS:In 33 patients aged 32-79 years, BP measurements were performed alternately u...
journal_title:Blood pressure monitoring
pub_type: 临床试验,杂志文章
doi:10.1097/MBP.0000000000000216
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Ambulatory blood pressure monitoring allows characterization of the patient's average blood pressure load as well as various profiles of blood pressure. Results from clinical studies suggest that dippers (patients whose blood pressures decrease during night-time) have a lower risk of cardiovascular events th...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/00126097-200002000-00004
更新日期:2000-02-01 00:00:00
abstract:OBJECTIVES:Hypertension in children may be defined by blood pressure elevated above the 95th percentile according to sex and age. Population data for ambulatory blood pressure provide different age-related and sex-related threshold limits to office-derived data. We sought to determine whether, when using ambulatory blo...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/01.mbp.0000209085.55364.73
更新日期:2006-06-01 00:00:00
abstract::OBJECTIVE: To assess the spontaneous changes in clinic blood pressure, ambulatory blood pressure (ABP) and left ventricular structure in untreated subjects with white-coat hypertension (WCH). DESIGN: A prospective observational study. PATIENTS AND METHODS: In 83 untreated subjects with WCH, 24 h non-invasive ABP monit...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVE:In this study, we aimed to assess the relationship between radial artery spasm (RAS) and arterial stiffness (AS) measured by the oscillometric method. MATERIALS AND METHODS:A total of 123 consecutive patients scheduled for elective coronary angiography in a single default radial center were enrolled for the ...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0000000000000340
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:How far should blood pressure (BP) be lowered to achieve the greatest reduction in the risk of cardiovascular disease? Although a few trials have tried to answer this question, they failed to convincingly establish an optimal target BP level, in part because of poor reproducibility and the wide variability o...
journal_title:Blood pressure monitoring
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00126097-200202000-00016
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVE:The validation of sphygmomanometer is important in accurate blood pressure measurement. This study presents the validation results by the Medipro MediCare 100f upper arm blood pressure monitor according to the European Society of Hypertension International Protocol (ESH-IP) revision 2010. METHODS:The ESH-IP ...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0b013e328346d715
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:We have developed a new blood pressure (BP)-measuring device with a double-cuff, and evaluated its accuracy and applicability for practical use. DESIGN:The double-cuff method features a small cuff placed in the centre of the compression cuff to detect the oscillation of arterial pulsation, by which algorith...
journal_title:Blood pressure monitoring
pub_type: 临床试验,杂志文章
doi:10.1097/00126097-200310000-00005
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:In patients with hypertensive intracerebral hemorrhage (HICH), intravenous nicardipine is primarily used to lower blood pressure (BP). However, there are few studies investigating the role of oral antihypertensives administered after intravenous nicardipine to prevent BP from rising. Angiotensi...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,随机对照试验
doi:10.1097/MBP.0000000000000225
更新日期:2017-02-01 00:00:00
abstract::Hypertension is highly prevalent in pediatric patients with end-stage renal disease (ESRD). Ambulatory blood pressure monitoring (ABPM) has been used to characterize the altered circadian blood pressure patterns in ESRD in order to improve our understanding of the blood pressure dysregulation that occurs in these chil...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,评审
doi:
更新日期:1999-06-01 00:00:00
abstract::BACKGROUND: The lack of prospective data on the relative value of ambulatory blood pressure compared with office blood pressure as well as concern about increased costs have led to cautious endorsement of such monitoring in the clinical arena. Several consensus bodies have reviewed the scientific evidence and have sug...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract::BACKGROUND: Ambulatory measurement for the QKD interval is a new method for evaluation of the rigidity of large arterial trunks. Reliable indices of arterial rigidity can be distilled from the large number of measurements (usually around 100) obtained during 24 h monitoring. OBJECTIVE: To describe a shorter standardiz...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:Guidelines for office blood pressure reading techniques do not warn us about the possibility that patients may clench their fist during cuff-inflation. It is unknown how often patients do this, and what effect it has on measured blood pressure readings. DESIGN AND METHODS:We registered double blood pressure...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/00126097-200206000-00001
更新日期:2002-06-01 00:00:00