Effects of the angiotensin II receptor blockers telmisartan versus valsartan in combination with hydrochlorothiazide: a large, confirmatory trial.

Abstract:

:In 2004-2005, the antihypertensive effects of telmisartan 80 mg versus valsartan 160 mg combined with hydrochlorothiazide 25 mg were assessed in a large placebo-controlled trial in patients with stages 1 and 2 hypertension and demonstrated that both agents were highly effective in lowering blood pressure (BP) compared with placebo and that telmisartan lowered BP significantly greater than valsartan. To confirm this finding according to Food and Drug Administration guidelines, we performed a second large trial using the same design in an entirely separate patient population. The trial was double-blind with a 4 : 4 : 1 randomization scheme to compare once daily telmisartan 80 mg plus hydrochlorothiazide 25 mg versus once daily valsartan 160 mg plus hydrochlorothiazide 25 mg versus once daily placebo on reductions in seated clinic BP in patients with stages 1 and 2 hypertension. The primary endpoints were the changes from baseline in seated diastolic and systolic BP at the end of the 8-week treatment period. Safety endpoints included adverse events, changes in laboratory parameters and pulse rate. In total, 1185 patients were randomized (of which 1181 were treated and included in the primary analysis: 528 in the telmisartan-hydrochlorothiazide group, 523 in the valsartan-hydrochlorothiazide group, and 130 in the placebo group), changes from baseline in BP following telmisartan-hydrochlorothiazide (-24.6/-18.2 mmHg) were significantly greater than both placebo (-4.1/-6.1 mmHg) and valsartan-hydrochlorothiazide (-22.5/-17.0 mmHg) (versus placebo, P<0.0001 for systolic and diastolic BP; versus valsartan-hydrochlorothiazide, P=0.017 for systolic BP and P=0.025 for diastolic BP). The total number of patients with at least one adverse event reported was similar among the three treatment groups (placebo, 42%, telmisartan-hydrochlorothiazide, 36%, and valsartan-hydrochlorothiazide, 37%). Thus, this large, second trial confirms that telmisartan-hydrochlorothiazide at doses of 80/25 mg lowered both systolic and diastolic BP to a greater extent than valsartan-hydrochlorothiazide at doses of 160/25 mg in stages 1-2 hypertension. Although these are not the highest doses of these agents at present, at the time that the studies were conducted, they were the maximally approved dosages. Both studies support the strategy of using angiotensin receptor blockers with a higher dose of a thazide diuretic (25 mg) for enhancing the control of hypertension.

journal_name

Blood Press Monit

authors

White WB,Murwin D,Chrysant SG,Koval SE,Davidai G,Guthrie R

doi

10.1097/MBP.0b013e3282f3859d

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

21-7

issue

1

eissn

1359-5237

issn

1473-5725

pii

00126097-200802000-00004

journal_volume

13

pub_type

杂志文章,随机对照试验
  • Comparison of the effects of two different teaching methods in blood pressure measurement training: a randomized controlled study.

    abstract:OBJECTIVE:To compare the effects of a high-fidelity simulator and conventional teaching model used during blood pressure measurement training on students' self-confidence, self-efficacy and anxiety levels. METHODS:A randomized controlled trial design was used. The study was conducted on 59 first-year nursing students ...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MBP.0000000000000401

    authors: Terzi B,Topbaş E,Bingöl G,Mavi Aydoğdu SG

    更新日期:2019-12-01 00:00:00

  • Validation of the Tiba Medical Ambulo 2400 ambulatory blood pressure monitor to the ISO Standard and BHS protocol.

    abstract:OBJECTIVE:We evaluated the Tiba Medical Ambulo 2400 ambulatory blood pressure monitor accuracy by both the International Standards Organization (ISO) Standard and the British Hypertension Society (BHS) protocol. METHODS:We tested children, adolescents, and adults. The requirements for both ISO and BHS were completed f...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章

    doi:10.1097/MBP.0b013e32833c8b39

    authors: Alpert BS

    更新日期:2010-10-01 00:00:00

  • Automated office blood pressure - being alone and not location is what matters most.

    abstract:OBJECTIVE:Measurement of office blood pressure using a fully automated sphygmomanometer that takes multiple readings with the patient resting quietly alone has been called automated office blood pressure (AOBP). Almost all AOBP research has involved the patient resting alone in an examining room, which is often impract...

    journal_title:Blood pressure monitoring

    pub_type: 临床试验,杂志文章

    doi:10.1097/MBP.0000000000000133

    authors: Armstrong D,Matangi M,Brouillard D,Myers MG

    更新日期:2015-08-01 00:00:00

  • The importance of the sympathetic nervous system and systolic hypertension in patients with hypertension: benefits in treating patients with increased cardiovascular risk.

    abstract::The sympathetic nervous system is intimately involved in both the origin and the perpetuation of the hypertensive state, although there is some debate as to its precise contribution to the long-term hypertensive condition. Catecholamines are leading candidates to be both the pressor mechanism that initiates the rise i...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章,评审

    doi:10.1097/00126097-200010002-00005

    authors: Sica DA

    更新日期:2000-01-01 00:00:00

  • Canadian valsartan study in patients with mild-to-moderate hypertension.

    abstract:OBJECTIVE:This study was designed mainly to establish the rates of response to valsartan 80mg once daily (qd) and to valsartan 160mg qd given to non-responders to 80mg qd, as well as to determine the safety of valsartan and the blood pressure control achieved using valsartan over a period of 24 h or more, using ambulat...

    journal_title:Blood pressure monitoring

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/00126097-200104000-00005

    authors: Lasko BH,Laplante A,Hébert D,Bonnefis-Boyer S

    更新日期:2001-04-01 00:00:00

  • The effect of crossing legs on blood pressure: a randomized single-blind cross-over study.

    abstract:BACKGROUND:Although there is a theoretical basis for crossing legs to increase blood pressure, there are no published data addressing this question. As a result guidelines for measurement of blood pressure are not consistent in recommending that patients legs should not be crossed during measurement. OBJECTIVE:To dete...

    journal_title:Blood pressure monitoring

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Peters GL,Binder SK,Campbell NR

    更新日期:1999-04-01 00:00:00

  • Aortic systolic pressure derived with different calibration methods: associations to brachial systolic pressure in the general population.

    abstract:BACKGROUND:There is increasing evidence that the method of calibration directly influences the association between brachial systolic blood pressure (bSBP) and estimated aortic systolic blood pressure (aSBP) and subsequently affects prognostic and diagnostic differentiation power of the latter. OBJECTIVE:The aim of thi...

    journal_title:Blood pressure monitoring

    pub_type: 临床试验,杂志文章

    doi:10.1097/MBP.0000000000000319

    authors: Wassertheurer S,Hametner B,Mayer CC,Hafez A,Negishi K,Papaioannou TG,Protogerou AD,Sharman JE,Weber T

    更新日期:2018-06-01 00:00:00

  • Blood pressure measurements by the Keito machine. Evaluation versus office blood pressure by physicians.

    abstract:BACKGROUND:The Keito machine offers automatic measurements of blood pressure (BP), height and weight on insertion of coins and has been introduced in pharmacies. DESIGN:Cross-sectional study comparing automatic BP measurements by the Keito machine to office BP measurements by physicians. METHODS:Patients scheduled fo...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章

    doi:10.1097/01.mbp.0000130223.80658.3d

    authors: Staal EM,Nygård OK,Omvik P,Gerdts E

    更新日期:2004-06-01 00:00:00

  • Blood pressure monitoring in sleep: time to wake up.

    abstract::Hypertension is a highly common condition with well-established adverse consequences. Ambulatory blood pressure monitoring has repeatedly been shown to better predict cardiovascular outcomes and mortality, compared to single office visit blood pressure. Non-dipping of sleep-time blood pressure is an independent marker...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章,评审

    doi:10.1097/MBP.0000000000000426

    authors: Kwon Y,Stafford PL,Lim DC,Park S,Kim SH,Berry RB,Calhoun DA

    更新日期:2020-04-01 00:00:00

  • Clinical use of ambulatory blood pressure monitoring in a Veteran's Medical Center.

    abstract::BACKGROUND: The lack of prospective data on the relative value of ambulatory blood pressure compared with office blood pressure as well as concern about increased costs have led to cautious endorsement of such monitoring in the clinical arena. Several consensus bodies have reviewed the scientific evidence and have sug...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章

    doi:

    authors: Mansoor GA

    更新日期:1997-10-01 00:00:00

  • Simultaneous validation of the SunTech 247 diagnostic station blood pressure measurement device according to the British Hypertension Society protocol, the International Protocol and the Association for the Advancement of Medical Instrumentation standards

    abstract:OBJECTIVE:SunTech 247 is an oscillometric blood pressure (BP) monitor manufactured by SunTech Medical Inc., Morrisville, North Carolina, USA. The aims of this study were (i) to determine its accuracy using the 1993 modified British Hypertension Society (BHS) protocol, the 2002 International Protocol (IP) and the 2002/2...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章

    doi:10.1097/MBP.0b013e328330c873

    authors: Polo Friz H,Facchetti R,Primitz L,Beltrame L,Galbiati V,Ricioppo A,Bombelli M,Sega R

    更新日期:2009-10-01 00:00:00

  • Accuracy of oscillometric blood pressure algorithms in healthy adults and in adults with cardiovascular risk factors.

    abstract:BACKGROUND:Fixed-ratio and slope-based algorithms are used to derive oscillometric blood pressure (BP). However, a paucity of published data exists assessing the accuracy of these methods. Our objective was to determine the accuracy of fixed-ratio and slope-based algorithms in healthy adults and in adults with cardiova...

    journal_title:Blood pressure monitoring

    pub_type: 临床试验,杂志文章

    doi:10.1097/MBP.0000000000000356

    authors: Padwal R,Jalali A,McLean D,Anwar S,Smith K,Raggi P,Ringrose JS

    更新日期:2019-02-01 00:00:00

  • Propaq Neonatal monitor used with its own single- or with Critikon twin-hose cuffs: does it matter?.

    abstract::Some oscillometric non-invasive blood pressure (NIBP) monitors use twin-hose cuffs, whereas others use single-hose cuffs. The incompatibility hinders the transfer of patients from monitors using a single-hose cuff to monitors using twin-hose cuffs and vice versa. In particular, the Propaq Encore uses a single-hose cuf...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章

    doi:

    authors: Amoore JN

    更新日期:1997-12-01 00:00:00

  • Endothelial dysfunction predicted increased left atrial volume index in newly diagnosed nondiabetic hypertensive patients.

    abstract:BACKGROUND:Arterial hypertension is associated with cardiovascular morbidity and mortality. It was previously shown that left atrium volume increase associated with mortality and atherosclerotic heart disease. The aim of the present study was to demonstrate the value of endothelial dysfunction in predicting left atrium...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章

    doi:10.1097/MBP.0000000000000419

    authors: Çetin M,Erdoğan T,Kiriş T,Aykan AÇ,Çinier G,Emlek N,Durak H,Kalaycioğlu E,Yilmaz AS

    更新日期:2020-04-01 00:00:00

  • Hypertension in psoriasis patients: based on office and ambulatory blood pressure measurement.

    abstract:OBJECTIVE:Psoriasis is a chronic inflammatory disorder, which is associated with high risk of metabolic comorbidities. Hypertension (HTN) is among the most common and serious associations. In this study, we aimed to evaluate HTN in psoriatic patients through office and ambulatory blood pressure monitoring (ABPM). MATE...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章

    doi:10.1097/MBP.0000000000000489

    authors: Abedini R,Najafi MT,Azizpour A,Nasimi M,Darreshiri M,Teymourpour A

    更新日期:2020-12-01 00:00:00

  • Assessment of antihypertensive efficacy by non-invasive ambulatory blood pressure monitoring.

    abstract::The session devoted to the usefulness of non-invasive ambulatory blood pressure monitoring (ABPM) in the evaluation of antihypertensive therapy allowed us to discuss a number of important issues. ABPM emerged as a widely accepted technique to measure blood pressure in clinical trials. Actually, it was generally consid...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章

    doi:

    authors: Asmar R,Waeber B

    更新日期:1996-06-01 00:00:00

  • Clinical test of a blood pressure measurement device with a wrist cuff.

    abstract::OBJECTIVE: To test a semi-automatic oscillometric blood pressure measurement device with a wrist cuff. METHODS: Two different test methods, partly based on European and American standards for clinical investigation of non-invasive sphygmomanometers, were worked out and compared. Mostly German guidelines were considere...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章

    doi:

    authors: Wonka F,Thümmler M,Schöppe A

    更新日期:1996-08-01 00:00:00

  • Using the Finometer to examine sex differences in hemodynamic responses to orthostasis in older people.

    abstract:OBJECTIVES:In young and middle age, women have higher orthostatic intolerance (OI) than men, and hemodynamic differences have been found supporting this finding. In older people, these sex differences are less studied. Our aim was to contribute evidence. METHODS:Two hundred and twenty-four community-dwelling older par...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章

    doi:10.1097/MBP.0b013e3283353199

    authors: Romero-Ortuno R,Cogan L,Foran T,Fan CW,Kenny RA

    更新日期:2010-02-01 00:00:00

  • Accuracy of automated auscultatory blood pressure measurement during supine exercise and treadmill stress electrocardiogram-testing.

    abstract:OBJECTIVES:Monitoring of brachial blood pressure during exercise-electrocardiogram (ECG) testing is mandatory and changes in blood pressure (BP) can provide critical management evidence. Patient movement, mechanical vibration, artifactual sounds and observer variability make standard manual techniques problematic. This...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章

    doi:10.1097/00126097-200410000-00007

    authors: Cameron JD,Stevenson I,Reed E,McGrath BP,Dart AM,Kingwell BA

    更新日期:2004-10-01 00:00:00

  • Rationale and design of HOMED-BP Study: hypertension objective treatment based on measurement by electrical devices of blood pressure study.

    abstract:BACKGROUND:How far should blood pressure (BP) be lowered to achieve the greatest reduction in the risk of cardiovascular disease? Although a few trials have tried to answer this question, they failed to convincingly establish an optimal target BP level, in part because of poor reproducibility and the wide variability o...

    journal_title:Blood pressure monitoring

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00126097-200202000-00016

    authors: Fujiwara T,Nishimura T,Ohkuko T,Imai Y,HOMED-BP Study Group.

    更新日期:2002-02-01 00:00:00

  • Comparison of ambulatory blood pressure reference standards in children evaluated for hypertension.

    abstract:OBJECTIVE:The purpose of this study was to systematically compare methods for standardization of blood pressure levels obtained by ambulatory blood pressure monitoring (ABPM) in a group of 111 children studied at our institution. METHODS:Blood pressure indices, blood pressure loads and standard deviation scores were c...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章

    doi:10.1097/MBP.0b013e32832ce11e

    authors: Jones DP,Richey PA,Alpert BS

    更新日期:2009-06-01 00:00:00

  • Relationship between noninvasive and invasive blood pressure values in end-stage renal disease patients on dialysis.

    abstract:BACKGROUND:End-stage renal disease (ESRD) is complicated by high blood pressure (BP) and severe atherosclerosis, which may lead to different values of BP measured by invasive and noninvasive methods. However, the differences in BP values between these two methods and their possible mechanisms in ESRD have not been inve...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章

    doi:10.1097/MBP.0000000000000026

    authors: Chen Y,Zhu Y,Chen C,Chen X,Pan H,Chen S,Tan X

    更新日期:2014-04-01 00:00:00

  • Comparison of two automated sphygmomanometers for use in the office setting.

    abstract:OBJECTIVE:To compare readings obtained using two automated blood pressure (BP) recording devices, BpTRU and Omron 907, in a clinical setting. METHODS:Two series of 50 patients attending a hypertension unit for 24-h ambulatory BP monitoring had BP recorded either every 1 or every 2 min using BpTRU and Omron 907 devices...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章

    doi:10.1097/MBP.0b013e32831e314f

    authors: Myers MG,Valdivieso M,Kiss A,Tobe SW

    更新日期:2009-02-01 00:00:00

  • 'Diagnostic mode' improves adherence to the home blood pressure measurement schedule.

    abstract:BACKGROUND:The accuracy of home blood pressure measurement (HBPM) depends on adherence to the measurement schedule. We investigated the number of deviations from the requested schedule using an HBPM device equipped with a diagnostic mode that only allows patients to take a fixed number of BP readings at preset times. ...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MBP.0b013e328357352a

    authors: Wessel SE,van der Hoeven NV,Cammenga M,van Montfrans GA,van den Born BJ

    更新日期:2012-10-01 00:00:00

  • Frequency of spontaneous fist clenching during routine blood pressure measurements and its effect on measurement accuracy.

    abstract:BACKGROUND:Guidelines for office blood pressure reading techniques do not warn us about the possibility that patients may clench their fist during cuff-inflation. It is unknown how often patients do this, and what effect it has on measured blood pressure readings. DESIGN AND METHODS:We registered double blood pressure...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章

    doi:10.1097/00126097-200206000-00001

    authors: Smulders YM,Godfried MH,van Montfrans GA

    更新日期:2002-06-01 00:00:00

  • Methods of data analysis of ambulatory blood pressure monitoring in clinical trials.

    abstract::The objectives of the analysis are to compare the blood pressure levels at different phases of the trial and to be sure that the effect will continue until the next dose. There are problems before the analysis for which consensus is necessary. If the overall 24 h study is the first generally recognized stage, it is di...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章

    doi:

    authors: de Gaudemaris R,Chau NP

    更新日期:1996-06-01 00:00:00

  • The effect of crossing legs on blood pressure.

    abstract:OBJECTIVE:To determine whether crossing of the legs at the knee or at the ankles during blood pressure measurement in sitting position has an effect on blood pressure. METHODS:One hundred and eleven patients, 60 women, mean age 52+/-17 years (19-80): 49 chronically treated hypertensives, 28 treated diabetics and 34 no...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章

    doi:10.1097/MBP.0b013e3280b083a7

    authors: Adiyaman A,Tosun N,Elving LD,Deinum J,Lenders JW,Thien T

    更新日期:2007-06-01 00:00:00

  • A psychophysiologic reaction to application of ambulatory blood pressure monitor: fact or artifact?

    abstract:BACKGROUND:The study investigated the clinical significance of relatively high blood pressure (BP) elevations during the calibration of the ambulatory blood pressure monitor (ABPM). METHODS:Inferences were drawn from the analysis of differences between 'M', the average of five manually triggered responses, and 'W', th...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章

    doi:10.1097/MBP.0b013e328340ff51

    authors: Yanovski A,Townsend RR,Virginia F,Michael C

    更新日期:2011-02-01 00:00:00

  • Relationship between waking-sleep blood pressure and catecholamine changes in African-American and European-American women.

    abstract:BACKGROUND:A blunted decline in waking to sleep blood pressure (BP) is more common in African-American (AA) than European-American (EA) women. The causes of reduced BP 'dipping' in AA women are not known, although several factors including ethnic differences in catecholamine sensitivity have been suggested. The purpose...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章

    doi:10.1097/MBP.0b013e3283078f45

    authors: van Berge-Landry HM,Bovbjerg DH,James GD

    更新日期:2008-10-01 00:00:00

  • A novel predictor of radial spasm: arterial stiffness.

    abstract:OBJECTIVE:In this study, we aimed to assess the relationship between radial artery spasm (RAS) and arterial stiffness (AS) measured by the oscillometric method. MATERIALS AND METHODS:A total of 123 consecutive patients scheduled for elective coronary angiography in a single default radial center were enrolled for the ...

    journal_title:Blood pressure monitoring

    pub_type: 杂志文章

    doi:10.1097/MBP.0000000000000340

    authors: Omaygenc MO,Karaca IO,Ibisoglu E,Günes HM,Kizilirmak F,Cakal B,Guler E,Barutcu I,Boztosun B

    更新日期:2018-10-01 00:00:00