Abstract:
:In 2004-2005, the antihypertensive effects of telmisartan 80 mg versus valsartan 160 mg combined with hydrochlorothiazide 25 mg were assessed in a large placebo-controlled trial in patients with stages 1 and 2 hypertension and demonstrated that both agents were highly effective in lowering blood pressure (BP) compared with placebo and that telmisartan lowered BP significantly greater than valsartan. To confirm this finding according to Food and Drug Administration guidelines, we performed a second large trial using the same design in an entirely separate patient population. The trial was double-blind with a 4 : 4 : 1 randomization scheme to compare once daily telmisartan 80 mg plus hydrochlorothiazide 25 mg versus once daily valsartan 160 mg plus hydrochlorothiazide 25 mg versus once daily placebo on reductions in seated clinic BP in patients with stages 1 and 2 hypertension. The primary endpoints were the changes from baseline in seated diastolic and systolic BP at the end of the 8-week treatment period. Safety endpoints included adverse events, changes in laboratory parameters and pulse rate. In total, 1185 patients were randomized (of which 1181 were treated and included in the primary analysis: 528 in the telmisartan-hydrochlorothiazide group, 523 in the valsartan-hydrochlorothiazide group, and 130 in the placebo group), changes from baseline in BP following telmisartan-hydrochlorothiazide (-24.6/-18.2 mmHg) were significantly greater than both placebo (-4.1/-6.1 mmHg) and valsartan-hydrochlorothiazide (-22.5/-17.0 mmHg) (versus placebo, P<0.0001 for systolic and diastolic BP; versus valsartan-hydrochlorothiazide, P=0.017 for systolic BP and P=0.025 for diastolic BP). The total number of patients with at least one adverse event reported was similar among the three treatment groups (placebo, 42%, telmisartan-hydrochlorothiazide, 36%, and valsartan-hydrochlorothiazide, 37%). Thus, this large, second trial confirms that telmisartan-hydrochlorothiazide at doses of 80/25 mg lowered both systolic and diastolic BP to a greater extent than valsartan-hydrochlorothiazide at doses of 160/25 mg in stages 1-2 hypertension. Although these are not the highest doses of these agents at present, at the time that the studies were conducted, they were the maximally approved dosages. Both studies support the strategy of using angiotensin receptor blockers with a higher dose of a thazide diuretic (25 mg) for enhancing the control of hypertension.
journal_name
Blood Press Monitjournal_title
Blood pressure monitoringauthors
White WB,Murwin D,Chrysant SG,Koval SE,Davidai G,Guthrie Rdoi
10.1097/MBP.0b013e3282f3859dsubject
Has Abstractpub_date
2008-02-01 00:00:00pages
21-7issue
1eissn
1359-5237issn
1473-5725pii
00126097-200802000-00004journal_volume
13pub_type
杂志文章,随机对照试验abstract::BACKGROUND: The lack of significant correlation between sodium consumption and blood pressure in a population has tentatively been explained by individual differences in salt sensitivity. Previously we have shown that one-third of essential hypertensived patients respond to a salt load of 9 g daily for 5 days with an ...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:
更新日期:1996-02-01 00:00:00
abstract:OBJECTIVES:The nondipper pattern in hypertension is associated with worse cardiovascular outcomes. In this study, we hypothesized that high copeptin levels could predict nondippers among hypertensive patients and investigated the associations between copeptin levels and nondipper pattern in newly diagnosed hypertensive...
journal_title:Blood pressure monitoring
pub_type: 临床试验,杂志文章
doi:10.1097/MBP.0000000000000123
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Humour is used commonly to relax subjects when their blood pressure is being measured. However the short-term effect of laughter on blood pressure is not described. METHODS:Sixteen normotensive volunteers had blood pressure measured using a validated automated oscillometric sphygmomanometric device (Omron 7...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/00126097-200504000-00010
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:It is commonly believed that the associations of left ventricular mass and cardiovascular morbidity/mortality with blood pressure are stronger for 24-h ambulatory pressure than for conventional clinic or casual pressure. METHODS:The investigation comprised a review of relevant studies, with particular empha...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,meta分析
doi:10.1097/00126097-200202000-00006
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:Obstructive sleep apnea-hypopnea syndrome (OSAHS) is common in people with hypertension and cardiac rhythm disorder. The objectives of this study were to determine the effect of short-term continuous positive airway pressure (CPAP) on blood pressure (BP) and cardiac rhythm in Chinese patients with moderate t...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0000000000000324
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:Measurement of office blood pressure using a fully automated sphygmomanometer that takes multiple readings with the patient resting quietly alone has been called automated office blood pressure (AOBP). Almost all AOBP research has involved the patient resting alone in an examining room, which is often impract...
journal_title:Blood pressure monitoring
pub_type: 临床试验,杂志文章
doi:10.1097/MBP.0000000000000133
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVE:To analyze whether the number of blood pressure registrations per hour and/or different ways of defining day and night have any influence on the result of ambulatory blood pressure monitoring. DESIGN AND METHODS:The study used blood pressure data from 40 normotensive subjects (20 men) and 40 (20 men) treated...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/00126097-200110000-00005
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:The independent prognostic significance of ambulatory blood pressure variability in the elderly is incompletely clear. We investigated the prognostic value of average real variability of 24-hour blood pressure in elderly treated hypertensive patients. METHODS:The occurrence of a combined end-point including ...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0000000000000381
更新日期:2019-08-01 00:00:00
abstract:INTRODUCTION:Seventeen male patients with severe obstructive sleep apnea syndrome (OSAS; apnea-hypopnea index>30/h) were monitored by polysomnography in the sleep lab before and after about 8 weeks of continuous positive airway pressure (CPAP). Twelve of the patients were hypertensive, but treated by antihypertensive d...
journal_title:Blood pressure monitoring
pub_type: 临床试验,杂志文章
doi:10.1097/MBP.0000000000000173
更新日期:2016-06-01 00:00:00
abstract::OBJECTIVE: To test a semi-automatic oscillometric blood pressure measurement device with a wrist cuff. METHODS: Two different test methods, partly based on European and American standards for clinical investigation of non-invasive sphygmomanometers, were worked out and compared. Mostly German guidelines were considere...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:End-stage renal disease (ESRD) is complicated by high blood pressure (BP) and severe atherosclerosis, which may lead to different values of BP measured by invasive and noninvasive methods. However, the differences in BP values between these two methods and their possible mechanisms in ESRD have not been inve...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0000000000000026
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:The pathogenesis of dialysis-induced hypotension (DIH) is multifactorial and may include increased aortic stiffness. This study was undertaken to determine aortic elastic properties in patients undergoing hemodialysis with and without DIH, and to assess the effects of DIH on mortality. METHODS:Aortic stiffn...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,多中心研究
doi:10.1097/MBP.0b013e3282f13f75
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:The ankle-brachial index (ABI) is the most useful and efficient tool for assessing the presence of peripheral artery disease (PAD). The aim of this study was to evaluate the effect of multiple sequential blood pressure (BP) measurements on the estimation of the ABI and the consequent diagnosis of PAD in a hig...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,随机对照试验
doi:10.1097/MBP.0b013e328351de79
更新日期:2012-04-01 00:00:00
abstract::Masked hypertension (blood pressure that is normal in the physicians' office but elevated elsewhere) is a common phenomenon as prevalence among studies varies from 8 to 45% and is seen at all ages. large discrepancies, however, exist between studies that have dealt with masked hypertension. It is of high clinical impo...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,评审
doi:10.1097/mbp.0b013e3280fb2792
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:Although there is a theoretical basis for crossing legs to increase blood pressure, there are no published data addressing this question. As a result guidelines for measurement of blood pressure are not consistent in recommending that patients legs should not be crossed during measurement. OBJECTIVE:To dete...
journal_title:Blood pressure monitoring
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1999-04-01 00:00:00
abstract::Hypertension is a major risk factor for cardiovascular morbidity and mortality. Therefore, blood pressure self-measuring devices have emerged as valuable tools in patient care and the accuracy of these instruments is of fundamental importance. For this reason, several validation procedures for assessing the efficacy o...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,评审
doi:10.1097/MBP.0000000000000150
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:We aimed to analyze the difference in 24-h blood pressure values during Ramadan of fasting and nonfasting individuals with no previous history of hypertension. PATIENTS AND METHODS:This study was planned as a multicenter research study in the cities of Izmit, Zonguldak, Sivas, and Adana. The percentage chang...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,多中心研究
doi:10.1097/MBP.0000000000000244
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVES:To determine blood pressure (BP) reassessment rates and to describe the evaluation and outpatient referral rates of elderly emergency department (ED) patients with elevated BP. METHODS:This was a retrospective cohort of patients who were at least 60 years, presented with a systolic BP of at least 140 mmHg o...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,多中心研究
doi:10.1097/MBP.0b013e328332fd40
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Fixed-ratio and slope-based algorithms are used to derive oscillometric blood pressure (BP). However, a paucity of published data exists assessing the accuracy of these methods. Our objective was to determine the accuracy of fixed-ratio and slope-based algorithms in healthy adults and in adults with cardiova...
journal_title:Blood pressure monitoring
pub_type: 临床试验,杂志文章
doi:10.1097/MBP.0000000000000356
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:The objective of this study was to assess the effect of feedback on medium-term blood pressure (BP) measurement skills in medical students versus a control group. METHODS:A randomized controlled trial in first-year medical students was conducted. After theoretical-practical training on measuring BP, the stu...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,随机对照试验
doi:10.1097/MBP.0000000000000433
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVES:To determine the accuracy of the A&D UB-511 (UB-512) oscillometric wrist-cuff device for self-measurement of blood pressure, the only difference between the two devices being the size of storage memory. METHODS:Device evaluation was performed according to the modified British Hypertension Society protocol r...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.mbp.0000217995.12215.f2
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:The German Hypertension League (Deutsche Hochdruckliga) established a program to assess the accuracy and reliability of blood pressure (BP)-measuring devices in 1999 (Quality Seal Protocol). Here, we report on the results of a testing series of 105 devices designed for BP self-measurement. METHODS:The test p...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0000000000000186
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Manufacturer-supplied blood pressure (BP) cuffs are part of the automatic oscillometric BP devices algorithm. MATERIALS AND METHODS:This study assessed the differences in BP values using the Omron HEM 907-XL (Omron) device with two types of cuffs: the Baum cuff (BC) and the supplied Omron cuff (OC). A sampl...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,随机对照试验
doi:10.1097/MBP.0000000000000208
更新日期:2016-12-01 00:00:00
abstract::The objectives of the analysis are to compare the blood pressure levels at different phases of the trial and to be sure that the effect will continue until the next dose. There are problems before the analysis for which consensus is necessary. If the overall 24 h study is the first generally recognized stage, it is di...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVE:The influence of the Ramadan fasting on blood pressure (BP) in patients taking diuretics therapy has not been addressed specifically yet. The aim of this study was to examine the effect of long Ramadan fasting on BP with ambulatory BP monitoring in hypertensive patients using diuretics. METHODS:This prospect...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0000000000000451
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVES:A number of operator-independent oscillometric devices to measure hemodynamics and arterial stiffness became available recently, but some and in particular VaSera VS-1500 do not provide estimates of aortic pressures and aortic pulse wave velocity (aPWV). The aim of this work was the retrospective application...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0000000000000137
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:This study was designed mainly to establish the rates of response to valsartan 80mg once daily (qd) and to valsartan 160mg qd given to non-responders to 80mg qd, as well as to determine the safety of valsartan and the blood pressure control achieved using valsartan over a period of 24 h or more, using ambulat...
journal_title:Blood pressure monitoring
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/00126097-200104000-00005
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVE:To determine whether crossing of the legs at the knee or at the ankles during blood pressure measurement in sitting position has an effect on blood pressure. METHODS:One hundred and eleven patients, 60 women, mean age 52+/-17 years (19-80): 49 chronically treated hypertensives, 28 treated diabetics and 34 no...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0b013e3280b083a7
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVES:Wide-range 'one-size-fits-all' blood pressure (BP) cuffs are commonly sold with home BP monitors. Assessment of the accuracy of these cuffs is important because they do not adhere to the basic principles of proper cuffing. The aim of this systematic review was to review the published validation data evaluati...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0000000000000344
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:There is increasing evidence that the method of calibration directly influences the association between brachial systolic blood pressure (bSBP) and estimated aortic systolic blood pressure (aSBP) and subsequently affects prognostic and diagnostic differentiation power of the latter. OBJECTIVE:The aim of thi...
journal_title:Blood pressure monitoring
pub_type: 临床试验,杂志文章
doi:10.1097/MBP.0000000000000319
更新日期:2018-06-01 00:00:00