HSPA1B polymorphism in familial forms of inflammatory dilated cardiomyopathy.


:Mutations in genes encoding cytoskeletal proteins participate in the pathogenesis of familial dilated cardiomyopathy (fDCM). Additional factors including inflammatory reactions are believed to play a role in deterioration of left-ventricular function. An association of inflammatory fDCM with the HSPA1B 1267 A-->G polymorphism was identified. Since the HSPA1B 1267 A-->G polymorphism has been associated with autoimmune disorders, this finding might point to a pathogenetic role of (auto-) immune phenomena in distinct forms of familial DCM. HSPA1B 1267 A-->G is part of an extended DR3 haplotype explaining the strong association between both alleles. Recombinant haplotype mapping including neighboring genes might aid in identification and classification of susceptibility genes which in turn can point to the not yet identified causative agent.


Int J Cardiol


Portig I,Kliebe F,Kliebe C,Ruppert V,Maisch B




Has Abstract


2009-03-20 00:00:00














  • From functional pulmonary atresia to right ventricular restriction. Long term follow up of Uhl's anomaly.

    abstract::We report a 14 year old boy who presented as a neonate with functional pulmonary atresia due to Uhl's disease with emphasis on the later detection of restrictive right ventricular physiology. ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Tumbarello R,Adatia I,Yetman A,Boutin C,Izukawa T,Freedom RM

    更新日期:1998-12-01 00:00:00

  • Percutaneous balloon dilatation of subaortic membrane using an Inoue balloon.

    abstract::Left ventricular outflow tract obstruction caused by a discrete subaortic membrane in a young female was successfully dilated using an Inoue balloon catheter. The Inoue balloon catheter was used in a retrograde manner via the femoral artery. ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Bahl VK,Bhargava B,Chandra S

    更新日期:1996-04-19 00:00:00

  • Is 3D echocardiography superior to 2D echocardiography in general practice? A systematic review of studies published between 2007 and 2012.

    abstract:BACKGROUND:Recent developments in 3-dimensional echocardiography (3DE) have resulted in smaller probes, faster data acquisition and wider applicability. In spite of this, there is still an ongoing debate as to its ability to provide additional information to 2DE in general hospital clinical practice. METHODS:A systema...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Ruddox V,Mathisen M,Bækkevar M,Aune E,Edvardsen T,Otterstad JE

    更新日期:2013-09-30 00:00:00

  • Improved percent-predicted peak VO2 is associated with lower risk of hospitalization in patients with coronary heart disease. Analysis from the FRIEND registry.

    abstract:BACKGROUND:Normal standards for peak oxygen consumption (VO2peak) are controversial because they tend to be population and protocol specific. This study was undertaken to examine the association between percentage of age-predicted VO2peak and all-cause hospital readmission in cardiac outpatients who were referred to an...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Chiaranda G,Myers J,Arena R,Kaminsky L,Sassone B,Pasanisi G,Mandini S,Pizzolato M,Franchi M,Napoli N,Guerzoni F,Caruso L,Mazzoni G,Grazzi G

    更新日期:2020-07-01 00:00:00

  • Prevalence of M4 macrophages within human coronary atherosclerotic plaques is associated with features of plaque instability.

    abstract:BACKGROUND:The platelet chemokine CXCL4 induces monocyte differentiation resulting in a macrophage phenotype called "M4", which co-expresses CD68, MMP7, and S100A8. We hypothesized that M4 macrophages are associated with plaque destabilization. METHODS:Atherosclerotic arteries were obtained from explanted hearts of pa...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Erbel C,Wolf A,Lasitschka F,Linden F,Domschke G,Akhavanpoor M,Doesch AO,Katus HA,Gleissner CA

    更新日期:2015-01-01 00:00:00

  • Long term outcome of mechanical valve prosthesis in the pulmonary position.

    abstract:OBJECTIVES:Assessment of the long term outcome of mechanical valve prosthesis at pulmonary position in a population of grown-up congenital heart disease patients from a tertiary referral center. METHODS:From 1977 to 2007, 22 consecutive patients underwent a total of 25 pulmonary valve replacements with mechanical pros...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Dos L,Muñoz-Guijosa C,Mendez AB,Ginel A,Montiel J,Padro JM,Subirana MT

    更新日期:2011-07-15 00:00:00

  • Effects of disopyramide on the atrial fibrillation threshold in the human atrium.

    abstract::The effects of disopyramide on the atrial fibrillation threshold (AFT) in the human atrium were investigated. To evaluate atrial vulnerability, the following electrophysiologic parameters were measured before and after the administration of disopyramide (2 mg/kg) in 12 patients with paroxysmal atrial fibrillation: The...

    journal_title:International journal of cardiology

    pub_type: 临床试验,杂志文章


    authors: Ishibashi K,Inoue D,Sakai R,Inoue M,Shirayama T,Asayama J,Nakagawa M

    更新日期:1995-11-24 00:00:00

  • Acute stress-induced cardiomyopathy: a brief observation.

    abstract::Acute stress-induced cardiomyopathy is a syndrome originally described in Japan but increasingly recognized all over the world. Patients typically present with chest pain triggered by an intense emotional or physiological stressor, electrocardiographic changes, and mild cardiac enzyme elevation. Patients typically ret...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Banihashemi MR,Khan IA

    更新日期:2009-05-15 00:00:00

  • QTc interval prolongation during infusion with dipyridamole or adenosine.

    abstract::The aim of our study was to discover whether there was a relationship between the QTc interval prolongation on the standard 12-lead electrocardiogram (ECG) and provoked myocardial ischemia. Since the increase of adenosine plasma levels, obtained either with adenosine or dipyridamole (an adenosine reuptake inhibitor) i...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Guideri F,Ferber D,Galgano G,Isidori S,Blardi P,Pasini FL,Di Perri T

    更新日期:1995-01-27 00:00:00

  • Circulating endothelial progenitor cells in congestive heart failure.

    abstract:BACKGROUND:Endothelial progenitor cells (EPCs) circulate in the adult peripheral blood and contribute to neovascularization. EPCs are considered to be included in CD34 positive mononuclear cells (CD34+ MNCs). Kinetics of circulating EPCs in congestive heart failure (CHF) has not been fully investigated. METHODS:We det...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Nonaka-Sarukawa M,Yamamoto K,Aoki H,Nishimura Y,Tomizawa H,Ichida M,Eizawa T,Muroi K,Ikeda U,Shimada K

    更新日期:2007-07-31 00:00:00

  • A prospective validation of the HEART score for chest pain patients at the emergency department.

    abstract:BACKGROUND:The focus of the diagnostic process in chest pain patients at the emergency department is to identify both low and high risk patients for an acute coronary syndrome (ACS). The HEART score was designed to facilitate this process. This study is a prospective validation of the HEART score. METHODS:A total of 2...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究


    authors: Backus BE,Six AJ,Kelder JC,Bosschaert MA,Mast EG,Mosterd A,Veldkamp RF,Wardeh AJ,Tio R,Braam R,Monnink SH,van Tooren R,Mast TP,van den Akker F,Cramer MJ,Poldervaart JM,Hoes AW,Doevendans PA

    更新日期:2013-10-03 00:00:00

  • Six-month follow-up evaluation for everolimus-eluting stents by intracoronary optical coherence tomography: comparison with paclitaxel-eluting stents.

    abstract:BACKGROUND:Although several clinical trials have shown the superior efficacy and safety of second-generation everolimus-eluting stents (EES) in comparison with first-generation paclitaxel-eluting stents (PES), the differences in the vascular healing process between EES and PES in a human coronary artery during an early...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Takano M,Murakami D,Yamamoto M,Kurihara O,Murai K,Inami T,Kimata N,Ohba T,Seino Y,Mizuno K

    更新日期:2013-06-05 00:00:00

  • New assessment of endothelial function measured by short time flow-mediated vasodilation: Comparison with conventional flow-mediated vasodilation measurement.

    abstract:BACKGROUND:Measurement of flow-mediated vasodilation (FMD) is an established method for assessing endothelial function. Measurement of FMD is useful for showing the relationship between atherosclerosis and endothelial function, mechanisms of endothelial dysfunction, and clinical implications including effects of interv...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Matsui S,Kajikawa M,Maruhashi T,Hashimoto H,Kihara Y,Chayama K,Goto C,Aibara Y,Yusoff FM,Kishimoto S,Nakashima A,Noma K,Kawaguchi T,Matsumoto T,Higashi Y

    更新日期:2018-08-15 00:00:00

  • Electromechanical delay by speckle-tracking echocardiography: A novel tool to distinguish between Brugada syndrome and isolated right bundle branch block.

    abstract:BACKGROUND:The electrocardiographic (ECG) definition of Brugada syndrome (BS) can be challenging because benign ECG abnormalities, such as right bundle branch block (RBBB), may mimic pathological ECG characteristics of BrS. However, although myocardial delay and deformation can be quantified by advanced imaging, it has...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: D'Ascenzi F,Sanz-De La Garza M,Anselmi F,Nunno L,Arbelo E,Jordà P,Marzotti T,Aprile F,Piu P,Natali BM,Brugada J,Sitges M,Mondillo S

    更新日期:2020-12-01 00:00:00

  • Fiftieth anniversary of aldosterone: from discovery to cardiovascular therapy.

    abstract::Half a century after the elucidation of its molecular structure, aldosterone is generating the greatest interest, not in the fields of endocrinology or renal medicine but in cardiology-where aldosterone over-activation is now perceived as detrimental in heart failure (HF) and ischaemic heart disease. Clinically, exces...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Tan LB,Schlosshan D,Barker D

    更新日期:2004-09-01 00:00:00

  • Critical potential of early cardiac surgery for infective endocarditis with cardio-embolic strokes.

    abstract:BACKGROUND:Early cardiac surgery may have a trade-off between stabilized hemodynamics with controlled infection and a risk of peri-operative death in patients with infective endocarditis (IE) complicated with cardio-embolic strokes. METHODS:We retrospectively studied clinical characteristics and outcomes in 68 consecu...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Suzuki M,Takanashi S,Ohshima Y,Nagatomo Y,Seki A,Takamisawa I,Tobaru T,Naito K,Kin H,Umemura J,Takayama M,Sumiyoshi T,Tomoike H

    更新日期:2017-01-15 00:00:00

  • Impaired glucose tolerance: a possible contributor to left ventricular hypertrophy and diastolic dysfunction.

    abstract:BACKGROUND:Approximately 40% of patients with heart failure have preserved left ventricular systolic function with latent diastolic dysfunction associated with left ventricular hypertrophy, suggesting that diastolic dysfunction participates in the pathophysiology of heart failure. However, the cause or prerequisite sta...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Fujita M,Asanuma H,Kim J,Liao Y,Hirata A,Tsukamoto O,Minamino T,Hori M,Goto M,Node K,Kitakaze M

    更新日期:2007-05-16 00:00:00

  • Regulation of ROS-independent ERK signaling rescues replicative cellular senescence in ex vivo expanded human c-kit-positive cardiac progenitor cells.

    abstract:BACKGROUNDS:Although the rescue of cellular senescence during ex vivo expansion of human-derived cardiac progenitor cells (hCPC) is critical for the application of autologous stem cell therapy in cardiovascular disease, the underlying molecular pathways during replicative senescence in hCPC have not been fully defined....

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Choi SH,Jung SY,Yoo SY,Yoo SM,Kim DY,Kang S,Baek SH,Kwon SM

    更新日期:2013-10-25 00:00:00

  • Paleopathology of cardiovascular diseases in South American mummies.

    abstract:BACKGROUND:Cardiovascular disease has emerged as the world's leading cause of death in the last century. An epidemiological focus of this disease that extends not only beyond the developed world but also far back into antiquity asks new questions about associated risk factors. Ancient mummies found in the Atacama deser...

    journal_title:International journal of cardiology

    pub_type: 历史文章,杂志文章


    authors: Gabrovsky AN,O'Neill KD,Gerszten E

    更新日期:2016-11-15 00:00:00

  • Variable effects of anti-diabetic drugs in animal models of myocardial ischemia and remodeling: a translational perspective for the cardiologist.

    abstract::Diabetes and heart failure are very prevalent, and affect each other's incidence and severity. Novel therapies to reduce post-myocardial infarction (MI) remodeling that progresses into heart failure are urgently needed, especially in diabetic patients. Clinical studies have suggested that some oral anti-diabetic agent...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Yin M,Westenbrink BD,Meissner M,van Gilst WH,de Boer RA

    更新日期:2013-11-30 00:00:00

  • Current antithrombotic agents for acute coronary syndromes: focus on bleeding risk.

    abstract::The formation of an intravascular thrombus underlies the clinical symptoms associated with acute coronary syndromes (ACS). Plaque rupture signals the recruitment and activation of platelets, initiation of the coagulation cascade, and generation of thrombin, resulting in the formation of a platelet-rich thrombus. Use o...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Bassand JP

    更新日期:2013-02-10 00:00:00

  • Surgical therapy for drug-refractory ventricular tachycardia: role of additional aneurysmectomy or bypass grafting.

    abstract::To assess whether additional aneurysmectomy and/or bypass grafting influence prognosis we studied 97 patients with recurrent sustained monomorphic ventricular tachycardia after an old myocardial infarction. All patients underwent subendocardial resection due to drug-refractory ventricular tachycardia. There were 41 pa...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Trappe HJ,Klein H,Frank G,Wenzlaff P,Lichtlen PR

    更新日期:1992-03-01 00:00:00

  • Degeneration of capsaicin sensitive sensory nerves enhances myocardial injury in acute myocardial infarction in rats.

    abstract:BACKGROUND:Evidence indicated an involvement of afferent nerves in the pathology of acute myocardial infarction. This study was undertaken to clarify the role and mechanisms by which the sensory afferent degeneration exacerbates the myocardial injury in acute myocardial infarction in rats. METHODS:The myocardial injur...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Zhang RL,Guo Z,Wang LL,Wu J

    更新日期:2012-09-20 00:00:00

  • Recovery of electrophysiological parameters after conversion of atrial fibrillation.

    abstract::We investigated the recovery of electrophysiological parameters from electrical remodeling after conversion of chronic lone atrial fibrillation in humans. Clinical studies have shown that the longer atrial fibrillation lasts, the more difficult it becomes to maintain the sinus rhythm after cardioversion. To explore th...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Sato T,Mitamura H,Kurita Y,Takeshita A,Shinagawa K,Miyoshi S,Kanki H,Hara M,Takatsuki S,Soejima K,Ogawa S

    更新日期:2001-07-01 00:00:00

  • A recurrent patent ductus arteriosus.

    abstract::Patent ductus arteriosus (PDA) can occur as part of more congenital cardiac malformations or as an isolate finding. Spontaneous, transcatheter, surgical closure, and pharmacological treatment have been reported. We present a case of recurrent PDA after the initial course of a pharmacological treatment. Also this case ...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Tulino V,Dattilo G,Tulino D,Marte F,Patanè S

    更新日期:2011-05-05 00:00:00

  • Blood rheological properties are strongly related to the metabolic syndrome in middle-aged Chinese.

    abstract::The current investigation sought to evaluate the relation between hemorheological properties and the metabolic syndrome. 1400 office workers aged 35 to 59 years were enrolled in this study. Waist circumference and blood pressure were determined. Plasma high-density lipoprotein (HDL cholesterol), triglyceride, fasting ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Zhang L,Pu K,Zhang SY,Ren WQ

    更新日期:2006-09-20 00:00:00

  • Acute coronary syndromes in low- and middle-income countries: Moving forward.

    abstract::Cardiovascular disease remains the leading cause of death worldwide, particularly in low- and middle-income countries (LMICs), with substantial mortality from acute coronary syndromes. These deaths, when compared against high-income countries, occur at younger ages, and, beyond the lives lost, often result in economic...

    journal_title:International journal of cardiology



    authors: Seligman B,Vedanthan R,Fuster V

    更新日期:2016-08-01 00:00:00

  • Calcium channel blocking drugs for chronic, stable angina.

    abstract::The slow channel calcium blocking drugs have been shown to be efficacious in patients with chronic stable angina. They provide effective first alternative therapy to beta-blockers in preventing recurrent episodes of myocardial ischemia in patients who do not tolerate treatment with beta-blocking drugs because of, for ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: O'Rourke RA

    更新日期:1982-01-01 00:00:00

  • Pharmacogenetic-guided and clinical warfarin dosing algorithm assessments with bleeding outcomes risk-stratified by genetic and covariate subgroups.

    abstract:BACKGROUND:Safe administration of warfarin presents challenges due to a narrow therapeutic INR range and significant variability in inter-individual dose response. Bleeding secondary to warfarin use is a leading cause of hospitalization. METHODS:Five warfarin dosing algorithms were assessed for accuracy of predicted c...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Dietz N,Ruff C,Giugliano RP,Mercuri MF,Antman EM

    更新日期:2020-10-15 00:00:00

  • Ultrafiltration for acute decompensated heart failure: a systematic review and meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:Current clinical guidelines recommend ultrafiltration (UF) for patients with acute decompensated heart failure (ADHF) who are unresponsive or resistant to diuretics. We systematically reviewed the latest randomized evidence on the efficacy and safety of UF in ADHF. METHODS:MEDLINE, EMBASE and the Cochrane d...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,meta分析,评审


    authors: Kwong JS,Yu CM

    更新日期:2014-03-15 00:00:00