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Do short-term markers of treatment efficacy predict long-term sequelae of pelvic inflammatory disease?

Abstract：

OBJECTIVE:This study was undertaken to assess whether short-term markers, often used to measure clinical cure after treatment for pelvic inflammatory disease, predict sequelae of lack of pregnancy, recurrent pelvic inflammatory disease, and chronic pelvic pain. STUDY DESIGN:Women with mild-to-moderate pelvic inflammatory disease were assessed after treatment initiation at 5 days for tenderness (n = 713) and at 30 days for tenderness, cervical infections and endometritis (n = 298). Pregnancy, recurrent pelvic inflammatory disease, and chronic pelvic pain were evaluated after 84 months, on average. RESULTS:Pelvic tenderness at 5 and at 30 days significantly elevated the risk for developing chronic pelvic pain; tenderness at 30 days was also significantly associated with recurrent pelvic inflammatory disease. However, pelvic tenderness at 5 and at 30 days was only modestly clinically predictive of chronic pelvic pain or recurrent pelvic inflammatory disease (positive predictive values 22.1-66.9%). No short-term marker significantly influenced the likelihood of achieving a pregnancy. CONCLUSION:Tenderness at 5 or 30 days did not accurately predict the occurrence of pelvic inflammatory disease-related reproductive morbidities.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Trautmann GM,Kip KE,Richter HE,Soper DE,Peipert JF,Nelson DB,Trout W,Schubeck D,Bass DC,Ness RB

doi

10.1016/j.ajog.2007.05.021

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

30.e1-7

issue

1

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(07)00635-7

journal_volume

198

pub_type

杂志文章,多中心研究,随机对照试验

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