Tormentil for active ulcerative colitis: an open-label, dose-escalating study.

Abstract:

BACKGROUND:Tormentil extracts (TE) have antioxidative properties and are used as a complementary therapy for chronic inflammatory bowel disease. In individual patients with ulcerative colitis (UC) positive effects have been observed. GOALS:To assess the safety, pharmacology, and clinical effects of different doses of TE in patients with active UC. STUDY:Sixteen patients with active UC [clinical activity index (CAI) >/=5] received TE in escalating doses of 1200, 1800, 2400 and 3000 mg/d for 3 weeks each. Each treatment phase was followed by a 4-week washout phase. The outcome parameters were side effects, CAI, C-reactive protein, and tannin levels in patient sera. RESULTS:Mild upper abdominal discomfort was experienced by 6 patients (38%), but did not require discontinuation of the medication. During therapy with 2400 mg TE per day, median CAI and C-reactive protein improved from 8 (6 to 10.75) and 8 (3 to 17.75) mg/L at baseline to 4.5 (1.75 to 6) and 3 (3 to 6) mg/L, respectively. During therapy, the CAI decreased in all patients, whereas it increased during the washout phase. Neither undegraded nor metabolized tannins could be detected by liquid-mass spectrometry (LC-MS) in patient sera. CONCLUSIONS:TE appeared safe up to 3000 mg/d. Tannins from TE are not systemically absorbed. The efficacy in patients with UC should be further evaluated.

journal_name

J Clin Gastroenterol

authors

Huber R,Ditfurth AV,Amann F,Güthlin C,Rostock M,Trittler R,Kümmerer K,Merfort I

doi

10.1097/MCG.0b013e31804b2173

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

834-8

issue

9

eissn

0192-0790

issn

1539-2031

pii

00004836-200710000-00008

journal_volume

41

pub_type

杂志文章
  • Endoscopic and surgical therapy for intrahepatic cholangiocarcinoma in the united states: a population-based study.

    abstract:BACKGROUND:Intrahepatic cholangiocarcinoma (ICC) is a highly fatal disease with limited therapeutic options. The determinants, trends, and outcomes of different therapies for ICC are largely unknown in the United States. METHODS:Using data from the Surveillance, Epidemiology, and End-Results-(SEER) Medicare database, ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e31802f3132

    authors: Shaib YH,Davila JA,Henderson L,McGlynn KA,El-Serag HB

    更新日期:2007-11-01 00:00:00

  • Nephrolithiasis and intestinal disease.

    abstract::Kidney stones in patients with inflammatory bowel disease are usually composed of calcium oxalate. Two factors are important in the increased absorption of dietary oxalate which is responsible for those stones: 1) increased absorption of oxalate in the presence of steatorrhea, and 2) increased permeability of the colo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198502000-00002

    authors: Dobbins JW

    更新日期:1985-02-01 00:00:00

  • Comparative analysis of noninvasive models to predict early liver fibrosis in hepatitis B e Antigen-negative Chronic Hepatitis B.

    abstract:BACKGROUND:Portal or bridging fibrosis is an indication for antiviral treatment in patients with chronic hepatitis B (CHB). An early marker predictive of liver fibrosis in hepatitis B e antigen (HBeAg)-negative CHB patients can alert clinicians to plan for treatment before disease progression. GOALS:To predict early a...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3181dd5357

    authors: Lee IC,Chan CC,Huang YH,Huo TI,Chu CJ,Lai CR,Lee PC,Su CW,Hung HH,Wu JC,Lin HC,Lee SD

    更新日期:2011-03-01 00:00:00

  • Small intestinal changes in enterocolitis complicating Hirschsprung's disease.

    abstract::Hirschsprung's disease is one of the more common causes of childhood bowel obstruction. The disease can cause enterocolitis which, untreated, may result in considerable mortality. We describe our evaluation of two infants who suffered from intractable diarrhea of infancy secondary to Hirschsprung's disease. We found t...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-197909000-00009

    authors: Branski D,Lebenthal E

    更新日期:1979-09-01 00:00:00

  • Duodenal ulcer therapy with low-dose antacids: a multicenter trial.

    abstract::One hundred outpatients with endoscopically verified duodenal ulcer were treated in a double-blind, randomized, multicenter trial with either low-dose antacid (AA, Supralox, 1 tablet three times a day 1 h a.c. and 2 tablets at bedtime, with acid binding capacity of 225 mEq) or misoprostol (MS, Cytotec, 400 micrograms ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00004836-199112001-00025

    authors: Nauert C,Caspary WF

    更新日期:1991-01-01 00:00:00

  • Digital Chromoendoscopy With i-Scan for In Vivo Prediction of Advanced Colorectal Neoplasia: A Multicenter Study.

    abstract:BACKGROUND:Recent studies have analyzed the potential of advanced endoscopic imaging techniques for differentiating hyperplastic and adenomatous colorectal lesions. Latest endoscopic resection techniques now also allow for treatment of more advanced staged lesions including treatment of early cancerous lesions. AIMS:T...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MCG.0000000000000527

    authors: Albrecht H,Nägel A,Tasdelen H,Rath T,Grauer M,Vieth M,Neurath MF,Neumann H

    更新日期:2016-11-01 00:00:00

  • Follow-up of a patient with chronic hepatitis C-associated cryoglobulinemia during four and a half years of maintenance interferon treatment.

    abstract::In this report, we present a patient with chronic hepatitis C-associated cryoglobulinemia who was kept on maintenance interferon treatment because of flare-ups in cryoglobulinemia-associated signs and hepatitis after withdrawal, dose reduction, and increase in dose intervals of interferon. This type of interferon use ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200110000-00015

    authors: Celik AF,Ozaras R,Ozbay G

    更新日期:2001-10-01 00:00:00

  • Serum lipid and fat-soluble vitamin levels in primary sclerosing cholangitis.

    abstract::We reviewed the initial lipid and fat-soluble vitamin levels in 56 patients with primary sclerosing cholangitis (PSC) enrolled in a randomized, placebo-controlled trial evaluating ursodeoxycholic acid. We also evaluated lipid and vitamin levels in a group of 87 patients with advanced PSC being evaluated for liver tran...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004836-199504000-00011

    authors: Jorgensen RA,Lindor KD,Sartin JS,LaRusso NF,Wiesner RH

    更新日期:1995-04-01 00:00:00

  • Plasma intestinal fatty acid-binding protein levels correlate with morphologic epithelial intestinal damage in a human translational ischemia-reperfusion model.

    abstract:BACKGROUND AND AIM:Intestinal fatty acid-binding protein (I-FABP) is a useful marker in the detection of intestinal ischemia. However, more insight into the test characteristics of I-FABP release is needed. This study aimed to investigate the relationship between plasma I-FABP levels and the severity of ischemic mucosa...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3182a87e3e

    authors: Schellekens DH,Grootjans J,Dello SA,van Bijnen AA,van Dam RM,Dejong CH,Derikx JP,Buurman WA

    更新日期:2014-03-01 00:00:00

  • Alcoholic recidivism after liver transplantation for alcoholic cirrhosis.

    abstract::Liver transplantation (LT) for alcoholic cirrhosis remains controversial. This controversy surrounding LT in alcoholics focuses on the risk of alcohol recidivism and on potential noncompliance with the immunosuppressive regimen, both of which result in graft failure. Our study examined alcohol recidivism after LT by m...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199804000-00011

    authors: Fábrega E,Crespo J,Casafont F,De las Heras G,de la Peña J,Pons-Romero F

    更新日期:1998-04-01 00:00:00

  • Same-day Versus Split-dose Bowel Preparation Before Colonoscopy: A Meta-analysis.

    abstract:BACKGROUND:Split-dose regimens (SpDs) were recommended as a first choice for bowel preparation, whereas same-day regimens (SaDs) were recommended as an alternative; however, randomized trials compared them with mixed results. The meta-analysis was aimed at clarifying efficacy level between the 2 regimens. MATERIALS AN...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.1097/MCG.0000000000000860

    authors: Cheng YL,Huang KW,Liao WC,Luo JC,Lan KH,Su CW,Wang YJ,Hou MC

    更新日期:2018-05-01 00:00:00

  • Ultrasonography-guided percutaneous radiofrequency ablation for treatment of a huge symptomatic hepatic cavernous hemangioma.

    abstract::Hepatic cavernous hemangioma is the most common benign tumor of the liver. Appropriate management of this tumor remains a controversial topic. We have accumulated a number of cases with successful management of local hepatic tumors. Here we report a case where we performed an ultrasound-guided percutaneous radiofreque...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000196404.07487.1d

    authors: Tak WY,Park SY,Jeon SW,Cho CM,Kweon YO,Kim SK,Choi YH,Chung JM

    更新日期:2006-02-01 00:00:00

  • Intestinal Failure: Adaptation, Rehabilitation, and Transplantation.

    abstract::Intestinal failure (IF) is a state in which the nutritional demands are not met by the gastrointestinal absorptive surface. A majority of IF cases are associated with short-bowel syndrome, which is a result of malabsorption after significant intestinal resection for numerous reasons, some of which include Crohn's dise...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0000000000000512

    authors: Bharadwaj S,Tandon P,Meka K,Rivas JM,Jevenn A,Kuo NT,Steiger E

    更新日期:2016-05-01 00:00:00

  • Predicting clinical recovery from alcoholic liver disease.

    abstract::We postulated that three tests could be used to advantage in the prognosis of patients with alcoholic liver disease. Ninety-eight patients who entered the hospital in hepatic failure, and who survived that illness, were observed for an average of 3.5 years after discharge. At the time of entry, most had jaundice, asci...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198308000-00003

    authors: Patek AJ Jr,Koff RS

    更新日期:1983-08-01 00:00:00

  • Chronic Pneumocystis carinii infection of the liver. A case report and review of the literature.

    abstract::Pneumocystis carinii infection of the liver is being reported with increasing frequency in patients with acquired immune deficiency syndrome (AIDS). The clinical picture typically resembles hepatitis. We report such an occurrence in a patient with persistent elevation of alkaline phosphatase and gamma-glutamyl transpe...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199207000-00013

    authors: Merkel IS,Good CB,Nalesnik M,Roseman SR

    更新日期:1992-07-01 00:00:00

  • Comparison of commercially available serologic kits for the detection of celiac disease.

    abstract:BACKGROUND:The sensitivity and specificity of current antihuman tissue transglutaminase (tTG) IgA assays used to detect celiac disease reportedly approach 100%. In addition, the sensitivity of new generation deamidated gliadin peptide (alpha-DGP) antibody assays has also been reported to be similar to the tTG IgA assay...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e31816200e5

    authors: Naiyer AJ,Hernandez L,Ciaccio EJ,Papadakis K,Manavalan JS,Bhagat G,Green PH

    更新日期:2009-03-01 00:00:00

  • Push enteroscopy in the era of capsule endoscopy.

    abstract:GOALS:To evaluate the diagnostic yield of push enteroscopy in relation to indication and compare the yield in patients who had capsule endoscopy followed by push enteroscopy against capsule endoscopy naive patients. BACKGROUND:With the advent of capsule endoscopy the role of push enteroscopy needs to be reevaluated. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000225655.85060.74

    authors: Sidhu R,McAlindon ME,Kapur K,Hurlstone DP,Wheeldon MC,Sanders DS

    更新日期:2008-01-01 00:00:00

  • Orocecal transit time and bacterial overgrowth in patients with Crohn's disease.

    abstract::Bacterial overgrowth is frequent in patients with Crohn's disease (CD) and can contribute to symptoms. Motility abnormalities can predispose to bacterial overgrowth. The hydrogen (H2) and methane (CH4) breath test is a sensitive and simple tool for the diagnosis of bacterial overgrowth and for the evaluation of orocec...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200007000-00015

    authors: Castiglione F,Del Vecchio Blanco G,Rispo A,Petrelli G,Amalfi G,Cozzolino A,Cuccaro I,Mazzacca G

    更新日期:2000-07-01 00:00:00

  • Hepatic iron overload or cirrhosis may occur in acquired copper deficiency and is likely mediated by hypoceruloplasminemia.

    abstract:BACKGROUND:The metabolic fates of copper and iron are closely linked through ceruloplasmin and hephaestin. Ceruloplasmin is the principal copper carrying protein and decreases in acquired copper deficiency. Congenital absence of ceruloplasmin (aceruloplasminemia) results in tissue iron overload. Animal studies suggest ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3181dc25f7

    authors: Thackeray EW,Sanderson SO,Fox JC,Kumar N

    更新日期:2011-02-01 00:00:00

  • Histologic findings and Helicobacter pylori in duodenal biopsies.

    abstract::We have studied the morphologic aspects of the duodenal bulb in relation to Helicobacter pylori infection in a large group of patients with endoscopically assessed duodenitis to learn more about the pathogenesis of nonspecific duodenitis (bulbitis) and to clarify the specific role of H. pylori. Eight duodenal biopsy s...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199801000-00020

    authors: Caselli M,Gaudio M,Chiamenti CM,Trevisani L,Sartori S,Saragoni L,Boldrini P,Dentale A,Ruina M,Alvisi V

    更新日期:1998-01-01 00:00:00

  • Long-term prognosis for patients with ulcerative proctosigmoiditis (ulcerative colitis confirmed to the rectum and sigmoid colon).

    abstract::Despite its frequency, ulcerative proctosigmoiditis is poorly recognized and its prognosis is not well understood. This study reviews experience at the Cleveland Clinic from 1960 through 1972, with a 97% follow-up. A total of 359 patients with a diagnosis of ulcerative proctosigmoiditis were followed for a mean of 11 ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-197903000-00006

    authors: Farmer RG

    更新日期:1979-03-01 00:00:00

  • Validation of a graded response questionnaire for the diagnosis of gastroesophageal reflux disease in an Asian primary care population.

    abstract:BACKGROUND:Diagnosis of gastroesophageal reflux disease (GERD) based on subjective evaluation of symptoms alone is challenging. GOALS:To test the validity and reliability of a graded response questionnaire to identify patients with GERD. STUDY:Patients presenting with upper abdominal symptoms for more than a month, a...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3180653613

    authors: Ho KY,Gwee KA,Khor JL,Selamat DS,Yeoh KG

    更新日期:2008-07-01 00:00:00

  • Impact of Knowledge and Risk Perceptions on Older Adults' Intention for Surveillance Colonoscopy.

    abstract:GOALS:The authors aimed to characterize older adults' intentions for future surveillance colonoscopy, knowledge of polyps, and predictors of colonoscopy plans. BACKGROUND:Guidelines recommend that the decision to continue or stop surveillance colonoscopy in older adults with colon polyps be "individualized." Although ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001401

    authors: Calderwood AH,Carter C,Durand MA,O'Connor S,Boardman M

    更新日期:2020-07-29 00:00:00

  • Microvascular endothelium--a major target for alcohol injury of the human gastric mucosa. Histochemical and ultrastructural study.

    abstract::In healthy volunteers, we studied the effect in intragastric administration of 100 ml 40% alcohol or isotonic saline on the ultrastructure of gastric oxyntic mucosa with emphasis on gastric mucosal microvasculature. We found that a single dose of 40% alcohol produces exfoliation of the surface epithelium, damage to th...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Tarnawski A,Stachura J,Gergely H,Hollander D

    更新日期:1988-01-01 00:00:00

  • Nodules less than 20 mm and vascular invasion are predictors of survival in small hepatocellular carcinoma.

    abstract:BACKGROUND:The aims of this study were to analyze the overall survival of patients with cirrhosis and small hepatocellular carcinoma (HCC) and identify independent pretreatment predictors of survival in Brazil. METHODS:Between 1998 and 2003, 74 patients with cirrhosis and small HCC were evaluated. Predictors of surviv...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e31817ff199

    authors: Kikuchi LO,Paranaguá-Vezozzo DC,Chagas AL,Mello ES,Alves VA,Farias AQ,Pietrobon R,Carrilho FJ

    更新日期:2009-02-01 00:00:00

  • Issues in hyperlipidemic pancreatitis.

    abstract::Hypertriglyceridemia (HTG) is a rare cause of pancreatitis. Pancreatitis secondary to HTG, presents typically as an episode of acute pancreatitis (AP) or recurrent AP, rarely as chronic pancreatitis. A serum triglyceride (TG) level of more than 1,000 to 2,000 mg/dL in patients with type I, IV, or V hyperlipidemia (Fre...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-200301000-00016

    authors: Yadav D,Pitchumoni CS

    更新日期:2003-01-01 00:00:00

  • Effect of acute mucosal exposure to Lactobacillus rhamnosus GG on human colonic smooth muscle cells.

    abstract:AIM:To define whether human colonic mucosa exposure to Lactobacillus rhamnosus GG (LGG), American Type Culture Collection (ATCC) 53103, may influence intestinal muscle cell contractility. METHODS:Human colon specimens were obtained from disease-free margins of resected segments for cancer. The mucosa and submucosa, af...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e31817e1cac

    authors: Guarino MP,Altomare A,Stasi E,Marignani M,Severi C,Alloni R,Dicuonzo G,Morelli L,Coppola R,Cicala M

    更新日期:2008-09-01 00:00:00

  • The association between metabolic syndrome and colorectal neoplasm: systemic review and meta-analysis.

    abstract:BACKGROUND:There has been constant speculation about the association between metabolic syndrome (MetS) and colorectal neoplasia (CN); however, the published results are conflicting. The aims of this study are to conduct a systematic search, and assess the literature to determine the available evidence on the associatio...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MCG.0b013e3182688c15

    authors: Jinjuvadia R,Lohia P,Jinjuvadia C,Montoya S,Liangpunsakul S

    更新日期:2013-01-01 00:00:00

  • Characterizing Abdominal Pain in Patients With Gastroparesis Into Neuropathic and Nociceptive Components.

    abstract:INTRODUCTION:The cause of abdominal pain (AP) in gastroparesis (Gp) is often not known; hence, its treatment can be challenging. Preoccupation with or increased attention (hypervigilance) to pain is associated with perceived pain severity and psychosocial disability. The aims of this study were to (1) characterize AP i...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001059

    authors: Jehangir A,Abdallah RT,Parkman HP

    更新日期:2019-07-01 00:00:00

  • Progression to cirrhosis in Latinos with chronic hepatitis C: differences in Puerto Ricans with and without human immunodeficiency virus coinfection and along gender.

    abstract:BACKGROUND:Hepatitis C virus (HCV) infection is prevalent in Latinos. There is some evidence that progression to cirrhosis is more rapid. END POINTS:To calculate time of cirrhosis from time of HCV infection in a large Latino population. Other end points were to assess variables that predict cirrhosis and the effect of...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000210105.66994.dc

    authors: Rodríguez-Torres M,Ríos-Bedoya CF,Rodríguez-Orengo J,Fernández-Carbia A,Marxuach-Cuétara AM,López-Torres A,Salgado-Mercado R,Bräu N

    更新日期:2006-04-01 00:00:00