Abstract：
OBJECTIVE:To determine whether zinc with oral rehydration solution (ORS) is more cost effective than ORS alone in the treatment of acute diarrhea. STUDY DESIGN AND SETTING:Cost-effectiveness analysis among patients consulting the emergency room of a government institution. METHOD:Cost of treatment and outcome of participants of a randomized trial of zinc+ORS vs. ORS alone for acute diarrhea were investigated. Included were subjects 2-59 months with diarrhea <7 days and no dehydration. The direct medical, nonmedical and indirect costs were obtained, using the societal perspective. The incremental cost-effectiveness ratio (ICER) was calculated. RESULTS:Sixty patients were given zinc+ORS and 57 were given ORS alone. Mean duration of diarrhea was 17 hours shorter and mean total cost of treatment was 5% cheaper in the zinc than ORS group . The ICER showed that with use of zinc, the society saves $ 2.4 per day of diarrhea <4 days and spends $ 0.03 per case of diarrhea averted <4 days from consult, although the confidence interval included the null value of zero. CONCLUSION:Use of zinc with ORS reduced the total cost and duration of acute diarrhea. The ICER suggests cost effectiveness of zinc supplementation but there is a need to further assess the role of zinc supplementation in a larger population.
journal_name
J Clin Epidemioljournal_title
Journal of clinical epidemiologyauthors
Gregorio GV,Dans LF,Cordero CP,Panelo CAdoi
10.1016/j.jclinepi.2006.08.004subject
Has Abstractpub_date
2007-06-01 00:00:00pages
560-6issue
6eissn
0895-4356issn
1878-5921pii
S0895-4356(06)00321-0journal_volume
60pub_type
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journal_title：Journal of clinical epidemiology
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journal_title：Journal of clinical epidemiology
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abstract：OBJECTIVES:We sought to identify the proportion of systematic reviews of adverse effects which search for unpublished data and the success rates of identifying unpublished data for inclusion in a systematic review. STUDY DESIGN AND SETTING:Two reviewers independently screened all records published in 2014 in the Datab...
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abstract：OBJECTIVE:A method to generate hypotheses about iatrogenic risk factors and complications from administrative data was developed and tested using hospitalization of the elderly for depression as a model. STUDY DESIGN AND SETTING:Hospital claims were selected for 30,998 elderly inpatients admitted for the first time fo...
journal_title：Journal of clinical epidemiology
pub_type： 杂志文章
doi：10.1016/j.jclinepi.2004.08.002
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abstract：OBJECTIVE:The Kaplan-Meier method may overestimate absolute mortality risk (AMR) in the presence of competing risks. Urgent heart transplantation (UHT) and ventricular assist device implantation (VADi) are important competing events in heart failure. We sought to quantify the extent of bias of the Kaplan-Meier method i...
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abstract：OBJECTIVES:Interpretation of clinical research findings using the paradigm of null hypothesis significance testing has a number of limitations. These include arbitrary dichotomization of results, lack of incorporation of study power and prior probability, and the confusing use of conditional probability. This study aim...
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journal_title：Journal of clinical epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1016/s0895-4356(98)00148-6
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abstract：:Validation of the London School of Hygiene (Rose) Questionnaire with objective measures of myocardial ischemia is incomplete. Therefore, we compared the Rose Questionnaire with exercise thallium-201 myocardial scintigraphy in 147 male and 97 female patients with chest pain referred for clinical exercise testing. Of th...
journal_title：Journal of clinical epidemiology
pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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journal_title：Journal of clinical epidemiology
pub_type： 杂志文章
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更新日期：1995-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
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journal_title：Journal of clinical epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jclinepi.2009.01.021
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pub_type： 杂志文章,评审
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更新日期：2011-09-01 00:00:00
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更新日期：2018-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2002-05-01 00:00:00
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journal_title：Journal of clinical epidemiology
pub_type： 杂志文章
doi：10.1016/j.jclinepi.2013.10.008
更新日期：2014-05-01 00:00:00
abstract：:The "iatrotropic stimulus" is a typical example of Alvan Feinstein's terminology and his clinical way of thinking about medical research. Feinstein specified "interiatric referral" as an additional important factor affecting "the likelihood that patients will appear at the particular setting in which research is being...
journal_title：Journal of clinical epidemiology
pub_type： 杂志文章
doi：10.1016/s0895-4356(02)00528-0
更新日期：2002-12-01 00:00:00
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更新日期：2012-03-01 00:00:00
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更新日期：2016-01-01 00:00:00
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更新日期：2019-11-01 00:00:00
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journal_title：Journal of clinical epidemiology
pub_type： 杂志文章
doi：10.1016/j.jclinepi.2015.05.001
更新日期：2016-01-01 00:00:00
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journal_title：Journal of clinical epidemiology
pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
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pub_type： 杂志文章,meta分析,评审
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更新日期：2013-03-01 00:00:00
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journal_title：Journal of clinical epidemiology
pub_type： 杂志文章
doi：10.1016/j.jclinepi.2015.01.009
更新日期：2015-11-01 00:00:00
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journal_title：Journal of clinical epidemiology
pub_type： 杂志文章
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更新日期：2014-12-01 00:00:00
