Abstract：
BACKGROUND:Implantation of neural cells has been proposed as a therapeutic strategy for repairing the injured or diseased brain. In the present study we have examined the potential of olfactory ensheathing cells (OEC) to promote brain repair after surgical implantation in a rodent model of parkinsonism. METHODS:Neonatal OECs were implanted in the striatum after a 6-hydroxydopamine lesion of the ipsilateral substantia nigra. Amphetamine-induced rotational asymmetry scores were determined 48 hours before and 4, 6 and 8 weeks after OEC implantation. The density of immunostaining for tyrosine hydroxylase and synaptophysin in the striatum and the number of tyrosine hydroxylase-positive cells remaining in the substantia nigra were also determined. RESULTS:Rotational asymmetry scores were similar in OEC-implanted and vehicle-treated groups at all time points examined, and at each time were similar to those observed prior to implantation. Levels of striatal tyrosine-hydroxylase and synaptophysin immunoreactivity were similar in OEC- and vehicle-treated groups. The number of tyrosine-hydroxylase-positive cells in the substantia nigra was similar in both groups indicating that severity of the lesion was similar. Visualisation of GFP-labelled OECs one week after implantation in a separate group of animals revealed the cells to be located in the area immediately surrounding the needle tract. CONCLUSION:This study demonstrates that implantation of OECs alone is not sufficient to promote tissue repair and functional recovery in a rodent model of parkinsonism. The results add to a growing number of studies that propose a caveat for the use of pure OECs as a neurosurgical strategy for the treatment of brain disease or injury.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Dewar D,Bentley D,Barnett SCdoi
10.1007/s00701-007-1121-5subject
Has Abstractpub_date
2007-01-01 00:00:00pages
407-14issue
4eissn
0001-6268issn
0942-0940journal_volume
149pub_type
杂志文章abstract：:The monoclonal antibody Ki-67 has been tested as a marker of proliferating cells in 52 stereotactic brain tumour biopsies. The antibody reacts with a nuclear protein expressed in G1,S, G2n and M-phases of the cell cycle. Using the immunoperoxidase technique on squash preparations the percentage of Ki-67 positive cells...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01560376
更新日期：1987-01-01 00:00:00
abstract：:The article presents an autosomal dominant Currarino syndrome with incomplete penetrance in three out of four members of the same family. The mother had only a bony sacral defect and no other signs. In the older daughter, the syndrome was completely developed with presacral cystic teratoma, a sacral defect and abdomin...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-009-0220-x
更新日期：2009-09-01 00:00:00
abstract：PURPOSE:To analyse the intraoperative complications of a single neurosurgeon, with emphasis on devastating intraoperative incidents, and how they possibly could have been avoided. METHODS:All the patients operated upon by the author between 1986 and 2002, i.e. 252 patients with 270 craniotomies for 294 aneurysms, were...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-009-0452-9
更新日期：2009-09-01 00:00:00
abstract：OBJECTIVE:This study is aimed to describe the observable anatomical variants of the innervation of extensor hallucis longus muscle (EHLM) in order to have the surgical coordinates to perform neurotomy on the targeted branches of its innervation and to give a valuable alternative to the commonly used technique of fascic...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-009-0504-1
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:Predicting the fate of patients who are given a misdiagnosis of aneurysmal subarachnoid hemorrhage (aSAH) remains unclear. The purpose was to examine factors associated with initial misdiagnosis of aSAH and to investigate the impact of initial misdiagnosis of aSAH on clinical outcomes. METHODS:Between Janua...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-018-3552-6
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:The effect of anterior cervical discectomy without fusion (ACD), ACD with fusion by stand-alone cage (ACDF) or with arthroplasty (ACDA) on cervical sagittal alignment is not known and is the subject of this study. METHODS:A total of 142 adult patients with single-level cervical disease were at random alloca...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00701-017-3312-z
更新日期：2017-12-01 00:00:00
abstract：:In the last 3.5 years (up to August 1988) out of 450 patients with surgically treated intracranial aneurysms in 100 cases (22%) acute surgery was performed (up to 72 h after SAH). Patients in grade I-III (WFNS scale) were operated upon. In all the cases there were supratentorial aneurysms. CSF drainage during the oper...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01420184
更新日期：1990-01-01 00:00:00
abstract：:The purification of a substance which protects mitochondrial activity against its decay in association with various cerebral pathologies, and the effect of this substance in vitro and in vivo have been mentioned. Defatted egg albumin was hydrolyzed with pronase, and diafiltrated through mesh, to obtain fractions of mo...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01405239
更新日期：1977-01-01 00:00:00
abstract：OBJECTIVES:The purpose of this report was to review our experience with stereotactic radiosurgery in the management of patients with residual neurocytomas after initial surgery. METHODS:Between October 1996 and December 2001, four patients with central neurocytoma were treated by surgery and subsequently underwent lin...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-003-0076-4
更新日期：2003-09-01 00:00:00
abstract：:BAK-C is a new autostabilizing interbody cage which is implanted during an anterior cervical procedure to provide stability to the motion segment and allow fusion to occur. Special instrumentation is provided with a bone collecting reamer. The system utilizes surgical site bone graft as the osteo-inductive material wi...
journal_title：Acta neurochirurgica
pub_type： 临床试验,杂志文章
doi：10.1007/s007010050049
更新日期：1998-01-01 00:00:00
abstract：:Two cases of primary extraosseous intradural spinal Ewing's sarcoma are reported with a review of the current literature. This rare neoplasm shares features with cerebral primitive neuroectodermal tumors, complicating a correct diagnosis. Gross total resection seems to be the main treatment, although adjuvant therapie...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,评审
doi：10.1007/s00701-013-1739-4
更新日期：2013-07-01 00:00:00
abstract：:Cavernous hemangiomas are most commonly found within the subcortical neural parenchyma near the fissura Rolandi, in the basal ganglia, or in the brain stem. Because of advancing neuro-imaging technology and thus resulting in a higher incidence of cavernous hemangiomas they have rising impact in neurosurgery. We presen...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,评审
doi：10.1007/s00701-005-0567-6
更新日期：2005-10-01 00:00:00
abstract：:Parafalcine chondrosarcoma is extremely rare, and may be difficult to differentiate preoperatively from falx meningioma. An 18-year-old woman presented with a parafalcine chondrosarcoma incidentally detected as a small lesion 2 years before admission, suggesting falx meningioma. Brain computed tomography and magnetic ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-005-0530-6
更新日期：2005-07-01 00:00:00
abstract：BACKGROUND:By now it has been well established that vertebral artery injury (VAI) is associated with unstable cervical spine injuries resulting from blunt trauma. A more complete understanding of predisposing factors and the mechanism of injury in VAI should result in improved outcomes and reduced risk for patients wit...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-012-1499-6
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND:Gamma Knife radiosurgery (GKRS) inverse dose planning is currently far from competing effectively with the quality of dose planning developed by experienced experts. A new inverse planning (IP) method based on « efficient convex optimization algorithms » is proposed, providing high-quality dose plans in real...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-020-04695-x
更新日期：2021-01-05 00:00:00
abstract：BACKGROUND:Treatment of complex intracranial aneurysms requires strategic pre-interventional or preoperative planning. In addition to modern three-dimensional (3D) rotational angiography, computed tomography angiography (CTA) or magnetic resonance angiogram (MRA), a solid, tangible 3D model may improve anatomical compr...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-016-2892-3
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:The understanding of molecular alterations of tumors has severely changed the concept of classification in all fields of pathology. The availability of high-throughput technologies such as next-generation sequencing allows for a much more precise definition of tumor entities. Also in the field of brain tumor...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,评审
doi：10.1007/s00701-016-3062-3
更新日期：2017-03-01 00:00:00
abstract：INTRODUCTION:An open collaborative international network has been established which aims to improve inter-centre standards for collection of high-resolution, neurointensive care data on patients with traumatic brain injury. The group is also working towards the creation of an open access, detailed and validated databas...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,多中心研究
doi：10.1007/s00701-003-0066-6
更新日期：2003-08-01 00:00:00
abstract：:Arachnoid cysts are frequent anomalies of the CNS. They are benign lesions within the arachnoid membrane and have been reported to occur in virtually all locations where arachnoid is present. An intraventricular location, however, is rare and occurrence within the fourth ventricle is particularly uncommon. The first r...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,评审
doi：10.1007/s00701-009-0309-2
更新日期：2010-01-01 00:00:00
abstract：:Octreotide is a potent agonist of somatostatin that lowers the serum level of growth hormone (GH), and reduces the size of somatotropinomas. However, the detailed mechanism of shrinkage of this tumour is not known. We, therefore, evaluated 11 patients with somatotropinomas who were treated with octreotide 300 microgra...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01411403
更新日期：1997-01-01 00:00:00
abstract：:We present our clinical experience and the results of surgical management with 25 cavernomas of the CNS, treated in our hospital in the last 10 years. The location of the lesion assessed by clinical and CT scan examinations, proved to be the most significative factor determining the prognosis of cavernomas of the CNS,...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01402366
更新日期：1987-01-01 00:00:00
abstract：:We previously showed that a canine basilar artery manifested tonic and potent, protein kinase C (PKC)-dependent contractions when nitric oxide (NO) was inhibited. We also reported a linear correlation between chronological changes in the angiographic severity of vasospasm, enhanced PKC, and attenuated guanosine, 13',1...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010050215
更新日期：1998-01-01 00:00:00
abstract：:We described two histochemical patterns of IgG deposits in meningioma and discussed the pathogenesis of IgG deposits. In meningioma with pseudopsammoma bodies, IgG was secreted from tumour cells which differentiated to secretory epithelial cells, and was found to deposit in the pseudopsammoma bodies. However, in menin...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01809239
更新日期：1985-01-01 00:00:00
abstract：BACKGROUND:Catheter-assisted Guglielmi detachable coiling (CAGDC) is a technical option that was developed to allow the endovascular treatment of wide-necked aneurysms. We report upon our experiences of the CAGDC in treating aneurysms with an assessment of its efficacy and safety. METHODS:The effect of CAGDC of wide-n...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-006-0881-7
更新日期：2006-10-01 00:00:00
abstract：:Forty-two patients with 44 cephaloceles treated between 1966 and 1993 are presented. Eighteen lesions were occipital, 2 parietal, 1 at the anterior fontanelle, 11 sincipital, and 12 basal. In recent years computerized tomography (CT) and magnetic resonance imaging (MRI) provided better information on the site and natu...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01417678
更新日期：1995-01-01 00:00:00
abstract：:The authors report seven cases of cerebellar infarcts in the distribution of the PICA, of whom six were treated surgically. Only one patient died and he was not operated on. Although of the remaining six patients four were comatose, and two presented obvious signs of midbrain decerebration, all of them subsequently sh...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01401324
更新日期：1984-01-01 00:00:00
abstract：:The introduction of transcranial Doppler ultrasonography (TCD) has made it possible to examine blood flow characteristics in carotid-cavernous sinus fistulae (CCSF) in a noninvasive, relatively simple, and reliable way. This study investigated the usefulness of TCD in the diagnosis and follow-up of various CCSF subtyp...
journal_title：Acta neurochirurgica
pub_type： 临床试验,杂志文章
doi：10.1007/s007010100022
更新日期：2001-12-01 00:00:00
abstract：BACKGROUND:The effectiveness of repeated gamma knife radiosurgery (GKS) for the treatment of multiple metastatic brain tumours was evaluated. METHODS:This study included 16 patients with 242 tumours, 10 men and 6 women with a mean age of 60.3 years at initial GKS, who underwent GKS four times or more for newly develop...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-004-0306-4
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND:Brainstem cavernous malformations (CM) carry high risks of hemorrhage and neurologic morbidity. While much is published on physical effects of brainstem CM, very little is known about these patients' quality of life. This study aimed to assess the quality of life PROMIS-29 health domains of brainstem CM pati...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-019-04075-0
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVES:Optimal selection of idiopathic normal pressure hydrocephalus (iNPH) patients for shunt surgery is challenging. Disease State Index (DSI) is a statistical method that merges multimodal data to assist clinical decision-making. It has previously been shown to be useful in predicting progression in mild cogniti...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-016-2980-4
更新日期：2016-12-01 00:00:00
