Abstract：
:We previously showed that a canine basilar artery manifested tonic and potent, protein kinase C (PKC)-dependent contractions when nitric oxide (NO) was inhibited. We also reported a linear correlation between chronological changes in the angiographic severity of vasospasm, enhanced PKC, and attenuated guanosine, 13',15'-cyclic monophosphate (cGMP) activity in a canine subarachnoid haemorrhage model. The activity of cGMP is an indicator of NO-function. Based on this evidence, we have hypothesized that PKC and NO regulate cerebral vascular tone. We particularly focused on the role of NO in a negative feedback mechanism on PKC activity in the maintenance of vascular tone. To further confirm our hypothesis, we investigated the effect of PKC down-regulation on the tonic vascular contraction induced by NO-inhibition. Canine basilar artery was used in the experiment. Significant down-regulation of PKC activity in vascular smooth muscle cells was obtained by incubation with 10(-5) mole/L of phorbol 12-myristate 13-acetate (PMA) for 24 hours. The tonic and potent contraction induced by NO-inhibition was completely suppressed in the PKC down-regulated artery, even though the artery manifested a significant contraction in high-K+ solutions. These results indicate an obligatory role of PKC activity in tonic contraction when NO is inhibited, and support our previous data. Nitric oxide induces vascular relaxation by inhibiting PKC activity. Subarachnoid haemorrhage impairs this inhibition, resulting in PKC-dependent vascular contraction, such as vasospasm.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Nishizawa S,Yokota N,Yokoyama T,Uemura Kdoi
10.1007/s007010050215subject
Has Abstractpub_date
1998-01-01 00:00:00pages
1063-8issue
10eissn
0001-6268issn
0942-0940journal_volume
140pub_type
杂志文章abstract：BACKGROUND:We verified the effectiveness of training in endoscopic endonasal transsphenoidal surgery (eETSS) techniques using chicken eggs and a skull model. METHODS:We verified the area of eggshell removed by drilling when five residents and four experts used the chicken eggs and a skull model. RESULTS:When resident...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-014-2035-7
更新日期：2014-07-01 00:00:00
abstract：:We performed cordectomy, a surgical technique that is infrequently used at present, for a patient with post-traumatic syringomyelia (following complete paraplegia of both lower limbs due to dislocation fracture of the 9th thoracic vertebra), yielding a favourable result. We recommend cordectomy as a surgical technique...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-007-1421-9
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:The use of endoscopes in transnasal surgery offers increased visualization. To minimize rhinological morbidity without restriction in manipulation, we introduced the mononostril transethmoidal-paraseptal approach. METHODS:The aim of the transethmoidal-paraseptal approach is to create sufficient space within...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-017-3075-6
更新日期：2017-03-01 00:00:00
abstract：:The anterior choroidal artery (A.ch.a.) was studied in 140 hemispheres of the human brain. In 50 specimens the artery was cannulated and perfused with acrylic resin, in 20 specimens the A.ch.a., was selectively cannulated and perfused with dye. The artery then was microsurgically dissected and photographically documen...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01401968
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND:Post-traumatic stress disorder (PTSD) is common after subarachnoid haemorrhage (SAH) and causes poor outcome. Knowing which SAH events cause the stress leading to PTSD development could allow for their severity, and so the chances of PTSD, to be reduced. The dramatic nature of SAH onset has meant ictal event...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-010-0843-y
更新日期：2011-04-01 00:00:00
abstract：:Cell-mediated cytotoxicity (CTX) of meningioma patients towards meningioma cells and fibroblasts was studied in vitro before and after surgery, using the 3H-proline microcytotoxicity test. When incubated with allogeneic target cells before surgery, lymphocytes from three out of seven donors showed a specific destructi...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01808518
更新日期：1979-01-01 00:00:00
abstract：:The cerebral pareses occurring in early childhood or produced subsequently by trauma or spontaneous cerebral haemorrhages, present a heterogenous symptomatic picture. In the forefront we find the spastic pareses associated with extra-pyramidal motor hyperkinesia (athetosis, dystonia, ballism). 36 C.P.-patients were su...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/978-3-7091-8482-0_2
更新日期：1977-01-01 00:00:00
abstract：:Superficial radial intraneural ganglion cysts are rare. Only nine previous cases have been described. We provide two examples with a wrist joint connection and review the literature to provide further support for the unifying articular (synovial) theory for the pathogenesis and treatment of intraneural ganglia. ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-018-3715-5
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:We used [F-18] FDG microPET imaging as part of a longitudinal study to investigate changes in the brain. METHODS:Glucose metabolism during the development of neuropathic pain after tibial and sural nerve transection (TST) model rats. MicroPET images were obtained 1 week before operation and then weekly for ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-015-2415-7
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVES:Ballistic injuries to peripheral nerves pose special challenges in terms of indications, timing and type of surgical intervention. The aim of the present work was to analyze our experience in the surgical treatment of peripheral nerve ballistic injuries with respect to the mechanism of injury (gunshot versus...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-014-2139-0
更新日期：2014-08-01 00:00:00
abstract：:Ten patients with severe spasticity were evaluated according to a standardized protocol in order to be treated by intraspinal baclofen. Entry criteria in the protocol were the following: 1) Stable central nervous system lesion, 2) Severe spasticity and/or flexo-extensor spasms not controllable by oral treatment, 3) No...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01400686
更新日期：1991-01-01 00:00:00
abstract：:The authors outline the possible approaches to vertebromedullary tumours of the thoraco-lumbar spine using unilateral or bilateral transverso-arthro-pediculectomy and corporectomy. In a personal series of 20 cases. The technique and indications are described and the results. ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01456263
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:Many anatomical anomalies have the potential to impair the efficacy of endoscopic third ventriculostomy (ETV) and increase the surgical morbidity. By virtual magnetic resonance imaging (MRI) endoscopy, the real endoscopic view into the ventricular system can be simulated. It was the objective of the present ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010100000
更新日期：2001-11-01 00:00:00
abstract：:Over the past 5 years 9 patients underwent partial or complete corpus callosotomy for treatment of medically intractable epileptic seizures. A beneficial effect of the procedure was observed in 8 patients. Criteria for performance of the procedure included CT evidence of unilateral cerebral damage and non-localized ep...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01406608
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND:Computer-assisted design and manufacturing (CAD/CAM) techniques have been implemented in craniosynostosis surgery to facilitate cranial remodeling. However, until now, computed tomography (CT) scans with ionizing radiation were necessary to plan the procedure and create guiding templates. The purpose of this...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-020-04445-z
更新日期：2020-06-09 00:00:00
abstract：BACKGROUND:The aim is to study the clinical, radiological and pathological features of childhood and adolescent meningiomas and analyse outcome prognosticators. METHOD:A retrospective analysis of the case records of patients less than 20 years of age operated for a meningioma in our institute since 1982 was performed....
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-009-0206-8
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:An Afghani man presented to a U.S. military facility in Afghanistan with a 3-month history of clear fluid from his left naris and frequent sinusitis. Eleven years earlier, he had been struck in the forehead by an object falling from the sky. MATERIALS AND METHODS:Neurologic examination revealed decreased se...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-008-0148-6
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:Transsphenoidal surgery has been well established as an effective primary treatment for tumours of the sellar region. During the dural opening, the prominent intercavernous sinus poses limitations for this approach and may contribute to incomplete tumour resections. METHOD:Based on our experience from 940 c...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-009-0356-8
更新日期：2009-07-01 00:00:00
abstract：:Forty one cases of subdural empyema treated between 1977 and 1988 at the Postgraduate Institute of Medical Education and Research. Chandigarh, have been analysed. The patients ranged from 9 days to 80 years of age. There were 22 children, including 11 infants. Fever, altered sensorium and seizures were the most common...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,评审
doi：10.1007/BF01402182
更新日期：1990-01-01 00:00:00
abstract：:The review of the literature on Cheyne-Stokes respiratory periods reveals enormous variation of the opinions expressed. The original description concerned periodicity characterized by rhythmic changes of respiratory phases and respiratory pauses in a relation of 60 : 15 seconds. In the respiratory phase there were 30 ...
journal_title：Acta neurochirurgica
pub_type： 历史文章,杂志文章,评审
doi：10.1007/BF01809226
更新日期：1978-01-01 00:00:00
abstract：BACKGROUND:Impairment of cerebral autoregulation is known to adversely affect outcome following traumatic brain injury (TBI). The phase shift (PS) method of cerebral autoregulation (CA) assessment describes the time lag between fluctuations in arterial blood pressure (ABP) and cerebral blood flow velocity (CBFV) in the...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-007-1447-z
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:To investigate the natural history and the growth rate of spheno-orbital meningiomas (SOMs). METHODS:Ninety patients with a diagnosis of SOM were included, and patient charts and imaging were evaluated. In a subset of 32 patients, volumetric studies were performed. RESULTS:The median follow-up for the enti...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-010-0878-0
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:Nicardipine prolonged release implants (NPRI) have been shown to decrease the incidence of cerebral vasospasm and infarcts significantly in patients after aneurysmal subarachnoid haemorrhage (SAH) following microsurgical clipping. Yet, the comparison with results after endovascular coiling is lacking. This s...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-011-1129-8
更新日期：2011-11-01 00:00:00
abstract：:In the last 3.5 years (up to August 1988) out of 450 patients with surgically treated intracranial aneurysms in 100 cases (22%) acute surgery was performed (up to 72 h after SAH). Patients in grade I-III (WFNS scale) were operated upon. In all the cases there were supratentorial aneurysms. CSF drainage during the oper...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01420184
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become an established therapeutic approach for the management of patients with late-stage idiopathic Parkinson's disease (PD). The aim of the present study was to assess regional cerebral blood flow (rCBF) changes related to mot...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-012-1610-z
更新日期：2013-03-01 00:00:00
abstract：:A case of bilateral internal carotid artery thrombosis after blunt injury to the head in a 54 years old male is described. The literature is reviewed and comment is made on the causes. Unilateral thrombosis of the internal carotid artery after closed or blunt injury to the head and neck is well known but not common. T...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01401637
更新日期：1978-01-01 00:00:00
abstract：BACKGROUND:Pituitary apoplexy is a rare and life-threatening complication occurring in 0.6-10.5% of all cases of pituitary adenomas. Although the association between pituitary apoplexy and visual dysfunction has been recognized for a long time, the optimal management of this problem still remains controversial. The pur...
journal_title：Acta neurochirurgica
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s00701-009-0595-8
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND:Meticulous haemostasis is one of the most important factors during microneurosurgical resection of brain arteriovenous malformation (AVM). Controlling major arterial feeders and draining veins with clips and bipolar coagulation are well-established techniques, while managing with bleeding from deep tiny vess...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-017-3138-8
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVE:Lately, morphological parameters of the surrounding vasculature aside from aneurysm size, specific for the aneurysm location, e.g., posterior cerebral artery angle for basilar artery tip aneurysms, could be identified to correlate with the risk of rupture. We examined further image-based morphological paramet...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-020-04593-2
更新日期：2020-10-06 00:00:00
abstract：:This report describes a rare case of a distal anterior choroidal artery aneurysm which developed intraventricular haemorrhage without subarachnoid haemorrhage as shown on computerized tomographic (CT) scan. A 69-year-old hypertensive man suddenly became unconscious. An emergency CT scan showed a severe intraventricula...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,评审
doi：10.1007/s007010050082
更新日期：1998-01-01 00:00:00
