Abstract:
:The monoclonal antibody Ki-67 has been tested as a marker of proliferating cells in 52 stereotactic brain tumour biopsies. The antibody reacts with a nuclear protein expressed in G1,S, G2n and M-phases of the cell cycle. Using the immunoperoxidase technique on squash preparations the percentage of Ki-67 positive cells was determined as a fraction of the total number of tumour cells present. This Ki-67 index was in close correlation with the histological grade. Highest values were found in a pineal germinoma (46.3%) and in 3 primary cerebral non-Hodgkin lymphomas (mean 39.5%). Among the gliomas, the highest fraction of proliferating cells was seen in 2 anaplastic paediatric brain stem gliomas (mean 17.4%) and in an anaplastic ependymoma (12.5%). Anaplastic astrocytomas and glioblastomas varied considerably with mean values of 9.5% and 8%, respectively. To some extent this variability may reflect tumour heterogeneity which is more likely to manifest in small stereotactic samples than in large tissue specimens obtained during open surgery. Pilocytic astrocytomas, mixed gliomas and fibrillary astrocytomas had moderate to low percentages. Ki-67 staining of squash preparations can easily be performed on a routine basis and is, in our experience, superior to frozen sections. This method allows the determination of the growth fraction of an individual tumour and could become an important additional criterion for the decision among alternative and potentially harmful therapeutic regimens.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Ostertag CB,Volk B,Shibata T,Burger P,Kleihues Pdoi
10.1007/BF01560376subject
Has Abstractpub_date
1987-01-01 00:00:00pages
117-21issue
3-4eissn
0001-6268issn
0942-0940journal_volume
89pub_type
杂志文章abstract:BACKGROUND:Within the realm of neurosurgery, petroclival meningiomas are regarded as probably the most difficult tumour to be treated by microsurgery. This is due to the not infrequently large size of the tumours which, although predominantly located in the posterior fossa, may occupy more than one cranial compartment,...
journal_title:Acta neurochirurgica
pub_type: 历史文章,杂志文章
doi:10.1007/s00701-010-0633-6
更新日期:2010-07-01 00:00:00
abstract::Fifteen cases of large thalamic gliomas were treated by laser surgery and CUSA under X8 magnification and subsequently they were subjected to radiotherapy. More than 50% of the tumours were located in the dominant hemisphere and therefore an interhemispheric approach was carried out to avoid disturbances of speech and...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01418796
更新日期:1985-01-01 00:00:00
abstract::The prevention of cerebral vasospasm with OKY-046, an imidazole derivative and a thromboxane synthetase inhibitor, was studied co-operatively at ten neurosurgical services. Intravenous administrations of 2, 5 or 10 mu/kg/minute of OKY-046 were given continuously from the earliest possible day to the 14th SAH-day to 82...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01476216
更新日期:1985-01-01 00:00:00
abstract::We retrospectively analysed 13 patients (pts.) treated at the University of Tübingen from 1985 to 1993 to evaluate the results of radiation therapy (XRT) given as an adjuvant to totally or subtotally resected meningiomas. The overall survival was 38% at five years with a probability of relapse of 50% at this time. Rec...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF02187764
更新日期:1995-01-01 00:00:00
abstract::Indirect carotid-cavernous sinus dural arterio-venous fistulae (cDAVF) can be treated by transarterial and/or transvenous embolisation. This study evaluated patients with cDAVF who underwent transvenous embolisation using the direct superior ophthalmic vein (SOV) approach. Between January 2004 and October 2006, eight ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-008-1573-2
更新日期:2008-06-01 00:00:00
abstract::Arachnoid cysts are frequent anomalies of the CNS. They are benign lesions within the arachnoid membrane and have been reported to occur in virtually all locations where arachnoid is present. An intraventricular location, however, is rare and occurrence within the fourth ventricle is particularly uncommon. The first r...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-009-0309-2
更新日期:2010-01-01 00:00:00
abstract::Leptomeningeal cysts are commonly seen in children usually following trauma and associated with bulging leptomeninges at the site of fracture. Intradiploic leptomeningeal cyst is an important differential for an expansile lytic lesion in the bony calvarium especially in a patient with a previous history of trauma. Her...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-015-2660-9
更新日期:2016-02-01 00:00:00
abstract::As an alternative to the gauze often used on scalp incisions, we prepared a pad made of non-woven sheets, coated with adhesive on one side. Unlike conventional gauze, the pad did not slip away from the incision line or become entangled with the scalp clips, thus demonstrating its high usefulness for this purpose. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01411309
更新日期:1997-01-01 00:00:00
abstract::The effectiveness of percutaneous epidural stimulation has been evaluated in 11 patients with multiple sclerosis. Trial stimulation was performed at the thoracic level and lasted for 4 to 10 days. Evaluation was accomplished before the start and at regular intervals during and after the treatment. The scoring systems ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01809178
更新日期:1979-01-01 00:00:00
abstract::Retroclival arachnoid cysts are rarely reported. A 40-year-old woman had a sudden onset of occipitocervical pain. Magnetic resonance imaging (MRI) revealed a cystic mass lesion located in the retroclival region and complicated with intracystic haemorrhage. At operation, by a right lateral suboccipital approach, an old...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0381-7
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:To determine cerebrospinal fluid (CSF) dynamics and morphology in Chiari I malformation (CMI) and assess the response to surgery of the posterior cranial fossa, we examined midsagittal imaging along with anterior cervical 2-3 (AC2-3), posterior cervical 2-3 (PC2-3), and aqueduct CSF flow hydrodynamics in axi...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-013-1958-8
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:In an increasingly complex and competitive professional environment, improving methods to educate neurosurgical residents is key to ensure high-quality patient care. Electronic (e)Learning resources promise interactive knowledge acquisition. We set out to give a comprehensive overview on available eLearning ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,meta分析
doi:10.1007/s00701-016-3042-7
更新日期:2017-02-01 00:00:00
abstract::Twiddler syndrome occurs when a patient intentionally or unintentionally manipulates an implantable generator (usually a pacemaker) and dislodges the pacing leads, causing malfunction of the device. Though the syndrome has been described in patients with pacemakers, to our knowledge only one spontaneous case has been ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0366-6
更新日期:2010-03-01 00:00:00
abstract::Effectiveness of stereotactic radiosurgery (SRS) has been shown in patients with one to four brain metastases. Work has been done to evaluate the role of SRS alone treatment without whole-brain radiation therapy in patients with more than four metastases. A recent multiinstitutional JLGK 0901 prospective study reveale...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-016-2707-6
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Multicentric WHO grade II gliomas constitute a rare entity. Their pathogenesis and treatment are still a matter of debate. OBJECTIVE:We present a 23 year-old female with two synchronous but separate WHO grade II oligodendrogliomas in the temporal and frontal lobes. CLINICAL FEATURES:The two lesions showed ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0306-5
更新日期:2009-12-01 00:00:00
abstract::MRI is routinely used in the evaluation and management of patients with failed back surgery syndrome (FBSS). However, its value is unclear in the early detection of signs that can negatively affect that later course of surgical cases. The purpose of the present study is to describe the MR images of early postoperative...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01844746
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Spinal epidural arachnoid cysts (EAC) are rare and may present with myelopathy, which can be completely curable with surgery. The majority of investigators believe that the repairment of dural defect is important to treat EAC. However, the necessity of excising EACs remains controversial. The purpose of this...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-012-1356-7
更新日期:2012-07-01 00:00:00
abstract::Modern neuro-imaging techniques have significantly increased the accuracy of stereotactic procedures and have thereby generated a renewed interest in guided brain surgery. This paper describes the neuroradiological aspects of stereotaxic target calculation (x-, y-, z- coordinates) using the Riechert-Mundinger (Fisher)...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01400713
更新日期:1993-01-01 00:00:00
abstract:OBJECT:The authors analyzed the cases of 163 patients with syringomyelia to assess the appropriate surgical procedure. METHODS:Depending on the aetiological factors and treatment considerations the series was classified into three groups. Group I were cases where there was no definite demonstrable aetiological factor;...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010050038
更新日期:2000-01-01 00:00:00
abstract::Selection of the approach and technique for surgical repair of aneurysm of the vertebrobasilar artery system is mainly based on angiographic features. This report emphasizes that planning the surgical procedure should also include preoperative evaluation of the individual skull base configuration, as well as the relat...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01428505
更新日期:1995-01-01 00:00:00
abstract::171 patients with an instability-related failed back surgery syndrome underwent internal fixation. The operative indication was based on specific diagnostic procedures such as anaesthesia of articular nerves and the trial external immobilization in a plaster jacket. Taking account of the different types of hypermobili...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01401868
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:To establish the risk of recurrence in patients with chronic subdural hematoma (cSDH) on antithrombotic treatment (AT, i.e., antiplatelets and anticoagulants). Secondary end points were perioperative morbidity and mortality between groups (AT vs. no-AT group) and exploration if timing of resumption of AT trea...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-017-3330-x
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:The frontal bridging vein, which is the venous drainage route of the frontal cortex into the superior sagittal sinus (SSS), sometimes poses an obstacle in the anterior interhemispheric approach during surgery for anterior cerebral artery aneurysms. Although severe complications including venous infarction or...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-017-3285-y
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Even in specialized centers, suboptimal aneurysm clipping can be as high as 12%. Intraoperative fluorescence angiography with indocyanine green and, more recently, fluorescein sodium have been shown to be a good method for intraoperative flow assessment. However, the cost with the apparatus it entails limits...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-019-03904-6
更新日期:2019-07-01 00:00:00
abstract::The system consists of an inverted U-shaped frame with right angled corners, so mounted that it can be adjusted vertically, antero-posteriorly and made to rotate on an axis ("the axis of the frame") formed by its free ends. The frame carries an arc probe carrier whose probe holder slides on an arc which is centered on...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01406198
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Neurogenic pulmonary edema (NPE) is a clinical syndrome characterized by the acute onset of pulmonary edema after a significant central nervous system (CNS) insult. NPE occurs as a result of release of catecholamines into the blood immediately after aneurysm rupture. The aim of this study is to investigate t...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-017-3091-6
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:We compared the electrode positions of subthalamic nucleus (STN) deep brain stimulation (DBS) estimated at the immediate postoperative period with those estimated 6 months after surgery. METHODS:Brain CT scans were taken immediately and 6 months after bilateral STN DBS in 53 patients with Parkinson's disease...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-010-0771-x
更新日期:2010-12-01 00:00:00
abstract::After clipping of intracranial aneurysms, postoperative vasospasm may occur remote from the distribution area of the artery and may cause death. The authors report two cases and give the clinical, neuroradiological, and neuroanatomical findings. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01773115
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:The relationship of pain relief from a recently presented CT-guided indirect cervical nerve root injection with local anesthetics and steroids to surgical decompression as a treatment for single-level cervical radiculopathy is not clear. This retrospective study aimed to compare the immediate and 6-week post...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-016-2933-y
更新日期:2016-10-01 00:00:00
abstract::The effect of acetazolamide on the cerebral blood flow was studied in gerbils with unilateral carotid ligation. According to the effect of ligation the animals were divided into three groups: first group-the reduction more than 70%, second-CBF reduction 30-70% and the third group-CBF reduction less than 30%. The effec...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01411729
更新日期:1996-01-01 00:00:00