Is valproate encephalopathy under-recognised in older people? A case series.

abstract：:We have measured the rate of induction of the microsomal monooxygenase enzyme aryl hydrocarbon hydroxylase (AHH) in isolated peripheral blood monocytes from young and elderly donors. There was no effect of age on rate of induction. The mechanisms underlying impaired induction of drug metabolism in elderly people remai...

journal_title：Age and ageing

authors： George G,Wynne H,Woodhouse K

更新日期：1991-11-01 00:00:00

abstract：:The type of environmental hazards implicated in the aetiology of a consecutive series of 787 hip-fracture patients was prospectively studied. Most falls occurred between 09 h 00 and midday and there was no seasonal variation. Fifty-one different environmental hazards were implicated in the aetiology of the fall for 58...

journal_title：Age and ageing

authors： Parker MJ,Twemlow TR,Pryor GA

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:dementia is associated with an excess risk of death but mortality after chronic subdural hematoma (CSDH) evacuation in older people with dementia is unknown. We assessed the association between dementia and 1-year case-fatality in older persons undergoing CSDH evacuation. METHODS:we conducted a nationwide F...

journal_title：Age and ageing

authors： Tommiska P,Korja M,Siironen J,Kaprio J,Raj R

更新日期：2020-10-06 00:00:00

abstract：BACKGROUND:animal studies suggest a neuroprotective role for leptin, but human studies have shown mixed results. We examined whether plasma leptin levels in individuals with mild cognitive impairment (MCI) were related to cognitive function at baseline and whether higher leptin levels were associated with reduced risk ...

journal_title：Age and ageing

authors： Oania R,McEvoy LK

更新日期：2015-01-01 00:00:00

abstract：Introduction:identifying the most at risk older people in Emergency Departments (EDs) may help guide clinical practice, and service improvement in emergency care, but little is known about how to implement such tools in practice. Methods:consensus building was used to determine the desirable characteristics of a risk ...

journal_title：Age and ageing

authors： Elliott A,Phelps K,Regen E,Conroy SP

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:The risk/benefit ratio of warfarin therapy changes in the over 75s, when haemorrhagic side-effects become more common. These may not always be reported in the literature. CASE REPORT:A woman of 80 years, on long-term warfarin therapy presented with an acute dissecting thoracic aortic aneurysm; on investigat...

journal_title：Age and ageing

authors： Blunt DM,Impallomeni MG

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:frequent emergency department (ED) attendance at the end of life disrupts care continuity and contradicts most patients' preference for home-based care. OBJECTIVE:to examine factors associated with frequent (≥3) end of life ED attendances among older people to identify opportunities to improve care. METHOD...

journal_title：Age and ageing

authors： Bone AE,Evans CJ,Henson LA,Gao W,Higginson IJ,BUILDCARE study.

更新日期：2019-09-01 00:00:00

abstract：Background:harmful alcohol consumption is reported to be increasing in older people. To intervene and reduce associated risks, evidence currently available needs to be identified. Methods:two systematic reviews in older populations (55+ years): (1) Interventions to prevent or reduce excessive alcohol consumption; (2) ...

journal_title：Age and ageing

authors： Kelly S,Olanrewaju O,Cowan A,Brayne C,Lafortune L

更新日期：2018-03-01 00:00:00

abstract：:We evaluated the effect of impaired hearing and vision on balance in a sample of 977 elderly people residing in the community. Of the sample, 21% reported balance problems, 27% vision problems, and 30% hearing problems. The increased relative risk for balance problems was 1.7 for each 10-year age increment. Women were...

journal_title：Age and ageing

authors： Gerson LW,Jarjoura D,McCord G

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:oropharyngeal dysphagia is a common condition among the elderly but not systematically explored. OBJECTIVE:to assess the prevalence and the prognostic significance of oropharyngeal dysphagia among elderly patients with pneumonia. DESIGN:a prospective cohort study. SETTING:an acute geriatric unit in a gene...

journal_title：Age and ageing

authors： Cabre M,Serra-Prat M,Palomera E,Almirall J,Pallares R,Clavé P

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The Timed Up and Go Test (TUGT) has been recommended as a simple screening tool to identify those at risk of falling. However, subsequent detailed assessment is required to identify underlying falls risk factors to provide direction for optimal targeted intervention strategies. METHODS:110 consecutive falls...

journal_title：Age and ageing

authors： Whitney JC,Lord SR,Close JC

更新日期：2005-11-01 00:00:00

abstract：:An outline is given of simple urodynamic investigations applicable to elderly subjects. The type of patient presenting primarily to geriatric departments with urinary incontinence, whose management is aided by such studies, is described under various clinical groupings. The requirement for urodynamic studies and the b...

journal_title：Age and ageing

authors： Eastwood HD

更新日期：1979-02-01 00:00:00

abstract：:Plasma and red-cell folate levels and dietary folate intake were monitored for about six months, including two months during which supplementary vitamin C was given, in 21 healthy elderly men and women living at home in the north of England. Although biochemical values were consistently low in some subjects, no clinic...

journal_title：Age and ageing

authors： Bates CJ,Fleming M,Paul AA,Black AE,Mandal AR

更新日期：1980-11-01 00:00:00

abstract：BACKGROUND:intracranial volume (ICV) is commonly used as a marker of premorbid brain size in neuroimaging studies as it is thought to remain fixed throughout adulthood. However, inner skull table thickening would encroach on ICV and could mask actual brain atrophy. OBJECTIVE:we investigated the effect that thickening ...

journal_title：Age and ageing

authors： Aribisala BS,Royle NA,Valdés Hernández MC,Murray C,Penke L,Gow A,Maniega SM,Starr JM,Bastin M,Deary I,Wardlaw J

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:delirium is under-recognised in comparison to other common and serious acute disorders. A 2006 survey of UK junior doctors (not undertaking specialist training) identified poor knowledge of the diagnostic criteria and treatment of delirium. We hypothesised that increased prominence accorded to delirium in th...

journal_title：Age and ageing

authors： Jenkin RP,Al-Attar A,Richardson S,Myint PK,MacLullich AM,Davis DH

更新日期：2016-07-01 00:00:00

abstract：:Tests of intestinal permeability are used as a reflection of upper-small-intestinal mucosal damage. Thirty-two elderly in-patients aged 75-96 years, and 64 hospital volunteers aged 22-64 years with no overt gastro-intestinal disease were studied to determine whether permeability changes with increasing age. Intestinal...

journal_title：Age and ageing

authors： Saweirs WM,Andrews DJ,Low-Beer TS

更新日期：1985-09-01 00:00:00

abstract：OBJECTIVES:to test the hypothesis as to whether persons newly discharged into the community following an acute stroke and assigned a stroke case manager would experience, compared to usual post-hospital care, better health-related quality of life (HRQL), fewer emergency room visits and less non-elective hospitalisation...

journal_title：Age and ageing

authors： Mayo NE,Nadeau L,Ahmed S,White C,Grad R,Huang A,Yaffe MJ,Wood-Dauphinee S

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The very old are expected to become a growing part of the stroke population in the industrialised part of the world. The aims of this study were to evaluate clinical characteristics of patients aged 85 years or more at stroke onset and to investigate very old age as an independent predictor of sh...

journal_title：Age and ageing

authors： Kammersgaard LP,Jørgensen HS,Reith J,Nakayama H,Pedersen PM,Olsen TS,Copenhagen Stroke Study.

更新日期：2004-03-01 00:00:00

abstract：:In a study of two representative population samples of 70-year-olds, one of which was followed up at 75 years of age, digitalis treatment was associated with oestrogen-like metabolic effects, indicated by changes in the composition of the plasma phospholipid fraction. Digitalis treatment, at least at these ages, is re...

journal_title：Age and ageing

authors： Persson G,Landahl S,Svanborg A

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND:two common anti-diabetic treatments used are sitagliptin and sulphonylureas however evidence examining their comparative effectiveness in older people is limited. OBJECTIVE:to evaluate effectiveness of sitagliptin vs sulphonylureas when added to metformin in older (aged ≥75) vs younger people (18-75). DESI...

journal_title：Age and ageing

authors： Sharma M,Nazareth I,Petersen I

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:a fall occurs when an individual experiences a loss of balance from which they are unable to recover. Assessment of balance recovery ability in older adults may therefore help to identify individuals at risk of falls. The purpose of this 12-month prospective study was to assess whether the ability to recover...

journal_title：Age and ageing

authors： Carty CP,Cronin NJ,Nicholson D,Lichtwark GA,Mills PM,Kerr G,Cresswell AG,Barrett RS

更新日期：2015-01-01 00:00:00

abstract：:Formal assessment of cognitive decline with cognitive tests can be difficult, requiring either two measurement points or a comparison of 'hold' with 'don't hold' tests. Informant-based assessment provides an alternative approach because informants can adopt a longitudinal perspective and directly rate cognitive change...

journal_title：Age and ageing

authors： Jorm AF,Christensen H,Henderson AS,Jacomb PA,Korten AE,Mackinnon A

更新日期：1996-03-01 00:00:00

abstract：PURPOSE OF THE STUDY:to examine the costs and cost-effectiveness of 'second-generation' telecare, in addition to standard support and care that could include 'first-generation' forms of telecare, compared with standard support and care that could include 'first-generation' forms of telecare. DESIGN AND METHODS:a pragm...

journal_title：Age and ageing

authors： Henderson C,Knapp M,Fernández JL,Beecham J,Hirani SP,Beynon M,Cartwright M,Rixon L,Doll H,Bower P,Steventon A,Rogers A,Fitzpatrick R,Barlow J,Bardsley M,Newman SP

更新日期：2014-11-01 00:00:00

abstract：:Guidelines state that doctors should reveal the diagnosis to the carer and the person with dementia. Carers may, however, not wish the diagnosis to be disclosed. We investigated carer and patient characteristics associated with the wish for disclosure. Fifty-four per cent of 100 carers wished the diagnosis to be revea...

journal_title：Age and ageing

authors： Fahy M,Wald C,Walker Z,Livingston G

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:in recent years, the NHS has been accused of ageism frequently and from many fronts. Previous studies have shown that the number of critical care beds in the UK is inadequate to meet the needs of the population. This study asks whether there is discrimination against older people in access to these critical ...

journal_title：Age and ageing

authors： Hubbard RE,Lyons RA,Woodhouse KW,Hillier SL,Wareham K,Ferguson B,Major E

更新日期：2003-07-01 00:00:00

abstract：Background:overactive bladder (OAB) is a common condition in older persons. Antimuscarinic treatment remains the mainstay of treatment of OAB but clinicians have been reluctant to prescribe this to older patients. This study examined efficacy and safety information from patients >65 in fesoterodine trials to reaffirm e...

journal_title：Age and ageing

authors： Wagg A,Arumi D,Herschorn S,Angulo Cuesta J,Haab F,Ntanios F,Carlsson M,Oelke M

更新日期：2017-07-01 00:00:00

abstract：:Two hundred and eighteen subjects, out of 250 individuals taken from a general practice register, returned completed questionnaires giving details about rest cramps, and a further 15 were contacted by telephone. The overall prevalence of rest cramps in the survey population was 37%. The symptom was more prevalent in o...

journal_title：Age and ageing

authors： Naylor JR,Young JB

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVES:To compare costs and outcome of occupational therapy-led assessment with social worker-led assessment of older people, in terms of their independence and quality of life. DESIGN:Cost-effectiveness analysis alongside a randomised controlled trial. The analysis took viewpoints of health services and patients....

journal_title：Age and ageing

authors： Flood C,Mugford M,Stewart S,Harvey I,Poland F,Lloyd-Smith W

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:in the UK the Department of Health recommends influenza vaccination for elderly people resident in institutional care. However, the efficacy of vaccination may be reduced in very frail elderly people with functional impairment, undernutrition and multiple pathologies. Nutritional and functional status is c...

journal_title：Age and ageing

authors： Potter JM,O'Donnel B,Carman WF,Roberts MA,Stott DJ

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:chronic knee pain is still considered a fairly benign disease by many, an 'unavoidable' consequence of ageing. This passive acceptance may be unnecessarily exposing older people to disability and serious co-morbidity. The aim of this study was to determine the disease burden associated with chronic knee pain...

journal_title：Age and ageing

authors： Fransen M,Su S,Harmer A,Blyth FM,Naganathan V,Sambrook P,Le Couteur D,Cumming RG

更新日期：2014-03-01 00:00:00