Abstract:
:Studies on the use and outcome of highly active antiretroviral therapy (HAART) in HIV-infected Chinese have been scarce. We evaluated risk of progression to (1) nonaccidental death and (2) new AIDS-defining illness (ADI) or death in 223, 89.9% of 248 HIV-1-infected adult Chinese patients who were first initiated on HAART between 1997 and 2002, and followed through 2003. The study subjects were mostly male (88.3%), aged between 30-49 years (43.9%), and acquired HIV via sexual contact (95.7%). After a median follow-up of 38.6 months, 13 nonaccidental deaths were observed. Overall, 25 patients developed new ADI or died. Using Kaplan-Meier analyses, there was no survival difference of starting HAART at various CD4 strata but a higher risk of progression to new ADI/death in patients with pretreatment CD4 count less than 100 cells per microliter (p = 0.01). On Cox proportional hazards multivariate regression analyses, pretreatment CD4 counts of less than 100 cells per microliter and less than 150 cells per microliter but not higher levels were the cutoffs for increased progression to death (adjusted hazard ratio [HR] = 4.90, 95% confidence interval [CI]: 1.08-22.22) and new ADI/death (adjusted HR = 14.44, 95% CI: 1.95-106.89), respectively. Age 50 years or greater was the only other independent predictor of mortality and new ADI/death after HAART. Further studies are indicated to validate and discern implications of these preliminary findings of a lower CD4 threshold for antiretroviral therapy in a small Chinese HIV cohort.
journal_name
AIDS Patient Care STDSjournal_title
AIDS patient care and STDsauthors
Wong KH,Chan KC,Cheng KL,Chan WK,Kam KM,Lee SSdoi
10.1089/apc.2006.0037subject
Has Abstractpub_date
2007-02-01 00:00:00pages
106-15issue
2eissn
1087-2914issn
1557-7449journal_volume
21pub_type
杂志文章abstract::Adolescents of parents infected with HIV/AIDS (HIV-affected adolescents) were recruited from August 1993 to March 1995 to examine their depression as a function of their social support. Adolescent depression and the size, frequency of contact, satisfaction, negative role model influence, and positive social support we...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2006.0066
更新日期:2007-06-01 00:00:00
abstract::This article argues that enhancing efficacious social networks or developing new adaptive social ties for HIV-infected individuals without adequate social resources may enhance their adaptive response to the disease and its treatment. It further suggests that the success of an adaptive response to the disease may to s...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/108729100750018326
更新日期:2000-10-01 00:00:00
abstract::In a sample of perinatally HIV-infected (PHIV+) and perinatally HIV-exposed, uninfected (PHEU) adolescents, we examined the co-occurrence of behavioral health risks including mental health problems, onset of sexual and drug use behaviors, and (in PHIV+ youth) nonadherence to antiretroviral therapy (ART). Participants,...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2011.0025
更新日期:2011-07-01 00:00:00
abstract::Young men who have sex with men (YMSM) of color are at particularly increased risk for HIV infection compared to white MSM. National data highlight the need to link YMSM of color to care to improve their overall health and stem further infections, yet, there is limited data on interventions and clinical outcomes focus...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2010.0192
更新日期:2011-01-01 00:00:00
abstract::The objectives of this research were to assess prevalence and predictors of early antiretroviral therapy adherence using multiple indicators and to estimate effects of early adherence on subsequent HIV viral load and CD4+ lymphocyte responses. Study subjects were adults with HIV infection referred to an antiretroviral...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/10872910252930867
更新日期:2002-04-01 00:00:00
abstract::HIV-seropositive, active injection-drug users (IDUs), compared with other HIV populations, continue to have low rates of highly active antiretroviral therapy (HAART) use, contributing to disparities in their HIV health outcomes. We sought to identify individual-level, interpersonal, and structural factors associated w...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2009.0240
更新日期:2010-07-01 00:00:00
abstract::The purpose of this study was to examine the results of implementing a rapid counselor-based HIV testing program in community pharmacies. A prospective cross-sectional study was conducted on a convenience sample of clients at five community pharmacies in New York City (NYC). In 294 days of pharmacy testing, 2805 clien...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2013.0076
更新日期:2013-08-01 00:00:00
abstract::Despite the advent of effective antiretroviral therapy (ART), HIV-seropositive injection drug users (IDU) continue to suffer from elevated levels of morbidity and mortality. Evidence is needed to identify social- and structural-level barriers to effective ART. We investigated the impact of homelessness on plasma HIV R...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2011.0169
更新日期:2012-01-01 00:00:00
abstract::Recent data suggest that the prevalence of HIV/syphilis infections among men who have sex with men (MSM) in China increased rapidly. This cohort study was to assess the correlates of the incident infections for HIV, syphilis, and hepatitis B virus (HBV) among sexually active and HIV-negative MSM in China. A cohort of ...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2010.0083
更新日期:2010-09-01 00:00:00
abstract::The average reported age of sexual debut for youth in the United States is 14.4 years, with approximately 7% reporting their sexual debut prior to age 13. While the research literature on sexual debut for youth addresses gender and ethnic differences (with males and African-American youth experiencing earlier sexual d...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2011.9879
更新日期:2011-08-01 00:00:00
abstract::Zambia has a generalized HIV epidemic, and HIV is concentrated along transit routes. Female sex workers (FSWs) are disproportionately affected by the epidemic. HIV testing is the crucial first step for engagement in HIV care and HIV prevention activities. However, to date little work has been done with FSWs in Zambia,...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2017.0016
更新日期:2017-07-01 00:00:00
abstract::Treatment with highly active antiretroviral therapy (HAART) decreases morbidity and mortality for persons with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and reduces costs of care. Yet many patients for whom HAART is indicated do not receive it. This study investigated the reasons why c...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/10872910151133701
更新日期:2001-04-01 00:00:00
abstract::Although rates of crystal methamphetamine use in the United States have fallen from their peak in the mid-2000s, use remains a major public health concern, which disproportionately affects gay and bisexual men (GBM). It poses a particular challenge for HIV-positive men, for whom it has been linked to medication adhere...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2016.0196
更新日期:2017-02-01 00:00:00
abstract::To determine the recent trends in AIDS-defining cancers in Western Europe, we analyzed the June 2002 European Non-Aggregate AIDS Data Set. We obtained the percentage of people with AIDS aged 15 years or older (n = 125,691; males, 99,560, females, 26,131) who had cancers as the initial AIDS-defining illness in 17 Europ...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2004.18.501
更新日期:2004-09-01 00:00:00
abstract::This qualitative study explored the dynamics of adolescent HIV risk through focus group interviews of male and female adolescents at an Alabama juvenile detention facility, key informant interviews, and through interviews of HIV-positive and -negative adults in institutional settings and public health clinics in Alaba...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/108729100317894
更新日期:2000-03-01 00:00:00
abstract::Since the end of the 1980s, primary anti-Pneumocystis carinii pneumonia (PCP) prophylaxis has become a fundamental part of the global AIDS control strategy in industrialized countries. The widespread adoption of anti-PCP chemoprophylaxis has been a key element in prolonging the survival of patients with AIDS. There is...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/apc.1998.12.843
更新日期:1998-11-01 00:00:00
abstract::The efficacy of highly active antiretroviral therapy (HAART) has been well documented, particularly among HIV-infected individuals with CD4 cell counts below 200/mm(3). Despite this, eligible individuals may continue to show some reluctance to use HAART. The present study explored the factors influencing patients' dec...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2006.20.848
更新日期:2006-12-01 00:00:00
abstract::Mortality rates have decreased in medically compliant patients with HIV. More HIV-positive patients are requesting procedures that improve their quality of life. Reduction mammoplasty has been proven to predictably relieve back, neck, and shoulder pain related to macromastia. A case report is presented demonstrating a...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2005.19.353
更新日期:2005-06-01 00:00:00
abstract::Although crucial for efficacy of pharmacotherapy, adherence to prescribed medication regimens for both antiretrovirals and antidepressants is often suboptimal. As many depressed HIV-infected individuals are prescribed both antiretrovirals and antidepressants, it is important to know whether correlates of nonadherence ...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1089/apc.2011.0218
更新日期:2012-05-01 00:00:00
abstract::Development of resistance to antiretroviral drugs (ARVs) is a major impediment to optimum treatment of HIV-1 infection. Although resistance testing can help to select subsequent regimens when virologic failure occurs, cross-resistance, which affects all classes of ARVs, may make it more difficult to achieve optimum co...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/108729104323076007
更新日期:2004-05-01 00:00:00
abstract::Acquired resistance to antiretroviral agents is an established sequela of HIV pharmacotherapy. Viral mutations can confer reduced susceptibility to antiretroviral medications, resulting in virologic and clinical failure in more than half of treated patients. Cross-resistance that can develop within each drug class lea...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/108729104323038874
更新日期:2004-04-01 00:00:00
abstract::Among places where people living with HIV experience and anticipate HIV-related stigma, stigma in health care settings may be particularly harmful. Utilizing an exploratory sequential mixed methods approach, we conducted interviews (n = 76) and questionnaires (N = 460) with older adult women living with HIV enrolled i...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2018.0282
更新日期:2019-04-01 00:00:00
abstract::The problem of inadequate adherence to prescribed highly active antiretroviral therapy (HAART) drug regimens to treat HIV infection and AIDS is ubiquitous. Adherence can be inadequate despite both provider and patient understanding of the consequences of nonadherence. Successful long-term treatment of HIV/AIDS require...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/108729103321619773
更新日期:2003-04-01 00:00:00
abstract::This secondary analysis compares health behavior outcomes for two groups of HIV+ substance users randomized in a 3-arm trial [1] to receive Patient Navigation with (PN+CM) or without (PN) contingent financial incentives (CM). Mean age of participants was 45 years; the majority was male (67%), African American (78%), u...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,随机对照试验
doi:10.1089/apc.2018.0014
更新日期:2018-07-01 00:00:00
abstract::Hypogonadism and erectile dysfunction (ED) appear to be more common among men infected with HIV compared to age-matched men within the general U.S. population. HIV providers should consider these conditions and utilize standardized evaluation and diagnostic criteria. Treatment of both hypogonadism and ED increases sex...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/apc.2005.19.655
更新日期:2005-10-01 00:00:00
abstract::The introduction of protease inhibitors (PIs) and highly active antiretroviral therapy in the mid-1990s dramatically altered the treatment of HIV infection, enabling suppression of viral replication to undetectable levels and preventing disease progression. Most PIs present a strong barrier against viral resistance; t...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2007.0099
更新日期:2008-04-01 00:00:00
abstract::The once daily, single-tablet regimen (STR) combining rilpivirine (RPV), emtricitabine (FTC), and tenofovir disoproxil fumarate (TDF) provides a simplified treatment option for antiretroviral therapy (ART)-naïve patients with baseline HIV-1 RNA (BLVL) of ≤100,000 copies/mL. The aim of this analysis is to compare long-...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,随机对照试验
doi:10.1089/apc.2013.0310
更新日期:2014-04-01 00:00:00
abstract::Men who have sex with men (MSM) of color are disproportionately affected by HIV in the United States. Pre-exposure prophylaxis (PrEP) using antiretroviral medications is a newer biomedical prevention modality with established efficacy for reducing the risk of acquiring HIV. We conducted formative qualitative research ...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2016.0123
更新日期:2016-10-01 00:00:00
abstract::In 2004, Cambodia, a low-income country, undertook a rapid scale-up of free antiretroviral therapy (ART) through the public sector in order to respond to the need for treatment for those living with HIV/AIDS. A cohort of patients initiating ART in a provincial national hospital was set up at the beginning of the progr...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2008.0241
更新日期:2009-08-01 00:00:00
abstract::HIV infection is increasing in minority groups, particularly in African American and Hispanic women. Although the incidence of HIV dementia has decreased since the advent of highly active antiretroviral treatment, prevalence of neurocognitive complications has increased as patients are now living longer. This study's ...
journal_title:AIDS patient care and STDs
pub_type: 临床试验,杂志文章
doi:10.1089/apc.2006.0180
更新日期:2007-12-01 00:00:00