Abstract:
:Development of resistance to antiretroviral drugs (ARVs) is a major impediment to optimum treatment of HIV-1 infection. Although resistance testing can help to select subsequent regimens when virologic failure occurs, cross-resistance, which affects all classes of ARVs, may make it more difficult to achieve optimum control of HIV. We have known for some time that our first choice of antiretroviral therapy offers the best chance to control HIV replication and that initial therapy should be selected with an eye on future options. Potency is the first line of defense against the development of resistance. Other factors that affect resistance development include: tolerability, potential for optimum adherence, and genetic and pharmacologic barriers to development of resistance. If resistance emerges, only a single drug may be affected initially, and a rapid change in ARVs may preserve the efficacy of other components. One cautionary note is that we can no longer assume that a patient's HIV is fully susceptible to all ARVs even in the initial regimen. Transmission of drug-resistant HIV means that the genetic composition may be that of an "experienced" virus with reduced susceptibility to ARVs. Resistance testing at the time of transmission is most likely to reveal this resistance, but over time the dominant genetic pattern may revert to wild-type, and be missed by resistance testing. Because "archived" resistant HIV may emerge quickly once treatment is initiated, we need to keep this in mind when selecting initial therapy.
journal_name
AIDS Patient Care STDSjournal_title
AIDS patient care and STDsauthors
Kuritzkes DRdoi
10.1089/108729104323076007subject
Has Abstractpub_date
2004-05-01 00:00:00pages
259-73issue
5eissn
1087-2914issn
1557-7449journal_volume
18pub_type
杂志文章,评审abstract::Adolescents account for most undiagnosed HIV infections in the United States. Although the Centers for Disease Control and Prevention (CDC) recommends universal HIV screening for all patients ≥13 years, <10% of adolescents have been tested for HIV. To identify earlier opportunities for adolescent HIV prevention and di...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2020.0033
更新日期:2020-09-01 00:00:00
abstract::HIV stigma is rooted in culture and, therefore, it is essential to investigate it within the context of culture. The objective of this study was to examine the interrelationships among individualism-collectivism, HIV stigma, and social network support. A social network study was conducted among 118 people living with ...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2014.0015
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abstract::Injection drug use (IDU) is an important vector of HIV infection in the United States. Many patients with HIV infection have comorbid substance use disorders. Integrated treatment for HIV and substance use disorders has been shown to improve HIV and other health outcomes, but significant barriers to integrated treatme...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2009.0242
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/10872910252972276
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abstract::In an effort to understand issues affecting prenatal care access and utilization from the perspectives of human immunodeficiency virus (HIV)-infected women who receive inadequate prenatal care, we conducted three in-depth qualitative and quantitative interviews. From a thematic analysis of the narrative interviews, fo...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2018.0040
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2008.0241
更新日期:2009-08-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2009.0027
更新日期:2009-08-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/108729102320231162
更新日期:2002-07-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2011.9879
更新日期:2011-08-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2018.0117
更新日期:2019-01-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2007-09-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2007.0017
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,随机对照试验
doi:10.1089/apc.2013.0310
更新日期:2014-04-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/10872910151133701
更新日期:2001-04-01 00:00:00
abstract::This secondary analysis compares health behavior outcomes for two groups of HIV+ substance users randomized in a 3-arm trial [1] to receive Patient Navigation with (PN+CM) or without (PN) contingent financial incentives (CM). Mean age of participants was 45 years; the majority was male (67%), African American (78%), u...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,随机对照试验
doi:10.1089/apc.2018.0014
更新日期:2018-07-01 00:00:00
abstract::Acquired resistance to antiretroviral agents is an established sequela of HIV pharmacotherapy. Viral mutations can confer reduced susceptibility to antiretroviral medications, resulting in virologic and clinical failure in more than half of treated patients. Cross-resistance that can develop within each drug class lea...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/108729104323038874
更新日期:2004-04-01 00:00:00
abstract::Superior mesenteric artery (SMA) syndrome is a unique type of small bowel obstruction resulting from the compression of the duodenum by the SMA. This is a case of SMA syndrome in a cachectic 6-year-old boy with AIDS who presented after a 2.3-kg weight loss in the preceding month. Unfamiliarity with this condition coup...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
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abstract::Recommendations suggest that older children and adolescents perinatally infected with HIV (PHIV+) be informed of their HIV diagnosis; however, delayed disclosure is commonly reported. This study examined the prevalence and timing of HIV disclosure to PHIV+ adolescents and the associations between the timing of disclos...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2010.0161
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abstract::Young men who have sex with men (YMSM) of color are at particularly increased risk for HIV infection compared to white MSM. National data highlight the need to link YMSM of color to care to improve their overall health and stem further infections, yet, there is limited data on interventions and clinical outcomes focus...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2010.0192
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abstract::The threat of social stigma may prevent people living with HIV from revealing their status to others and serve as a barrier to HIV treatment adherence. We evaluated the effect of such concerns on self-reported treatment adherence using a short, three-item measure among 204 people living with HIV. Overall, the mean age...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2006.20.359
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abstract::Growth failure is a common problem in HIV-infected children. The extent to which this growth failure could be reversed after the children receive antiretroviral therapy (ART) is not known. This study assessed the incidence of growth failure in HIV-infected Thai children, impact of ART on growth, and the predictors of ...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2009.0093
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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abstract::In the past few years, major advances have been made in the field of primary HIV-1 infection. Several studies have reevaluated the clinical syndrome. The emergence of new molecular laboratory techniques has permitted a detailed analysis of viral dynamics and subsequent immunologic changes. Measurements of subsets of T...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
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更新日期:1998-10-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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abstract::In the United States, the publically supported national HIV medical care system is designed to provide HIV medical care to those who would otherwise not receive such care. Nevertheless, many HIV-infected persons are not receiving medical care. Limited information is available from HIV-infected persons not currently in...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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abstract::There is increasing interest in promoting and supporting self-management of HIV and antiretroviral treatment (ART), including in resource-limited settings. Although the impact of HIV and ART on people in Uganda has been explored, little attention has been paid to how people self-manage. This qualitative study collecte...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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abstract::The efficacy of highly active antiretroviral therapy (HAART) has been well documented, particularly among HIV-infected individuals with CD4 cell counts below 200/mm(3). Despite this, eligible individuals may continue to show some reluctance to use HAART. The present study explored the factors influencing patients' dec...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2006.20.848
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