Abstract:
:In the past few years, major advances have been made in the field of primary HIV-1 infection. Several studies have reevaluated the clinical syndrome. The emergence of new molecular laboratory techniques has permitted a detailed analysis of viral dynamics and subsequent immunologic changes. Measurements of subsets of T-lymphocytes have allowed greater insight into the early pathogenesis of HIV-1 disease. There is now evidence that HIV-1-specific cytotoxic T-lymphocytes occur early during primary HIV-1 infection and are probably the most important immune defense against HIV-1. However, HIV-1 immune escape mutants have been identified during primary infection, which may be one reason for the failure of the immune system to completely eradicate the virus. Cytokines have been shown to play a role in primary HIV-1 infection, and the therapy of primary infection has gained more interest due to the introduction of potent triple combinations, including protease inhibitors.
journal_name
AIDS Patient Care STDSjournal_title
AIDS patient care and STDsauthors
Kaufmann GR,Duncombe C,Zaunders J,Cunningham P,Cooper Ddoi
10.1089/apc.1998.12.759subject
Has Abstractpub_date
1998-10-01 00:00:00pages
759-67issue
10eissn
1087-2914issn
1557-7449journal_volume
12pub_type
杂志文章,评审abstract::Women of color (WOC) are at increased risk of dying from HIV/AIDS, a disparity that may be partially explained by the care barriers they face. Based in a health care disparity model and the socio-ecological framework, the objective of this study was to identify the barriers and facilitators to HIV care at three points...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2012.0435
更新日期:2013-07-01 00:00:00
abstract::Despite successful implementation of anonymous voluntary human immunodeficiency virus (HIV) counseling and testing (aVCT) in Taiwan, the trend of late HIV presentation in sexually active populations has remained unchanged in Taiwan over the past decade. We evaluated the effect and acceptance of an aVCT cascade program...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2020.0044
更新日期:2020-07-01 00:00:00
abstract::Patient adherence (the degree to which patients follow their therapeutic regimen as prescribed within a set period of time) and persistence (the time to treatment discontinuation, with a permissible gap) with drug therapy are essential components of HIV/AIDS treatment. Select community pharmacies offer specialized ser...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,多中心研究
doi:10.1089/apc.2012.0189
更新日期:2012-09-01 00:00:00
abstract::This study compared a multiple method measurement model of highly active antiretroviral therapy (HAART) adherence with single-method models to determine optimal validity in predicting HIV viral load. Repeated measures of antiretroviral adherence were collected over a 15-month period using three different measurement m...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,随机对照试验
doi:10.1089/apc.2006.20.701
更新日期:2006-10-01 00:00:00
abstract::The objective of this study was to estimate racial/ethnic differences in retention in HIV care and viral suppression and to identify related individual and neighborhood determinants. Florida HIV surveillance records of cases aged ≥13 years diagnosed during the years 2000-2014 were analyzed. Retention in care was defin...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2016.0197
更新日期:2017-04-01 00:00:00
abstract::The first generation of young people with perinatally acquired HIV is moving into adulthood, precipitating a transition from pediatric to adult care. As the first research appraisal of Australian clinician perspectives on this process, this article makes a unique contribution by examining the particular challenges ass...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2013.0346
更新日期:2014-07-01 00:00:00
abstract::The average reported age of sexual debut for youth in the United States is 14.4 years, with approximately 7% reporting their sexual debut prior to age 13. While the research literature on sexual debut for youth addresses gender and ethnic differences (with males and African-American youth experiencing earlier sexual d...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2011.9879
更新日期:2011-08-01 00:00:00
abstract::The HIV care continuum illustrates steps needed to reach HIV viral suppression, including retention in care. The continuum's retention measure does not account for gaps or reengagement in care and thus provides an incomplete picture of long-term engagement. We used a claims database to determine the proportion of priv...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2016.0188
更新日期:2016-11-01 00:00:00
abstract::Infections of the liver and biliary tract are common during the course of AIDS. A variety of viral, bacterial, fungal, and other opportunistic infections can present with hepatobiliary involvement as either the primary site of infection or secondary to a disseminated process. Coinfection with hepatitis B and C are par...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/apc.1998.12.347
更新日期:1998-05-01 00:00:00
abstract::Chronic viral hepatitis has emerged as one of the leading causes of morbidity and mortality among HIV-positive patients. These individuals are at risk for aggressive chronic active hepatitis, cirrhosis, and hepatocellular carcinoma, and eventually, death. Currently available therapies for hepatitis B are limited and i...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/108729103322395456
更新日期:2003-09-01 00:00:00
abstract::The purpose of this study was to examine retrospective reports of rates of HIV disclosure to family and friends over a 15-year time span. Participants included 116 HIV-positive men who have sex with men recruited primarily from an AIDS clinical trials unit associated with a large Midwestern university. Disclosure data...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2005.0002
更新日期:2007-07-01 00:00:00
abstract::Depression is highly prevalent among HIV-infected patients, yet little is known about the quality of HIV providers' depression treatment practices. We assessed depression treatment practices of 72 HIV providers at three academic medical centers in 2010-2011 with semi-structured interviews. Responses were compared to n...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2012.0406
更新日期:2013-03-01 00:00:00
abstract::Little is known about the effectiveness of outreach interventions to engage and retain underserved populations living with HIV in stable, primary medical care. This study provided an opportunity to adapt a patient navigation model first developed for cancer care to assess its effectiveness with HIV-infected disadvanta...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2007.9987
更新日期:2007-01-01 00:00:00
abstract::We conducted a demonstration project to design, implement, and evaluate a risk-reduction intervention delivered by medical providers to patients with HIV during routine care in 2005 and 2006. Medical providers at seven HIV clinics in the United States received training to deliver an intervention in which they screened...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2007.0210
更新日期:2008-08-01 00:00:00
abstract::HIV infection is increasing in minority groups, particularly in African American and Hispanic women. Although the incidence of HIV dementia has decreased since the advent of highly active antiretroviral treatment, prevalence of neurocognitive complications has increased as patients are now living longer. This study's ...
journal_title:AIDS patient care and STDs
pub_type: 临床试验,杂志文章
doi:10.1089/apc.2006.0180
更新日期:2007-12-01 00:00:00
abstract::The National HIV/AIDS Strategy (NHAS) calls for a reduction in health disparities, a reduction in new HIV infections, and improved retention in HIV care and treatment. It acknowledges that HIV-positive peers can play an important role in supporting these aims. However, peer training must be comprehensive enough to equ...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/apc.2011.0224
更新日期:2012-01-01 00:00:00
abstract::Growth failure is a common problem in HIV-infected children. The extent to which this growth failure could be reversed after the children receive antiretroviral therapy (ART) is not known. This study assessed the incidence of growth failure in HIV-infected Thai children, impact of ART on growth, and the predictors of ...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2009.0093
更新日期:2009-12-01 00:00:00
abstract::We evaluated pain frequency and severity in 339 women enrolled in the Women's Interagency HIV Study (WIHS). Among these, 63% were 39 years of age or younger, 17% were white, 54% African American, and 29% Hispanic; 32% did not complete high school; 58% had a CD4 less than 200; 65% had clinical AIDS; 60% were on highly ...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,多中心研究
doi:10.1089/apc.2008.0128
更新日期:2009-07-01 00:00:00
abstract::The efficacy of highly active antiretroviral therapy (HAART) has been well documented, particularly among HIV-infected individuals with CD4 cell counts below 200/mm(3). Despite this, eligible individuals may continue to show some reluctance to use HAART. The present study explored the factors influencing patients' dec...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2006.20.848
更新日期:2006-12-01 00:00:00
abstract::Little is known about how people living with HIV in low prevalence contexts face the challenges of stigma and discrimination. Low prevalence and rural communities are unique environments in which HIV-related stigma and discrimination may be intensified due to lower tolerance of differences among people and greater fea...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2008.0168
更新日期:2009-04-01 00:00:00
abstract::The prevalence of smoking in HIV-infected subjects is high. As a smoking cessation aid, varenicline (Champix(®), Pfizer, Saint-Laurent, QC, Canada or Chantix(®), Pfizer, Mission, KS) has not been previously evaluated in HIV-infected smokers. In this multicenter pilot open label study, varenicline 1.0 mg was used twice...
journal_title:AIDS patient care and STDs
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1089/apc.2011.0199
更新日期:2012-01-01 00:00:00
abstract::The introduction of protease inhibitors (PIs) and highly active antiretroviral therapy in the mid-1990s dramatically altered the treatment of HIV infection, enabling suppression of viral replication to undetectable levels and preventing disease progression. Most PIs present a strong barrier against viral resistance; t...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2007.0099
更新日期:2008-04-01 00:00:00
abstract::Hypogonadism and erectile dysfunction (ED) appear to be more common among men infected with HIV compared to age-matched men within the general U.S. population. HIV providers should consider these conditions and utilize standardized evaluation and diagnostic criteria. Treatment of both hypogonadism and ED increases sex...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/apc.2005.19.655
更新日期:2005-10-01 00:00:00
abstract::HIV vaccine availability does not guarantee uptake. Given suboptimal uptake of highly efficacious and already accessible vaccines in the United States, low vaccine coverage in the developing world, and the expectation that initial HIV vaccines will be only partially efficacious, the public health community will face f...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/apc.2004.18.691
更新日期:2004-12-01 00:00:00
abstract::Despite the advent of effective antiretroviral therapy (ART), HIV-seropositive injection drug users (IDU) continue to suffer from elevated levels of morbidity and mortality. Evidence is needed to identify social- and structural-level barriers to effective ART. We investigated the impact of homelessness on plasma HIV R...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2011.0169
更新日期:2012-01-01 00:00:00
abstract::The incidence of arterial and venous thrombosis in HIV-infected patients is increased compared to healthy controls. In this cross-sectional analysis we measured markers of endothelial cell activation, thrombin generation, fibrinolysis and anticoagulation combined with endogenous thrombin potential (ETP) and activated ...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2009.0173
更新日期:2009-12-01 00:00:00
abstract::Mortality rates have decreased in medically compliant patients with HIV. More HIV-positive patients are requesting procedures that improve their quality of life. Reduction mammoplasty has been proven to predictably relieve back, neck, and shoulder pain related to macromastia. A case report is presented demonstrating a...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2005.19.353
更新日期:2005-06-01 00:00:00
abstract::Among places where people living with HIV experience and anticipate HIV-related stigma, stigma in health care settings may be particularly harmful. Utilizing an exploratory sequential mixed methods approach, we conducted interviews (n = 76) and questionnaires (N = 460) with older adult women living with HIV enrolled i...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2018.0282
更新日期:2019-04-01 00:00:00
abstract::Addressing women's low uptake of HIV pre-exposure prophylaxis (PrEP) requires improved understanding of their product preferences. Such preferences should be contextualized according to other aspects of their reproductive health, including their contraception practices. We investigated women's preferences across 10 Pr...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2019.0242
更新日期:2020-03-01 00:00:00
abstract::In 2004, Cambodia, a low-income country, undertook a rapid scale-up of free antiretroviral therapy (ART) through the public sector in order to respond to the need for treatment for those living with HIV/AIDS. A cohort of patients initiating ART in a provincial national hospital was set up at the beginning of the progr...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2008.0241
更新日期:2009-08-01 00:00:00