A measurement model of medication adherence to highly active antiretroviral therapy and its relation to viral load in HIV-positive adults.

Abstract:

:This study compared a multiple method measurement model of highly active antiretroviral therapy (HAART) adherence with single-method models to determine optimal validity in predicting HIV viral load. Repeated measures of antiretroviral adherence were collected over a 15-month period using three different measurement methods: a self-report questionnaire, an adherence interview item, and electronic medication monitoring. The participants included HIV-positive men and women (n = 323) who were currently prescribed HAART. Single-factor models composed of multiple measurements over time were developed for each adherence method and HIV viral load. The three adherence methods were then combined in a second order factor measurement model. Structural equation modeling was used to test the models. Mean adherence, defined as percent of doses taken, was 92%, 90%, and 57% by self-report, interview, and electronic monitoring, respectively. Reliability of individual measurements of adherence was low. Four or seven assessments were needed to attain acceptable stability, depending on the method. The second-order factor model of adherence fit the data and explained 45% of the variability in HIV viral load. Models including only one method of assessing adherence explained between 20% and 24% of the variability. Models that included both self-report and electronic monitoring optimized predictive validity. Using at least two different methods of adherence measurement, each assessed at multiple times is recommended to derive reliable and valid measurement of medication adherence, which is predictive of biological outcomes such as HIV viral load.

journal_name

AIDS Patient Care STDS

authors

Llabre MM,Weaver KE,Durán RE,Antoni MH,McPherson-Baker S,Schneiderman N

doi

10.1089/apc.2006.20.701

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

701-11

issue

10

eissn

1087-2914

issn

1557-7449

journal_volume

20

pub_type

杂志文章,随机对照试验
  • Challenges for HIV vaccine dissemination and clinical trial recruitment: if we build it, will they come?

    abstract::HIV vaccine availability does not guarantee uptake. Given suboptimal uptake of highly efficacious and already accessible vaccines in the United States, low vaccine coverage in the developing world, and the expectation that initial HIV vaccines will be only partially efficacious, the public health community will face f...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章,评审

    doi:10.1089/apc.2004.18.691

    authors: Newman PA,Duan N,Rudy ET,Anton PA

    更新日期:2004-12-01 00:00:00

  • Acceptability of HIV Pre-Exposure Prophylaxis Among Transgender Women in India: A Qualitative Investigation.

    abstract::Despite high HIV prevalence among transgender women (TGW) in India, there is limited exploration of pre-exposure prophylaxis (PrEP) acceptability. With PrEP licensure pending, we conducted six focus group discussions (FGDs) with diverse TGW (n = 36), and eight key informant interviews with community leaders and physic...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2019.0237

    authors: Chakrapani V,Shunmugam M,Rawat S,Baruah D,Nelson R,Newman PA

    更新日期:2020-02-01 00:00:00

  • Individual variability in barriers affecting people's decision to take HAART: a qualitative study identifying barriers to being on HAART.

    abstract::The efficacy of highly active antiretroviral therapy (HAART) has been well documented, particularly among HIV-infected individuals with CD4 cell counts below 200/mm(3). Despite this, eligible individuals may continue to show some reluctance to use HAART. The present study explored the factors influencing patients' dec...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2006.20.848

    authors: Alfonso V,Bermbach N,Geller J,Montaner JS

    更新日期:2006-12-01 00:00:00

  • Safety and tolerability of varenicline tartrate (Champix(®)/Chantix(®)) for smoking cessation in HIV-infected subjects: a pilot open-label study.

    abstract::The prevalence of smoking in HIV-infected subjects is high. As a smoking cessation aid, varenicline (Champix(®), Pfizer, Saint-Laurent, QC, Canada or Chantix(®), Pfizer, Mission, KS) has not been previously evaluated in HIV-infected smokers. In this multicenter pilot open label study, varenicline 1.0 mg was used twice...

    journal_title:AIDS patient care and STDs

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1089/apc.2011.0199

    authors: Cui Q,Robinson L,Elston D,Smaill F,Cohen J,Quan C,McFarland N,Thabane L,McIvor A,Zeidler J,Smieja M

    更新日期:2012-01-01 00:00:00

  • A pilot study of the effects of cognitive-behavioral group therapy and peer support/counseling in decreasing psychologic distress and improving quality of life in Chinese patients with symptomatic HIV disease.

    abstract::Forty-six Chinese patients with symptomatic human immunodeficiency virus (HIV) participated in a comparative study assessing the effectiveness of cognitive-behavioral group therapy (CBT) and peer support/counseling group therapy (PSC) in relation to improving mood and quality of life and decreasing uncertainty in illn...

    journal_title:AIDS patient care and STDs

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1089/10872910252806135

    authors: Molassiotis A,Callaghan P,Twinn SF,Lam SW,Chung WY,Li CK

    更新日期:2002-02-01 00:00:00

  • The relationship of post-traumatic stress disorder and depression to antiretroviral medication adherence in persons with HIV.

    abstract::In HIV/AIDS, symptoms of depression or post-traumatic stress may interfere with important self-care behaviors such as the ability to adhere to one's medical treatment regimen. However, these problems may frequently go undetected in HIV care settings. The present study used brief self-report screening measures of depre...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1089/apc.2007.0069

    authors: Vranceanu AM,Safren SA,Lu M,Coady WM,Skolnik PR,Rogers WH,Wilson IB

    更新日期:2008-04-01 00:00:00

  • Correlates of Never Testing for HIV Among Sexually Active Internet-Recruited Gay, Bisexual, and Other Men Who Have Sex with Men in the United States.

    abstract::In the United States, gay, bisexual, and other men who have sex with men (GBMSM) are disproportionately affected by the HIV/AIDS epidemic. Despite great strides in HIV prevention, including biobehavioral HIV prevention strategies such as pre-exposure prophylaxis and treatment as prevention, there has been relatively l...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2017.0244

    authors: Nelson KM,Pantalone DW,Gamarel KE,Carey MP,Simoni JM

    更新日期:2018-01-01 00:00:00

  • Collectivism culture, HIV stigma and social network support in Anhui, China: a path analytic model.

    abstract::HIV stigma is rooted in culture and, therefore, it is essential to investigate it within the context of culture. The objective of this study was to examine the interrelationships among individualism-collectivism, HIV stigma, and social network support. A social network study was conducted among 118 people living with ...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2014.0015

    authors: Zang C,Guida J,Sun Y,Liu H

    更新日期:2014-08-01 00:00:00

  • Factors Associated with Postpartum Loss to Follow-Up and Detectable Viremia After Delivery Among Pregnant Women Living with HIV.

    abstract::Pregnant women living with HIV are at risk for loss to follow-up and viral rebound after delivery. We conducted a retrospective cohort study of women with HIV who delivered at Parkland Hospital, Dallas, to identify factors associated with postpartum loss to HIV care 1 year after delivery. Logistic regression was used ...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2018.0117

    authors: Adhikari EH,Yule CS,Roberts SW,Rogers VL,Sheffield JS,Kelly MA,McIntire DD,Barnes A

    更新日期:2019-01-01 00:00:00

  • The effect of a multidisciplinary program on HAART adherence.

    abstract::Although emerging evidence suggests differing interventions may improve antiretroviral adherence, there has not been a formal evaluation to identify the impact of a clinic-based multidisciplinary program designed to provide education and identify and correct potential adherence barriers prior to the initiation of high...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2006.20.511

    authors: Frick P,Tapia K,Grant P,Novotny M,Kerzee J

    更新日期:2006-07-01 00:00:00

  • Keeping them in "STYLE": finding, linking, and retaining young HIV-positive black and Latino men who have sex with men in care.

    abstract::Young men who have sex with men (YMSM) of color are at particularly increased risk for HIV infection compared to white MSM. National data highlight the need to link YMSM of color to care to improve their overall health and stem further infections, yet, there is limited data on interventions and clinical outcomes focus...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2010.0192

    authors: Hightow-Weidman LB,Smith JC,Valera E,Matthews DD,Lyons P

    更新日期:2011-01-01 00:00:00

  • The hemostatic balance in HIV-infected patients with and without antiretroviral therapy: partial restoration with antiretroviral therapy.

    abstract::The incidence of arterial and venous thrombosis in HIV-infected patients is increased compared to healthy controls. In this cross-sectional analysis we measured markers of endothelial cell activation, thrombin generation, fibrinolysis and anticoagulation combined with endogenous thrombin potential (ETP) and activated ...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2009.0173

    authors: Jong E,Louw S,Meijers JC,de Kruif MD,ten Cate H,Büller HR,Mulder JW,van Gorp EC

    更新日期:2009-12-01 00:00:00

  • "You must take the medications for you and for me": family caregivers promoting HIV medication adherence in China.

    abstract::China is experiencing a rapid increase in the incidence of HIV infections, which it is addressing proactively with broad implementation of antiretroviral therapy (ART). Within a cultural context extolling familial responsibility, family caregiving may be an important component to promote medication adherence for perso...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2010.0261

    authors: Fredriksen-Goldsen KI,Shiu CS,Starks H,Chen WT,Simoni J,Kim HJ,Pearson C,Zhao H,Zhang F

    更新日期:2011-12-01 00:00:00

  • Autoimmune hepatitis in the HIV-infected patient: a therapeutic dilemma.

    abstract::Autoimmune hepatitis (AIH) is a progressive, chronic hepatitis that has rarely been reported in HIV-infected individuals. Among patients who are candidates for hepatitis C virus (HCV) treatment, screening for AIH should be considered, because interferon has the potential to cause fulminant hepatic failure in the setti...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2008.0149

    authors: Wan DW,Marks K,Yantiss RK,Talal AH

    更新日期:2009-06-01 00:00:00

  • A pediatric AIDS patient with superior mesenteric artery syndrome.

    abstract::Superior mesenteric artery (SMA) syndrome is a unique type of small bowel obstruction resulting from the compression of the duodenum by the SMA. This is a case of SMA syndrome in a cachectic 6-year-old boy with AIDS who presented after a 2.3-kg weight loss in the preceding month. Unfamiliarity with this condition coup...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/108729100318073

    authors: Hoffman RJ,Arpadi SM

    更新日期:2000-01-01 00:00:00

  • Knowledge of HIV Testing Guidelines Among US Internal Medicine Residents: A Decade After the Centers for Disease Control and Prevention's Routine HIV Testing Recommendations.

    abstract::Ten years after the Centers for Disease Control and Prevention recommended universal HIV screening, rates remain low. Internal medicine residents are the front-line medical providers for large groups of patients. We evaluated the knowledge of internal medicine residents about HIV testing guidelines and examined adhere...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2018.0035

    authors: Dandachi D,Dang BN,Wilson Dib R,Friedman H,Giordano T

    更新日期:2018-05-01 00:00:00

  • Unusual presentations of primary human immunodeficiency virus infection.

    abstract::Opportunistic infections during primary infection with human immunodeficiency virus (HIV) are rare, with the exception of oral and esophageal candidiasis. HIV-associated nephropathy (HIVAN) and Pneumocystis carinii pneumonia (PCP) typically occur during advanced HIV infection. We report two patients who developed HIVA...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/10872910260066688

    authors: Szabo S,James CW,Telford G

    更新日期:2002-06-01 00:00:00

  • Factors associated with delays in accessing HIV primary care in rural Arkansas.

    abstract::While debate continues at what stage of human immunodeficiency virus (HIV) disease to begin combination antiretroviral therapy, a number of clinical and public health benefits are linked to early entry into primary care soon after first testing HIV positive. However, HIV-infected patients continue to test late and del...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/108729101753205694

    authors: Milberg J,Sharma R,Scott F,Conviser R,Marconi K,Parham D

    更新日期:2001-10-01 00:00:00

  • Review of metabolic, immunologic, and virologic consequences of suboptimal vitamin D levels in HIV infection.

    abstract::Low 25-hydroxyvitamin D levels are common in the general and HIV-infected populations alike. Defined as levels less than 30 ng/mL, suboptimal vitamin D is known to afflict over 70% of representative samples from each group in resource-rich countries with even greater prevalence in resource-poor regions of the world. I...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章,评审

    doi:10.1089/apc.2012.0145

    authors: Griffin AT,Arnold FW

    更新日期:2012-09-01 00:00:00

  • Stages of change for adherence to antiretroviral medications.

    abstract::Providers do not predict reliably which of their HIV-positive patients are having difficulty adhering to antiretroviral therapy (ART). The transtheoretical, or stages of change model, may be a useful tool to help providers identify patients who are having difficulty with ART adherence. The objective of the current stu...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/apc.2013.0126

    authors: Genberg BL,Lee Y,Rogers WH,Willey C,Wilson IB

    更新日期:2013-10-01 00:00:00

  • HIV-1 infected women and prenatal care utilization: barriers and facilitators.

    abstract::In an effort to understand issues affecting prenatal care access and utilization from the perspectives of human immunodeficiency virus (HIV)-infected women who receive inadequate prenatal care, we conducted three in-depth qualitative and quantitative interviews. From a thematic analysis of the narrative interviews, fo...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/108729100416623

    authors: Napravnik S,Royce R,Walter E,Lim W

    更新日期:2000-08-01 00:00:00

  • Reengagement in Care After a Gap in HIV Care Among a Population of Privately Insured Persons with HIV in the United States.

    abstract::The HIV care continuum illustrates steps needed to reach HIV viral suppression, including retention in care. The continuum's retention measure does not account for gaps or reengagement in care and thus provides an incomplete picture of long-term engagement. We used a claims database to determine the proportion of priv...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2016.0188

    authors: Byrd KK,Furtado M,Bush T,Gardner L

    更新日期:2016-11-01 00:00:00

  • Evaluation of Pharmacy-Based HIV Testing in a High-Risk New York City Community.

    abstract::Blacks/Hispanics face limited access to HIV testing. We examined in-pharmacy HIV testing among customers in pharmacies participating in a nonprescription syringe program in New York City. Participants were recruited in two pharmacies to complete a survey and receive an optional HIV test. Bivariate and multivariable an...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2015.0017

    authors: Amesty S,Crawford ND,Nandi V,Perez-Figueroa R,Rivera A,Sutton M,Weidle PJ,Willis L,Smith DK,Hernandez C,Harripersaud K,Fuller Lewis C

    更新日期:2015-08-01 00:00:00

  • Preventing and managing antiretroviral drug resistance.

    abstract::Development of resistance to antiretroviral drugs (ARVs) is a major impediment to optimum treatment of HIV-1 infection. Although resistance testing can help to select subsequent regimens when virologic failure occurs, cross-resistance, which affects all classes of ARVs, may make it more difficult to achieve optimum co...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章,评审

    doi:10.1089/108729104323076007

    authors: Kuritzkes DR

    更新日期:2004-05-01 00:00:00

  • Metabolic syndrome in older HIV-infected patients: data from the CORE50 cohort.

    abstract::Metabolic abnormalities and cardiovascular disease are increasingly recognized in HIV-infected patients. While HIV-infected patients older than 50 years of age account for up to 25% of HIV cases in the United States, there are limited data on these individuals. To determine the prevalence and predictors of the metabol...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2008.0119

    authors: Adeyemi O,Rezai K,Bahk M,Badri S,Thomas-Gossain N

    更新日期:2008-12-01 00:00:00

  • Depression and posttraumatic stress disorder among HIV-infected Gambians on antiretroviral therapy.

    abstract::Mood disorders are more frequent among people with HIV infection than among non-HIV-infected individuals of the same age, socioeconomic status, and HIV risks. They have been associated with worse adherence and clinical outcomes, yet remain underdiagnosed and undertreated in sub-Saharan Africa. We explored the relation...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2012.0089

    authors: Peterson K,Togun T,Klis S,Menten J,Colebunders R

    更新日期:2012-10-01 00:00:00

  • Rilpivirine versus efavirenz with emtricitabine/tenofovir disoproxil fumarate in treatment-naïve HIV-1-infected patients with HIV-1 RNA ≤100,000 copies/mL: week 96 pooled ECHO/THRIVE subanalysis.

    abstract::The once daily, single-tablet regimen (STR) combining rilpivirine (RPV), emtricitabine (FTC), and tenofovir disoproxil fumarate (TDF) provides a simplified treatment option for antiretroviral therapy (ART)-naïve patients with baseline HIV-1 RNA (BLVL) of ≤100,000 copies/mL. The aim of this analysis is to compare long-...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/apc.2013.0310

    authors: Behrens G,Rijnders B,Nelson M,Orkin C,Cohen C,Mills A,Elion RA,Vanveggel S,Stevens M,Rimsky L,Thorpe D,Bosse M,White K,Zhong L,DeMorin J,Chuck SK

    更新日期:2014-04-01 00:00:00

  • Burkitt's/Burkitt's-like lymphoma presenting as bacterial sinusitis in two HIV-infected children.

    abstract::Two children (ages 12 and 13 years) with transfusion-acquired human immunodeficiency virus (HIV) infection presented with facial pain and rhinorrhea. Radiographic imaging showed extensive paranasal sinus disease, presumed to be bacterial sinusitis, and the patients were treated with broad-spectrum oral antibiotics. Bo...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/108729101753145439

    authors: Robinson MR,Salit RB,Bryant-Greenwood PK,Zeichner SL,Wood LV,Jaffe ES,van Waes C,Magrath IT

    更新日期:2001-09-01 00:00:00

  • Early virologic failure in a pilot study evaluating the efficacy of therapy containing once-daily abacavir, lamivudine, and tenofovir DF in treatment-naive HIV-infected patients.

    abstract::Previous investigational data using abacavir (ABC), lamuvidine (3TC), and zidovudine has suggested the possibility of triple nucleoside analogue reverse transcriptase inhibitors (NRTI) therapy as an option in the treatment of HIV infection. We performed a pilot study to assess the potency of once daily ABC+ 3TC+ tenof...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2005.19.135

    authors: Khanlou H,Yeh V,Guyer B,Farthing C

    更新日期:2005-03-01 00:00:00

  • Pelvic inflammatory disease in women infected with HIV.

    abstract::Pelvic inflammatory disease (PID) and HIV infection are frequently coincident. The diagnosis of PID can be more difficult to make in HIV-infected than in uninfected women. In general, HIV-infected women with PID have a good response to standard intravenous antibiotic therapy. However, surgical therapy is more frequent...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章,评审

    doi:10.1089/apc.1998.12.431

    authors: Korn AP

    更新日期:1998-06-01 00:00:00