Abstract:
:The prevalence of smoking in HIV-infected subjects is high. As a smoking cessation aid, varenicline (Champix(®), Pfizer, Saint-Laurent, QC, Canada or Chantix(®), Pfizer, Mission, KS) has not been previously evaluated in HIV-infected smokers. In this multicenter pilot open label study, varenicline 1.0 mg was used twice daily for 12 weeks with dose titration in the first week. Adverse events (AEs) during the treatment period were recorded. Changes from baseline in laboratory tests, vital signs, daily cigarette consumption, nicotine dependence, and withdrawal were measured through week 24. Self-reported abstinence was validated by serum cotinine at week 12. We enrolled 36 subjects with a mean of 29 pack-years of smoking and a minimum of 4 cigarettes per day. All but 1 were male, 33 (92%) were white. The most frequently reported AEs were nausea (33%), abnormal dreams (31%), affect lability (19%), and insomnia (19%). Six (17%) subjects discontinued varenicline due to AEs. No grade 3/4 laboratory abnormalities or serious AEs occurred during the study. There was no significant change in HIV viral load. CD4 counts increased by 69 cells/mm3 (p = 0.001) at week 24. Serum cotinine-verified 4-week continuous abstinence rate through weeks 9-12 was 42% (95% confidence interval [CI]: 26-58%). AEs and abstinence rates were comparable to those in published randomized controlled trials conducted in generally healthy HIV-negative smokers. Varenicline was safe and appears effective among HIV-infected smokers in this exploratory study, although AEs were common. The most common AE was nausea, with no adverse effect on HIV treatment outcome. Close monitoring of liver enzymes and blood pressure is recommended for HIV-positive smokers taking varenicline.
journal_name
AIDS Patient Care STDSjournal_title
AIDS patient care and STDsauthors
Cui Q,Robinson L,Elston D,Smaill F,Cohen J,Quan C,McFarland N,Thabane L,McIvor A,Zeidler J,Smieja Mdoi
10.1089/apc.2011.0199subject
Has Abstractpub_date
2012-01-01 00:00:00pages
12-9issue
1eissn
1087-2914issn
1557-7449journal_volume
26pub_type
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2014.0279
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/108729102320231162
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2008-04-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2008.0168
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2008.0142
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2011.0169
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2010.0020
更新日期:2010-08-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/108729103321619773
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.1998.12.677
更新日期:1998-09-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/108729104323076007
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2007.0052
更新日期:2008-02-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2006.0066
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2014.0196
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2008.0056
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2008.0213
更新日期:2009-09-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2015.0017
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2016.0196
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,多中心研究
doi:10.1089/apc.2008.0128
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abstract::With the approval of rapid HIV testing and the expected broader use of this technology, community-based organizations incorporating its use face both opportunities and challenges. The primary advantage of rapid testing is the ability to dramatically increase the number of individuals who become aware of their HIV stat...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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abstract::China is experiencing a rapid increase in the incidence of HIV infections, which it is addressing proactively with broad implementation of antiretroviral therapy (ART). Within a cultural context extolling familial responsibility, family caregiving may be an important component to promote medication adherence for perso...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
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