Abstract:
:Combination antiretroviral therapy (ART) has markedly improved survival in HIV-infected patients, but not without significant adverse effects including ART-associated dyslipdemia and insulin resistance, which may in part contribute to an increased risk of cardiovascular events. Other contributing factors to cardiovascular risk may include uncontrolled HIV replication, the effects of HIV and ART on vascular endothelium and inflammatory cytokines. Diastolic dysfunction may be an early sign of cardiovascular disease. Our objective was to determine the prevalence of diastolic dysfunction in HIV-infected patients without cardiovascular symptoms. We enrolled 91 subjects in a cross-sectional study of HIV-infected patients without cardiovascular symptoms between September 2004 and August 2005, to assess whether demographics, HIV-related factors, cardiac risk factors, and ART were associated with diastolic dysfunction. All subjects underwent two-dimensional transthoracic echocardiography with tissue Doppler imaging. Subjects were predominately male with a median age of 38 (interquartile range [IQR]: 33, 42) years and median ART duration 6.15 (IQR: 2.1, 8.4) years. Subjects had low Framingham risk scores. Diastolic dysfunction was observed in 34 patients (37%; 95% confidence interval [CI] 27.4, 48.1). Cardiac risk factors or poor prognostic indicators of AIDS progression were uncommon with no difference between subjects with or without diastolic dysfunction. A nonstatistically significant trend in increased rate of diastolic dysfunction was observed in patients receiving protease inhibitors 1 year or more, 44% versus 28%, respectively (univariate odds ratio 2.02, 95% CI 0.83 to 4.90). This was not observed with prolonged use of either non-nucleoside or nucleoside reverse transcriptase inhibitors. A high prevalence of diastolic dysfunction (37%) in a cohort of HIV-infected patients on ART at low risk for AIDS and cardiovascular disease was demonstrated.
journal_name
AIDS Patient Care STDSjournal_title
AIDS patient care and STDsauthors
Nayak G,Ferguson M,Tribble DR,Porter CK,Rapena R,Marchicelli M,Decker CFdoi
10.1089/apc.2008.0142subject
Has Abstractpub_date
2009-04-01 00:00:00pages
231-8issue
4eissn
1087-2914issn
1557-7449journal_volume
23pub_type
杂志文章abstract::In the United States, gay, bisexual, and other men who have sex with men (GBMSM) are disproportionately affected by the HIV/AIDS epidemic. Despite great strides in HIV prevention, including biobehavioral HIV prevention strategies such as pre-exposure prophylaxis and treatment as prevention, there has been relatively l...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2017.0244
更新日期:2018-01-01 00:00:00
abstract::The influence of HIV on sexual activity and functioning presents a unique set of issues. HIV transmissibility, partner disclosure, potential vertical transmission and, for some HIV-infected women, problems associated with illicit drug use, may affect sexuality. Few studies have examined HIV-infected women's sexuality ...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/108729103321150809
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abstract::In the past few years, major advances have been made in the field of primary HIV-1 infection. Several studies have reevaluated the clinical syndrome. The emergence of new molecular laboratory techniques has permitted a detailed analysis of viral dynamics and subsequent immunologic changes. Measurements of subsets of T...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/apc.1998.12.759
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abstract::The objective of this study was to describe the AIDS-defining conditions (ADC) and survival experience of pediatric AIDS cases (< 13 years age) reported in Puerto Rico. A descriptive analysis of the data gathered by the Puerto Rico AIDS Surveillance System was performed. Data for the 377 pediatric AIDS cases reported ...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.1999.13.651
更新日期:1999-11-01 00:00:00
abstract::Despite the myriad advances in antiretroviral therapy since the original highly active antiretroviral therapy regimens were developed, there remain numerous important and pressing unmet needs that, if addressed, would substantially improve the quality of life and longevity of HIV-infected patients. The most achievable...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2004.18.501
更新日期:2004-09-01 00:00:00
abstract::HIV-seropositive, active injection-drug users (IDUs), compared with other HIV populations, continue to have low rates of highly active antiretroviral therapy (HAART) use, contributing to disparities in their HIV health outcomes. We sought to identify individual-level, interpersonal, and structural factors associated w...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2009.0240
更新日期:2010-07-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,多中心研究
doi:10.1089/apc.2012.0132
更新日期:2012-12-01 00:00:00
abstract::HIV infection and substance use disorders are chronic diseases with complex contributions to health-related quality of life (HRQOL). We conducted a cross-sectional survey of 951 HIV-infected adults receiving care at 14 HIV Research Network sites in 2003 to estimate associations between HRQOL and specific substance use...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2008.0005
更新日期:2008-11-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2012.0435
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2020.0044
更新日期:2020-07-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2016.0197
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abstract::Although many methods for assessing adherence have been developed, most are not feasible for busy clinical settings. Using patients from the Adherence and Efficacy of Protease inhibitor Therapy (ADEPT) study (1998-2000), we systematically evaluated the relationship between psychosocial, environmental, clinical, and ot...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2006.20.760
更新日期:2006-11-01 00:00:00
abstract::This article discusses some of the issues specifically associated with women and HIV. The myth is that women do not get AIDS and that lesbians do not get AIDS either. It also explores the unique sociocultural context in which HIV-infected women exist. The hope is to put faces on the numbers that are increasing each da...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.1999.13.119
更新日期:1999-02-01 00:00:00
abstract::While debate continues at what stage of human immunodeficiency virus (HIV) disease to begin combination antiretroviral therapy, a number of clinical and public health benefits are linked to early entry into primary care soon after first testing HIV positive. However, HIV-infected patients continue to test late and del...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/108729101753205694
更新日期:2001-10-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/apc.1998.12.843
更新日期:1998-11-01 00:00:00
abstract::Two children (ages 12 and 13 years) with transfusion-acquired human immunodeficiency virus (HIV) infection presented with facial pain and rhinorrhea. Radiographic imaging showed extensive paranasal sinus disease, presumed to be bacterial sinusitis, and the patients were treated with broad-spectrum oral antibiotics. Bo...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/108729101753145439
更新日期:2001-09-01 00:00:00
abstract::Imaging is often vital in the diagnosis and staging of acquired immune deficiency syndrome (AIDS) patients with regard to infections and malignancies. Non-Hodgkin's lymphoma is an AIDS-defining illness and a common AIDS-related malignancy. These lymphomas are usually high-grade immunoblastic, primary central nervous s...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/10872910260196422
更新日期:2002-08-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 临床试验,杂志文章
doi:10.1089/apc.2004.18.629
更新日期:2004-11-01 00:00:00
abstract::The National HIV/AIDS Strategy (NHAS) calls for a reduction in health disparities, a reduction in new HIV infections, and improved retention in HIV care and treatment. It acknowledges that HIV-positive peers can play an important role in supporting these aims. However, peer training must be comprehensive enough to equ...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
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journal_title:AIDS patient care and STDs
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2008.0053
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abstract::In 2004, Cambodia, a low-income country, undertook a rapid scale-up of free antiretroviral therapy (ART) through the public sector in order to respond to the need for treatment for those living with HIV/AIDS. A cohort of patients initiating ART in a provincial national hospital was set up at the beginning of the progr...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2008.0241
更新日期:2009-08-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 临床试验,杂志文章,随机对照试验
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abstract::We report a case of dual Mycobacterium tuberculosis (TB) and Pneumocystis jiroveci (carinii) (PCP) lymphadenitis in a patient with HIV who had been receiving trimethoprim-sulfamethoxazole (TMP-SMX) as systemic prophylaxis for PCP. This patient was successfully treated with antituberculosis medications and TMP-SMX. Our...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
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abstract::HIV stigma is rooted in culture and, therefore, it is essential to investigate it within the context of culture. The objective of this study was to examine the interrelationships among individualism-collectivism, HIV stigma, and social network support. A social network study was conducted among 118 people living with ...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2014.0015
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abstract::The problem of inadequate adherence to prescribed highly active antiretroviral therapy (HAART) drug regimens to treat HIV infection and AIDS is ubiquitous. Adherence can be inadequate despite both provider and patient understanding of the consequences of nonadherence. Successful long-term treatment of HIV/AIDS require...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
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abstract::The success of highly active antiretroviral therapy (HAART) among persons living with HIV is largely dependent on strict medication adherence. Recent research suggests that alcohol and other drug use (AOD) may be an important barrier to HAART adherence. In this study, we examined the impact of AOD on HAART adherence a...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2010.0314
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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