Hepatitis C virus activation in HIV-infected patients initiating highly active antiretroviral therapy.

Abstract:

:We describe repeated episodes of hepatitis C (HCV) activation associated with initiation of highly active antiretroviral therapy (HAART) in two HIV/HCV coinfected individuals with undetectable serum HCV RNA. Both patients developed high HCV viremia (>1 million IU/mL) and elevations in aminotransferases >10 times upper limit of normal) within 4 months of starting HAART. This is the first report of clinically significant HCV activation in HCV-seropositive patients with initially undetectable HCV viremia. These observations suggest that flares of hepatitis C in the setting of the immune reconstitution inflammatory syndrome can occur even in those patients who have undetectable serum HCV levels prior to HAART initiation.

journal_name

AIDS Patient Care STDS

authors

Kim HN,Harrington RD,Shuhart MC,Cook L,Morishima C,Jerome KR,Wang CC

doi

10.1089/apc.2007.0017

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

718-23

issue

10

eissn

1087-2914

issn

1557-7449

journal_volume

21

pub_type

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