Abstract:
:Since the end of the 1980s, primary anti-Pneumocystis carinii pneumonia (PCP) prophylaxis has become a fundamental part of the global AIDS control strategy in industrialized countries. The widespread adoption of anti-PCP chemoprophylaxis has been a key element in prolonging the survival of patients with AIDS. There is general agreement on the need to begin chemoprophylaxis when individual CD4+ cell counts drop below the value of 200/microL. However, PCP still develops in up to 27% of susceptible HIV-infected patients despite regular prophylaxis intake. Failure of chemoprophylaxis may depend on different factors. The choice of the regimen and the patient's compliance to it have been the first variables to be identified, whereas the importance of the residual cellular immune function as complementary protective mechanism against PCP has emerged in subsequent clinical studies. Albeit of limited general concern, issues such as P. carinii drug resistance and defective drug absorption may play some role in prophylaxis failure in selected patients. Regarding the epidemiology of primary and recurrent episodes of PCP, recent studies based on genetic fingerprinting techniques revealed that interhuman transmission of the organism could be more relevant than so far expected, thus raising some concern of the possibility of nosocomial spread among susceptible individuals. The downgrading tendency of immune competence in HIV infection and the related increasing risk of developing PCP make it possible to envisage a two-step chemoprophylactic strategy, with the most effective compound, cotrimoxazole, to be reserved for the last and most risky disease stage, when immune response no longer provides any support for preventing the development of PCP.
journal_name
AIDS Patient Care STDSjournal_title
AIDS patient care and STDsauthors
Bonora S,Di Perri G,Vento S,Cazzadori A,Concia Edoi
10.1089/apc.1998.12.843subject
Has Abstractpub_date
1998-11-01 00:00:00pages
843-8issue
11eissn
1087-2914issn
1557-7449journal_volume
12pub_type
杂志文章,评审abstract::With the advent of the highly active antiretroviral therapy (HAART), adherence became one of the key issues within the behavioral management of the treatment of human immunodeficiency virus (HIV) infection. One of the central limitations in studying adherence to HAART is that usually one has to rely on self-reported m...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/10872910260351267
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abstract::In the past few years, major advances have been made in the field of primary HIV-1 infection. Several studies have reevaluated the clinical syndrome. The emergence of new molecular laboratory techniques has permitted a detailed analysis of viral dynamics and subsequent immunologic changes. Measurements of subsets of T...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/apc.1998.12.759
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abstract::Guidelines for HIV primary care include visits every 3 months (up to 6 months in those with stable HIV). During pregnancy, women with HIV commonly attend once weekly to once monthly visits; however, after delivery, many are lost to follow-up. Our goal was to assess the frequency of loss to primary care follow-up postp...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2008.0056
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abstract::To describe the epidemiology, outcomes, and risk factors of acute kidney injury (AKI) among human immunodeficiency virus (HIV)-infected patients admitted to the intensive care unit (ICU).We reviewed all the HIV-infected admissions to the ICU at Beijing Ditan hospital in the time span from June 2005 to May 2017 and col...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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abstract::HIV infection is increasing in minority groups, particularly in African American and Hispanic women. Although the incidence of HIV dementia has decreased since the advent of highly active antiretroviral treatment, prevalence of neurocognitive complications has increased as patients are now living longer. This study's ...
journal_title:AIDS patient care and STDs
pub_type: 临床试验,杂志文章
doi:10.1089/apc.2006.0180
更新日期:2007-12-01 00:00:00
abstract::We examined the relationships between survival after AIDS diagnosis and outpatient mental health service use among men with history of highly active antiretroviral therapy (HAART). Analysis involved 1913 black and 1684 white men with AIDS who received HIV care in 2003 in the Veterans Affairs health care system. Negati...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2009.0177
更新日期:2010-01-01 00:00:00
abstract::In 2010, New York (NY) passed new legislation mandating Emergency Departments (EDs) to offer HIV tests to patients 13-64 presenting for care. We evaluated the requirement's implementation and determined differences based on HIV prevalence or site-specific designated AIDS centers (DACs). We also evaluated policies for ...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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更新日期:2002-07-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-02-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/108729103322277402
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,多中心研究
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
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journal_title:AIDS patient care and STDs
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
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