Failure of prophylaxis against PCP in patients with HIV infection.

Abstract:

:Since the end of the 1980s, primary anti-Pneumocystis carinii pneumonia (PCP) prophylaxis has become a fundamental part of the global AIDS control strategy in industrialized countries. The widespread adoption of anti-PCP chemoprophylaxis has been a key element in prolonging the survival of patients with AIDS. There is general agreement on the need to begin chemoprophylaxis when individual CD4+ cell counts drop below the value of 200/microL. However, PCP still develops in up to 27% of susceptible HIV-infected patients despite regular prophylaxis intake. Failure of chemoprophylaxis may depend on different factors. The choice of the regimen and the patient's compliance to it have been the first variables to be identified, whereas the importance of the residual cellular immune function as complementary protective mechanism against PCP has emerged in subsequent clinical studies. Albeit of limited general concern, issues such as P. carinii drug resistance and defective drug absorption may play some role in prophylaxis failure in selected patients. Regarding the epidemiology of primary and recurrent episodes of PCP, recent studies based on genetic fingerprinting techniques revealed that interhuman transmission of the organism could be more relevant than so far expected, thus raising some concern of the possibility of nosocomial spread among susceptible individuals. The downgrading tendency of immune competence in HIV infection and the related increasing risk of developing PCP make it possible to envisage a two-step chemoprophylactic strategy, with the most effective compound, cotrimoxazole, to be reserved for the last and most risky disease stage, when immune response no longer provides any support for preventing the development of PCP.

journal_name

AIDS Patient Care STDS

authors

Bonora S,Di Perri G,Vento S,Cazzadori A,Concia E

doi

10.1089/apc.1998.12.843

subject

Has Abstract

pub_date

1998-11-01 00:00:00

pages

843-8

issue

11

eissn

1087-2914

issn

1557-7449

journal_volume

12

pub_type

杂志文章,评审
  • Therapy adherence and highly active antiretroviral therapy: comparison of three sources of information.

    abstract::With the advent of the highly active antiretroviral therapy (HAART), adherence became one of the key issues within the behavioral management of the treatment of human immunodeficiency virus (HIV) infection. One of the central limitations in studying adherence to HAART is that usually one has to rely on self-reported m...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/10872910260351267

    authors: Vincke J,Bolton R

    更新日期:2002-10-01 00:00:00

  • Primary HIV-1 infection: a review of clinical manifestations, immunologic and virologic changes.

    abstract::In the past few years, major advances have been made in the field of primary HIV-1 infection. Several studies have reevaluated the clinical syndrome. The emergence of new molecular laboratory techniques has permitted a detailed analysis of viral dynamics and subsequent immunologic changes. Measurements of subsets of T...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章,评审

    doi:10.1089/apc.1998.12.759

    authors: Kaufmann GR,Duncombe C,Zaunders J,Cunningham P,Cooper D

    更新日期:1998-10-01 00:00:00

  • Predictive factors for loss to postpartum follow-up among low income HIV-infected women in Texas.

    abstract::Guidelines for HIV primary care include visits every 3 months (up to 6 months in those with stable HIV). During pregnancy, women with HIV commonly attend once weekly to once monthly visits; however, after delivery, many are lost to follow-up. Our goal was to assess the frequency of loss to primary care follow-up postp...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2013.0321

    authors: Siddiqui R,Bell T,Sangi-Haghpeykar H,Minard C,Levison J

    更新日期:2014-05-01 00:00:00

  • High Awareness, Yet Low Uptake, of Pre-Exposure Prophylaxis Among Adolescent Girls and Young Women Within Family Planning Clinics in Kenya.

    abstract::Adolescent girls and young women (AGYW) are a priority population for HIV prevention in high-burden settings. We evaluated psychosocial characteristics, behavioral risk factors for HIV, and pre-exposure prophylaxis (PrEP) awareness and uptake among AGYW seeking contraceptive services at four public sector family plann...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2020.0037

    authors: Sila J,Larsen AM,Kinuthia J,Owiti G,Abuna F,Kohler PK,John-Stewart G,Pintye J

    更新日期:2020-08-01 00:00:00

  • Protease inhibitor resistance update: where are we now?

    abstract::The introduction of protease inhibitors (PIs) and highly active antiretroviral therapy in the mid-1990s dramatically altered the treatment of HIV infection, enabling suppression of viral replication to undetectable levels and preventing disease progression. Most PIs present a strong barrier against viral resistance; t...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2007.0099

    authors: Kim R,Baxter JD

    更新日期:2008-04-01 00:00:00

  • Impact of service delivery model on health care access among HIV-positive women in New York City.

    abstract::As the New York City HIV=AIDS epidemic began generalizing beyond traditionally high-risk groups in the early 1990s, AIDS Service Organizations (ASO) sought to increase access to medical care and broaden service offerings to incorporate the needs of low-income women and their families. Strategies to achieve entry into ...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2008.0056

    authors: Pillai NV,Kupprat SA,Halkitis PN

    更新日期:2009-01-01 00:00:00

  • Acute Kidney Injury in Chinese HIV-Infected Patients: A Retrospective Analysis from the Intensive Care Unit.

    abstract::To describe the epidemiology, outcomes, and risk factors of acute kidney injury (AKI) among human immunodeficiency virus (HIV)-infected patients admitted to the intensive care unit (ICU).We reviewed all the HIV-infected admissions to the ICU at Beijing Ditan hospital in the time span from June 2005 to May 2017 and col...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2018.0040

    authors: Pu L,Liu J,Luo Y,Zeng H,Guo H,Hao J,Yin N,Liu Y,Xiong H,Xiong J,Li A

    更新日期:2018-10-01 00:00:00

  • Spanish validation of the HIV dementia scale in women.

    abstract::HIV infection is increasing in minority groups, particularly in African American and Hispanic women. Although the incidence of HIV dementia has decreased since the advent of highly active antiretroviral treatment, prevalence of neurocognitive complications has increased as patients are now living longer. This study's ...

    journal_title:AIDS patient care and STDs

    pub_type: 临床试验,杂志文章

    doi:10.1089/apc.2006.0180

    authors: Wojna V,Skolasky RL,McArthur JC,Maldonado E,Hechavarria R,Mayo R,Selnes O,Ginebra T,de la Torre T,Garcia H,Kraiselburd E,Melendez-Guerrero LM,Zorrilla CD,Nath A

    更新日期:2007-12-01 00:00:00

  • Race, outpatient mental health service use, and survival after an AIDS diagnosis in the highly active antiretroviral therapy era.

    abstract::We examined the relationships between survival after AIDS diagnosis and outpatient mental health service use among men with history of highly active antiretroviral therapy (HAART). Analysis involved 1913 black and 1684 white men with AIDS who received HIV care in 2003 in the Veterans Affairs health care system. Negati...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2009.0177

    authors: Mkanta WN,Mejia MC,Duncan RP

    更新日期:2010-01-01 00:00:00

  • Legislated human immunodeficiency virus testing in New York State Emergency Departments: reported experience from Emergency Department providers.

    abstract::In 2010, New York (NY) passed new legislation mandating Emergency Departments (EDs) to offer HIV tests to patients 13-64 presenting for care. We evaluated the requirement's implementation and determined differences based on HIV prevalence or site-specific designated AIDS centers (DACs). We also evaluated policies for ...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2013.0124

    authors: Egan DJ,Cowan E,Fitzpatrick L,Savitsky L,Kushner J,Calderon Y,Agins BD

    更新日期:2014-02-01 00:00:00

  • Long-term treatment with subcutaneous T-20, a fusion inhibitor, in HIV-infected patients: patient satisfaction and impact on activities of daily living.

    abstract::T-20 is a novel antiretroviral agent that inhibits the fusion of human immunodeficiency virus (HIV) with target cell membranes. It is delivered by self-administered, twice-daily, subcutaneous injections. The impact of this mode of administration on patients' ability to conduct normal activities of daily living (ADL) a...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/108729102320231162

    authors: Cohen CJ,Dusek A,Green J,Johns EL,Nelson E,Recny MA

    更新日期:2002-07-01 00:00:00

  • Sexual Risk Behaviors Associated with Sexually Transmitted Infections in a US Military Population Living with HIV After the Repeal of "Don't Ask, Don't Tell".

    abstract::Risk behaviors associated with sexually transmitted infections (STIs) among people living with HIV (PLWH) have not been well characterized in the US military. We identified risk behaviors associated with a new STI in this population after the repeal of "Don't Ask, Don't Tell." US Military HIV Natural History Study par...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2020.0095

    authors: Noiman A,Macalino G,Won SH,Byrne M,Deiss R,Haw NJ,Ganesan A,Okulicz JF,Schofield C,Lalani T,Maves RC,Wang X,Agan BK,Infectious Disease Clinical Research Program HIV Working Group.

    更新日期:2020-12-01 00:00:00

  • Effect of highly active antiretroviral therapy on the incidence of HIV-related cytomegalovirus retinitis and retinal detachment.

    abstract::Cytomegalovirus retinitis (CMVR) is the most common intraocular infection encountered in ophthalmic practices. To assess the impact of highly active antiretroviral therapy (HAART) on the incidence of CMVR and subsequent retinal detachments, a retrospective review of the HIV+ patients seen at a single university and co...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/108729100413202

    authors: Jalali S,Reed JB,Mizoguchi M,Flynn N,Gordon J,Morse LS

    更新日期:2000-07-01 00:00:00

  • A pilot study of the effects of cognitive-behavioral group therapy and peer support/counseling in decreasing psychologic distress and improving quality of life in Chinese patients with symptomatic HIV disease.

    abstract::Forty-six Chinese patients with symptomatic human immunodeficiency virus (HIV) participated in a comparative study assessing the effectiveness of cognitive-behavioral group therapy (CBT) and peer support/counseling group therapy (PSC) in relation to improving mood and quality of life and decreasing uncertainty in illn...

    journal_title:AIDS patient care and STDs

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1089/10872910252806135

    authors: Molassiotis A,Callaghan P,Twinn SF,Lam SW,Chung WY,Li CK

    更新日期:2002-02-01 00:00:00

  • Thrombotic thrombocytopenic purpura in HIV infection: a report of two cases.

    abstract::Thrombotic thrombocytopenic purpura (TTP) is a rare but well-described complication of HIV infection, which occurs equally frequently during the early asymptomatic phase of HIV infection and with clinical AIDS. The clinical spectrum varies from a low-grade asymptomatic thrombocytopenia with mild renal insufficiency to...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.1996.10.349

    authors: Sood R,Rakkar AS,Carmosino L,Mir T,Khan FA

    更新日期:1996-12-01 00:00:00

  • Timing of antiretroviral therapy initiation in a nationally representative sample of HIV-infected adults receiving medical care in the United States.

    abstract::Early antiretroviral therapy (ART) initiation reduces the risk of disease progression and HIV transmission, but data on time from HIV care entry to ART initiation are lacking. Using data from the Medical Monitoring Project (MMP), a population-based probability sample of HIV-infected adults receiving medical care in th...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2014.0194

    authors: Adedinsewo DA,Wei SC,Robertson M,Rose C,Johnson CH,Dombrowski J,Skarbinski J

    更新日期:2014-12-01 00:00:00

  • Development pharmaceutics of microbicide formulations. Part II: formulation, evaluation, and challenges.

    abstract::In recent years, AIDS and sexually transmitted diseases (STDs) have become a burgeoning problem and are spreading at an alarming rate. Microbicides are being developed as a new therapeutic category for prevention of transmission of sexually transmitted infections (STIs) and HIV. Many of the microbicide formulations (M...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章,评审

    doi:10.1089/108729103322277402

    authors: Garg S,Tambwekar KR,Vermani K,Kandarapu R,Garg A,Waller DP,Zaneveld LJ

    更新日期:2003-08-01 00:00:00

  • Preventing and managing antiretroviral drug resistance.

    abstract::Development of resistance to antiretroviral drugs (ARVs) is a major impediment to optimum treatment of HIV-1 infection. Although resistance testing can help to select subsequent regimens when virologic failure occurs, cross-resistance, which affects all classes of ARVs, may make it more difficult to achieve optimum co...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章,评审

    doi:10.1089/108729104323076007

    authors: Kuritzkes DR

    更新日期:2004-05-01 00:00:00

  • Nurses' knowledge, attitudes, and practice related to HIV transmission in northeastern China.

    abstract::The purpose of this study was to describe what nurses know about HIV/AIDS in the First Affiliated Hospital of Jiamusi University, Heilongjiang Province, China. This was a descriptive, cross-sectional study. Only 7.9% of the nurse (n = 177) used condoms during their first experience of sexual intercourse. Eight-six per...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/1087291041518247

    authors: Chen WT,Han M,Holzemer WL

    更新日期:2004-07-01 00:00:00

  • Sadness in the SUN: using computerized screening to analyze correlates of depression and adherence in HIV-infected adults in the United States.

    abstract::We used a standardized screening tool to examine frequency of depression and its relation to antiretroviral medication adherence among HIV-infected persons on highly active antiretroviral therapy (HAART) in the Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy (SUN Study). This is a p...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章,多中心研究

    doi:10.1089/apc.2012.0132

    authors: Tedaldi EM,van den Berg-Wolf M,Richardson J,Patel P,Durham M,Hammer J,Henry K,Metzler S,Önen N,Conley L,Wood K,Brooks JT,Buchacz K,SUN Study Investigators.

    更新日期:2012-12-01 00:00:00

  • Reactions and Receptivity to Framing HIV Prevention Message Concepts About Pre-Exposure Prophylaxis for Black and Latino Men Who Have Sex with Men in Three Urban US Cities.

    abstract::Men who have sex with men (MSM) of color are disproportionately affected by HIV in the United States. Pre-exposure prophylaxis (PrEP) using antiretroviral medications is a newer biomedical prevention modality with established efficacy for reducing the risk of acquiring HIV. We conducted formative qualitative research ...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2016.0123

    authors: Mimiaga MJ,Closson EF,Battle S,Herbst JH,Denson D,Pitts N,Holman J,Landers S,Mansergh G

    更新日期:2016-10-01 00:00:00

  • The effect of a multidisciplinary program on HAART adherence.

    abstract::Although emerging evidence suggests differing interventions may improve antiretroviral adherence, there has not been a formal evaluation to identify the impact of a clinic-based multidisciplinary program designed to provide education and identify and correct potential adherence barriers prior to the initiation of high...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2006.20.511

    authors: Frick P,Tapia K,Grant P,Novotny M,Kerzee J

    更新日期:2006-07-01 00:00:00

  • The multidimensional context of HIV/AIDS patient care.

    abstract::This article argues that enhancing efficacious social networks or developing new adaptive social ties for HIV-infected individuals without adequate social resources may enhance their adaptive response to the disease and its treatment. It further suggests that the success of an adaptive response to the disease may to s...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章,评审

    doi:10.1089/108729100750018326

    authors: Tsasis P

    更新日期:2000-10-01 00:00:00

  • Barriers and Facilitators to HIV Testing Among Zambian Female Sex Workers in Three Transit Hubs.

    abstract::Zambia has a generalized HIV epidemic, and HIV is concentrated along transit routes. Female sex workers (FSWs) are disproportionately affected by the epidemic. HIV testing is the crucial first step for engagement in HIV care and HIV prevention activities. However, to date little work has been done with FSWs in Zambia,...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2017.0016

    authors: Chanda MM,Perez-Brumer AG,Ortblad KF,Mwale M,Chongo S,Kamungoma N,Kanchele C,Fullem A,Barresi L,Bärnighausen T,Oldenburg CE

    更新日期:2017-07-01 00:00:00

  • Screening and Management of HIV-2-Infected Individuals in Northern Italy.

    abstract::There is a lack of updated estimates of HIV-2 infection in Italy. Moreover, lack of standardized HIV-2 viral load (VL) and drug resistance tests challenges clinical practice. Among 2941 HIV-positive patients followed in our center (Brescia, Northern Italy), 220 (7.5%) were African at the beginning of the study period....

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2007.0149

    authors: Costarelli S,Torti C,Rodella A,Baldanti F,Paolucci S,Lapadula G,Manca N,Quiros-Roldan E,Izzo I,Carosi G

    更新日期:2008-06-01 00:00:00

  • The hemostatic balance in HIV-infected patients with and without antiretroviral therapy: partial restoration with antiretroviral therapy.

    abstract::The incidence of arterial and venous thrombosis in HIV-infected patients is increased compared to healthy controls. In this cross-sectional analysis we measured markers of endothelial cell activation, thrombin generation, fibrinolysis and anticoagulation combined with endogenous thrombin potential (ETP) and activated ...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2009.0173

    authors: Jong E,Louw S,Meijers JC,de Kruif MD,ten Cate H,Büller HR,Mulder JW,van Gorp EC

    更新日期:2009-12-01 00:00:00

  • Psychosocial challenges and strategies for coping with HIV among adolescents in Uganda: a qualitative study.

    abstract::Although more than 90% of youth perinatally infected with HIV live in sub-Saharan Africa, little is known about the psychosocial factors that impact their wellbeing, or how these youth cope with these challenges. The purpose of this study was to identify the psychosocial challenges and coping strategies among perinata...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2014.0222

    authors: Mutumba M,Bauermeister JA,Musiime V,Byaruhanga J,Francis K,Snow RC,Tsai AC

    更新日期:2015-02-01 00:00:00

  • Psychosocial issues of women with HIV/AIDS.

    abstract::This article discusses some of the issues specifically associated with women and HIV. The myth is that women do not get AIDS and that lesbians do not get AIDS either. It also explores the unique sociocultural context in which HIV-infected women exist. The hope is to put faces on the numbers that are increasing each da...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.1999.13.119

    authors: Broun SN

    更新日期:1999-02-01 00:00:00

  • The spectrum of eye disease in hospitalized adults living with HIV, 1995-2010.

    abstract::Eye disease is a well-documented complication of HIV infection. Opportunistic infections generally comprised the majority of pre-antiretroviral therapy (ART) eye complications. With the introduction of ART, opportunistic infections diminished. However, early ART regimens were cumbersome regarding side effects and pill...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章

    doi:10.1089/apc.2013.0258

    authors: Miller C,Short WR,Perez-Povis L,Lontok J,Fecarotta C,Liu M,Sendecki J,Belden K

    更新日期:2014-02-01 00:00:00

  • Challenges for HIV vaccine dissemination and clinical trial recruitment: if we build it, will they come?

    abstract::HIV vaccine availability does not guarantee uptake. Given suboptimal uptake of highly efficacious and already accessible vaccines in the United States, low vaccine coverage in the developing world, and the expectation that initial HIV vaccines will be only partially efficacious, the public health community will face f...

    journal_title:AIDS patient care and STDs

    pub_type: 杂志文章,评审

    doi:10.1089/apc.2004.18.691

    authors: Newman PA,Duan N,Rudy ET,Anton PA

    更新日期:2004-12-01 00:00:00